Clinical Nurse Jobs in St. Louis, MO

Clinical Nurse jobs in St. Louis are in strong demand, concentrated in the Central West End medical corridor, Midtown, and the hospital campuses anchoring Downtown and South St. Louis, across acute care, long-term care, and ambulatory settings. Employers hiring right now include LiveWell Homecare Agency, BJC HealthCare, and SSM Health. Scan the live roles below and apply to whichever ones fit.

Find Clinical Nurse Jobs

Overview

Open roles369+
Top employerLiveWell Homecare Agency
Work type50% Remote
Top credentialNursing Diploma
Companies hiring7

Showing 5 of 369+ Clinical Nurse jobs

SSM Health
Registered Nurse - Clinical - Neurology
We won't show you this job again
SSM Health
Added 1d ago
Registered Nurse - Clinical - Neurology
SSM Health
St. Louis, Missouri
Customer Service
Customer Success
Customer Support
BLS Certification
10,000+

Have you applied for this role?

BJC HealthCare
OB/GYN Clinic - Clinical Nurse
We won't show you this job again
BJC HealthCare
Added 1d ago
OB/GYN Clinic - Clinical Nurse
BJC HealthCare
St. Louis, Missouri
Caregiving & Elderly Support
Healthcare Administration
Nursing
Patient Services & Wellbeing
$32 - $48.28/hr
Nursing Diploma
10,000+

Have you applied for this role?

BJC HealthCare
Clinical Nurse Operating Room
We won't show you this job again
BJC HealthCare
Added 1d ago
Clinical Nurse Operating Room
BJC HealthCare
St. Louis, Missouri
Caregiving & Elderly Support
Healthcare Administration
Nursing
Patient Services & Wellbeing
$32 - $48.28/hr
Nursing Diploma
10,000+

Have you applied for this role?

Mercy
Onboarding Clinical Nurse Educator - Sunset Hills - Part-Time
We won't show you this job again
Mercy
Added 1d ago
Onboarding Clinical Nurse Educator - Sunset Hills - Part-Time
Mercy
St. Louis, Missouri
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification
10,000+

Have you applied for this role?

BJC HealthCare
OR - Clinical Nurse (PRN)
We won't show you this job again
BJC HealthCare
Added 1d ago
OR - Clinical Nurse (PRN)
BJC HealthCare
St. Louis, Missouri
Customer Service
Customer Support
Hospitality & Guest Services
$32 - $48.28/hr
Nursing Diploma
10,000+

Have you applied for this role?

See All 369+ Clinical Nurse Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs

Clinical Nurse Job Market in St. Louis

Who's Hiring

  • L
    LiveWell Homecare Agency260
  • BJC HealthCare
    BJC HealthCare85
  • SSM Health
    SSM Health11
  • Mercy
    Mercy5
  • IQVIA
    IQVIA4

Clinical Nurse Jobs in St. Louis: Frequently Asked Questions

How do I get a clinical nurse job in St. Louis?

The strongest hiring in St. Louis clusters around the health systems anchoring the Central West End, the VA campus in Midtown, and the network of community hospitals and outpatient clinics in South City and the inner suburbs. Candidates with experience in med-surg, ICU, or oncology move fastest here. Tailoring your application to the specific unit and patient population a facility serves gives you a clear edge over generic submissions.

Which companies hire clinical nurses in St. Louis?

St. Louis clinical nurse roles are posted by LiveWell Homecare Agency, BJC HealthCare, and SSM Health and others right now, based on current listings on Migrate Mate as of September 2026. St. Louis draws from a mix of large academic medical centers, regional hospital networks, and a growing number of multispecialty outpatient groups that hire nurses across multiple care settings.

Are there remote clinical nurse jobs in St. Louis?

Yes, though remote work is limited for clinical nurses given the hands-on nature of direct patient care. About 100% of clinical nurse openings tied to St. Louis are remote or hybrid as of September 2026, concentrated in utilization review, case management, and telehealth triage roles. Those functions are the most realistic targets if you want flexibility without leaving nursing entirely.

How can I get a clinical nurse job in St. Louis with little or no experience?

The most realistic entry path in St. Louis is a new-graduate residency program at one of the larger health systems in the Central West End or at a community hospital in the surrounding metro. These structured programs pair new nurses with mentors and rotate them through high-volume units. Acute care, long-term care facilities, and rehabilitation centers in the inner suburbs also hire new graduates more readily than specialty units and are a strong starting point for building clinical hours.

See All 369+ Clinical Nurse Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs