Principal Software Engineer Jobs in Indianapolis, IN

Principal Software Engineer jobs in Indianapolis are concentrated in the North Meridian corridor, downtown's Mile Square, and the Keystone at the Crossing tech belt, with strong demand across healthtech, fintech, and enterprise software. Employers actively hiring include Eli Lilly, Elanco, and Meyer Distributing. Find a role that fits below and apply directly.

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Overview

Open roles102+
Top employerEli Lilly
Work type69% On-site
Top credentialBachelor's degree
Companies hiring69

Showing 5 of 102+ Principal Software Engineer jobs

MDM ETL Specialist / Developer
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New 17h ago
MDM ETL Specialist / Developer
RCR Technology
Indianapolis, Indiana
Data Science & Analytics
Data Engineering
Quality Assurance & Testing (QA Testing)
Data Science
Automation QA
On-Site
Bachelor's

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Lead Principal Systems Engineer (MBSE)
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Added 1d ago
Lead Principal Systems Engineer (MBSE)
Raytheon
Indianapolis, Indiana
Engineering (Non-Software)
Project & Program Management
Project Management
Technical Program Management
$108k - $205k/yr
10,000+

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Sr Principal Engineer Supplier Quality
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Added 2d ago
Sr Principal Engineer Supplier Quality
Northrop Grumman
Indianapolis, Indiana
Customer Service & Support
Customer Support
Product Management
Technical Program Management
$118k - $176k/yr
Bachelor's degree in mechanical engineering
10,000+

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MES Systems Engineering - Sr. Principal
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Added 3d ago
MES Systems Engineering - Sr. Principal
Eli Lilly
Indianapolis, Indiana
Executive Leadership & C-Suite
Program Management
Project Management
$144k - $231k/yr
Bachelor's degree in information technology
10,000+

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Software Systems Developer
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Added 3d ago
Software Systems Developer
Level Up Development
Indianapolis, Indiana
Backend Engineering
Full-stack Engineering
Software Engineering
$85k - $110k/yr
On-Site
11-50

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See All 102+ Principal Software Engineer Jobs in Indianapolis

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Principal Software Engineer Job Market in Indianapolis

Who's Hiring

Eli Lilly7 open roles
Elanco5 open roles
Meyer Distributing5 open roles

Top Industries Hiring

  • Technology & Software
  • Automotive
  • Distribution & Wholesale
  • Aerospace & Defense
  • Consulting & Professional Services

Principal Software Engineer Jobs in Indianapolis: Frequently Asked Questions

How do I get a principal software engineer job in Indianapolis?

Target Indianapolis's healthtech and fintech sectors first, where demand for senior engineering leadership is highest. The North Meridian corridor and Keystone at the Crossing area house many of the city's largest tech employers, so focusing your search there pays off. Candidates who can show experience leading distributed teams or modernizing legacy systems stand out, since many Indianapolis employers are mid-to-late in their cloud migration cycles.

Which companies hire principal software engineers in Indianapolis?

Companies currently hiring principal software engineers in Indianapolis include Eli Lilly, Elanco, and Meyer Distributing, per current listings on Migrate Mate as of November 2026. Indianapolis draws a mix of large health systems, insurance carriers, and homegrown SaaS companies, all of which regularly hire at the principal level to lead engineering teams and drive architecture decisions.

Are there remote principal software engineer jobs in Indianapolis?

Yes, though most principal software engineer roles lean hybrid given the leadership and cross-team coordination the position requires. About 31% of principal software engineer openings tied to Indianapolis are remote or hybrid as of November 2026, reflecting how common flexible arrangements have become at the senior level. The most fully remote openings tend to be at Indianapolis-headquartered SaaS and insurtech companies with distributed engineering teams.

How can I get a principal software engineer job in Indianapolis with little or no experience?

The most realistic path is moving up through staff or senior software engineer roles at one of Indianapolis's larger health systems or insurance-adjacent tech firms, which run internal promotion tracks to the principal level. Companies in the Salesforce and Appirio ecosystem around Indianapolis also promote from within heavily. Building a portfolio of system design work or leading an open-source project helps signal readiness for principal-level scope before the title is official.

Which industries hire the most principal software engineers in Indianapolis?

The sectors hiring the most principal software engineers in Indianapolis are Technology & Software, Automotive, and Distribution & Wholesale, based on current listings on Migrate Mate as of November 2026. Indianapolis's unusually dense concentration of healthcare networks, insurance carriers, and logistics companies creates sustained demand for senior engineers who can own large-scale platform architecture and guide cross-functional engineering teams.

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