H-1B Visa Bioinformatics Jobs
Bioinformatics roles sit squarely within H-1B specialty occupation requirements, as the work demands at minimum a bachelor's degree in computational biology, bioinformatics, or a closely related field. Pharma, biotech, and academic medical centers are consistent H-1B sponsors for these positions, filing LCAs under SOC codes that include biological scientists and computer occupations.
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Get Access To All JobsINTRODUCTION
Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
ABOUT THE ROLE
We are seeking an Associate Director of Bioinformatics, Diagnostics to lead and manage a team of bioinformatics software engineers building the clinical pipelines and tooling that power Tempus's diagnostics platform. This is a primarily management role at the intersection of science and engineering: You won't be writing production code day-to-day, but you'll be deeply engaged in technical design, architectural decisions, and code review.
You'll report to the Senior Director of Diagnostics Technology and own the day-to-day operations of a team of 4-6 engineers. This means driving execution, unblocking your team, and serving as the primary technical and organizational point of contact across product, engineering, and scientific stakeholders.
This is the right role for someone who has grown out of pure individual contribution and is ready to lead but who still gets energized by hard technical problems and wants to stay close to the work.
DUTIES AND RESPONSIBILITIES:
Team Leadership & Management
- Lead and manage a team of 4-6 bioinformatics software engineers, including workload planning, mentorship, and career development.
- Run daily standups and own the team's sprint planning; write, refine, and prioritize tickets in close collaboration with product and scientific stakeholders.
- Conduct regular 1:1s and performance conversations; foster a team culture of technical rigor, collaboration, and continuous improvement.
Technical Oversight
- Lead software design and architecture discussions; author and review technical design documents.
- Provide thorough and constructive PR reviews across the team's codebase.
- Drive adoption of engineering best practices across the team, including workflow standards, testing, and documentation.
- Serve as a technical escalation point; capable of contributing directly to code or design when the team needs it.
Cross-Functional Collaboration
- Act as the primary day-to-day liaison between the bioinformatics engineering team and product, software engineering, and clinical science partners.
- Translate scientific requirements into actionable engineering work; translate engineering constraints back to scientific and product stakeholders clearly and proactively.
- Represent the team in planning, roadmap, and prioritization discussions with leadership.
Clinical Pipeline Development
- Oversee the design, development, and maintenance of bioinformatics pipelines operating in a clinical production environment.
- Ensure high-quality, validated software through rigorous testing, QA processes, and documentation practices appropriate for a regulated clinical setting.
REQUIRED EXPERIENCE
- 5+ years of experience in bioinformatics software engineering or a closely related field, including at least 2 years in a team lead, tech lead, or people management capacity.
- Strong Python engineering skills — not just scripting, but production-quality software development.
- Experience with next-generation sequencing data and clinical or research genomics pipelines.
- Demonstrated ability to lead technical design and provide meaningful code review, even when not the primary implementer.
- Strong written and verbal communication skills; comfortable working across scientific and engineering audiences.
PREFERRED EXPERIENCE
- Experience with Nextflow or similar workflow orchestration frameworks.
- Experience with Google Cloud Platform or other cloud environments.
- Experience developing software in a GxP, CLIA, or other regulated clinical setting.
- Familiarity with SQL and relational data systems.
- Exposure to FDA regulatory processes or clinical diagnostics development.
- Experience with TypeScript/React or other frontend tooling (a plus, not a requirement).
- Background in cancer genomics, molecular biology, or immunology.
COMPENSATION
- Salary Range: $150,000-$220,000
The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
INTRODUCTION
Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
ABOUT THE ROLE
We are seeking an Associate Director of Bioinformatics, Diagnostics to lead and manage a team of bioinformatics software engineers building the clinical pipelines and tooling that power Tempus's diagnostics platform. This is a primarily management role at the intersection of science and engineering: You won't be writing production code day-to-day, but you'll be deeply engaged in technical design, architectural decisions, and code review.
You'll report to the Senior Director of Diagnostics Technology and own the day-to-day operations of a team of 4-6 engineers. This means driving execution, unblocking your team, and serving as the primary technical and organizational point of contact across product, engineering, and scientific stakeholders.
This is the right role for someone who has grown out of pure individual contribution and is ready to lead but who still gets energized by hard technical problems and wants to stay close to the work.
DUTIES AND RESPONSIBILITIES:
Team Leadership & Management
- Lead and manage a team of 4-6 bioinformatics software engineers, including workload planning, mentorship, and career development.
- Run daily standups and own the team's sprint planning; write, refine, and prioritize tickets in close collaboration with product and scientific stakeholders.
- Conduct regular 1:1s and performance conversations; foster a team culture of technical rigor, collaboration, and continuous improvement.
Technical Oversight
- Lead software design and architecture discussions; author and review technical design documents.
- Provide thorough and constructive PR reviews across the team's codebase.
- Drive adoption of engineering best practices across the team, including workflow standards, testing, and documentation.
- Serve as a technical escalation point; capable of contributing directly to code or design when the team needs it.
Cross-Functional Collaboration
- Act as the primary day-to-day liaison between the bioinformatics engineering team and product, software engineering, and clinical science partners.
- Translate scientific requirements into actionable engineering work; translate engineering constraints back to scientific and product stakeholders clearly and proactively.
- Represent the team in planning, roadmap, and prioritization discussions with leadership.
Clinical Pipeline Development
- Oversee the design, development, and maintenance of bioinformatics pipelines operating in a clinical production environment.
- Ensure high-quality, validated software through rigorous testing, QA processes, and documentation practices appropriate for a regulated clinical setting.
REQUIRED EXPERIENCE
- 5+ years of experience in bioinformatics software engineering or a closely related field, including at least 2 years in a team lead, tech lead, or people management capacity.
- Strong Python engineering skills — not just scripting, but production-quality software development.
- Experience with next-generation sequencing data and clinical or research genomics pipelines.
- Demonstrated ability to lead technical design and provide meaningful code review, even when not the primary implementer.
- Strong written and verbal communication skills; comfortable working across scientific and engineering audiences.
PREFERRED EXPERIENCE
- Experience with Nextflow or similar workflow orchestration frameworks.
- Experience with Google Cloud Platform or other cloud environments.
- Experience developing software in a GxP, CLIA, or other regulated clinical setting.
- Familiarity with SQL and relational data systems.
- Exposure to FDA regulatory processes or clinical diagnostics development.
- Experience with TypeScript/React or other frontend tooling (a plus, not a requirement).
- Background in cancer genomics, molecular biology, or immunology.
COMPENSATION
- Salary Range: $150,000-$220,000
The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
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Get Access To All JobsTips for Finding H-1B Visa Sponsorship in Bioinformatics
Map your degree to the role
USCIS requires your degree field to directly relate to bioinformatics work. A degree in computer science or biology alone can trigger an RFE, document how your coursework covers both computational and biological domains before applying.
Target employers with LCA filing history
Search OFLC disclosure data filtered to bioinformatics-related SOC codes to see which pharma, genomics, and research employers have filed LCAs. Migrate Mate surfaces this data so you can prioritize companies with active sponsorship records.
Check prevailing wage before negotiating
Your offered salary must meet the DOL prevailing wage for your job zone and location. Run the OFLC Wage Search using your specific SOC code before any offer discussion so you can negotiate within a range USCIS won't flag.
Use O*NET to frame your specialty occupation case
Bioinformatics spans multiple SOC codes and adjudicators sometimes challenge specialty occupation status. Pull the O*NET occupation profile for your specific role title and use its education and training data to anchor your employer's support letter.
File premium processing if your start date is rigid
Bioinformatics grant cycles and clinical trial timelines often mean rigid start dates. USCIS premium processing guarantees a 15-business-day adjudication decision, reducing the risk that delayed approval disrupts a project-tied onboarding date.
Bioinformatics jobs are hiring across the US. Find yours.
Find Bioinformatics JobsBioinformatics H-1B Visa: Frequently Asked Questions
Does bioinformatics qualify as a specialty occupation for H-1B purposes?
Yes, bioinformatics qualifies as a specialty occupation because the work requires at minimum a bachelor's degree in a directly related field such as computational biology, bioinformatics, or computer science with a biological sciences minor. USCIS expects the employer to document why a specialized degree, not just any bachelor's, is required for the specific role.
Which SOC code applies to bioinformatics jobs for LCA filing?
Most bioinformatics positions are filed under SOC 19-1029 (Biological Scientists, All Other) or 15-2099 (Mathematical Science Occupations, All Other), depending on whether the role is research-focused or computationally weighted. The employer chooses the code, but it directly determines your prevailing wage tier, so confirm it matches your actual job duties before the LCA is submitted to DOL.
How do I find employers who actively sponsor H-1B visas for bioinformatics roles?
Migrate Mate filters job listings by employers with verified H-1B LCA filing history, including companies in pharma, genomics, and academic medical research. Searching by role type and location shows you which organizations have a track record of sponsoring bioinformatics professionals, rather than guessing based on company size or industry.
Can a bioinformatics employer file my H-1B if I'm still finishing my degree?
Yes, if you'll complete your degree before the H-1B start date of October 1, your employer can submit the registration in March for a cap-subject H-1B. USCIS allows filing before graduation as long as the degree is conferred by the time the petition is approved or the employment begins, whichever is later.
What happens to my H-1B status if my bioinformatics role shifts from research to software development?
A material change in job duties requires your employer to file an amended H-1B petition before the change takes effect. If the new role falls under a different SOC code or prevailing wage level, the employer must also file a new LCA with DOL. Failing to amend can put your status out of compliance, so flag any significant duty changes to your employer's immigration counsel promptly.
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