Clinical Operations Lead Jobs in St. Louis, MO
Clinical Operations Lead jobs in St. Louis are concentrated in the medical corridor around Forest Park Southeast, Cortex Innovation Community, and the Central West End, driven by the city's deep base of academic medical centers, pharmaceutical firms, and contract research organizations. Employers hiring right now include BJC HealthCare, SSM Health, and WSP. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 63+ Clinical Operations Lead jobs
Join a collaborative HR team where your insights and initiative help shape workforce strategies and employee experiences. In this role, you will partner closely with HR Business Partners to deliver data-driven insights, streamline processes, and support key talent initiatives. This is an opportunity to grow your HR expertise while making meaningful contributions to enterprise priorities.
- Deliver actionable HR insights by preparing and analyzing workforce data, including retention, diversity, and talent metrics.
- Enable strategic talent processes by supporting talent reviews, compensation planning, and leadership development initiatives.
- Partner with HR Business Partners to develop reports, scorecards, and presentations that inform business decisions.
- Drive operational efficiency by managing HR requests, resolving escalated issues, and coordinating with HR Operations and Employee Service teams.
- Support enterprise programs by promoting participation, tracking outcomes, and enhancing reporting capabilities.
- Prepare and consolidate data for HR initiatives to ensure accuracy and alignment across teams.
- Contribute to onboarding and leadership materials that enhance the experience of new and senior leaders.
- Anticipate team needs and proactively identify opportunities to improve processes and outcomes.
Qualifications
- 3+ years of Human Resources experience or equivalent.
- Strong analytical skills with the ability to interpret data and translate insights into action.
- Advanced proficiency in Microsoft Office, including Excel and PowerPoint.
- Ability to manage multiple priorities and work independently with a high level of organization and attention to detail.
- Demonstrated professionalism and ability to handle sensitive and confidential information.
- Strong interpersonal skills with the ability to collaborate across all levels of the organization.
- Bachelor’s degree in Human Resources, Business, or a related field.
- Experience with Workday, Tableau, or other HR systems.
- Project management experience.
- Experience supporting HR Business Partner teams or enterprise HR initiatives.
- Interest in developing into an HR Business Partner role.
If you will be working at home occasionally or permanently, the internet connection must be obtained through a cable broadband or fiber optic internet service provider with speeds of at least 10Mbps download/5Mbps upload. For this position, we anticipate offering an annual salary of 80,000 - 133,400 USD / yearly, depending on relevant factors, including experience and geographic location.
This role is also anticipated to be eligible to participate in an annual bonus plan.
At The Cigna Group, you’ll enjoy a comprehensive range of benefits, with a focus on supporting your whole health. Starting on day one of your employment, you’ll be offered several health-related benefits including medical, vision, dental, and well-being and behavioral health programs. We also offer 401(k), company paid life insurance, tuition reimbursement, a minimum of 18 days of paid time off per year, paid holidays, and leaves of absence. For more details on our employee benefits programs, click here.
About The Cigna Group
Doing something meaningful starts with a simple decision, a commitment to changing lives. At The Cigna Group, we’re dedicated to improving the health and vitality of those we serve. Through our divisions Cigna Healthcare and Evernorth Health Services, we are committed to enhancing the lives of our clients, customers and patients. Join us in driving growth and improving lives.Qualified applicants will be considered without regard to race, color, age, disability, sex, childbirth (including pregnancy) or related medical conditions including but not limited to lactation, sexual orientation, gender identity or expression, veteran or military status, religion, national origin, ancestry, marital or familial status, genetic information, status with regard to public assistance, citizenship status or any other characteristic protected by applicable equal employment opportunity laws.
If you need a reasonable accommodation to complete the online application process, please email seeyourself@thecignagroup.com for assistance. Please note that this email inbox is dedicated to accommodation requests only and cannot provide application updates or accept resumes.
The Cigna Group has a tobacco-free policy and reserves the right not to hire tobacco/nicotine users in states where that is legally permissible. Candidates in such states who use tobacco/nicotine will not be considered for employment unless they enter a qualifying smoking cessation program prior to the start of their employment. These states include: Alabama, Alaska, Arizona, Arkansas, Delaware, Florida, Georgia, Hawaii, Idaho, Iowa, Kansas, Maryland, Massachusetts, Michigan, Nebraska, Ohio, Pennsylvania, Texas, Utah, Vermont, and Washington State.
Qualified applicants with criminal histories will be considered for employment in a manner consistent with all federal, state and local ordinances.
Join a collaborative HR team where your insights and initiative help shape workforce strategies and employee experiences. In this role, you will partner closely with HR Business Partners to deliver data-driven insights, streamline processes, and support key talent initiatives. This is an opportunity to grow your HR expertise while making meaningful contributions to enterprise priorities.
- Deliver actionable HR insights by preparing and analyzing workforce data, including retention, diversity, and talent metrics.
- Enable strategic talent processes by supporting talent reviews, compensation planning, and leadership development initiatives.
- Partner with HR Business Partners to develop reports, scorecards, and presentations that inform business decisions.
- Drive operational efficiency by managing HR requests, resolving escalated issues, and coordinating with HR Operations and Employee Service teams.
- Support enterprise programs by promoting participation, tracking outcomes, and enhancing reporting capabilities.
- Prepare and consolidate data for HR initiatives to ensure accuracy and alignment across teams.
- Contribute to onboarding and leadership materials that enhance the experience of new and senior leaders.
- Anticipate team needs and proactively identify opportunities to improve processes and outcomes.
Qualifications
- 3+ years of Human Resources experience or equivalent.
- Strong analytical skills with the ability to interpret data and translate insights into action.
- Advanced proficiency in Microsoft Office, including Excel and PowerPoint.
- Ability to manage multiple priorities and work independently with a high level of organization and attention to detail.
- Demonstrated professionalism and ability to handle sensitive and confidential information.
- Strong interpersonal skills with the ability to collaborate across all levels of the organization.
- Bachelor’s degree in Human Resources, Business, or a related field.
- Experience with Workday, Tableau, or other HR systems.
- Project management experience.
- Experience supporting HR Business Partner teams or enterprise HR initiatives.
- Interest in developing into an HR Business Partner role.
If you will be working at home occasionally or permanently, the internet connection must be obtained through a cable broadband or fiber optic internet service provider with speeds of at least 10Mbps download/5Mbps upload. For this position, we anticipate offering an annual salary of 80,000 - 133,400 USD / yearly, depending on relevant factors, including experience and geographic location.
This role is also anticipated to be eligible to participate in an annual bonus plan.
At The Cigna Group, you’ll enjoy a comprehensive range of benefits, with a focus on supporting your whole health. Starting on day one of your employment, you’ll be offered several health-related benefits including medical, vision, dental, and well-being and behavioral health programs. We also offer 401(k), company paid life insurance, tuition reimbursement, a minimum of 18 days of paid time off per year, paid holidays, and leaves of absence. For more details on our employee benefits programs, click here.
About The Cigna Group
Doing something meaningful starts with a simple decision, a commitment to changing lives. At The Cigna Group, we’re dedicated to improving the health and vitality of those we serve. Through our divisions Cigna Healthcare and Evernorth Health Services, we are committed to enhancing the lives of our clients, customers and patients. Join us in driving growth and improving lives.Qualified applicants will be considered without regard to race, color, age, disability, sex, childbirth (including pregnancy) or related medical conditions including but not limited to lactation, sexual orientation, gender identity or expression, veteran or military status, religion, national origin, ancestry, marital or familial status, genetic information, status with regard to public assistance, citizenship status or any other characteristic protected by applicable equal employment opportunity laws.
If you need a reasonable accommodation to complete the online application process, please email seeyourself@thecignagroup.com for assistance. Please note that this email inbox is dedicated to accommodation requests only and cannot provide application updates or accept resumes.
The Cigna Group has a tobacco-free policy and reserves the right not to hire tobacco/nicotine users in states where that is legally permissible. Candidates in such states who use tobacco/nicotine will not be considered for employment unless they enter a qualifying smoking cessation program prior to the start of their employment. These states include: Alabama, Alaska, Arizona, Arkansas, Delaware, Florida, Georgia, Hawaii, Idaho, Iowa, Kansas, Maryland, Massachusetts, Michigan, Nebraska, Ohio, Pennsylvania, Texas, Utah, Vermont, and Washington State.
Qualified applicants with criminal histories will be considered for employment in a manner consistent with all federal, state and local ordinances.
See All 63 Clinical Operations Lead Jobs in St. Louis
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Find Clinical Operations Lead JobsClinical Operations Lead Job Market in St. Louis
Who's Hiring
- BJC HealthCare10
- SSM Health5
- WSP3
- The Cigna3
- Speechify2
Top Industries Hiring
- Technology & Software4
- Consulting & Professional Services4
- Insurance3
- Construction & Real Estate3
- Healthcare & Medical Services3
Clinical Operations Lead Jobs in St. Louis: Frequently Asked Questions
How do I get a clinical operations lead job in St. Louis?
Focus your search on St. Louis's academic medical systems, CROs operating out of the Cortex Innovation Community, and the pharmaceutical and biotech companies clustered along the Interstate 270 corridor in west St. Louis County. Candidates who combine direct trial management experience with familiarity in oncology or cardiovascular research stand out locally. Networking through the St. Louis chapter of industry associations and attending BJC or SSM Health career events also opens doors that online applications alone do not.
Which companies hire clinical operations leads in St. Louis?
St. Louis clinical operations lead roles are posted by BJC HealthCare, SSM Health, and WSP and others right now, based on current listings on Migrate Mate as of July 2026. The hiring mix reflects St. Louis's strength in large nonprofit health systems, specialty CROs, and mid-size biopharma companies with regional headquarters in the metro area.
Are there remote clinical operations lead jobs in St. Louis?
Yes, though remote availability is limited because many clinical operations lead functions require on-site oversight of trial staff, vendor coordination, and facility compliance. About 65% of clinical operations lead openings tied to St. Louis are remote or hybrid as of July 2026, with remote arrangements most common for roles focused on data review, regulatory submissions, and sponsor-facing project management rather than site monitoring.
How can I get a clinical operations lead job in St. Louis with little or no experience?
The most realistic entry path in St. Louis is moving through a clinical research coordinator or site coordinator role at one of the major academic medical centers such as Washington University School of Medicine or Saint Louis University's research programs. Those positions build the protocol management and regulatory experience that St. Louis employers expect before promoting into a lead role. Volunteering for sponsor audits or co-monitoring visits while in a coordinator position accelerates that transition significantly.
Which industries hire the most clinical operations leads in St. Louis?
St. Louis clinical operations lead roles concentrate in Technology & Software, Consulting & Professional Services, and Insurance, based on current listings on Migrate Mate as of July 2026. St. Louis's combination of nationally ranked academic medical centers, a growing biotech corridor in Cortex, and established pharmaceutical manufacturing in the region sustains consistent demand across those sectors.
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