Senior Level Senior Bioinformatics Scientist Jobs
Senior level senior bioinformatics scientist jobs place experienced scientists at the helm of computational research programs, owning analytical pipelines, setting methodological direction, and leading the cross-functional teams that translate genomic data into actionable outcomes. Openings are concentrated across Healthcare & Medical Services, Science & Research, and Biotechnology & Pharmaceuticals, with a mix of on-site, hybrid, and remote positions available, and employers like St. Jude Children's Research Hospital, Veracyte, and Rezo Therapeutics hiring at this level now.
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INTRODUCTION
St. Jude is seeking a Senior Bioinformatics Research Scientist for data science projects within the Center for Pharmacogenomics in the Department of Pharmacy and Pharmaceutical Sciences. In particular, this individual will focus on electronic health record (EHR)-driven phenotyping to support pharmacogenomics discovery research. The successful candidate will be responsible for developing and implementing new informatics tools and resources to enhance phenotyping performance or enable deep phenotyping through terminology/ontology, natural language processing, and machine learning. The role involves working with large external biobank datasets such as All of US, eMERGE, TopMed, UK BioBank, as well as internal EHR data. This Bioinformatics Research Scientist will collaborate extensively with disease and/or drug experts (clinicians, clinician scientists, data scientists, and laboratory investigators) to co-develop phenotyping algorithms but is expected to serve as the domain expert in high-throughput phenotyping. Demonstrated expertise in EHR-based phenotype extraction and curation are strongly preferred.
Responsibilities
- Provide research support and deliver high-quality results by formulating an efficient analytical approach with the available data.
- Deliver data files, and document the analytical process. May participate in manuscript preparation at project's conclusion.
- Assist with establishing and documenting protocols or best practices for common research tasks, and in the formulation of analytical plans that use the best approach to address challenging data analysis questions.
- Assist in the evaluation and testing of new methods and technologies.
- Contribute ideas to automate or improve existing analysis methods. Implement the improvement or work with others to do so.
- Participate in the department's developmental projects and interdepartmental team projects.
MINIMUM QUALIFICATIONS
- Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work experience in relevant area (e.g., bioinformatics, cheminformatics, statistics/computer science with a background in biological sciences or chemistry) (OR) Master's degree with 5+ years of relevant experience (OR) PhD with 2+ years of relevant experience.
- Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred.
MINIMUM EDUCATION AND/OR TRAINING
- Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
- Master's degree or PhD preferred.
MINIMUM EXPERIENCE
- Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
- Experience Exception: Master's degree with 5+ years of relevant post-degree experience (OR) PhD with 2+ years of relevant post-degree experience.
- Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred.
COMPENSATION
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Bioinformatics Research Scientist. Explore our exceptional benefits!
St. Jude is an Equal Opportunity Employer
No Search Firms
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
INTRODUCTION
St. Jude is seeking a Senior Bioinformatics Research Scientist for data science projects within the Center for Pharmacogenomics in the Department of Pharmacy and Pharmaceutical Sciences. In particular, this individual will focus on electronic health record (EHR)-driven phenotyping to support pharmacogenomics discovery research. The successful candidate will be responsible for developing and implementing new informatics tools and resources to enhance phenotyping performance or enable deep phenotyping through terminology/ontology, natural language processing, and machine learning. The role involves working with large external biobank datasets such as All of US, eMERGE, TopMed, UK BioBank, as well as internal EHR data. This Bioinformatics Research Scientist will collaborate extensively with disease and/or drug experts (clinicians, clinician scientists, data scientists, and laboratory investigators) to co-develop phenotyping algorithms but is expected to serve as the domain expert in high-throughput phenotyping. Demonstrated expertise in EHR-based phenotype extraction and curation are strongly preferred.
Responsibilities
- Provide research support and deliver high-quality results by formulating an efficient analytical approach with the available data.
- Deliver data files, and document the analytical process. May participate in manuscript preparation at project's conclusion.
- Assist with establishing and documenting protocols or best practices for common research tasks, and in the formulation of analytical plans that use the best approach to address challenging data analysis questions.
- Assist in the evaluation and testing of new methods and technologies.
- Contribute ideas to automate or improve existing analysis methods. Implement the improvement or work with others to do so.
- Participate in the department's developmental projects and interdepartmental team projects.
MINIMUM QUALIFICATIONS
- Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work experience in relevant area (e.g., bioinformatics, cheminformatics, statistics/computer science with a background in biological sciences or chemistry) (OR) Master's degree with 5+ years of relevant experience (OR) PhD with 2+ years of relevant experience.
- Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred.
MINIMUM EDUCATION AND/OR TRAINING
- Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
- Master's degree or PhD preferred.
MINIMUM EXPERIENCE
- Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
- Experience Exception: Master's degree with 5+ years of relevant post-degree experience (OR) PhD with 2+ years of relevant post-degree experience.
- Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred.
COMPENSATION
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Bioinformatics Research Scientist. Explore our exceptional benefits!
St. Jude is an Equal Opportunity Employer
No Search Firms
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
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Senior Level Senior Bioinformatics Scientist Jobs: Frequently Asked Questions
How do I get a senior level senior bioinformatics scientist job?
Employers at this level look for candidates who have independently owned end-to-end bioinformatics projects, not just contributed to them. Demonstrated expertise in pipeline development, multi-omics data analysis, and statistical modeling is expected. What sets candidates apart is a portfolio of published or internally recognized work, experience mentoring junior scientists, and the ability to translate complex computational findings into decisions that drive research or product strategy.
Which companies hire senior level senior bioinformatics scientists?
Companies hiring senior level senior bioinformatics scientists right now include St. Jude Children's Research Hospital, Veracyte, and Rezo Therapeutics, based on current listings on Migrate Mate as of August 2026. Hiring at this level tends to come from pharmaceutical and biotech firms running large-scale genomics programs, cancer research institutes, and technology companies building health data platforms.
Are there remote senior level senior bioinformatics scientist jobs?
Yes, remote and hybrid options are well established at this experience level. About 0% of senior level senior bioinformatics scientist openings are remote or hybrid as of August 2026, reflecting the nature of computational work that can be performed without a fixed lab bench. Fully on-site roles typically involve wet-lab collaboration or regulated research environments.
What makes a senior bioinformatics scientist role senior level?
Senior level roles are defined by ownership and scope rather than task execution. At this stage, scientists are expected to architect and maintain production-grade analytical pipelines, make independent decisions on methodology, and represent bioinformatics strategy in cross-functional or external collaborations. Mentoring junior and mid-level scientists is a standard expectation, and the impact of the work typically extends across multiple research programs or product lines.
Which industries hire the most senior level senior bioinformatics scientists?
Senior Level senior bioinformatics scientist roles concentrate in Healthcare & Medical Services, Science & Research, and Biotechnology & Pharmaceuticals, based on current listings on Migrate Mate as of August 2026. These sectors drive hiring at this level because they operate large genomic, proteomic, or clinical data programs that require seasoned scientists who can lead the computational infrastructure behind drug discovery, diagnostics, or precision medicine initiatives.