Clinical Nurse Jobs in Durham, NC

Clinical Nurse jobs in Durham, North Carolina concentrate in the Duke University Hospital corridor, downtown Durham, and the Research Triangle Park edge near RTP, across academic medical centers, community health systems, and specialty clinics, with demand running strong across critical care, oncology, and emergency settings. Employers hiring right now include Duke Health, CenterWell, and Institute for Medical Research. Scan the live roles below and apply to whichever ones fit.

Find Clinical Nurse Jobs

Overview

Open roles23
Top employerDuke Health
Work type50% On-site
Top credentialBLS Certification
Companies hiring3

Showing 5 of 23+ Clinical Nurse jobs

Duke Health
Clinical Nurse Leader (MIDS) - Emergency Department
We won't show you this job again
Duke Health
New 1m ago
Clinical Nurse Leader (MIDS) - Emergency Department
Duke Health
Durham, North Carolina
Biotech & Life Sciences
Clinical Trials
Healthcare Administration
BLS Certification
10,000+

Have you applied for this role?

Duke Health
Clinical Nurse Specialist (CNS Certified) - Cardiac Stepdown
We won't show you this job again
Duke Health
New 1m ago
Clinical Nurse Specialist (CNS Certified) - Cardiac Stepdown
Duke Health
Durham, North Carolina
Business Strategy
Consulting & Professional Services
Strategy & Corporate Development
Master's degree in nursing
10,000+

Have you applied for this role?

Institute for Medical Research
Clinical Research Nurse
We won't show you this job again
Institute for Medical Research
New 1m ago
Clinical Research Nurse
Institute for Medical Research
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
On-Site
BLS Certification
51-200

Have you applied for this role?

Duke Health
Clinical Services Nurse Ii/Iii - Vad Coordinator
We won't show you this job again
Duke Health
New 1m ago
Clinical Services Nurse Ii/Iii - Vad Coordinator
Duke Health
Durham, North Carolina
Clinical Support
Healthcare Administration
Nursing
BLS Certification
10,000+

Have you applied for this role?

Duke Health
Clinical Nurse Educator
We won't show you this job again
Duke Health
New 1m ago
Clinical Nurse Educator
Duke Health
Durham, North Carolina
Business Operations
Project & Program Management
Project Management
BLS Certification
10,000+

Have you applied for this role?

See All 23 Clinical Nurse Jobs in Durham

Find roles in Durham that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs

Clinical Nurse Job Market in Durham

Who's Hiring

  • Duke Health
    Duke Health21
  • CenterWell
    CenterWell1
  • Institute for Medical Research
    Institute for Medical Research1

Clinical Nurse Jobs in Durham: Frequently Asked Questions

How do I get a clinical nurse job in Durham?

Focus your search on Durham's academic medical centers, community hospitals, and the network of specialty clinics that cluster near Duke University Hospital and downtown. Candidates with experience in critical care, oncology, or emergency nursing move fastest in this market. Tailoring your application to the specific unit or service line, and showing familiarity with the patient population those Durham systems serve, gives you a clear edge over generic applicants.

Which companies hire clinical nurses in Durham?

Employers hiring clinical nurses in Durham right now include Duke Health, CenterWell, and Institute for Medical Research, based on current listings on Migrate Mate as of July 2026. Durham's hiring landscape is anchored by large academic health systems alongside community health organizations and outpatient specialty practices serving the broader Triangle region.

Are there remote clinical nurse jobs in Durham?

Yes, though with an important qualifier: clinical nursing is predominantly a hands-on, bedside role, so fully remote openings are uncommon. About 50% of clinical nurse openings tied to Durham are remote or hybrid as of July 2026, and those positions tend to concentrate in telephonic triage, care management, and utilization review roles rather than direct patient care.

How can I get a clinical nurse job in Durham with little or no experience?

The most realistic entry path in Durham is applying to new-graduate residency or transition-to-practice programs offered by the academic health systems in the area, which are designed specifically to bring early-career nurses onto inpatient units with structured mentorship. Community health centers and outpatient clinics near downtown Durham also hire nurses with limited hospital experience for lower-acuity roles, and those positions frequently serve as stepping stones to larger system employment.

See All 23 Clinical Nurse Jobs in Durham

Find roles in Durham that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs