Principal Software Engineer Jobs

Job Title: Principal Software Engineer

Location: South San Francisco, CA preferred; Remote optional

Job Type: Full-time

About the Role

We're seeking a Principal Software Engineer to join Natera's R&D Platform Infrastructure team. The team builds the cloud infrastructure, workflow platforms, and data platforms that R&D uses to do its science — including a Kubernetes-based workflow execution platform, a custom R&D LIMS system, and a set of supporting tools that routinely handle production-scale workloads.

This is a senior technical role. You'll own the full architecture, implementation, and delivery of large projects across our platform. You'll partner with the team lead on roadmap and tough technical calls, mentor mid-level engineers, and help the team find the right solution for the problem — not the most elaborate one. We're a small team (4 engineers + lead) with broad scope, and we're heavily AI-augmented: every engineer uses Claude Code / Cursor as a daily tool, and we build our own AI tooling (custom plugins, MCP servers, agents) to multiply ourselves.

Responsibilities

• Architecture & Delivery: Own the design, implementation, and delivery of major initiatives across our platform. Take fuzzy problems through to shipped, working software used in production.
• Technical Leadership: Lead architecture and design reviews. Help the team find the right solution for the problem and avoid unnecessary complexity. Influence technical decisions across the team.
• Mentorship: Mentor mid-level engineers through code review, design docs, and pairing. Raise the engineering bar by example.
• AI-Native Development: Build and improve our AI-coding tooling alongside the rest of the team. Help us push the frontier of agent-driven software development inside the company.
• Cross-Functional Partnership: Work with bioinformaticians, scientists, and other R&D engineers to understand their needs and translate them into platform capabilities. Partner with the team lead on roadmap, prioritization, and tough technical calls.

Required Experience

• Years of Experience: 10+ years of professional software engineering experience across a range of systems and problem types.
• Cloud Infrastructure: Production experience with a major cloud platform (AWS preferred; GCP or Azure equivalent). You've designed for a cloud, not just deployed to one.
• Container Orchestration: Production experience with Kubernetes (or equivalent). Comfortable reasoning about cluster design, scheduling, networking, and workload patterns.
• Infrastructure as Code: Production experience with Terraform (or equivalent). Comfortable owning shared modules and multi-environment deployments.
• Programming: Strong proficiency in at least one general-purpose language (Python, Go, Java, or similar). Comfortable picking up new languages as needed — and comfortable using AI tooling to accelerate that.
• End-User Software: You've shipped software to end users (internal or external). You understand the realities of running a product — incongruent user feedback, competing priorities, the gap between requirements and what users actually need.
• Team Leadership: You've led an engineering team before and have mentored junior engineers. You're comfortable being the technical owner of multi-quarter initiatives.
• Startup Background: You've worked in fast-moving environments where results need to be delivered quickly. Scrappy, MVP-first, comfortable shipping in days rather than weeks.
• Familiarity with our tech stack: AWS, Kubernetes, Python, Go, Groovy, Terraform, Helm, Nextflow, WDL, Django, React.

How You Work

• Product-Minded: You think in terms of business and user problems, not tickets. You ask "should we build this?" before "how do I build this?"
• Calibrated Judgement: You know when to move fast and break things, and when to slow down and double-check. The ability to dial this in based on context is something we hire specifically for.
• AI-Native Development: Actively excited about AI-native development. Not just willing to use Claude / Cursor, but actively interested in building tooling that makes your colleagues 10x faster.

Bonus

• Domain-Adjacent Experience: Prior work in any of the following helps you ramp faster, but is not required: scientific or bioinformatics computing, LIMS or laboratory data systems, workflow orchestration engines (Nextflow, WDL, Airflow, Argo, Temporal, Dagster, etc.), large-scale ETL or data pipeline systems, or HPC/batch-compute platforms.

Why Join Us

• Work on the platform that powers Natera's R&D — a small, high-leverage team where individual contribution is highly visible.
• Operate at the frontier of AI-augmented software engineering. We don't just talk about AI tooling — we build it, and use it daily.
• Significant autonomy and influence over the team's technical direction.
• Competitive salary and benefits.

We value diversity and are committed to creating an inclusive environment for all employees. We encourage applicants of all backgrounds to apply.

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.