Principal Jobs in Durham, NC

Principal jobs in Durham, North Carolina are concentrated in Research Triangle Park, downtown Durham, and the Ninth Street and Duke University corridors, with strong demand across K-12 education, life sciences, and professional services. Employers hiring right now include IQVIA, Fidelity Investments, and City of Durham, NC. See the openings below and apply to the ones that match your experience.

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Overview

Open roles39
Top employerIQVIA
Work type47% On-site
Top credentialBachelor's
Companies hiring21

Showing 5 of 39+ Principal jobs

IQVIA
Associate Principal, Strategic Consulting, Patient Centered Solutions
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IQVIA
New 1m ago
Associate Principal, Strategic Consulting, Patient Centered Solutions
IQVIA
Durham, North Carolina
Product Management
Project Management
Solutions Engineering & Architecture
10,000+

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Alcon
Principal 1, Organic Synthesis Chemistry
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Alcon
New 1m ago
Principal 1, Organic Synthesis Chemistry
Alcon
Durham, North Carolina
Chemistry & Materials Science
Manufacturing Operations
Quality Control
High school diploma or GED
10,000+

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Labcorp
Principal Software Engineer - Variant Knowledge Platform
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Labcorp
New 1m ago
Principal Software Engineer - Variant Knowledge Platform
Labcorp
Durham, North Carolina
Cloud Engineering
DevOps
IT Support
Bachelor's degree
10,000+

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Fidelity Investments
Principal Full Stack Java Engineer (REST, AWS, Kafka, Python)
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Fidelity Investments
New 1m ago
Principal Full Stack Java Engineer (REST, AWS, Kafka, Python)
Fidelity Investments
Durham, North Carolina
Customer Support
Software Engineering
Technical Program Management
Remote (US)
Bachelor's degree
10,000+

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Fidelity Investments
Principal ZTNA Network Engineer – Employee Remote Access
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Fidelity Investments
New 1m ago
Principal ZTNA Network Engineer – Employee Remote Access
Fidelity Investments
Durham, North Carolina
Cloud Architecture
Network Engineering
Solutions Architecture
ITIL Certification
10,000+

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See All 39 Principal Jobs in Durham

Find roles in Durham that match your experience and apply in just a few clicks.

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Principal Job Market in Durham

Who's Hiring

  • IQVIA
    IQVIA5
  • Fidelity Investments
    Fidelity Investments5
  • City of Durham, NC
    City of Durham, NC4
  • NVIDIA
    NVIDIA3
  • Fortrea
    Fortrea2

Top Industries Hiring

  • Biotechnology & Pharmaceuticals7
  • Technology & Software6
  • Consulting & Professional Services4
  • Electronics & Hardware3
  • Manufacturing2

Principal Jobs in Durham: Frequently Asked Questions

How do I get a principal job in Durham?

Focus your search on Durham's K-12 public and charter school systems, the research and administrative operations anchored near Duke University and Research Triangle Park, and the growing life sciences and professional services firms downtown. Candidates who demonstrate direct leadership experience in Durham's specific demographics and a familiarity with its community-centered school culture consistently stand out. Networking through Durham Public Schools and local education nonprofits also opens doors that online applications alone rarely do.

Which companies hire principals in Durham?

Durham principal roles are posted by IQVIA, Fidelity Investments, and City of Durham, NC and others right now, based on current listings on Migrate Mate as of July 2026. Durham's employer mix is distinctive, pulling from a combination of large public institutions, charter networks, research-driven organizations near Research Triangle Park, and an expanding base of corporate offices that use the principal title for senior technical and product leadership.

Are there remote principal jobs in Durham?

Yes, though availability depends heavily on the type of principal role. School-based principal positions are almost entirely on-site by nature, while principal engineers, principal scientists, and principal consultants tied to Durham's tech and life sciences sectors are far more likely to offer flexibility. About 53% of principal openings tied to Durham are remote or hybrid as of July 2026, with the highest share found in software, data, and research-oriented roles connected to the Research Triangle Park corridor.

How can I get a principal job in Durham with little or no experience?

The most realistic entry path in Durham is building toward the role through assistant or vice principal positions within Durham Public Schools or the city's charter networks, which actively develop internal candidates. For corporate principal titles in Durham's tech and life sciences sectors, lateral moves from senior individual contributor roles at Research Triangle Park employers are common stepping stones. Volunteering with Durham education nonprofits or joining mentorship programs tied to Duke and North Carolina Central University also builds the local visibility that hiring managers notice.

Which industries hire the most principals in Durham?

The sectors hiring the most principals in Durham are Biotechnology & Pharmaceuticals, Technology & Software, and Consulting & Professional Services, based on current listings on Migrate Mate as of July 2026. Durham's concentration of public schools, charter networks, university-affiliated research institutions, and a rapidly expanding life sciences and technology corridor around Research Triangle Park makes it one of the more diverse markets in the state for the principal title across both education and corporate contexts.

See All 39 Principal Jobs in Durham

Find roles in Durham that match your experience and apply in just a few clicks.

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