Septerna Visa Sponsorship USA
Septerna is a clinical-stage biotechnology company focused on GPCR-targeted drug discovery. It sponsors H-1B visas, making it a viable option for international scientists and researchers seeking U.S. work authorization in a specialized, science-driven environment.
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INTRODUCTION
Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date. We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team. We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.
ABOUT THE ROLE
Septerna is seeking an experienced and highly motivated Director of Clinical Development to provide scientific and operational leadership across our early clinical development programs. This individual will play a critical role in the design, execution, and interpretation of clinical studies, working cross-functionally to ensure high-quality, decision-ready data that advances our pipeline. The ideal candidate will bring deep expertise in clinical development, a strong scientific foundation, and the ability to operate effectively in a fast-paced biotech environment. This position will work closely with Clinical Development, Clinical Operations, Regulatory, Early Development, Biometrics, and Program Management functions and will report to the Senior Medical Director, Clinical Development.
Responsibilities:
- Lead the design, planning, and execution of early-phase clinical trials (Phase 1 and Phase 2), including protocol development and study-related documents.
- Drive development of key study documents including protocols, investigator brochures, clinical study reports (CSRs), and informed consent forms.
- Collaborate with Clinical Operations to ensure effective study execution, including site selection, enrollment strategies, and timeline management.
- Partner with multi-disciplinary team to define endpoints, biomarkers, and data analysis plans that enable clear interpretation of study results.
- Contribute to clinical development plans, including indication strategy, study design, and dose selection.
- Analyze and interpret clinical data; present findings to internal stakeholders and support decision-making at governance forums.
- Support regulatory submissions (e.g., INDs/CTAs, briefing documents) and participate in health authority interactions as needed.
- Identify clinical and operational risks and work proactively with cross-functional teams to develop mitigation strategies.
- Ensure clinical studies are conducted in compliance with GCP and applicable regulatory requirements.
- Contribute to building scalable Clinical Sciences processes and capabilities.
QUALIFICATIONS
- Bachelor’s degree in life sciences or related field; advanced degree (PhD, PharmD, or MD) strongly preferred.
- 10+ years of experience in Clinical Sciences, Clinical Development, or a related function within the biopharmaceutical industry.
- Demonstrated experience supporting or leading early-phase clinical trials (Phase 1/2), including protocol development and data interpretation.
- Strong understanding of clinical drug development, including study design, endpoints, and regulatory considerations.
- Experience working in cross-functional teams, with the ability to influence without authority.
- Excellent analytical, organizational, and communication skills, with the ability to translate complex data into clear insights.
- High attention to detail and commitment to data quality and scientific rigor.
- Ability to thrive in a dynamic, fast-paced environment and manage multiple priorities effectively.
- Collaborative, hands-on, and solution-oriented mindset with a passion for advancing innovative therapies.
COMPENSATION
- The anticipated salary range for candidates who will work in South San Francisco, CA is $235,000 - $260,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Septerna participates in the E-Verify program.
California Consumer Privacy Act Privacy Notice For Job Applicants. If you are a California resident, click here for our CCPA Notice.

INTRODUCTION
Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date. We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team. We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.
ABOUT THE ROLE
Septerna is seeking an experienced and highly motivated Director of Clinical Development to provide scientific and operational leadership across our early clinical development programs. This individual will play a critical role in the design, execution, and interpretation of clinical studies, working cross-functionally to ensure high-quality, decision-ready data that advances our pipeline. The ideal candidate will bring deep expertise in clinical development, a strong scientific foundation, and the ability to operate effectively in a fast-paced biotech environment. This position will work closely with Clinical Development, Clinical Operations, Regulatory, Early Development, Biometrics, and Program Management functions and will report to the Senior Medical Director, Clinical Development.
Responsibilities:
- Lead the design, planning, and execution of early-phase clinical trials (Phase 1 and Phase 2), including protocol development and study-related documents.
- Drive development of key study documents including protocols, investigator brochures, clinical study reports (CSRs), and informed consent forms.
- Collaborate with Clinical Operations to ensure effective study execution, including site selection, enrollment strategies, and timeline management.
- Partner with multi-disciplinary team to define endpoints, biomarkers, and data analysis plans that enable clear interpretation of study results.
- Contribute to clinical development plans, including indication strategy, study design, and dose selection.
- Analyze and interpret clinical data; present findings to internal stakeholders and support decision-making at governance forums.
- Support regulatory submissions (e.g., INDs/CTAs, briefing documents) and participate in health authority interactions as needed.
- Identify clinical and operational risks and work proactively with cross-functional teams to develop mitigation strategies.
- Ensure clinical studies are conducted in compliance with GCP and applicable regulatory requirements.
- Contribute to building scalable Clinical Sciences processes and capabilities.
QUALIFICATIONS
- Bachelor’s degree in life sciences or related field; advanced degree (PhD, PharmD, or MD) strongly preferred.
- 10+ years of experience in Clinical Sciences, Clinical Development, or a related function within the biopharmaceutical industry.
- Demonstrated experience supporting or leading early-phase clinical trials (Phase 1/2), including protocol development and data interpretation.
- Strong understanding of clinical drug development, including study design, endpoints, and regulatory considerations.
- Experience working in cross-functional teams, with the ability to influence without authority.
- Excellent analytical, organizational, and communication skills, with the ability to translate complex data into clear insights.
- High attention to detail and commitment to data quality and scientific rigor.
- Ability to thrive in a dynamic, fast-paced environment and manage multiple priorities effectively.
- Collaborative, hands-on, and solution-oriented mindset with a passion for advancing innovative therapies.
COMPENSATION
- The anticipated salary range for candidates who will work in South San Francisco, CA is $235,000 - $260,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Septerna participates in the E-Verify program.
California Consumer Privacy Act Privacy Notice For Job Applicants. If you are a California resident, click here for our CCPA Notice.
Job Roles at Septerna Companies
How to Get Visa Sponsorship in Septerna Visa Sponsorship USA
Target scientific and research roles
Septerna's sponsorship activity aligns with its core drug discovery mission. Focus your applications on roles in structural biology, medicinal chemistry, and pharmacology, where H-1B sponsorship is most likely to be part of the offer.
Understand the GPCR research focus
Septerna's platform is built around G protein-coupled receptor biology. Candidates with direct GPCR research experience or relevant drug discovery backgrounds are best positioned to stand out in a highly specialized hiring process.
Prepare for a technical interview process
Biotech companies at Septerna's stage prioritize deep scientific expertise. Expect detailed discussions about your research methodology, publications, and how your work connects to their therapeutic pipeline during the interview process.
Engage early in the H-1B cap cycle
If you need cap-subject H-1B sponsorship, time your application outreach for late 2025 or early 2026. This gives Septerna sufficient runway to file a petition before the April 1 filing deadline and avoid missing the lottery window.
Verify sponsorship history before applying
Not every biotech company sponsors visas consistently. Use Migrate Mate to filter by verified sponsorship history, so you can confirm Septerna's track record before investing time in a full application.
Highlight advanced degrees prominently
H-1B specialty occupation requirements are most easily satisfied in biotechnology with a relevant PhD or master's degree. Make sure your resume clearly connects your academic credentials to Septerna's specific research areas from the first page.
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Get Access To All JobsFrequently Asked Questions
Does Septerna sponsor H-1B visas?
Yes, Septerna sponsors H-1B visas. As a biotechnology company engaged in specialized drug discovery research, Septerna hires candidates who require H-1B work authorization. Sponsorship is most commonly associated with scientific and research-oriented roles that demand advanced expertise in fields like structural biology or pharmacology.
Which roles at Septerna are most likely to receive visa sponsorship?
Sponsorship at Septerna is concentrated in highly technical roles tied to its GPCR drug discovery platform. Positions in structural biology, computational chemistry, medicinal chemistry, and preclinical research are the most natural fit. These roles require specialized academic training that directly supports an H-1B specialty occupation classification, making sponsorship a practical part of the hiring process.
What is the typical timeline for H-1B sponsorship at a company like Septerna?
The H-1B process has fixed federal deadlines. USCIS opens registration in early March, the lottery runs in late March, and approved petitions can be filed from April 1 for an October 1 start date. If you're currently on F-1 OPT, you may be able to start earlier. Plan to begin conversations with Septerna's recruiting team several months before the registration window opens.
How do I find open roles at Septerna that offer visa sponsorship?
Migrate Mate lets you search for jobs at verified H-1B sponsors, including Septerna, so you can filter by real sponsorship history rather than guessing from job descriptions. Once you identify a relevant opening, review Septerna's published job requirements carefully and tailor your application to highlight how your scientific background aligns with their therapeutic pipeline.
Is Septerna a strong option for international candidates in biotechnology?
Septerna is a focused clinical-stage biotech with a clear scientific mission, which makes it a credible sponsorship option for international researchers with the right background. While it sponsors a more selective volume of visas than large pharmaceutical corporations, candidates with deep GPCR or drug discovery expertise are applying into a highly targeted environment where their skills are directly relevant.
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