Senior Level Principal Medical Science Liaison Jobs
Senior level principal medical science liaison jobs place experienced professionals in strategic ownership of medical affairs initiatives, leading field teams, shaping evidence communication plans, and driving cross-functional alignment with clinical and commercial stakeholders. Roles are concentrated across Biotechnology & Pharmaceuticals and Healthcare & Medical Services, with a mix of field-based and remote opportunities, and employers like Revolution Medicines, Revolution Medicines, and Praxis Precision Medicines hiring at this level now.
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Showing 5 of 13+ Senior Level Principal Medical Science Liaison jobs
About this role
The (Senior) Medical Science Liaison role is a part of US Medical Affairs, a strategic partner within Biogen, that helps inform medical practice across our therapeutic areas and pipeline to improve meaningful patient outcomes. The (Senior) Medical Science Liaison enables critical stakeholder engagement with Key Medical Experts (KMEs) and other healthcare professionals (HCPs) so they understand the clinical and scientific narrative for Biogen’s therapies. Biogen’s priority is to continue to foster and enable a diverse and inclusive workforce – representing age, gender, sexual identity, race, ethnicity, Veterans, and people with disabilities – that reflects the communities where we operate and the patients who we serve.
This territory will cover the following states: PA, NJ, NY, CT, RI, MA, NH, VT, and ME. The successful candidate must reside within the boundaries of the territory.
What You Will Do
- Be a credible medical/ scientific expert who engages with KME and HCP to increase confidence in making the best clinical decisions pertaining to disease state and Biogen’s products in the near and long term for the benefit of patient care.
- Focus on building deep, strategic, long-term relationships with internal & external stakeholder to be viewed as a partner rather than transactional.
- Be a “partner in the trenches”—be responsive, engage often and be a solutions-driven conduit to leaders in the medical community.
- Engage in projects and/or initiatives aligned to US Medical strategy, objectives and tactics
- Be highly accountable to qualitative and quantitative medical excellence performance goals, standards, and measurements. Deliver against KME engagement plans that add high value by navigating resources at the office in collaboration with field and non-field colleagues. Capture and report KME/HCP medical insights using Veeva with the highest level of consistency and accuracy to help inform the medical and clinical strategies.
Who You Are
You are a scientific or clinical professional with a passion for science and deep scientific knowledge. You have a marked curiosity about healthcare and business opportunities. You keep patients, payers and physicians top of mind in your daily work and collaborate to solve critical scientific and business challenges.
Required Skills
- Doctoral level degree (MD, PhD, PharmD, DNP) in clinical/scientific related field is required.
- This territory will cover the following states: PA, NJ, NY, CT, RI, MA, NH, VT, and ME. The successful candidate must reside within the boundaries of the territory.
- Established relationships with healthcare professionals and key medical experts within the territory relevant to therapeutic area is required.
- Effective communication : Communicates concisely, confidently, and credibly; Easily understands other points of view and responds appropriately; Listens with empathy to respond to current and future needs and adjust the communication according to the audience.
- Digital potential : Comfortable using and experimenting with technology; Embraces and optimally utilizes new tools and systems; Demonstrates a willingness and aptitude to learn if not yet well versed.
- Accountability : Delivers reliably against goals; Motivated to perform to meet and even exceed metrics and Key Performance Indicators (KPIs). Views metrics and KPIs as a positive opportunity to communicate value to internal stakeholders.
- Ethical: Understands rules for industry and is committed to following them for the benefit of patients.
- Able to travel at least 60% of the time, including ability to travel overnight and occasionally on weekends. Must be 18 years of age or older with valid driver’s license and an acceptable driving record. Must have authorization and ability to drive a company leased vehicle or rental.
Preferred Skills & Therapeutic Area Specific Skills
- Clinical experience and subject matter expertise in the respective therapeutic area is optimal.
- Subject matter expertise in nephrology, with a particular focus on IgA Nephropathy (IgAN) and Antibody-Mediated Rejection (AMR), is highly preferred.
Why Biogen?
Our Company mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.
Job Level: Management
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
About this role
The (Senior) Medical Science Liaison role is a part of US Medical Affairs, a strategic partner within Biogen, that helps inform medical practice across our therapeutic areas and pipeline to improve meaningful patient outcomes. The (Senior) Medical Science Liaison enables critical stakeholder engagement with Key Medical Experts (KMEs) and other healthcare professionals (HCPs) so they understand the clinical and scientific narrative for Biogen’s therapies. Biogen’s priority is to continue to foster and enable a diverse and inclusive workforce – representing age, gender, sexual identity, race, ethnicity, Veterans, and people with disabilities – that reflects the communities where we operate and the patients who we serve.
This territory will cover the following states: PA, NJ, NY, CT, RI, MA, NH, VT, and ME. The successful candidate must reside within the boundaries of the territory.
What You Will Do
- Be a credible medical/ scientific expert who engages with KME and HCP to increase confidence in making the best clinical decisions pertaining to disease state and Biogen’s products in the near and long term for the benefit of patient care.
- Focus on building deep, strategic, long-term relationships with internal & external stakeholder to be viewed as a partner rather than transactional.
- Be a “partner in the trenches”—be responsive, engage often and be a solutions-driven conduit to leaders in the medical community.
- Engage in projects and/or initiatives aligned to US Medical strategy, objectives and tactics
- Be highly accountable to qualitative and quantitative medical excellence performance goals, standards, and measurements. Deliver against KME engagement plans that add high value by navigating resources at the office in collaboration with field and non-field colleagues. Capture and report KME/HCP medical insights using Veeva with the highest level of consistency and accuracy to help inform the medical and clinical strategies.
Who You Are
You are a scientific or clinical professional with a passion for science and deep scientific knowledge. You have a marked curiosity about healthcare and business opportunities. You keep patients, payers and physicians top of mind in your daily work and collaborate to solve critical scientific and business challenges.
Required Skills
- Doctoral level degree (MD, PhD, PharmD, DNP) in clinical/scientific related field is required.
- This territory will cover the following states: PA, NJ, NY, CT, RI, MA, NH, VT, and ME. The successful candidate must reside within the boundaries of the territory.
- Established relationships with healthcare professionals and key medical experts within the territory relevant to therapeutic area is required.
- Effective communication : Communicates concisely, confidently, and credibly; Easily understands other points of view and responds appropriately; Listens with empathy to respond to current and future needs and adjust the communication according to the audience.
- Digital potential : Comfortable using and experimenting with technology; Embraces and optimally utilizes new tools and systems; Demonstrates a willingness and aptitude to learn if not yet well versed.
- Accountability : Delivers reliably against goals; Motivated to perform to meet and even exceed metrics and Key Performance Indicators (KPIs). Views metrics and KPIs as a positive opportunity to communicate value to internal stakeholders.
- Ethical: Understands rules for industry and is committed to following them for the benefit of patients.
- Able to travel at least 60% of the time, including ability to travel overnight and occasionally on weekends. Must be 18 years of age or older with valid driver’s license and an acceptable driving record. Must have authorization and ability to drive a company leased vehicle or rental.
Preferred Skills & Therapeutic Area Specific Skills
- Clinical experience and subject matter expertise in the respective therapeutic area is optimal.
- Subject matter expertise in nephrology, with a particular focus on IgA Nephropathy (IgAN) and Antibody-Mediated Rejection (AMR), is highly preferred.
Why Biogen?
Our Company mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.
Job Level: Management
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
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- Biotechnology & Pharmaceuticals
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Senior Level Principal Medical Science Liaison Jobs: Frequently Asked Questions
How do I get a senior level principal medical science liaison job?
Employers at this level look for candidates who have already operated independently as a principal or senior MSL and can demonstrate ownership over a therapeutic area, not just execution. Deep clinical expertise, a history of building KOL relationships that influenced clinical strategy, and evidence of mentoring junior liaisons all strengthen your candidacy. Publications, congress presentations, or advisory board contributions signal the scientific standing these roles require.
Which companies hire senior level principal medical science liaisons?
Companies hiring senior level principal medical science liaisons right now include Revolution Medicines, Revolution Medicines, and Praxis Precision Medicines, based on current listings on Migrate Mate as of November 2026. Hiring at this level concentrates among large pharmaceutical manufacturers, specialty biologics companies, and medical device firms with established or growing medical affairs functions.
Are there remote senior level principal medical science liaison jobs?
Yes, though most senior level roles carry a field or territory component tied to KOL engagement. About 83% of senior level principal medical science liaison openings are remote or hybrid as of November 2026, reflecting roles where medical strategy and internal leadership responsibilities can be performed off-site while field activity remains geographically defined.
What makes a principal medical science liaison role senior level?
Senior level principal medical science liaison roles are defined by scope of ownership and leadership responsibility rather than task execution. Professionals at this stage own a full therapeutic area or region, set the scientific engagement strategy for their team, mentor mid-level liaisons, and serve as internal subject matter experts for clinical, regulatory, and commercial partners. Reactive field support is a small fraction of the work.
Which industries hire the most senior level principal medical science liaisons?
Senior Level principal medical science liaison roles concentrate in Biotechnology & Pharmaceuticals and Healthcare & Medical Services, based on current listings on Migrate Mate as of November 2026. These sectors drive demand because they maintain large medical affairs organizations that require experienced liaisons to manage complex evidence landscapes and support late-stage or post-approval therapeutic portfolios.