Clinical Project Manager Jobs in Columbia, SC

Clinical Project Manager jobs in Columbia, South Carolina are in strong demand, concentrated in the Midlands Medical Corridor near Palmetto Health and the University of South Carolina Health System, as well as in the Forest Drive and Harbison business districts, across clinical research, healthcare IT, and pharmaceutical sectors. Employers hiring right now include Prisma Health, Lexington Health, and Circle K. See the openings below and apply to the ones that match your experience.

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Overview

Open roles76
Top employerPrisma Health
Work type58% On-site
Top credentialAssociate's
Companies hiring44

Showing 5 of 76+ Clinical Project Manager jobs

PruittHealth
RN Clinical Competency Coordinator HCC
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PruittHealth
New 1m ago
RN Clinical Competency Coordinator HCC
PruittHealth
Columbia, South Carolina
Clinical Support
Healthcare Administration
Human Resources
CPR Certification
10,000+

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LifeStance Health
Licensed Clinical Therapist (LPC/LISW-CP/LMFT)
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LifeStance Health
New 1m ago
Licensed Clinical Therapist (LPC/LISW-CP/LMFT)
LifeStance Health
Columbia, South Carolina
Caregiving & Elderly Support
Healthcare Administration
Nursing
Patient Services & Wellbeing
Hybrid
5,001-10,000

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Prisma Health
Mgr-Financial Analysis FT, Day
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Prisma Health
New 1m ago
Mgr-Financial Analysis FT, Day
Prisma Health
Columbia, South Carolina
Business Operations
Project Management
Bachelor's degree in finance
10,000+

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KidsCare Home Health
Pediatric Speech Language Pathologist - Clinical Fellow
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KidsCare Home Health
New 1m ago
Pediatric Speech Language Pathologist - Clinical Fellow
KidsCare Home Health
Columbia, South Carolina
Clinical Support
Healthcare Administration
Medical Specialists
CPR Certification
501-1,000

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Optum
RN Clinical Director- Heart of Hospice Columbia
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Optum
New 1m ago
RN Clinical Director- Heart of Hospice Columbia
Optum
Columbia, South Carolina
Program Management
Project & Program Management
Project Management
$67k - $101k/yr
On-Site
Managed Registered Nurses (RNs)
10,000+

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See All 76 Clinical Project Manager Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find Clinical Project Manager Jobs

Clinical Project Manager Job Market in Columbia

Who's Hiring

  • Prisma Health
    Prisma Health9
  • Lexington Health
    Lexington Health7
  • Circle K
    Circle K5
  • State of South Carolina
    State of South Carolina4
  • AgFirst Farm Credit Bank
    AgFirst Farm Credit Bank3

Top Industries Hiring

  • Healthcare & Medical Services21
  • Retail5
  • Technology & Software5
  • Medical Devices3
  • Banking & Financial Services3

Clinical Project Manager Jobs in Columbia: Frequently Asked Questions

How do I get a clinical project manager job in Columbia?

Columbia's strongest demand for clinical project managers comes from health systems, contract research organizations, and medical device companies concentrated near the Midlands medical district and the University of South Carolina's research enterprise. Candidates who stand out here typically hold PMP or clinical trial certifications and have direct experience with IRB processes or Phase II-III trial coordination. Networking through SCRA and local PMAC chapter events also gives Columbia applicants a real edge.

Which companies hire clinical project managers in Columbia?

Employers hiring clinical project managers in Columbia right now include Prisma Health, Lexington Health, and Circle K, based on current listings on Migrate Mate as of July 2026. Columbia's hiring mix skews toward academic medical centers, regional health systems, and mid-size CROs that support clinical trial activity tied to the Palmetto Health network and USC's research programs.

Are there remote clinical project manager jobs in Columbia?

Yes, though with important limits: clinical project manager roles that involve on-site trial oversight, site monitoring, or lab coordination are rarely fully remote. About 42% of clinical project manager openings tied to Columbia are remote or hybrid as of July 2026, reflecting that Columbia's research-heavy employers do offer flexibility for documentation, regulatory, and vendor management tasks performed from home.

How can I get a clinical project manager job in Columbia with little or no experience?

The most realistic entry path in Columbia is through clinical research coordinator or project coordinator roles at the USC School of Medicine, Prisma Health, or affiliated CROs, which regularly hire candidates who can demonstrate GCP training and strong data management skills. Volunteering with IRB committees or assisting on grant-funded research at USC gives local candidates direct trial exposure that Columbia employers treat as equivalent to entry-level professional experience.

Which industries hire the most clinical project managers in Columbia?

Most clinical project manager openings in Columbia sit in Healthcare & Medical Services, Retail, and Technology & Software, per current listings on Migrate Mate as of July 2026. Columbia's concentration of academic medical infrastructure, regional health systems, and state government health agencies creates sustained demand across those sectors, particularly for managers who can coordinate multi-site studies and manage regulatory submissions.

See All 76 Clinical Project Manager Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find Clinical Project Manager Jobs