Clinical Nurse Jobs in Chicago, IL
Clinical Nurse jobs in Chicago are in strong demand, with openings concentrated in the Medical District, Streeterville, and Hyde Park across major health systems, academic medical centers, and specialty clinics. Employers actively hiring right now include Northwestern Medicine, Rush University Medical Center, and UChicago Medicine. See the openings below and apply to the ones that match your experience.
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At Northwestern Medicine, every patient interaction makes a difference in cultivating a positive workplace. This patient-first approach is what sets us apart as a leader in the healthcare industry. As an integral part of our team, you'll have the opportunity to join our quest for better health care, no matter where you work within the Northwestern Medicine system. We pride ourselves on providing competitive benefits: from tuition reimbursement and loan forgiveness to 401(k) matching and lifecycle benefits, our goal is to take care of our employees. Ready to join our quest for better?
Job Description
The Clinical Research Nurse Coordinator reflects the mission, vision, and values of NM, adheres to the organization’s Code of Ethics and Corporate Compliance Program, and complies with all relevant policies, procedures, guidelines and all other regulatory and accreditation standards.
The Clinical Research Nurse Coordinator is a registered professional nurse who demonstrates exemplary clinical research knowledge, has strong communication skills and is responsible for serving as a liaison between Northwestern University (NU) clinical research investigator teams (e.g., investigator initiated trials, sponsor trials) and Northwestern Memorial Hospital; a joint collaboration between Northwestern Memorial Hospital and the NU Feinberg School of Medicine.
The Clinical Research Nurse Coordinator (CRNC) works collaboratively with the inter-professional team and peers to ensure appropriate implementation and conduct of clinical research studies in NMH throughout the lifecycle of a protocol. The CRNC adheres to the ANA Scope and Standards of Practice of Professional Nursing and the Code of Ethics. The CRNC utilizes the NIH Clinical Research Nurse Domain of Practice and Model of Care. The CRNC reflects the mission, vision, and values of Northwestern Medicine, adheres to the organization’s Code of Ethics and Corporate Compliance Program, and complies with all relevant policies, procedures, guidelines and all other regulatory and accreditation standards.
The MICU Clinical RN Coordinator (MCRC) adheres to the ANA Scope and Standards of Practice of Professional Nursing and the Code of Ethics. The MCRC utilizes the NIH Clinical Research Nurse Domain of Practice and Model of Care.
Responsibilities:
- Leads the coordination and support to Principal Investigator(s).
- Reviews research studies in pre-submission phase for feasibility of protocol implementation.
- Guides the review, revision, and maintenance of protocols. Assures established protocols meet compliance and regulatory requirements.
- Provides guidance to clinical research nurses on projects related to new research study submissions, utilization reviews, wording/phrasing of medical orders, protocols and workflows.
- Develops and maintains clinical nursing research policies, standard operating procedures, and guidelines.
- Reviews and trends research-related deviations and workflow events, reports findings to the Manager and Inter-professional Quality Committee, and recommends action to ensure compliance.
- Supports the development of projects created in response to research-related problems and events as identified and reported by staff and research study team members (e.g., events, deviations, corrective and preventative actions).
- Collaborates with Clinical Coordinators, Education Coordinators, and peer CRNCs to orient and train new staff to clinical research.
- Collaborates with Clinical Coordinators, Education Coordinators, and peer CRNCs to identify training needed for clinical research nurses about unfamiliar practices, procedures and medications to ensure patient/subject safety and compliance with protocols and regulatory requirements.
- Escalates research-related concerns to the appropriate leader or committee.
- Serves as a mentor and role model for communication and collaboration with investigator teams and clinical and technical research practices.
- Supports the clinical research nursing staff during adverse events, emergencies, and difficult clinical situations.
- Provides clinical nursing support to both inpatient and/or outpatient teams as needed as a cross trained resource.
Additional Functions:
- Participates in unit/departmental/divisional or hospital committees/task forces as assigned.
- Remains clinically proficient within area of expertise.
Qualifications
Required:
- Current license as a Registered Nurse State of Illinois Professional Nurse.
- Experience in clinical trials
- Certification in area of clinical specialty.
- BSN with a minimum of two years related clinical experience.
- CPR-BLS Certification through the American Heart Association (AHA)
Preferred:
- MSN
- Membership in Professional Nursing Organization
- ACLS Certification in clinical areas where required
- Society of Clinical Research Associates' (SOCRA) or Association of Clinical Research Professionals (ACRP) Certification
Additional Information
Northwestern Medicine is an equal opportunity employer (disability, VETS) and does not discriminate in hiring or employment on the basis of age, sex, race, color, religion, national origin, gender identity, veteran status, disability, sexual orientation or any other protected status.
Background Check
Northwestern Medicine conducts a background check that includes criminal history on newly hired team members and, at times, internal transfers. If you are offered a position with us, you will be required to complete an authorization and disclosure form that gives Northwestern Medicine permission to run the background check. Results are evaluated on a case-by-case basis, and we follow all local, state, and federal laws, including the Illinois Health Care Worker Background Check Act.
Artificial Intelligence Disclosure
Artificial Intelligence (AI) tools may be used in some portions of the candidate review process for this position, however, all employment decisions will be made by a person.
Benefits
We offer a wide range of benefits that provide employees with tools and resources to improve their physical, emotional, and financial well-being while providing protection for unexpected life events. Please visit our Benefits section to learn more.
Sign-on Bonus Eligibility (if sign-on bonus offered for position): Internal employees and rehires who left Northwestern Medicine within 1 year are not eligible for the sign on bonus. Exception: New graduate internal employees seeking their first licensed clinical position at NM may be eligible depending upon the job family.
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Find Clinical Nurse JobsClinical Nurse Job Market in Chicago
Who's Hiring
- Northwestern Medicine59

- Rush University Medical Center18

- UChicago Medicine10

- SAINT MARY OF NAZARETH HOSPITAL10

- University of Illinois8

Top Industries Hiring
- Healthcare & Medical Services18
- Education10
- Transportation & Logistics3
Clinical Nurse Jobs in Chicago: Frequently Asked Questions
How do I get a clinical nurse job in Chicago?
Your strongest path into Chicago's market is targeting its large academic medical centers, Level I trauma centers, and specialty hospitals, which hire across nearly every clinical specialty. The Medical District on the Near West Side and Streeterville's hospital corridor concentrate the densest openings. Candidates with ICU, ED, or oncology experience move quickly here. Networking through unit-specific nurse residency cohorts at major Chicago health systems and attending local American Nurses Association Illinois chapter events also sharpens your edge.
Which companies hire clinical nurses in Chicago?
Employers hiring clinical nurses in Chicago right now include Northwestern Medicine, Rush University Medical Center, and UChicago Medicine, based on current listings on Migrate Mate as of August 2026. Chicago's market is anchored by large integrated health systems, world-class academic medical centers affiliated with major universities, community hospital networks serving the city's diverse neighborhoods, and growing outpatient and specialty clinic groups.
Are there remote clinical nurse jobs in Chicago?
Yes, though remote work is limited for clinical nurses since most roles require direct patient care in a facility. About 14% of clinical nurse openings tied to Chicago are remote or hybrid as of August 2026, covering roles where it applies. In Chicago, the remote-friendly subset tends to include telephonic triage, utilization review, case management, and care coordination positions with health plans and managed care organizations headquartered in the city.
How can I get a clinical nurse job in Chicago with little or no experience?
The most realistic entry path in Chicago is applying to nurse residency programs at the city's large academic medical centers and community hospital networks, which are specifically structured for new graduates. Chicago's Federally Qualified Health Centers and safety-net hospitals in neighborhoods like Pilsen and Englewood also hire entry-level nurses and often offer mentorship. Completing clinical rotations at Chicago-area facilities during nursing school and expressing willingness to work nights or weekends strengthens your application considerably.
Which industries hire the most clinical nurses in Chicago?
The sectors hiring the most clinical nurses in Chicago are Healthcare & Medical Services, Education, and Transportation & Logistics, based on current listings on Migrate Mate as of August 2026. Chicago's concentration of nationally ranked academic medical centers, a large public health system, and a growing network of outpatient specialty and ambulatory surgery centers makes it one of the Midwest's highest-volume hiring markets for clinical nursing talent.
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