Clinical Nurse Jobs in Chicago, IL

Clinical Nurse jobs in Chicago are in strong demand, with openings concentrated in the Medical District, Streeterville, and Hyde Park across major health systems, academic medical centers, and specialty clinics. Employers actively hiring right now include Northwestern Medicine, Rush University Medical Center, and Cook County Health & Hospitals System. See the openings below and apply to the ones that match your experience.

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Overview

Open roles157+
Top employerNorthwestern Medicine
Work type100% On-site
Top credentialManaged Registered Nurses (RNs)
Companies hiring19

Showing 5 of 157+ Clinical Nurse jobs

Clinical Nurse Manager - ICU + IMCU
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New 22h ago
Clinical Nurse Manager - ICU + IMCU
Endeavor Health
Chicago, Illinois
Clinical Support
Healthcare Administration
Human Resources
$50.64 - $78.49/hr
Managed Registered Nurses (RNs)
10,000+

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Clinical Nurse I - Emergency Room Nursing
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Added 1d ago
Clinical Nurse I - Emergency Room Nursing
Cook County Health & Hospitals System
Chicago, Illinois
Clinical Support
Healthcare Administration
Human Resources
$38.2 - $52.06/hr
Managed Registered Nurses (RNs)

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Clinical Nurse, ICU Float Pool, Full-Time, Nights
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Added 1d ago
Clinical Nurse, ICU Float Pool, Full-Time, Nights
Northwestern Medicine
Chicago, Illinois
Healthcare Administration
Nursing
Patient Services & Wellbeing
CPR Certification
10,000+

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Clinical Nurse, Med Surg Float Pool, Full-Time, Nights
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Added 1d ago
Clinical Nurse, Med Surg Float Pool, Full-Time, Nights
Northwestern Medicine
Chicago, Illinois
Healthcare Administration
Nursing
Patient Services & Wellbeing
CPR Certification
10,000+

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Clinical Research Nurse
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Added 4d ago
Clinical Research Nurse
VIVA
Chicago, Illinois
Biotech & Life Sciences
Clinical Trials
Healthcare Administration
Research & Academia
$40 - $45/hr
Bachelor of Science
11-50

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See All 157+ Clinical Nurse Jobs in Chicago

Find roles in Chicago that match your experience and apply in just a few clicks.

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Clinical Nurse Job Market in Chicago

Who's Hiring

  • Northwestern Medicine37
  • Rush University Medical Center23
  • Cook County Health & Hospitals System20
  • Endeavor Health14
  • UChicago Medicine11

Top Industries Hiring

  • Education
  • Healthcare & Medical Services
  • Transportation & Logistics

Clinical Nurse Jobs in Chicago: Frequently Asked Questions

How do I get a clinical nurse job in Chicago?

Your strongest path into Chicago's market is targeting its large academic medical centers, Level I trauma centers, and specialty hospitals, which hire across nearly every clinical specialty. The Medical District on the Near West Side and Streeterville's hospital corridor concentrate the densest openings. Candidates with ICU, ED, or oncology experience move quickly here. Networking through unit-specific nurse residency cohorts at major Chicago health systems and attending local American Nurses Association Illinois chapter events also sharpens your edge.

Which companies hire clinical nurses in Chicago?

Employers hiring clinical nurses in Chicago right now include Northwestern Medicine, Rush University Medical Center, and Cook County Health & Hospitals System, based on current listings on Migrate Mate as of October 2026. Chicago's market is anchored by large integrated health systems, world-class academic medical centers affiliated with major universities, community hospital networks serving the city's diverse neighborhoods, and growing outpatient and specialty clinic groups.

Are there remote clinical nurse jobs in Chicago?

Yes, though remote work is limited for clinical nurses since most roles require direct patient care in a facility. About 0% of clinical nurse openings tied to Chicago are remote or hybrid as of October 2026, covering roles where it applies. In Chicago, the remote-friendly subset tends to include telephonic triage, utilization review, case management, and care coordination positions with health plans and managed care organizations headquartered in the city.

How can I get a clinical nurse job in Chicago with little or no experience?

The most realistic entry path in Chicago is applying to nurse residency programs at the city's large academic medical centers and community hospital networks, which are specifically structured for new graduates. Chicago's Federally Qualified Health Centers and safety-net hospitals in neighborhoods like Pilsen and Englewood also hire entry-level nurses and often offer mentorship. Completing clinical rotations at Chicago-area facilities during nursing school and expressing willingness to work nights or weekends strengthens your application considerably.

Which industries hire the most clinical nurses in Chicago?

The sectors hiring the most clinical nurses in Chicago are Education, Healthcare & Medical Services, and Transportation & Logistics, based on current listings on Migrate Mate as of October 2026. Chicago's concentration of nationally ranked academic medical centers, a large public health system, and a growing network of outpatient specialty and ambulatory surgery centers makes it one of the Midwest's highest-volume hiring markets for clinical nursing talent.

See All 157+ Clinical Nurse Jobs in Chicago

Find roles in Chicago that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs