Associate Director Clinical Operations Jobs
Associate Director Clinical Operations jobs are open across pharmaceutical, biotechnology, medical device, and contract research organizations, from mid-level management to senior director, with specializations in oncology trials, regulatory compliance, and site management. Find a role that fits from the openings below and apply directly.
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Shattuckians are a diverse group of physicians, scientists, drug developers and protein engineers that are linked through our shared desire to build transformative medicines for patients suffering from life-altering diseases. We are experts in the biology of TNF receptors, including DR3, and have assembled one of the most experienced teams in the industry with regard to understanding the immuno-biology of TNF receptor agonists and antagonists.
Summary
Responsibilities
- Lead the design, implementation, and management of clinical trial operations from study start-up through close-out.
- Provide primary oversight for the CRO, ensuring that CRO activities are executed per study timelines. Maintain frequent and meaningful contact with the CRO to assess performance and provide oversight and guidance as needed.
- Collaborate with cross-functional departments such as Regulatory Affairs, Data Management, and Clinical Development to ensure alignment and compliance.
- Ensure adherence to all regulatory requirements, company policies, and industry standards including FDA regulations and ICH-GCP guidelines.
- Identify and mitigate operational risks, implementing corrective actions as necessary to maintain study integrity and patient safety.
- Drive process improvements and implement best practices to enhance clinical trial efficiency and data quality.
- Contribute to review of other study documents such as protocols/amendments, eCRFs, clinical study reports, IBs, DSURs, conference presentations, publications, etc.
- In coordination with the cross-functional team, participate in the RFP process and ultimately select CROs and other vendors for clinical trials.
- Participate in the selection of investigational sites with input from relevant stakeholders. Lead the study and site feasibility process in association with the CRO. Assess site and investigator performance and enrollment on a regular basis.
- Develop and oversee clinical operations budgets, timelines, and resource plans to ensure project milestones are met.
- Work closely with Clinical team members to ensure investigational product needs for clinical studies are available and managed appropriately.
- Partner closely with internal functional areas to operationalize the procurement and analysis of biological samples for the study, including contributing to lab manuals, identifying vendors for lab kitting and sample management, and providing regular training and feedback to sites regarding completeness and quality of sample collection.
- Oversee the creation and maintenance of all trial files, including the trial master file. Work with quality assurance to ensure inspection readiness of sites and implement risk-based quality management of the clinical study.
- Mentor clinical operations team members to promote professional growth and high performance.
Qualifications and skills
- Bachelor’s or Masters degree in science or health care with a minimum of10+years of Clinical Operations experience, including at least 8 years in direct management of clinical trials.
- Knowledge of clinical drug development, with experience in Phases I-III, CRO/vendor oversight, global clinical trials, and budget/timeline management.
- Thorough understanding of ICH GCP and FDA guidelines.
- Strong interpersonal skills with demonstrated ability to effectively work with internal cross-functional as well as external groups.
- Good communication and interpersonal skills and ability to work with cross-functional teams.
- Self-starter with an entrepreneurial spirit and a good team player.
Employee Benefits
- Competitive salary and health benefits, 401k.
- Opportunities for training and career advancement.
- Collaborative and inclusive work environment.
- Access to cutting-edge research and technology.
Note to External Recruiters
Our Human Resources department manages all open positions and candidate recruitment. We ask that recruiters not contact employees or hiring managers directly to present candidates or solicit business. We will consider failure to comply with this request when determining whether to enter a professional relationship with a recruiting agency. The submission of unsolicited resumes does not create any obligations for Shattuck Labs, implied or otherwise.
Associate Director Clinical Operations Jobs by Experience Level
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Find JobsAssociate Director Clinical Operations Job Market
Who's Hiring
Top Industries Hiring
- Biotechnology & Pharmaceuticals11
- Science & Research6
- Medical Devices1
- Distribution & Wholesale1
- Healthcare & Medical Services1
What Employers Look For
The qualifications that appear most often in associate director clinical operations jobs.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- Five or more years of clinical trial management experience across multiple phases
- Deep knowledge of ICH-GCP guidelines, FDA regulations, and clinical operations SOPs
- Experience managing CROs, investigator sites, and cross-functional study teams
- Proficiency with clinical trial management systems such as Veeva Vault or Medidata Rave
- Strong budget oversight, resource planning, and risk mitigation experience across concurrent studies
Tips for Your Associate Director Clinical Operations Job Search
Quantify your trial portfolio on your resume
Hiring managers want to see the number of Phase I through IV trials you've overseen, the therapeutic areas involved, and the size of the site networks you managed. Replace vague responsibility statements with concrete scope so your experience reads at the right level.
Tailor your resume to each sponsor type
A pharma sponsor prioritizes GCP compliance and FDA submission readiness, while a CRO values throughput, client management, and multi-study oversight. Adjust which accomplishments you lead with depending on whether the employer runs its own pipeline or manages trials for clients.
Target openings by therapeutic area first
Associate director clinical operations roles in oncology, rare disease, and CNS attract narrower candidate pools than general listings, which means less competition if your background matches. Filter your search by indication before filtering by company size or location.
Apply early to roles that fit
Migrate Mate lists associate director clinical operations openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare a cross-functional leadership example for interviews
Interviewers at this level consistently ask how you've aligned clinical, regulatory, data management, and biostatistics teams under a single timeline. Have a specific trial ready where you resolved a cross-functional bottleneck, and walk through your decision-making rather than the outcome alone.
Negotiate start date and study assignment together
At the associate director level, the study you inherit on day one shapes your first year of performance reviews. When an offer is extended, it's reasonable to ask which programs you'd be assigned to and whether there's flexibility on timing if a trial is mid-enrollment.
Associate Director Clinical Operations Jobs: Frequently Asked Questions
Which companies are hiring the most associate director clinical operations?
The companies hiring the most associate director clinical operationss right now include Revolution Medicines, MannKind Corporation, and Flagship Pioneering, with the largest share of openings in California, Massachusetts, and Florida, based on current listings on Migrate Mate as of August 2026. Activity tends to be highest at large-cap pharma companies and mid-size biotechs advancing late-stage pipelines.
How many associate director clinical operations jobs are remote?
About 37% of associate director clinical operations openings are fully remote or hybrid as of August 2026, reflecting the field's shift toward centralized monitoring and virtual oversight models. Roles focused on data review, vendor oversight, and cross-functional program management tend to offer the most location flexibility, while positions tied to site activation or on-site auditing typically require more travel.
How do you become an associate director clinical operations?
Most associate director clinical operations professionals start as clinical research associates or study coordinators, then move into clinical trial manager or senior manager roles before stepping up. Building experience across multiple therapeutic areas and trial phases, leading cross-functional teams, and demonstrating budget and vendor management skills are the steps that consistently precede promotion into this level.
Can you get an associate director clinical operations job with limited experience?
Getting hired at the associate director level with limited direct experience is difficult, but candidates who have managed complex Phase II or III trials end-to-end, led CRO relationships, or stepped into acting leadership during a vacancy can make a credible case. Targeting smaller biotechs or CROs that promote from within gives you the best chance of bridging a gap in formal title history.
What does the associate director clinical operations interview process look like?
The process typically starts with a recruiter screen focused on therapeutic area background and trial phase experience, followed by a hiring manager interview that goes deep on study oversight, cross-functional leadership, and regulatory knowledge. Later rounds often involve panel interviews with clinical, regulatory, and data management stakeholders, and some organizations ask for a written case study or presentation on a hypothetical protocol challenge.
Where can I find and apply to associate director clinical operations jobs?
You can find and apply to associate director clinical operations jobs on Migrate Mate, which lists current openings from across the United States. Find the roles that fit your therapeutic area, experience level, and work location preferences, then apply directly to each listing from the page.
See All 45 Associate Director Clinical Operations Jobs
Find roles that match your experience and apply in just a few clicks.
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