Principal Scientist Jobs in Redwood City, CA

INTRODUCTION

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines is seeking a scientifically talented and highly motivated individual to join our Integrated Discovery Research team as Principal Scientist, Head of Analytical Chemistry. In this role, you will drive analytical chemistry strategy and execution within the Medicinal Chemistry function, supporting drug discovery programs from early hit identification through lead optimization and candidate selection. This position offers a unique opportunity to shape analytical science at the frontiers of small molecule beyond Rule-of-Five (bRo5) drug discovery.

Responsibilities:

• Design and lead analytical chemistry strategies and daily operations to support small molecule drug discovery programs across multiple stages.
• Develop and implement robust analytical methods (e.g., LC/MS, HPLC, SFC) for compound characterization, purity assessment (including chiral purity), and stability or reactivity studies (e.g. GSH assay).
• Lead and execute compound purification (including chiral separations), structural elucidation, and physicochemical property assessment in the beyond Rule-of-Five chemical space.
• Collaborate closely with medicinal chemists, process chemists, and DMPK scientists to develop and execute integrated analytical strategies; manage external analytical chemistry service providers to ensure high-quality, timely data delivery.
• Mentor and develop a team of analytical chemists, fostering scientific excellence and professional development.
• Design and implementation of discovery analytics, analytical data integration through collaboration with LabOS team, Data Sciences and Data Analytics functions to develop and implement automated high-throughput analytical methods that enhance efficiency and data quality.
• Ensure compliance with safety standards in laboratory operations.
• Contribute to invention disclosures, patent filings, and external scientific publications as appropriate.

REQUIRED SKILLS, EXPERIENCE AND EDUCATION:

• Ph.D. in Analytical or Organic Chemistry (or related discipline) with 12+ years of industry experience.
• Demonstrated expertise in advanced analytical method development, troubleshooting, and problem-solving in small molecule drug discovery.
• Strong hands-on experience with chromatographic and spectroscopic techniques, including LC/MS, HPLC, SFC, and NMR.
• Proven experience supporting drug discovery programs across multiple modalities, including small molecules, peptides, and antibody–drug conjugates (ADCs).
• Strong problem-solving skills with sound technically driven decision-making ability.
• Excellent communication skills and the ability to drive cross-disciplinary partnerships.
• A track record of innovation and execution in fast-paced, data-driven research environments.

PREFERRED SKILLS:

• Experience supporting beyond Rule-of-Five (bRo5) medicinal chemistry, including macrocycles, covalent inhibitors, or other alternative modalities.
• Ability to integrate analytical insights into medicinal chemistry decision-making.
• Working knowledge of lab automation and high-throughput analytical techniques.

COMPENSATION

• Base Pay Salary Range: $190,000—$238,000 USD

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.

Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.

If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to careers@revmed.com so we can share these impersonations with our IT team for tracking and awareness.