Scientist Jobs in Bethesda, MD
Scientist jobs in Bethesda, Maryland are concentrated in the National Institutes of Health campus corridor, the Pike & Rose area, and the Rockville Pike biomedical belt, with strong demand across federal research, life sciences, and pharmaceutical development. Employers hiring right now include Guidehouse, Total Wine & More, and National Institutes of Health. Find a role that fits below and apply directly.
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About the Role
Total Wine & More is seeking a Senior Data Scientist, Operations Research to join our Data Services team in Bethesda, MD. In this role, you will lead the design and deployment of optimization and decision science solutions that directly drive business outcomes across Total Wine & More. This role focuses on solving complex, large-scale mathematical problems to inform strategic and operational decisions, including pricing, inventory, supply chain, and marketing optimization. You will work at the intersection of data, mathematical modeling, and decisioning systems, translating business problems into formal optimization frameworks and delivering production ready solutions. This role requires deep hands-on experience in operations research (OR), including building and solving large-scale optimization models, alongside strong data engineering and software skills to operationalize those solutions. This role will report to the Sr. Director, Data Science.
You will
- Formulate decision problems as mathematical optimization models (LP, MILP, MINLP), translating business constraints and objectives into structured frameworks
- Design and implement large-scale optimization models, solving complex problems involving thousands to millions of variables and constraints
- Leverage solvers such as Gurobi (preferred) or equivalent tools to build high-performance solutions, including model tuning and performance optimization
- Develop end-to-end decision systems, integrating optimization outputs into production workflows and business processes
- Collaborate with business stakeholders to define objective functions, constraints, and trade-offs, ensuring solutions align with real-world decision-making
- Evaluate solution quality through scenario testing, sensitivity analysis, and stress testing of optimization results
- Scale and productionize models, including API development, automation, monitoring, and retraining workflows
- Build and maintain data pipelines to support optimization models, ensuring data quality, availability, and performance at scale
- Communicate model structure, assumptions, and results clearly to leadership, translating complex math into actionable business insights
You will come with
- Bachelor's Degree in Operations Research, Industrial Engineering, Applied Mathematics, Computer Science, or related field or equivalent years of experience
- Master's Degree in Operations Research, Industrial Engineering, Applied Mathematics, Computer Science, or related field or equivalent years of experience
- 3-6 years’ experience in Operations Research / Optimization or related fields preferred
- Hands-on experience with Gurobi (strongly preferred) or similar solvers (CPLEX, OR-Tools, etc.)
- Proven experience building and deploying large-scale mathematical models (LP, MILP, etc.) in production environments
- Ability to design and maintain data pipelines for large-scale modeling workflows and experience working with large, complex datasets, including feature engineering and data validation
- Proficiency in Python and SQL, with emphasis on scalable, maintainable code
- Familiarity with cloud environments (AWS, Azure, GCP) for scalable execution
We offer
- Paid Time Off (PTO)
- Generous store discounts
- Health care plans (medical, prescription, dental, vision)
- 401(k), HSA, FSA, Pre-tax commuter benefits
- Disability & life insurance coverage
- Paid parental leave
- Pet insurance
- Critical illness and accident insurance
- Discounted home and auto insurance
- College tuition assistance
- Career development & product training
- Consumer classes
- & More!
Crafted for you
We recognize our team members are our biggest asset, and we value the critical role each play in contributing to the company’s success. It is our commitment to support and provide access to the resources needed to take care of their health and wellbeing. That is why we offer a variety of benefits, tools, and resources to support through our Total Rewards program. To view our full career page, click here: https://careers.totalwine.com/!
Total Wine & More considers several factors when establishing compensation. Compensation may vary based on a number of factors including, but not limited to, market location, job-related knowledge, skills and/or experience. The actual hourly rate will equal or exceed the required minimum wage applicable to the job location. Estimated salaries determined by third parties have not been validated by Total Wine & More.
Total Wine & More is an equal opportunity employer and all qualified applicants will receive consideration for employment without discrimination based on race, color, religion, national origin, sex, sexual orientation, age, marital status, veteran status, disability, or any other characteristic protected by applicable law. Total Wine & More makes reasonable accommodations during all aspects of the employment process, including during the interview process. Total Wine & More is a Drug Free Workplace.
The information provided above indicates the general nature and level of work required of the position and is not a comprehensive list of all responsibilities or qualifications. Benefits list is only a highlight of some of the benefits offered to team members; eligibility for certain benefits apply. The anticipated close date of this posting is 120 days from the posted date indicated above.
Worker Type:
RegularPay Range:
$122,200.00 - $165,000.00 AnnualSee All 37 Scientist Jobs in Bethesda
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Who's Hiring



Top Industries Hiring
- Science & Research
- Insurance
- Human Resources
Scientist Jobs in Bethesda: Frequently Asked Questions
How do I get a scientist job in Bethesda?
The strongest path into Bethesda's scientist market runs through its federal biomedical research ecosystem and the private sector that surrounds it. NIH's campus anchors demand for research scientists across dozens of institutes, while the Rockville Pike corridor hosts pharma and biotech companies that hire consistently. Candidates with hands-on laboratory experience, publications or clearances, and familiarity with federal research protocols stand out most in this market.
Which companies hire scientists in Bethesda?
Bethesda scientist roles are posted by Guidehouse, Total Wine & More, and National Institutes of Health and others right now, based on current listings on Migrate Mate as of July 2026. Hiring is anchored by federal agencies, government contractors, and life sciences firms that cluster near the NIH campus and along the Rockville Pike research corridor.
Are there remote scientist jobs in Bethesda?
Yes, though availability depends heavily on the role type, since hands-on laboratory and clinical research positions require on-site presence while data science, regulatory affairs, and scientific writing roles are far more flexible. About 17% of scientist openings tied to Bethesda are remote or hybrid as of July 2026. Analytical and policy-adjacent scientist roles at federal agencies and contractors in Bethesda tend to offer the most remote or hybrid options.
How can I get a scientist job in Bethesda with little or no experience?
The most realistic entry point in Bethesda is a postbaccalaureate research fellowship or research assistant role, particularly through NIH's Intramural Research Program, which regularly recruits recent graduates into structured training positions. Government contractors and life sciences firms along the Rockville Pike corridor also hire junior scientists and research associates. Candidates who tailor their applications to specific institute missions and demonstrate lab technique proficiency gain the clearest advantage locally.
Which industries hire the most scientists in Bethesda?
The sectors hiring the most scientists in Bethesda are Science & Research, Insurance, and Human Resources, based on current listings on Migrate Mate as of July 2026. Bethesda's identity as a federal biomedical hub means those sectors are shaped heavily by NIH funding cycles, government contract activity, and the dense concentration of research-driven organizations in the area.
See All 37 Scientist Jobs in Bethesda
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