Senior Level Chief Operating Officer Jobs

Senior level chief operating officer jobs place experienced leaders at the center of enterprise-wide execution, where they own operational strategy, direct cross-functional teams, and are accountable for outcomes at scale. Openings concentrate in Biotechnology & Pharmaceuticals, Technology & Software, and Healthcare & Medical Services, with a mix of on-site, hybrid, and remote roles available, and employers like Revolution Medicines, Jobot, and The Waters hiring at this level now.

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Overview

Open roles132+
Top stateCalifornia
Top employerRevolution Medicines
Top cityBrisbane, CA
Work type67% On-site
Top industryBiotechnology

Showing 4 of 132+ Senior Level Chief Operating Officer jobs

Associate Director, Business Operations
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Added 1d ago
Associate Director, Business Operations
Revolution Medicines
San Francisco Bay Area
Project & Program Management
Business Operations
Project Management
$233k/yr
On-Site
Bachelor's

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Director of Pharmacy Operations - New York
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Added 2d ago
Director of Pharmacy Operations - New York
Optum
Albany, New York
Customer Service
Healthcare Administration
Human Resources
$135k - $231k/yr
10,000+

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Director DC Operations II
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Added 3d ago
Director DC Operations II
Bob's Discount Furniture
Solon, Ohio
Procurement & Supply Chain
Project & Program Management
Business Operations
Supply Chain
Logistics & Fleet Management
$141k - $176k/yr
On-Site
Bachelor's
5,001-10,000

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Regional Director of Operations
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Added 3d ago
Regional Director of Operations
PTS Advance
Denver, Colorado
Project & Program Management
Business Operations
Human Resources
Sales
Consulting & Professional Services
Project Management
On-Site
None

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Senior Level Chief Operating Officer Job Market

Who's Hiring

  • Revolution Medicines10
  • Jobot4
  • The Waters4
  • Michels3
  • Bain & Company3

Top Industries Hiring

  • Biotechnology & Pharmaceuticals23
  • Technology & Software18
  • Healthcare & Medical Services11
  • Consulting & Professional Services10
  • Education9

Senior Level Chief Operating Officer Jobs: Frequently Asked Questions

How do I get a senior level chief operating officer job?

Employers at this level look for candidates who have led large-scale operational change, owned P&L or enterprise-wide outcomes, and built or restructured teams. A strong edge comes from demonstrating cross-functional authority, not just functional expertise. Executives who can show measurable results from initiatives they personally drove, and who bring board-level communication experience, move to the top of candidate lists.

Which companies hire senior level chief operating officers?

Companies hiring senior level chief operating officers right now include Revolution Medicines, Jobot, and The Waters, based on current listings on Migrate Mate as of November 2026. Hiring at this level comes from a mix of enterprise corporations, high-growth companies scaling their operations, and organizations navigating significant transformation or expansion.

Are there remote senior level chief operating officer jobs?

Yes, though on-site and hybrid arrangements are common at this leadership tier. About 33% of senior level chief operating officer openings are remote or hybrid as of November 2026, reflecting that many organizations require executive presence for culture-setting and cross-functional alignment while still offering flexibility in how that presence is structured.

What makes a chief operating officer role senior level?

Senior level chief operating officer roles are defined by enterprise-wide scope, direct accountability for operational performance, and authority over multiple functions or business units. These positions typically involve setting operational strategy rather than executing within it, mentoring other leaders, and serving as a key decision-maker alongside the CEO. The distinction from mid-level roles is ownership of outcomes, not just oversight of processes.

Which industries hire the most senior level chief operating officers?

Senior Level chief operating officer roles concentrate in Biotechnology & Pharmaceuticals, Technology & Software, and Healthcare & Medical Services, based on current listings on Migrate Mate as of November 2026. These sectors tend to drive demand at this level because they operate at significant scale, face ongoing operational complexity, and require experienced executives who can align people, process, and technology across large organizations.