Clinical Nurse Jobs in Durham, NC
Clinical Nurse jobs in Durham, North Carolina concentrate in the Duke University Hospital corridor, downtown Durham, and the Research Triangle Park edge near RTP, across academic medical centers, community health systems, and specialty clinics, with demand running strong across critical care, oncology, and emergency settings. Employers hiring right now include Duke Health. Scan the live roles below and apply to whichever ones fit.
Find Clinical Nurse JobsOverview
Showing 5 of 326+ Clinical Nurse jobs
At Duke Health, we're driven by a commitment to compassionate care that changes the lives of patients, their loved ones, and the greater community. No matter where your talents lie, join us and discover how we can advance health together.
About Duke University Hospital
Pursue your passion for caring with Duke University Hospital in Durham, North Carolina, which is consistently ranked among the best in the United States. The largest of the four Duke Healthhospitals with 1062 patient beds, it features comprehensive diagnostic and therapeutic facilities, including a regional emergency/trauma center, an endo-surgery center, and more.
RN Clincal Nurse IV Leader – Duke University Hospital – Day Shift
Duke University Health System- Duke University Hospital seeks to hire an experienced Registered Nurse who will embrace our mission of Advancing Health Together.
Department Profile:
Our 23‑bed Antenatal & High‑Risk Postpartum Unit cares for pregnant and postpartum patients requiring close monitoring due to medical, obstetric, or fetal complications. We support a diverse patient population with conditions such as preeclampsia, placenta previa, preterm labor, multifetal gestations, surgical/post‑cesarean recovery, and medically complex postpartum needs. Our team promotes compassionate, family‑centered care while delivering high‑acuity clinical services. The Antenatal & High‑Risk Postpartum RN provides skilled, evidence‑based nursing care to pregnant and postpartum patients experiencing high‑risk conditions. This role includes continuous assessment, medication management (including high‑alert medications), patient education, and collaboration with multidisciplinary teams to support optimal maternal and fetal outcomes.
Work Hours & Shifts
Full Time: Hours will be 2-12 hour shifts and two 8 hour office hour shifts per week, but are subject to change with the needs of the department.
Occ Summary
Plan and provide advanced and/or specialized nursing care for patients in accordance with guidelines established within the Discipline of Nursing Clinical Ladder Program and the North Carolina Board of Nursing. The position will provide local level leadership in the areas of administration, education, informatics and quality.
Work Performed
Identify care needs for patient populations across the continuum of care. Collaborate and provide leadership in the development of standards of care, patient/family education and staff education to address the needs of specific populations. Collaborate with multidisciplinary team and provide leadership within the delivery of patient care. Provide leadership in educational activities, departmental committees, research projects and other health-related projects. Provide evaluation, direction and guidance in the proper selection, use, care and control of material resources. Appraise quality and effectiveness of material and equipment and collaborate with appropriate departments to assist with vendor selection and feedback on performance. Guide the professional growth of others across the continuum of care through role modeling, coaching and/or mentoring. This may include designing orientation modules, primary precepting of senior nursing students. Provide leadership at a departmental, entity, community or regional/national level for initiatives focused on improving the quality of care for populations of patients and growth of others. Conduct performance reviews. Effectively recommend personnel actions including, but not limited to, hiring, performance appraisals, disciplinary actions, terminations and other related activities. Perform other related duties incidental to the work described herein. CNIV Pathways Leadership/Regulatory: Monitor clinical practice and ensure compliance to practice standards and regulatory standards. Collaborate with unit/clinic leadership to coach and mentor nursing colleagues. Influence recruitment and development of staff. Education: Plan and deliver in house education sessions or collaborate with subject matter experts. Keep up to date with evidence-based nursing practices and adult education. Assess educational needsof staff. Partners with clinical nurse educator and clinical nurse specialist to address unit educational needs. Informatics: Serve as a superuser for clinical information systems. Disseminate and communicate information to staff regarding adoption of orchanges to technology. Facilitate service tickets and troubleshoot efficiency concerns with staff. Provide training and technology education support on the unit. Serve as a change agent and facilitate adoption of new technology on the unit. Quality/Research/Innovation: Collaborate with subject matter experts to analyze patient care data to identify trends and areas for improvement. Participate in multidisciplinary committees focused on quality and patient safety. Provide guidance and support to nursing staff in quality assurance and best practices. Engage in research and innovation initiatives to develop new methodologies and technologies for enhancing patient care.
Knowledge, Skills and Abilities
Knowledge of scope of the registered nurse, licensed practical nurse and Unlicensed staff. Knowledge of and appropriate application of the nursing process Knowledge of professional theory, practice and procedure Ability to assess nursing needs of acute and chronically ill patients and their families Ability to independently seek out resources and work collaboratively Ability to establish and maintain effective working relationships Ability to communicate clearly with patients, families, visitors, healthcare team, physicians, administrators, leadership and others Ability to teach patients and families in accordance with the nursing plan of care Ability to use sensory and cognitive functions to process and prioritize information, treatment, and follow-up Ability to use fine motor skills Competent in BLS and/or other specialized life support requirements designated by work area Ability to record activities, document assessments, plan of care, interventions, evaluation and re-evaluation of patient status Ability to use computer and learnnew software programs Ability to document and communicate pertinent information using computer and/or paper documentation tools Ability to navigate the entity to provide clinical care for patients Ability to withstand prolonged standing and walking Ability to remain focused and organized Working knowledge of procedures and techniques involved in administering routine and special treatments to patients Working knowledge of infection control procedures and safety precautionS Working knowledge and completion of appropriate The Joint Commission (TJC) and other regulatory requirements Pre-employment Physical Capacity Testing Required
Level Characteristics
Provide leadership at a CSU, departmental, institutional, community or regional/national level. Lead change by constantly seeking creative solutions to improve quality and efficiency in the delivery of patient care.
Minimum Qualifications
Education
Work requires graduation from anaccredited nursing program with a BSN degree.
Experience
Three years of experience required. Clinical Nurse II and III are eligible to apply for the CN IV Leader role. Applicants will perform the duties and responsibilities ofthe CN IV.
Degrees, Licensures, Certifications
Must have current or compact RN licensure in the state of North Carolina. BLS required.
Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
At Duke Health, we're driven by a commitment to compassionate care that changes the lives of patients, their loved ones, and the greater community. No matter where your talents lie, join us and discover how we can advance health together.
About Duke University Hospital
Pursue your passion for caring with Duke University Hospital in Durham, North Carolina, which is consistently ranked among the best in the United States. The largest of the four Duke Healthhospitals with 1062 patient beds, it features comprehensive diagnostic and therapeutic facilities, including a regional emergency/trauma center, an endo-surgery center, and more.
RN Clincal Nurse IV Leader – Duke University Hospital – Day Shift
Duke University Health System- Duke University Hospital seeks to hire an experienced Registered Nurse who will embrace our mission of Advancing Health Together.
Department Profile:
Our 23‑bed Antenatal & High‑Risk Postpartum Unit cares for pregnant and postpartum patients requiring close monitoring due to medical, obstetric, or fetal complications. We support a diverse patient population with conditions such as preeclampsia, placenta previa, preterm labor, multifetal gestations, surgical/post‑cesarean recovery, and medically complex postpartum needs. Our team promotes compassionate, family‑centered care while delivering high‑acuity clinical services. The Antenatal & High‑Risk Postpartum RN provides skilled, evidence‑based nursing care to pregnant and postpartum patients experiencing high‑risk conditions. This role includes continuous assessment, medication management (including high‑alert medications), patient education, and collaboration with multidisciplinary teams to support optimal maternal and fetal outcomes.
Work Hours & Shifts
Full Time: Hours will be 2-12 hour shifts and two 8 hour office hour shifts per week, but are subject to change with the needs of the department.
Occ Summary
Plan and provide advanced and/or specialized nursing care for patients in accordance with guidelines established within the Discipline of Nursing Clinical Ladder Program and the North Carolina Board of Nursing. The position will provide local level leadership in the areas of administration, education, informatics and quality.
Work Performed
Identify care needs for patient populations across the continuum of care. Collaborate and provide leadership in the development of standards of care, patient/family education and staff education to address the needs of specific populations. Collaborate with multidisciplinary team and provide leadership within the delivery of patient care. Provide leadership in educational activities, departmental committees, research projects and other health-related projects. Provide evaluation, direction and guidance in the proper selection, use, care and control of material resources. Appraise quality and effectiveness of material and equipment and collaborate with appropriate departments to assist with vendor selection and feedback on performance. Guide the professional growth of others across the continuum of care through role modeling, coaching and/or mentoring. This may include designing orientation modules, primary precepting of senior nursing students. Provide leadership at a departmental, entity, community or regional/national level for initiatives focused on improving the quality of care for populations of patients and growth of others. Conduct performance reviews. Effectively recommend personnel actions including, but not limited to, hiring, performance appraisals, disciplinary actions, terminations and other related activities. Perform other related duties incidental to the work described herein. CNIV Pathways Leadership/Regulatory: Monitor clinical practice and ensure compliance to practice standards and regulatory standards. Collaborate with unit/clinic leadership to coach and mentor nursing colleagues. Influence recruitment and development of staff. Education: Plan and deliver in house education sessions or collaborate with subject matter experts. Keep up to date with evidence-based nursing practices and adult education. Assess educational needsof staff. Partners with clinical nurse educator and clinical nurse specialist to address unit educational needs. Informatics: Serve as a superuser for clinical information systems. Disseminate and communicate information to staff regarding adoption of orchanges to technology. Facilitate service tickets and troubleshoot efficiency concerns with staff. Provide training and technology education support on the unit. Serve as a change agent and facilitate adoption of new technology on the unit. Quality/Research/Innovation: Collaborate with subject matter experts to analyze patient care data to identify trends and areas for improvement. Participate in multidisciplinary committees focused on quality and patient safety. Provide guidance and support to nursing staff in quality assurance and best practices. Engage in research and innovation initiatives to develop new methodologies and technologies for enhancing patient care.
Knowledge, Skills and Abilities
Knowledge of scope of the registered nurse, licensed practical nurse and Unlicensed staff. Knowledge of and appropriate application of the nursing process Knowledge of professional theory, practice and procedure Ability to assess nursing needs of acute and chronically ill patients and their families Ability to independently seek out resources and work collaboratively Ability to establish and maintain effective working relationships Ability to communicate clearly with patients, families, visitors, healthcare team, physicians, administrators, leadership and others Ability to teach patients and families in accordance with the nursing plan of care Ability to use sensory and cognitive functions to process and prioritize information, treatment, and follow-up Ability to use fine motor skills Competent in BLS and/or other specialized life support requirements designated by work area Ability to record activities, document assessments, plan of care, interventions, evaluation and re-evaluation of patient status Ability to use computer and learnnew software programs Ability to document and communicate pertinent information using computer and/or paper documentation tools Ability to navigate the entity to provide clinical care for patients Ability to withstand prolonged standing and walking Ability to remain focused and organized Working knowledge of procedures and techniques involved in administering routine and special treatments to patients Working knowledge of infection control procedures and safety precautionS Working knowledge and completion of appropriate The Joint Commission (TJC) and other regulatory requirements Pre-employment Physical Capacity Testing Required
Level Characteristics
Provide leadership at a CSU, departmental, institutional, community or regional/national level. Lead change by constantly seeking creative solutions to improve quality and efficiency in the delivery of patient care.
Minimum Qualifications
Education
Work requires graduation from anaccredited nursing program with a BSN degree.
Experience
Three years of experience required. Clinical Nurse II and III are eligible to apply for the CN IV Leader role. Applicants will perform the duties and responsibilities ofthe CN IV.
Degrees, Licensures, Certifications
Must have current or compact RN licensure in the state of North Carolina. BLS required.
Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
See All 326+ Clinical Nurse Jobs in Durham
Find roles in Durham that match your experience and apply in just a few clicks.
Find Clinical Nurse JobsClinical Nurse Job Market in Durham
Who's Hiring
Clinical Nurse Jobs in Durham: Frequently Asked Questions
How do I get a clinical nurse job in Durham?
Focus your search on Durham's academic medical centers, community hospitals, and the network of specialty clinics that cluster near Duke University Hospital and downtown. Candidates with experience in critical care, oncology, or emergency nursing move fastest in this market. Tailoring your application to the specific unit or service line, and showing familiarity with the patient population those Durham systems serve, gives you a clear edge over generic applicants.
Which companies hire clinical nurses in Durham?
Employers hiring clinical nurses in Durham right now include Duke Health, based on current listings on Migrate Mate as of August 2026. Durham's hiring landscape is anchored by large academic health systems alongside community health organizations and outpatient specialty practices serving the broader Triangle region.
Are there remote clinical nurse jobs in Durham?
Yes, though with an important qualifier: clinical nursing is predominantly a hands-on, bedside role, so fully remote openings are uncommon. About 75% of clinical nurse openings tied to Durham are remote or hybrid as of August 2026, and those positions tend to concentrate in telephonic triage, care management, and utilization review roles rather than direct patient care.
How can I get a clinical nurse job in Durham with little or no experience?
The most realistic entry path in Durham is applying to new-graduate residency or transition-to-practice programs offered by the academic health systems in the area, which are designed specifically to bring early-career nurses onto inpatient units with structured mentorship. Community health centers and outpatient clinics near downtown Durham also hire nurses with limited hospital experience for lower-acuity roles, and those positions frequently serve as stepping stones to larger system employment.
Related Jobs in North Carolina
See All 326+ Clinical Nurse Jobs in Durham
Find roles in Durham that match your experience and apply in just a few clicks.
Find Clinical Nurse Jobs