Green Card Real World Evidence Jobs
Real World Evidence roles sit at the intersection of clinical data science and regulatory strategy, making them strong candidates for EB-2 sponsorship under the advanced-degree pathway. Employers in pharma, biotech, and health economics file PERM labor certifications to permanently sponsor RWE professionals, bypassing annual visa caps that affect temporary work status.
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Get Access To All JobsINTRODUCTION
Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. Mineralys is a fully remote company.
Position Summary
The Associate Director, HEOR / Real-World Evidence (RWE) plays a strategic and scientific leadership role in developing and executing evidence strategies that support the clinical and economic value of our innovative therapy. This position is responsible for designing and delivering real-world and outcomes research evidence to support medical affairs, market access, and regulatory objectives. The role focuses on generating high-quality, decision-relevant evidence, including observational studies, external control arms, and economic models, and indirect treatment comparisons, to contextualize clinical outcomes, demonstrate value, and support stakeholder decision-making. The Associate Director collaborates cross-functionally with Medical Affairs, biostatistics, and commercial teams, while also engaging external partners such as academic researchers, key opinion leaders, and data vendors. This role contributes to strategic evidence planning, scientific communication, and advancing real-world data capabilities within a matrixed organization.
Key Responsibilities
- Lead the design, execution, and oversight of HEOR and RWE studies, including observational studies (retrospective/prospective cohorts), economic models, external control arms and indirect treatment comparisons.
- Oversee data analysis ensuring methodological rigor and contribute to research reports for internal and external consumption.
- Develop and execute integrated HEOR strategies aligned with product development and market access needs.
- Identify evidence gaps and define research strategies to address unmet needs, burden of disease, and treatment pathways.
- Support development of value messaging tools (e.g., cost-effectiveness models, budget impact models).
Cross-functional Collaboration & Stakeholder Engagement
- Partner cross-functionally with Medical Affairs, Clinical Development, Market Value & Access and Commercial teams to align with data needs.
- Build and manage relationships with external experts, academic collaborators, and vendors.
- Provide HEOR/RWE expertise to support interactions with HTA agencies.
- Lead publication planning and development of HEOR/RWE abstracts, manuscripts, and presentations for scientific congresses and peer-reviewed journals.
Operational Leadership & Governance
- Oversee vendor selection and management, ensuring timely, high-quality study execution.
- Manage timelines, budgets, and deliverables across multiple projects.
- Ensure all HEOR activities adhere to compliance guidelines, internal SOPs, regulatory standards, and ethical guidelines for RWD and economic modeling.
Qualifications
- Advanced degree required (PhD, PharmD, MD, MPH, or similar) in health economics, outcomes research, biostatistics, epidemiology or related field.
- Minimum of 8 years of relevant experience in HEOR, RWE, or outcomes research in pharmaceutical, biotech, consulting, or academic settings.
- Strong analytical skills and strong understanding of observational study design, real-world data sources (claims, EMR, registries), and health economic modeling.
- Experience with burden of illness studies, and comparative effectiveness research.
- Familiarity HTA requirements and RWE regulatory landscape.
- Demonstrated ability to successfully lead complex research projects independently and collaboratively.
- Strong communication, and scientific writing skills, including publication track record.
- Proven cross-functional collaboration and stakeholder engagement capabilities.
Travel
This position requires up to 20% travel. Frequently travel is outside the local area and overnight.
US Salary Range: $175,000 - $200,000
INTRODUCTION
Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. Mineralys is a fully remote company.
Position Summary
The Associate Director, HEOR / Real-World Evidence (RWE) plays a strategic and scientific leadership role in developing and executing evidence strategies that support the clinical and economic value of our innovative therapy. This position is responsible for designing and delivering real-world and outcomes research evidence to support medical affairs, market access, and regulatory objectives. The role focuses on generating high-quality, decision-relevant evidence, including observational studies, external control arms, and economic models, and indirect treatment comparisons, to contextualize clinical outcomes, demonstrate value, and support stakeholder decision-making. The Associate Director collaborates cross-functionally with Medical Affairs, biostatistics, and commercial teams, while also engaging external partners such as academic researchers, key opinion leaders, and data vendors. This role contributes to strategic evidence planning, scientific communication, and advancing real-world data capabilities within a matrixed organization.
Key Responsibilities
- Lead the design, execution, and oversight of HEOR and RWE studies, including observational studies (retrospective/prospective cohorts), economic models, external control arms and indirect treatment comparisons.
- Oversee data analysis ensuring methodological rigor and contribute to research reports for internal and external consumption.
- Develop and execute integrated HEOR strategies aligned with product development and market access needs.
- Identify evidence gaps and define research strategies to address unmet needs, burden of disease, and treatment pathways.
- Support development of value messaging tools (e.g., cost-effectiveness models, budget impact models).
Cross-functional Collaboration & Stakeholder Engagement
- Partner cross-functionally with Medical Affairs, Clinical Development, Market Value & Access and Commercial teams to align with data needs.
- Build and manage relationships with external experts, academic collaborators, and vendors.
- Provide HEOR/RWE expertise to support interactions with HTA agencies.
- Lead publication planning and development of HEOR/RWE abstracts, manuscripts, and presentations for scientific congresses and peer-reviewed journals.
Operational Leadership & Governance
- Oversee vendor selection and management, ensuring timely, high-quality study execution.
- Manage timelines, budgets, and deliverables across multiple projects.
- Ensure all HEOR activities adhere to compliance guidelines, internal SOPs, regulatory standards, and ethical guidelines for RWD and economic modeling.
Qualifications
- Advanced degree required (PhD, PharmD, MD, MPH, or similar) in health economics, outcomes research, biostatistics, epidemiology or related field.
- Minimum of 8 years of relevant experience in HEOR, RWE, or outcomes research in pharmaceutical, biotech, consulting, or academic settings.
- Strong analytical skills and strong understanding of observational study design, real-world data sources (claims, EMR, registries), and health economic modeling.
- Experience with burden of illness studies, and comparative effectiveness research.
- Familiarity HTA requirements and RWE regulatory landscape.
- Demonstrated ability to successfully lead complex research projects independently and collaboratively.
- Strong communication, and scientific writing skills, including publication track record.
- Proven cross-functional collaboration and stakeholder engagement capabilities.
Travel
This position requires up to 20% travel. Frequently travel is outside the local area and overnight.
US Salary Range: $175,000 - $200,000
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Get Access To All JobsTips for Finding Green Card Sponsorship in Real World Evidence
Document your RWE credential stack early
PERM requires your employer to advertise the role at your actual qualifications. If your background spans epidemiology, biostatistics, and health economics databases like Optum or MarketScan, document each credential separately so the job description captures your full profile.
Target sponsors through OFLC PERM filing data
Search DOL PERM disclosure data filtered to SOC codes for epidemiologists and health data analysts. Pharma companies and contract research organizations that filed PERM for RWE titles in the past two years are your highest-probability sponsorship targets.
Use Migrate Mate to filter by green card sponsorship history
Search Migrate Mate by RWE-adjacent job titles and filter for employers with active EB-2 or EB-3 sponsorship history. This cuts the time spent cold-applying to companies with no PERM infrastructure in place.
Understand how EB-2 versus EB-3 affects your timeline
EB-2 requires a master's degree or equivalent in a relevant field; EB-3 covers bachelor's-level professionals. Your degree level determines which preference category your employer files under, which directly affects your priority date queue, especially for Indian and Chinese nationals.
Align your job offer letter with PERM wage requirements
Your employer must offer at least the DOL prevailing wage for your RWE role before USCIS approves the I-140. Ask your employer's immigration counsel to run the OFLC Wage Search for your specific job title and work location before you accept the offer.
Flag concurrent filing eligibility during offer negotiation
If your priority date is current when the I-140 is approved, USCIS allows concurrent filing of I-140 and I-485. Negotiating this filing strategy upfront with your employer prevents months of unnecessary waiting between petition stages.
Green Card Real World Evidence: Frequently Asked Questions
Do Real World Evidence roles typically qualify for EB-2 sponsorship?
Most RWE positions require a master's degree or PhD in epidemiology, biostatistics, health economics, or a related field, which places them squarely in the EB-2 advanced-degree category. Employers file PERM labor certification with DOL, followed by an I-140 petition with USCIS. Roles requiring only a bachelor's degree may qualify under EB-3 instead, depending on the job description.
How is green card sponsorship different from H-1B for RWE professionals?
H-1B visa is a temporary nonimmigrant status capped at 85,000 annually with a lottery. EB-2 and EB-3 green card sponsorship has no annual cap at the petition level and results in permanent residency rather than temporary status. The PERM labor certification process is more document-intensive and takes longer, but there's no lottery risk and the outcome is lawful permanent residency.
Which employers sponsor green cards for Real World Evidence positions?
Pharmaceutical companies, contract research organizations, health economics and outcomes research consultancies, and large managed care organizations are the most active PERM filers for RWE roles. You can verify sponsorship history by searching DOL PERM disclosure data filtered to epidemiologist and health data analyst SOC codes before applying.
How long does the PERM green card process take for an RWE professional?
The PERM labor certification stage alone currently averages over a year at DOL. After certification, USCIS processes the I-140 petition, then you wait for your priority date to become current in the visa bulletin before filing I-485 for adjustment of status. Total timelines range from two to five or more years depending on your country of birth and preference category.
How can I find RWE jobs that offer green card sponsorship?
Migrate Mate lets you search RWE and adjacent job titles filtered specifically by employers with green card sponsorship history, so you avoid applying to companies with no PERM infrastructure. Pairing that search with DOL PERM disclosure data for epidemiology and health data analytics SOC codes gives you a targeted shortlist of high-probability sponsoring employers.