Remote Principal Scientist Jobs
Remote Principal Scientist jobs are open across biotech, pharmaceuticals, data science, and clinical research at remote-first firms and distributed enterprise teams that have built fully asynchronous scientific workflows. Roles range from individual contributor research positions through staff and distinguished scientist levels requiring cross-functional leadership. Employers hiring remotely right now include Optum, Instacart, and Zillow. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 94+ Remote Principal Scientist jobs
We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time.
Position Summary: Aetna Resources, LLC., a CVS Health company, is hiring for the following role in Woonsocket, RI: Principal Data Scientist to develop and implement analytics applications and models to transform data into meaningful information. Duties include: design and develop data solutions using industry leading tools, technologies and best practices to profile data and develop efficient ingestion by sourcing data from PBM, Specialty, Retail, and/or HealthCare business; develop advanced algorithms and statistical predictive models to evaluate scenarios, predict outcomes, and provide usable information on health metrics and potential future outcomes; utilize data mining, data modeling, natural language processing, and machine learning to extract and manipulate data from multiple large data sources and deliver predictive models that inform solutions for in-house teams (i.e. pharmacy pricing, medical costs, risk scores, onboarding) and customer engagement across critical journeys (i.e. calories, heart rate, breast cancer, maternity); utilize data-oriented programming languages and visualization software to explore, analyze, and interpret large volumes of data in various forms and solve complex business problems; visualize and interpret data and create reports, manipulate data using statistical software, and compare models using statistical performance metrics; and support deployment of insights across multiple channels using analysis methods, machine learning, and statistical analyses. Telecommuting available. Multiple positions. Requirements: Master’s degree (or foreign equivalent) in Computer Science, Data Science, Statistics, Mathematics, Analytics, or a related field and four (4) years of experience in the job offered or related occupation. Requires three (3) years of experience in each of the following: • Data analytics on large data sets in healthcare, business, or retail sector; • Machine learning, statistical analysis, and predictive modeling; • Hadoop and Hive; • R, Python, or SQL; • SAS or SQL programming languages; • Visualization tools, including PowerBI or Tableau; • Designing data models and solutions for analytical and reporting use cases; and • Machine learning, statistical analysis, and predictive modeling. Pay Range: $141565.00/year to $288400.00/year.
This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, geography and other relevant factors. This position is eligible for a CVS Health bonus, commission or short-term incentive program in addition to the base pay range listed above. This position also includes an award target in the company’s equity award program.
In addition to your compensation, enjoy the rewards of an organization that puts our heart into caring for our colleagues and our communities. The Company offers a full range of medical, dental, and vision benefits. Eligible employees may enroll in the Company’s 401(k) retirement savings plan, and an Employee Stock Purchase Plan is also available for eligible employees. The Company provides a fully-paid term life insurance plan to eligible employees, and short-term and long term disability benefits. CVS Health also offers numerous well-being programs, education assistance, free development courses, a CVS store discount, and discount programs with participating partners. As for time off, Company employees enjoy Paid Time Off (“PTO”) or vacation pay, as well as paid holidays throughout the calendar year. Number of paid holidays, sick time and other time off are provided consistent with relevant state law and Company policies.
Great benefits for great people
We take pride in offering a comprehensive and competitive mix of pay and benefits that reflects our commitment to our colleagues and their families.
This full‑time position is eligible for a comprehensive benefits package designed to support the physical, emotional, and financial well‑being of colleagues and their families. The benefits for this position include medical, dental, and vision coverage, paid time off, retirement savings options, wellness programs, and other resources, based on eligibility.
Additional details about available benefits are provided during the application process and on Benefits Moments.
This job does not have an application deadline, as CVS Health accepts applications on an ongoing basis.
Qualified applicants with arrest or conviction records will be considered for employment in accordance with all federal, state and local laws.
We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time.
Position Summary: Aetna Resources, LLC., a CVS Health company, is hiring for the following role in Woonsocket, RI: Principal Data Scientist to develop and implement analytics applications and models to transform data into meaningful information. Duties include: design and develop data solutions using industry leading tools, technologies and best practices to profile data and develop efficient ingestion by sourcing data from PBM, Specialty, Retail, and/or HealthCare business; develop advanced algorithms and statistical predictive models to evaluate scenarios, predict outcomes, and provide usable information on health metrics and potential future outcomes; utilize data mining, data modeling, natural language processing, and machine learning to extract and manipulate data from multiple large data sources and deliver predictive models that inform solutions for in-house teams (i.e. pharmacy pricing, medical costs, risk scores, onboarding) and customer engagement across critical journeys (i.e. calories, heart rate, breast cancer, maternity); utilize data-oriented programming languages and visualization software to explore, analyze, and interpret large volumes of data in various forms and solve complex business problems; visualize and interpret data and create reports, manipulate data using statistical software, and compare models using statistical performance metrics; and support deployment of insights across multiple channels using analysis methods, machine learning, and statistical analyses. Telecommuting available. Multiple positions. Requirements: Master’s degree (or foreign equivalent) in Computer Science, Data Science, Statistics, Mathematics, Analytics, or a related field and four (4) years of experience in the job offered or related occupation. Requires three (3) years of experience in each of the following: • Data analytics on large data sets in healthcare, business, or retail sector; • Machine learning, statistical analysis, and predictive modeling; • Hadoop and Hive; • R, Python, or SQL; • SAS or SQL programming languages; • Visualization tools, including PowerBI or Tableau; • Designing data models and solutions for analytical and reporting use cases; and • Machine learning, statistical analysis, and predictive modeling. Pay Range: $141565.00/year to $288400.00/year.
This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, geography and other relevant factors. This position is eligible for a CVS Health bonus, commission or short-term incentive program in addition to the base pay range listed above. This position also includes an award target in the company’s equity award program.
In addition to your compensation, enjoy the rewards of an organization that puts our heart into caring for our colleagues and our communities. The Company offers a full range of medical, dental, and vision benefits. Eligible employees may enroll in the Company’s 401(k) retirement savings plan, and an Employee Stock Purchase Plan is also available for eligible employees. The Company provides a fully-paid term life insurance plan to eligible employees, and short-term and long term disability benefits. CVS Health also offers numerous well-being programs, education assistance, free development courses, a CVS store discount, and discount programs with participating partners. As for time off, Company employees enjoy Paid Time Off (“PTO”) or vacation pay, as well as paid holidays throughout the calendar year. Number of paid holidays, sick time and other time off are provided consistent with relevant state law and Company policies.
Great benefits for great people
We take pride in offering a comprehensive and competitive mix of pay and benefits that reflects our commitment to our colleagues and their families.
This full‑time position is eligible for a comprehensive benefits package designed to support the physical, emotional, and financial well‑being of colleagues and their families. The benefits for this position include medical, dental, and vision coverage, paid time off, retirement savings options, wellness programs, and other resources, based on eligibility.
Additional details about available benefits are provided during the application process and on Benefits Moments.
This job does not have an application deadline, as CVS Health accepts applications on an ongoing basis.
Qualified applicants with arrest or conviction records will be considered for employment in accordance with all federal, state and local laws.
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Find JobsRemote Principal Scientist Job Market
Who's Hiring
- Optum5
- Instacart5
- Zillow3
- Cotiviti3
- Geisinger3
Top Industries Hiring
- Technology & Software15
- Healthcare & Medical Services14
- Consulting & Professional Services12
- Science & Research11
- Biotechnology & Pharmaceuticals7
What Employers Look For
The qualifications that appear most often in remote principal scientist jobs.
- PhD in a relevant scientific discipline such as biology, chemistry, biochemistry, or a related field
- Eight or more years of hands-on research experience in industry or government settings
- Demonstrated record of first- or senior-author peer-reviewed publications and patent contributions
- Proficiency with domain-specific tools such as molecular modeling software, analytical instrumentation, or statistical programming languages
- Experience leading cross-functional project teams and mentoring junior scientists or postdoctoral researchers
- Familiarity with regulatory submission processes such as IND, NDA, or equivalent documentation standards
Tips for Your Remote Principal Scientist Job Search
Apply early to remote roles that fit
Migrate Mate lists remote principal scientist openings from across the U.S. in one place, so you can find roles that match your domain and apply directly. Remote positions at well-known firms fill fast, so apply as soon as a role appears rather than waiting.
Document your async scientific communication style
Remote employers screen specifically for written communication. Update your materials to show examples of scientific memos, cross-functional research updates, or async decision documents you've authored, because these signal you can lead science without in-person context.
Highlight end-to-end program ownership
Remote principal scientist roles require you to move a research program forward independently. Describe specific programs you owned from hypothesis through data readout or publication, naming the decisions you made without escalating, to show you can operate without daily oversight.
Signal fluency with distributed research tools
List the collaboration and lab informatics tools you use, such as Benchling, Confluence, Notion, or electronic lab notebooks, alongside standard scientific software. Remote hiring managers look for candidates already comfortable in the async stack their distributed team runs on.
Prepare for remote-format scientific presentations
Remote interviews for principal scientist roles almost always include a research talk delivered over video. Practice presenting data-heavy slides without a physical whiteboard, managing pacing for a distributed audience, and fielding technical questions in a lag-prone environment before your first screen.
Remote Principal Scientist Jobs: Frequently Asked Questions
How do I get a remote principal scientist job?
Remote principal scientist roles go to candidates who demonstrate independent scientific leadership without needing on-site oversight. Employers screen hard for written communication, because async updates and documentation replace hallway conversations. Strong candidates show a publication or patent record, experience driving a research program end-to-end, and fluency with collaborative tools like Notion, Confluence, or Benchling. Remote-first biotech and pharma companies are the most consistent hirers for fully distributed principal scientist positions.
Which companies hire remote principal scientists?
Employers currently hiring remote principal scientists include Optum, Instacart, and Zillow, per current remote listings on Migrate Mate as of June 2026. Remote-first biotech firms, distributed pharma R&D teams, and tech companies with computational biology or data science functions are the most consistent sources of fully remote principal scientist openings.
Can you get a remote principal scientist job with no experience?
Yes, but remote entry paths at the principal scientist level are narrow, because remote employers expect you to drive research programs with minimal hand-holding from day one. Early-career candidates who land remote roles typically come from strong PhD or postdoctoral work, have first-author publications, or have led a discrete project they can describe in detail. Smaller remote-first startups and contract research roles are the most realistic entry points when direct industry experience is limited.
Do you need a degree for remote principal scientist jobs?
Usually, yes. The principal scientist title almost universally requires at minimum a master's degree, and the large majority of postings expect a PhD in a relevant scientific discipline. Remote employers weigh published research output, demonstrated program ownership, and domain depth alongside formal credentials. Candidates without advanced degrees who have built equivalent expertise through industry R&D roles can still compete, but a graduate degree remains the standard expectation.
Which industries hire the most remote principal scientists?
Remote principal scientist roles concentrate in Technology & Software, Healthcare & Medical Services, and Consulting & Professional Services, based on current remote listings on Migrate Mate as of June 2026. These sectors have adopted distributed research models because computational work, regulatory writing, and data-heavy scientific programs can run effectively across time zones without a shared lab bench.
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