Project Lead Jobs in St. Louis, MO

Project Lead jobs in St. Louis are in strong demand, concentrated in Clayton, Cortex Innovation Community, and the downtown Central Business District across healthcare IT, logistics, defense contracting, and financial services. Employers hiring right now include Esri, Ameren, and Vertiv. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles67
Top employerEsri
Work type69% Hybrid
Top credentialBachelor of Science
Companies hiring14

Showing 5 of 67+ Project Lead jobs

Project Manager - Specialist
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Added 2d ago
Project Manager - Specialist
University Missouri St.Louis
St. Louis, Missouri
Business Strategy
Project Management
Strategy & Corporate Development
$54k - $76k/yr
Bachelor's degree in information technology
201-500

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Project Manager - Federal Programs (TS/SCI)
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Added 3d ago
Project Manager - Federal Programs (TS/SCI)
Esri
St. Louis, Missouri
Business Strategy
Consulting & Professional Services
Strategy & Corporate Development
$84k - $142k/yr
Bachelor's degree in geography
1,001-5,000

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Assistant Project Manager
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Added 3d ago
Assistant Project Manager
Darwin Chambers Company, LLC
St. Louis, Missouri
Construction Management
Manufacturing Operations
Project Management
$65k - $75k/yr
On-Site
Associate's degree in construction management
51-200

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Project Manager - Federal (TS/SCI)
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Added 3d ago
Project Manager - Federal (TS/SCI)
Esri
St. Louis, Missouri
Software Engineering
Solutions Engineering & Architecture
Technical Program Management
$84k - $142k/yr
Bachelor's degree in geography
1,001-5,000

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Construction Project Manager III - St. Louis
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Added 4d ago
Construction Project Manager III - St. Louis
Clear Global Solutions LLC
St. Louis, Missouri
Business Operations
Compliance & Risk
Project Management
$90k - $100k/yr
Bachelor of Science

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See All 67 Project Lead Jobs in St. Louis

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Project Lead Job Market in St. Louis

Who's Hiring

Esri9 open roles
Ameren4 open roles
Vertiv4 open roles

Project Lead Jobs in St. Louis: Frequently Asked Questions

How do I get a project lead job in St. Louis?

Focus your search on St. Louis's dominant hiring sectors: healthcare systems, defense and aerospace contractors, logistics and supply chain firms, and financial technology companies. The Cortex Innovation Community and Clayton's corporate corridor concentrate a large share of openings. Candidates who demonstrate cross-functional coordination experience, familiarity with Agile or PMP frameworks, and the ability to manage stakeholders in regulated industries move fastest in this market.

Which companies hire project leads in St. Louis?

St. Louis project lead roles are posted by Esri, Ameren, and Vertiv and others right now, based on current listings on Migrate Mate as of November 2026. St. Louis draws hiring from large integrated health systems, legacy aerospace and defense firms, regional banks, and a growing cluster of logistics technology companies headquartered in or near the metro.

Are there remote project lead jobs in St. Louis?

Yes, though availability depends heavily on the role type. Project leads in software, IT, and analytics tend to work remotely or hybrid, while those in construction, manufacturing, and lab environments are almost always on-site. About 69% of project lead openings tied to St. Louis are remote or hybrid as of November 2026. The strongest remote options in this market come from healthcare IT and fintech employers based in the region.

How can I get a project lead job in St. Louis with little or no experience?

The most realistic entry path in St. Louis is moving into a project coordinator or junior project manager role at one of the city's large health systems or defense contractors, where structured training programs are common. Washington University, BJC HealthCare, and Boeing-affiliated suppliers regularly bring in early-career candidates for coordinator-level roles that ladder into project lead positions. Building proficiency in tools like Jira, Smartsheet, or MS Project and earning a CAPM or equivalent certificate gives local candidates a measurable edge over competitors.

See All 67 Project Lead Jobs in St. Louis

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