E-3 Visa Quality Control Manager Jobs
Quality Control Manager roles qualify for E-3 visa sponsorship because they meet the specialty occupation requirement, a bachelor's degree in engineering, science, or a related field is standard for the position. Australian professionals can enter the U.S. on an E-3 with no lottery and renewable two-year work periods tied to a qualifying employer.
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Get Access To All JobsAssociate Director, Chemical Engineering
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Position Description
Nurix is seeking an experienced, independent, and highly motivated individual who will be accountable for end-to-end chemical engineering support of bexobrutideg (NX-5948) drug substance (DS) from late-stage development through commercial launch, including oversight of external manufacturing sites. The Associate Director, Chemical Engineering will work closely with the CMC team and colleagues in cross-functional departments to provide scientific, technical, and hands-on leadership and oversight of facility and equipment operations at Contract Development Manufacturing Organizations (CDMOs) to support bexobrutideg drug substance manufacturing process optimization and scale-up. The position will report to the Director, Chemical Development.
Responsibilities Will Include But Are Not Limited To
- Provide engineering leadership to design, develop and optimize scalable routes for small-molecule DS manufacturing, including demonstrated knowledge in unit operation design, process modeling, process equipment selection and scale-up methodologies.
- Review equipment configurations, qualification packages, and maintenance records at CDMOs to ensure equipment trains are properly qualified, maintained and operating at optimal performance to support Nurix manufacturing operations.
- Oversee equipment engineering and scale-up operations at DS CDMOs, including hands-on process troubleshooting during engineering, clinical, registration and PPQ batches.
- Lead technology transfer to CDMOs including scale-up and demonstration of new chemical processes in development and commercial equipment.
- Coordinate with CDMOs and Nurix Quality Assurance, and Global Supply Chain functions to ensure timely manufacture and release of DS lots.
- Partner within Nurix CMC to drive process understanding (critical process parameters, critical quality attributes, control strategy) using engineering principles, DoE and QbD concepts.
- Review and approve Master Batch Records, campaign reports, deviation investigations and change controls for drug substance operations.
- Ensure manufacturing operations adhere to company quality, safety and regulatory standards (FDA, EMA, ICH, cGMP).
- Provide regular Person-In-Plant support for DS manufacturing and ongoing performance monitoring of key facility and operational KPIs across manufacturing sites, including schedule adherence, batch performance, deviation trends, and inspection readiness.
- Author and review CMC sections of regulatory filings including INDs/IMPD, and NDA/MAA, including responses to Health Authority queries.
- Define and drive the long-term engineering strategy for bexobrutideg DS, including process robustness, lifecycle management, and cost-of-goods optimization.
- Represent Chemical Engineering on CMC and cross-functional program teams, providing input to development strategy, risk assessments, and timelines.
- Manage and provide technical mentorship of scientists and engineers.
Required Qualifications
- Ph.D. in chemical engineering, or related field with at least 5 years (M.S. with 10 years or B.S. with 15 years) of industrial, late-phase, small-molecule drug substance development experience
- Extensive knowledge and experience in GMP drug substance manufacturing, characterization, process development, equipment evaluation/selection, scale up and process validation.
- Knowledge of solid-state properties, polymorphism, and crystallization principles relevant to small-molecule drug substance.
- Extensive third-party drug substance CDMO management experience including tech transfer activities, QbD and DoE studies, clinical supply production, registration batch production and commercial launch activities.
- In-depth knowledge of relevant cGMP, ICH, FDA and EMA guidelines.
- Proven track record of effective internal and external collaboration.
- Excellent oral and written communication skills, interpersonal skills and problem-solving abilities.
- Ability to multi-task, manage conflict and work in a fast-paced environment.
- Ability to travel up to 25% of their time.
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
Salary Range: $189,800 - $216,700
Location: Brisbane, CA - Onsite
Associate Director, Chemical Engineering
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Position Description
Nurix is seeking an experienced, independent, and highly motivated individual who will be accountable for end-to-end chemical engineering support of bexobrutideg (NX-5948) drug substance (DS) from late-stage development through commercial launch, including oversight of external manufacturing sites. The Associate Director, Chemical Engineering will work closely with the CMC team and colleagues in cross-functional departments to provide scientific, technical, and hands-on leadership and oversight of facility and equipment operations at Contract Development Manufacturing Organizations (CDMOs) to support bexobrutideg drug substance manufacturing process optimization and scale-up. The position will report to the Director, Chemical Development.
Responsibilities Will Include But Are Not Limited To
- Provide engineering leadership to design, develop and optimize scalable routes for small-molecule DS manufacturing, including demonstrated knowledge in unit operation design, process modeling, process equipment selection and scale-up methodologies.
- Review equipment configurations, qualification packages, and maintenance records at CDMOs to ensure equipment trains are properly qualified, maintained and operating at optimal performance to support Nurix manufacturing operations.
- Oversee equipment engineering and scale-up operations at DS CDMOs, including hands-on process troubleshooting during engineering, clinical, registration and PPQ batches.
- Lead technology transfer to CDMOs including scale-up and demonstration of new chemical processes in development and commercial equipment.
- Coordinate with CDMOs and Nurix Quality Assurance, and Global Supply Chain functions to ensure timely manufacture and release of DS lots.
- Partner within Nurix CMC to drive process understanding (critical process parameters, critical quality attributes, control strategy) using engineering principles, DoE and QbD concepts.
- Review and approve Master Batch Records, campaign reports, deviation investigations and change controls for drug substance operations.
- Ensure manufacturing operations adhere to company quality, safety and regulatory standards (FDA, EMA, ICH, cGMP).
- Provide regular Person-In-Plant support for DS manufacturing and ongoing performance monitoring of key facility and operational KPIs across manufacturing sites, including schedule adherence, batch performance, deviation trends, and inspection readiness.
- Author and review CMC sections of regulatory filings including INDs/IMPD, and NDA/MAA, including responses to Health Authority queries.
- Define and drive the long-term engineering strategy for bexobrutideg DS, including process robustness, lifecycle management, and cost-of-goods optimization.
- Represent Chemical Engineering on CMC and cross-functional program teams, providing input to development strategy, risk assessments, and timelines.
- Manage and provide technical mentorship of scientists and engineers.
Required Qualifications
- Ph.D. in chemical engineering, or related field with at least 5 years (M.S. with 10 years or B.S. with 15 years) of industrial, late-phase, small-molecule drug substance development experience
- Extensive knowledge and experience in GMP drug substance manufacturing, characterization, process development, equipment evaluation/selection, scale up and process validation.
- Knowledge of solid-state properties, polymorphism, and crystallization principles relevant to small-molecule drug substance.
- Extensive third-party drug substance CDMO management experience including tech transfer activities, QbD and DoE studies, clinical supply production, registration batch production and commercial launch activities.
- In-depth knowledge of relevant cGMP, ICH, FDA and EMA guidelines.
- Proven track record of effective internal and external collaboration.
- Excellent oral and written communication skills, interpersonal skills and problem-solving abilities.
- Ability to multi-task, manage conflict and work in a fast-paced environment.
- Ability to travel up to 25% of their time.
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
Salary Range: $189,800 - $216,700
Location: Brisbane, CA - Onsite
See all 34+ E-3 Visa Quality Control Manager Jobs
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Get Access To All JobsTips for Finding E-3 Visa Sponsorship as a Quality Control Manager
Align your credentials to U.S. specialty occupation standards
USCIS evaluates whether your QC Manager role requires a specific bachelor's degree field, not just any degree. Frame your engineering or science qualifications explicitly on your resume and in cover letters to support the specialty occupation determination.
Target manufacturers with active DOL LCA filing history
Employers who have previously filed Labor Condition Applications for QC or engineering roles already understand the E-3 visa process. Focus your search on industries like medical devices, aerospace, and food manufacturing, where Australian quality standards credentials carry direct relevance.
Request LCA filing before your start date is set
The DOL must certify your Labor Condition Application before your consulate appointment can proceed. Ask your prospective employer to begin the LCA as soon as you receive a verbal offer, not after contracts are signed, to avoid delays.
Use Migrate Mate's E-3 filing service to manage LCA paperwork
Employers unfamiliar with E-3 sponsorship often stall at the LCA stage. Use Migrate Mate's E-3 filing service to handle your LCA and visa paperwork end-to-end, reducing the burden on your employer's HR team and keeping your timeline on track.
Prepare ISO and Australian Standards documentation in advance
U.S. consular officers and employers may not immediately recognise Australian quality frameworks. Translate your experience with AS/NZS standards into equivalent ISO or FDA regulatory language before interviews, so your QC expertise reads as directly applicable.
Clarify E-3 renewal terms during salary negotiations
Each E-3 renewal requires a new LCA certifying the prevailing wage for your role and location. Confirm with your employer before signing that they're prepared to sponsor renewals, not just your initial entry, so you're not renegotiating sponsorship every two years.
E-3 Visa Quality Control Manager: Frequently Asked Questions
How do I find Quality Control Manager jobs that offer E-3 visa sponsorship?
Migrate Mate is built specifically for this search. It filters Quality Control Manager roles by employers with E-3 sponsorship history, so you're not cold-applying to companies that have never navigated Australian visa requirements. Standard job boards don't filter by visa type, which means most listings you find there won't lead to a sponsored offer.
How much does it cost to get an E-3 visa?
Migrate Mate's E-3 filing service covers the entire process for $499, including the Labor Condition Application, visa document preparation, and consulate appointment guidance. Traditional immigration lawyers charge $2,000–$5,000+ for the same work. The E-3 has less paperwork than most work visas, so paying thousands for legal help is usually unnecessary.
Does a Quality Control Manager role qualify as a specialty occupation for the E-3 visa?
Yes, provided the position genuinely requires a bachelor's degree or higher in a specific field such as engineering, manufacturing science, or a related discipline. Generalist QC roles that accept any bachelor's degree regardless of field are at higher risk of a specialty occupation challenge. Roles tied to regulated industries like pharmaceuticals, aerospace, or medical devices are the strongest candidates because degree specificity is well established.
How does the E-3 visa compare to the H-1B for Quality Control Manager roles?
The E-3 is available only to Australian citizens and has no annual lottery, which means you can apply and start work in a predictable timeframe once you have a job offer and a certified LCA. The H-1B visa is capped at 85,000 per year and subject to a random lottery, so most applicants wait at least a year for a slot. For Australian QC professionals, the E-3 is the faster and more reliable path.
What happens to my E-3 status if I change employers or move into a different QC role?
Each E-3 is employer-specific and tied to the job described in your LCA. If you change employers or your responsibilities shift substantially, your new employer must file a fresh LCA and you'll need a new E-3 visa stamp at a consulate abroad before you can work under the new arrangement. There is no cap-gap protection or portability provision for E-3 holders the way there is for some other visa categories.