Senior Level Clinical Research Manager Jobs
Senior level clinical research manager jobs place experienced professionals in charge of trial strategy, regulatory oversight, and the cross-functional teams that deliver study outcomes. Hiring is concentrated across Technology & Software, Healthcare & Medical Services, and Education, with a mix of on-site, hybrid, and remote roles available from employers like Amazon, Palo Alto Networks, and Apple hiring at this level now.
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Showing 5 of 247+ Senior Level Clinical Research Manager jobs
Our Mission
At Palo Alto Networks®, we’re united by a shared mission—to protect our digital way of life. We thrive at the intersection of innovation and impact, solving real-world problems with cutting-edge technology and bold thinking. Here, everyone has a voice, and every idea counts. If you’re ready to do the most meaningful work of your career alongside people who are just as passionate as you are, you’re in the right place.
Who We Are
In order to be the cybersecurity partner of choice, we must trailblaze the path and shape the future of our industry. This is something our employees work at each day and is defined by our values: Disruption, Collaboration, Execution, Integrity, and Inclusion. We weave AI into the fabric of everything we do and use it to augment the impact every individual can have. If you are passionate about solving real-world problems and ideating beside the best and the brightest, we invite you to join us!
We believe collaboration thrives in person. That’s why most of our teams work from the office full time, with flexibility when it’s needed. This model supports real-time problem-solving, stronger relationships, and the kind of precision that drives great outcomes.Job Summary
Your Career
You will be part of the team that builds and delivers the threat detection capabilities powering Palo Alto Networks’ Advanced Threat Prevention (ATP). The ATP detection team is responsible for decoding network protocols, identifying applications, and detecting threats across our enterprise customers’ networks.
As a Principal Security Researcher, you will play a key technical leadership role in shaping how ATP detects and prevents real-world attacks. You will propose and drive innovative technical ideas from concept to production, own multiple projects or a broader technical area with measurable impact, and provide technical leadership to other researchers or developers. This is a hands-on leadership role: you are expected to define direction, make technical decisions, and contribute directly to vulnerability research, exploit analysis, and production detection work.
Your Impact
Shape ATP detection strategy by identifying important vulnerability, exploit, and attack technique areas where new or improved protections are needed.
Drive innovative detection ideas from concept to production, delivering measurable improvements in coverage, quality, speed, or scalability.
Improve rapid response capability for zero-days, high-impact CVEs, and emerging attack vectors by guiding technical assessment, detection strategy, and release decisions.
Raise the quality and consistency of IPS protections by defining detection approaches, validation expectations, and technical review standards for complex cases.
Expand the team’s ability to deliver protections at scale through practical automation, detection pipeline improvements, and AI-assisted research workflows.
Provide hands-on technical leadership to researchers or developers through direction, review, problem decomposition, and execution guidance.
Influence cross-functional decisions with product, QA, engineering, and research partners to ensure detections are technically sound, customer-relevant, and production-ready.
Qualifications
Deep hands-on experience in vulnerability research, exploit analysis, IPS/IDS detection, offensive security, or closely related threat prevention work.
Proven ability to identify important technical problems, propose detection ideas, drive execution, and deliver measurable product or customer impact.
Deep understanding of common vulnerability classes and exploit techniques, including memory corruption, injection, authentication bypass, path traversal, SSRF, RCE, XSS, SQL injection, CSRF, MITM, and DoS.
Strong ability to analyze vulnerability root cause, exploitability, PoC behavior, network traffic, protocol behavior, application-layer attack patterns, and detection tradeoffs.
Experience translating vulnerability or exploit understanding into production-quality IPS signatures, IDS detections, network detections, or other customer-facing protections.
Strong understanding of network protocols and application-layer behavior, especially HTTP, DNS, SMB, FTP, SMTP, TCP/UDP, TLS, and related protocols.
Strong programming or scripting skills for research automation, tooling, test generation, detection development, or pipeline improvements.
Ability to lead complex technical work under ambiguity, guide other researchers or developers, and make sound technical decisions under time pressure.
Experience using AI, ML, automation, or research tooling to improve security analysis, detection development, validation, or response workflows is highly desirable.
Foundational understanding of AI security scenarios or AI-assisted security workflows is a plus.
Strong communication skills with the ability to influence technical direction across research, product, QA, and engineering partners.
BS/MS in Computer Science, Computer Engineering, Cybersecurity, or related field, or equivalent professional experience.
Compensation Disclosure
The compensation offered for this position will depend on qualifications, experience, and work location. For candidates who receive an offer at the posted level, the starting base salary (for non-sales roles) or base salary + commission target (for sales/com-missioned roles) is expected to be the annual range listed below. The offered compensation may also include restricted stock units and a bonus.
$162,700.00 - $263,175.00/yrOur Commitment
We’re trailblazers that dream big, take risks, and challenge cybersecurity’s status quo. It’s simple: we can’t accomplish our mission without diverse teams innovating, together.
We are committed to providing reasonable accommodations for all qualified individuals with a disability. If you require assistance or accommodation due to a disability or special need, please contact us at accommodations@paloaltonetworks.com.
Palo Alto Networks is an equal opportunity employer. We celebrate diversity in our workplace, and all qualified applicants will receive consideration for employment without regard to age, ancestry, color, family or medical care leave, gender identity or expression, genetic information, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran status, race, religion, sex (including pregnancy), sexual orientation, or other legally protected characteristics.
All your information will be kept confidential according to EEO guidelines.
Is role eligible for Immigration Sponsorship?: YesOur Mission
At Palo Alto Networks®, we’re united by a shared mission—to protect our digital way of life. We thrive at the intersection of innovation and impact, solving real-world problems with cutting-edge technology and bold thinking. Here, everyone has a voice, and every idea counts. If you’re ready to do the most meaningful work of your career alongside people who are just as passionate as you are, you’re in the right place.
Who We Are
In order to be the cybersecurity partner of choice, we must trailblaze the path and shape the future of our industry. This is something our employees work at each day and is defined by our values: Disruption, Collaboration, Execution, Integrity, and Inclusion. We weave AI into the fabric of everything we do and use it to augment the impact every individual can have. If you are passionate about solving real-world problems and ideating beside the best and the brightest, we invite you to join us!
We believe collaboration thrives in person. That’s why most of our teams work from the office full time, with flexibility when it’s needed. This model supports real-time problem-solving, stronger relationships, and the kind of precision that drives great outcomes.Job Summary
Your Career
You will be part of the team that builds and delivers the threat detection capabilities powering Palo Alto Networks’ Advanced Threat Prevention (ATP). The ATP detection team is responsible for decoding network protocols, identifying applications, and detecting threats across our enterprise customers’ networks.
As a Principal Security Researcher, you will play a key technical leadership role in shaping how ATP detects and prevents real-world attacks. You will propose and drive innovative technical ideas from concept to production, own multiple projects or a broader technical area with measurable impact, and provide technical leadership to other researchers or developers. This is a hands-on leadership role: you are expected to define direction, make technical decisions, and contribute directly to vulnerability research, exploit analysis, and production detection work.
Your Impact
Shape ATP detection strategy by identifying important vulnerability, exploit, and attack technique areas where new or improved protections are needed.
Drive innovative detection ideas from concept to production, delivering measurable improvements in coverage, quality, speed, or scalability.
Improve rapid response capability for zero-days, high-impact CVEs, and emerging attack vectors by guiding technical assessment, detection strategy, and release decisions.
Raise the quality and consistency of IPS protections by defining detection approaches, validation expectations, and technical review standards for complex cases.
Expand the team’s ability to deliver protections at scale through practical automation, detection pipeline improvements, and AI-assisted research workflows.
Provide hands-on technical leadership to researchers or developers through direction, review, problem decomposition, and execution guidance.
Influence cross-functional decisions with product, QA, engineering, and research partners to ensure detections are technically sound, customer-relevant, and production-ready.
Qualifications
Deep hands-on experience in vulnerability research, exploit analysis, IPS/IDS detection, offensive security, or closely related threat prevention work.
Proven ability to identify important technical problems, propose detection ideas, drive execution, and deliver measurable product or customer impact.
Deep understanding of common vulnerability classes and exploit techniques, including memory corruption, injection, authentication bypass, path traversal, SSRF, RCE, XSS, SQL injection, CSRF, MITM, and DoS.
Strong ability to analyze vulnerability root cause, exploitability, PoC behavior, network traffic, protocol behavior, application-layer attack patterns, and detection tradeoffs.
Experience translating vulnerability or exploit understanding into production-quality IPS signatures, IDS detections, network detections, or other customer-facing protections.
Strong understanding of network protocols and application-layer behavior, especially HTTP, DNS, SMB, FTP, SMTP, TCP/UDP, TLS, and related protocols.
Strong programming or scripting skills for research automation, tooling, test generation, detection development, or pipeline improvements.
Ability to lead complex technical work under ambiguity, guide other researchers or developers, and make sound technical decisions under time pressure.
Experience using AI, ML, automation, or research tooling to improve security analysis, detection development, validation, or response workflows is highly desirable.
Foundational understanding of AI security scenarios or AI-assisted security workflows is a plus.
Strong communication skills with the ability to influence technical direction across research, product, QA, and engineering partners.
BS/MS in Computer Science, Computer Engineering, Cybersecurity, or related field, or equivalent professional experience.
Compensation Disclosure
The compensation offered for this position will depend on qualifications, experience, and work location. For candidates who receive an offer at the posted level, the starting base salary (for non-sales roles) or base salary + commission target (for sales/com-missioned roles) is expected to be the annual range listed below. The offered compensation may also include restricted stock units and a bonus.
$162,700.00 - $263,175.00/yrOur Commitment
We’re trailblazers that dream big, take risks, and challenge cybersecurity’s status quo. It’s simple: we can’t accomplish our mission without diverse teams innovating, together.
We are committed to providing reasonable accommodations for all qualified individuals with a disability. If you require assistance or accommodation due to a disability or special need, please contact us at accommodations@paloaltonetworks.com.
Palo Alto Networks is an equal opportunity employer. We celebrate diversity in our workplace, and all qualified applicants will receive consideration for employment without regard to age, ancestry, color, family or medical care leave, gender identity or expression, genetic information, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran status, race, religion, sex (including pregnancy), sexual orientation, or other legally protected characteristics.
All your information will be kept confidential according to EEO guidelines.
Is role eligible for Immigration Sponsorship?: YesSee All 247+ Senior Level Clinical Research Manager Jobs
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Find JobsSenior Level Clinical Research Manager Job Market
Who's Hiring
- Amazon10
- Palo Alto Networks8
- Apple7
- Google6
- The Clear Fund6
Top Industries Hiring
- Technology & Software63
- Healthcare & Medical Services35
- Education22
- Retail16
- Science & Research15
Senior Level Clinical Research Manager Jobs: Frequently Asked Questions
How do I get a senior level clinical research manager job?
Employers at this level look for candidates who have owned full trial lifecycles, managed cross-functional teams, and navigated regulatory submissions independently. A strong candidate demonstrates depth in ICH-GCP compliance, experience mentoring junior staff, and a history of delivering complex studies on time. Tailoring your application to show leadership outcomes, not just task completion, gives you a real edge.
Which companies hire senior level clinical research managers?
Companies hiring senior level clinical research managers right now include Amazon, Palo Alto Networks, and Apple, based on current listings on Migrate Mate as of July 2026. Hiring at this level comes from a mix of large pharmaceutical manufacturers, contract research organizations, and biotech firms running late-phase or multi-site trials.
Are there remote senior level clinical research manager jobs?
Yes, though availability varies by employer and therapeutic area. About 36% of senior level clinical research manager openings are remote or hybrid as of July 2026, reflecting how many organizations have adapted oversight and monitoring workflows to distributed teams. On-site roles tend to be tied to sponsors with active investigator sites or internal lab operations.
What makes a clinical research manager role senior level?
Senior level roles are defined by ownership rather than execution. You are setting trial strategy, accountable for regulatory and protocol decisions, managing the performance of clinical teams, and serving as the primary point of escalation for site or vendor issues. These positions also carry mentoring responsibility, developing junior managers and coordinators as part of the day-to-day scope.
Which industries hire the most senior level clinical research managers?
Senior Level clinical research manager roles concentrate in Technology & Software, Healthcare & Medical Services, and Education, based on current listings on Migrate Mate as of July 2026. These sectors drive hiring at this level because they run the largest volume of regulated clinical programs, require experienced leadership to manage investigator networks, and face the most demanding submission timelines.