Senior Level Clinical Data Manager Jobs
Senior level clinical data manager jobs place experienced professionals at the helm of study-level data strategy, quality oversight, and the cross-functional teams that deliver clean, submission-ready datasets. The role is predominantly remote or hybrid across Biotechnology & Pharmaceuticals, Consulting & Professional Services, and Insurance, with employers like PTC Therapeutics, Revolution Medicines, and CVS Health hiring at this level now.
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Showing 5 of 28+ Senior Level Clinical Data Manager jobs
We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time.
Position Summary
CVS Health is seeking an experienced technical leader in AI and machine learning to join CVS Health's enterprise clinical intelligence platform as a Lead Director, Clinical AI. AI is unlocking new possibilities in healthcare at unprecedented pace, and with that pace comes the responsibility to build capabilities that are clinically rigorous, ethically grounded, and worthy of the trust patients and providers place in them. This role leads the AI strategy and talent behind a growing portfolio focused on maximizing the utility of clinical data to generate evidence-backed insights that power use cases across multiple CVS Health businesses.
The successful candidate will set the direction for how the portfolio develops, evaluates, and operates its clinical AI, spanning model development, evaluation rigor, governance and responsible AI, cost efficiency, latency, reliability, and scalability, in close partnership with product and engineering. This leader will partner with product and engineering peers to ensure the portfolio's capabilities fit coherently within the broader clinical intelligence platform and that all use of AI aligns with CVS Health and regulatory policies, procedures, and standards. They will directly manage and develop a team of data scientists staffed across the portfolio's squads, growing the bench of senior technical leaders who will scale with the work.
This role sits at the center of building and running production clinical AI at enterprise scale. It is not a research role, and the successful candidate will be energized by the discipline of shipping, operating, and continuously improving software that clinicians and members depend on every day. It requires close collaboration and partnership with product and engineering peers.
What You’ll Do
Set the AI strategy and technical goals for the portfolio in partnership with product and engineering, defining what excellent looks like for clinical AI capabilities in production and how progress against that bar is measured.
Co-shape the technical direction of the portfolio's capabilities in close partnership with product and engineering, resolving cross-discipline tradeoffs at the portfolio level so squads operate against a unified direction.
Ensure the portfolio's clinical AI capabilities fit coherently within the broader clinical intelligence platform, building on shared architectural patterns and data foundations rather than in isolation.
Ensure all use of AI in the portfolio aligns with CVS Health and regulatory policies, procedures, and standards, translating those requirements into concrete engineering and modeling practices the squads adopt.
Advance the portfolio's use of modern AI and machine learning techniques, including large language models and generative AI, to extract structured, evidence-linked insight from clinical data at scale.
Raise the bar on model evaluation, monitoring, and clinical validation so the portfolio ships and operates capabilities that are trustworthy, auditable, and clinically defensible.
Drive continuous improvement in the cost, latency, reliability, and scalability of the portfolio's clinical AI in production, so the platform can support growing demand across businesses and use cases without rework.
Accelerate time-to-market for new clinical AI capabilities by championing reusable model patterns, evaluation harnesses, and generalizable approaches that squads adopt rather than rebuild.
Directly manage and develop a team of data scientists staffed across the portfolio's squads, holding accountability for their performance, growth, and engagement.
Hire, coach, and retain top clinical AI talent, and grow the bench of senior technical leaders who will scale with the portfolio.
Required Qualifications
10+ years of experience in analytics, data science, or applied AI, with hands-on depth in developing and deploying machine learning and deep learning solutions, including modern approaches to natural language processing, large language models, and generative AI.
5+ years setting AI/ML technical direction across multiple teams, coordinating across product, engineering, and business stakeholders.
5+ years of people management experience with a proven track record of hiring, developing, and retaining strong technical teams.
Experience delivering healthcare AI or analytics capabilities to production at enterprise scale, including working with clinical, claims, or member data.
Deep, hands-on experience applying modern production ML discipline, including model evaluation, monitoring, lifecycle management, and managing tradeoffs across cost, latency, reliability, and scalability.
Hands-on experience operating inside healthcare AI regulatory and responsible AI constraints, including HIPAA, NCQA or equivalent quality standards, and emerging AI governance guidance.
Fluent in Python and SQL, with the ability to read, review, and guide the team's technical work at the code and model level.
Strong communication and collaboration skills, including the ability to operate as a peer with senior product and engineering leaders and to represent complex technical strategy and tradeoffs to executive audiences.
Preferred Qualifications
Experience leading in a squad-based or product operating model, or comparable cross-functional team-of-teams structure.
Deep experience with clinical data from EMR systems, digital chart ingestion pipelines, and unstructured clinical documents such as notes, discharge summaries, and imaging reports.
Experience partnering with clinical informatics, medical directors, screening & diagnosis, quality measurement, or care management stakeholders on AI-driven clinical products.
Experience with AI evaluation and benchmarking frameworks, including approaches for validating clinical AI performance against clinical ground truth and industry benchmarks.
Education
Bachelor's degree or equivalent work experience in Mathematics, Statistics, Computer Science, Economics, Physics, Engineering, Biomedical Engineering, Bioinformatics, Health Informatics, or a related discipline.
Master’s degree or higher preferred.
Pay Range
The typical pay range for this role is:
$144,200.00 - $288,400.00
This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, geography and other relevant factors. This position is eligible for a CVS Health bonus, commission or short-term incentive program in addition to the base pay range listed above. This position also includes an award target in the company’s equity award program.
Our people fuel our future. Our teams reflect the customers, patients, members and communities we serve and we are committed to fostering a workplace where every colleague feels valued and that they belong.
Great benefits for great people
We take pride in offering a comprehensive and competitive mix of pay and benefits that reflects our commitment to our colleagues and their families.
This full‑time position is eligible for a comprehensive benefits package designed to support the physical, emotional, and financial well‑being of colleagues and their families. The benefits for this position include medical, dental, and vision coverage, paid time off, retirement savings options, wellness programs, and other resources, based on eligibility.
Additional details about available benefits are provided during the application process and on Benefits Moments.
We anticipate the application window for this opening will close on: 10/30/2026
Qualified applicants with arrest or conviction records will be considered for employment in accordance with all federal, state and local laws.
We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time.
Position Summary
CVS Health is seeking an experienced technical leader in AI and machine learning to join CVS Health's enterprise clinical intelligence platform as a Lead Director, Clinical AI. AI is unlocking new possibilities in healthcare at unprecedented pace, and with that pace comes the responsibility to build capabilities that are clinically rigorous, ethically grounded, and worthy of the trust patients and providers place in them. This role leads the AI strategy and talent behind a growing portfolio focused on maximizing the utility of clinical data to generate evidence-backed insights that power use cases across multiple CVS Health businesses.
The successful candidate will set the direction for how the portfolio develops, evaluates, and operates its clinical AI, spanning model development, evaluation rigor, governance and responsible AI, cost efficiency, latency, reliability, and scalability, in close partnership with product and engineering. This leader will partner with product and engineering peers to ensure the portfolio's capabilities fit coherently within the broader clinical intelligence platform and that all use of AI aligns with CVS Health and regulatory policies, procedures, and standards. They will directly manage and develop a team of data scientists staffed across the portfolio's squads, growing the bench of senior technical leaders who will scale with the work.
This role sits at the center of building and running production clinical AI at enterprise scale. It is not a research role, and the successful candidate will be energized by the discipline of shipping, operating, and continuously improving software that clinicians and members depend on every day. It requires close collaboration and partnership with product and engineering peers.
What You’ll Do
Set the AI strategy and technical goals for the portfolio in partnership with product and engineering, defining what excellent looks like for clinical AI capabilities in production and how progress against that bar is measured.
Co-shape the technical direction of the portfolio's capabilities in close partnership with product and engineering, resolving cross-discipline tradeoffs at the portfolio level so squads operate against a unified direction.
Ensure the portfolio's clinical AI capabilities fit coherently within the broader clinical intelligence platform, building on shared architectural patterns and data foundations rather than in isolation.
Ensure all use of AI in the portfolio aligns with CVS Health and regulatory policies, procedures, and standards, translating those requirements into concrete engineering and modeling practices the squads adopt.
Advance the portfolio's use of modern AI and machine learning techniques, including large language models and generative AI, to extract structured, evidence-linked insight from clinical data at scale.
Raise the bar on model evaluation, monitoring, and clinical validation so the portfolio ships and operates capabilities that are trustworthy, auditable, and clinically defensible.
Drive continuous improvement in the cost, latency, reliability, and scalability of the portfolio's clinical AI in production, so the platform can support growing demand across businesses and use cases without rework.
Accelerate time-to-market for new clinical AI capabilities by championing reusable model patterns, evaluation harnesses, and generalizable approaches that squads adopt rather than rebuild.
Directly manage and develop a team of data scientists staffed across the portfolio's squads, holding accountability for their performance, growth, and engagement.
Hire, coach, and retain top clinical AI talent, and grow the bench of senior technical leaders who will scale with the portfolio.
Required Qualifications
10+ years of experience in analytics, data science, or applied AI, with hands-on depth in developing and deploying machine learning and deep learning solutions, including modern approaches to natural language processing, large language models, and generative AI.
5+ years setting AI/ML technical direction across multiple teams, coordinating across product, engineering, and business stakeholders.
5+ years of people management experience with a proven track record of hiring, developing, and retaining strong technical teams.
Experience delivering healthcare AI or analytics capabilities to production at enterprise scale, including working with clinical, claims, or member data.
Deep, hands-on experience applying modern production ML discipline, including model evaluation, monitoring, lifecycle management, and managing tradeoffs across cost, latency, reliability, and scalability.
Hands-on experience operating inside healthcare AI regulatory and responsible AI constraints, including HIPAA, NCQA or equivalent quality standards, and emerging AI governance guidance.
Fluent in Python and SQL, with the ability to read, review, and guide the team's technical work at the code and model level.
Strong communication and collaboration skills, including the ability to operate as a peer with senior product and engineering leaders and to represent complex technical strategy and tradeoffs to executive audiences.
Preferred Qualifications
Experience leading in a squad-based or product operating model, or comparable cross-functional team-of-teams structure.
Deep experience with clinical data from EMR systems, digital chart ingestion pipelines, and unstructured clinical documents such as notes, discharge summaries, and imaging reports.
Experience partnering with clinical informatics, medical directors, screening & diagnosis, quality measurement, or care management stakeholders on AI-driven clinical products.
Experience with AI evaluation and benchmarking frameworks, including approaches for validating clinical AI performance against clinical ground truth and industry benchmarks.
Education
Bachelor's degree or equivalent work experience in Mathematics, Statistics, Computer Science, Economics, Physics, Engineering, Biomedical Engineering, Bioinformatics, Health Informatics, or a related discipline.
Master’s degree or higher preferred.
Pay Range
The typical pay range for this role is:
$144,200.00 - $288,400.00
This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, geography and other relevant factors. This position is eligible for a CVS Health bonus, commission or short-term incentive program in addition to the base pay range listed above. This position also includes an award target in the company’s equity award program.
Our people fuel our future. Our teams reflect the customers, patients, members and communities we serve and we are committed to fostering a workplace where every colleague feels valued and that they belong.
Great benefits for great people
We take pride in offering a comprehensive and competitive mix of pay and benefits that reflects our commitment to our colleagues and their families.
This full‑time position is eligible for a comprehensive benefits package designed to support the physical, emotional, and financial well‑being of colleagues and their families. The benefits for this position include medical, dental, and vision coverage, paid time off, retirement savings options, wellness programs, and other resources, based on eligibility.
Additional details about available benefits are provided during the application process and on Benefits Moments.
We anticipate the application window for this opening will close on: 10/30/2026
Qualified applicants with arrest or conviction records will be considered for employment in accordance with all federal, state and local laws.
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Senior Level Clinical Data Manager Jobs: Frequently Asked Questions
How do I get a senior level clinical data manager job?
Employers at this level expect candidates who can own the full data management lifecycle across multiple concurrent trials, not just execute tasks. Demonstrating experience authoring and reviewing data management plans, leading CDM teams, and working directly with biostatistics and regulatory affairs sets a candidate apart. Proficiency in industry-standard systems like Medidata Rave or Oracle Clinical, combined with a history of mentoring junior staff, signals readiness for senior responsibility.
Which companies hire senior level clinical data managers?
Companies hiring senior level clinical data managers right now include PTC Therapeutics, Revolution Medicines, and CVS Health, based on current listings on Migrate Mate as of August 2026. Hiring at this level covers large pharmaceutical and biotechnology companies, global contract research organizations, and medical device manufacturers with active late-phase or post-market study portfolios.
Are there remote senior level clinical data manager jobs?
Yes, remote work is well established at this level given the desk-based, systems-driven nature of the role. About 57% of senior level clinical data manager openings are remote or hybrid as of August 2026, reflecting how broadly the industry has adopted distributed CDM teams since clinical operations shifted during the pandemic.
What makes a clinical data manager role senior level?
Senior level clinical data manager roles are defined by ownership and scope rather than task execution. Professionals at this stage lead data management strategy for entire programs or therapeutic areas, author and approve data management plans, resolve complex protocol and data issues with minimal oversight, and mentor or manage junior and mid-level CDM staff. Cross-functional leadership with biometrics, regulatory, and clinical operations teams is a core expectation, not an occasional responsibility.
Which industries hire the most senior level clinical data managers?
Senior level clinical data manager roles concentrate in Biotechnology & Pharmaceuticals, Consulting & Professional Services, and Insurance, based on current listings on Migrate Mate as of August 2026. These sectors drive hiring because they run the largest volumes of regulated clinical trials, require experienced data managers who understand submission requirements, and depend on high-quality datasets to support regulatory approvals and post-market commitments.