Senior Clinical Data Manager Jobs
Senior Clinical Data Manager jobs are open across pharmaceutical, biotechnology, contract research organization, and medical device industries, from mid-level to principal and director, with specializations in clinical trial management, data integrity, and regulatory submissions. Find a role that fits from the openings below and apply directly.
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Join the transformative team at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. Our dedicated and compassionate employees are driven by a common mission: To deliver the cures of tomorrow to the people who need them today.
ROLE AND RESPONSIBILITIES
The Senior Clinical Trials Data Coordinator supports complex oncology clinical trials from First-in-Human and Phase I through Phase IV by coordinating data collection, entry, quality assurance, and query resolution to ensure accurate, reliable, and compliant research data. The role involves interpreting research protocols, reviewing medical records, resolving discrepancies, and maintaining study visits and financial triggers within the Clinical Trial Management System (CTMS) aligned with Electronic Data Capture (EDC) systems. Working closely with physicians, clinical coordinators, and research teams, the coordinator ensures timely data reporting, supports adverse event data collection, and contributes to study monitoring and regulatory compliance. Additionally, the role includes performing peer data reviews, assisting in the development of data management plans and workflows, and providing training and guidance to research data staff to maintain high-quality clinical trial data and efficient research operations.
As a successful candidate, you will:
- Enter and manage clinical trial data in EMR, CTMS (OnCore), and EDC systems within required timelines while supporting studies from start-up through closeout.
- Ensure data accuracy, completeness, and compliance through quality checks, data cleaning, and timely resolution of queries.
- Maintain regulatory compliance with FDA, ICH-GCP, ALCOA+, HIPAA, and other applicable guidelines for clinical research data management.
- Collaborate with sponsors, physicians, and clinical coordinators to resolve protocol issues, data discrepancies, and ensure proper documentation.
- Manage adverse event documentation and classification using standard dictionaries such as MedDRA, CTCAE, and WHO-DDE, including SAE follow-up and query resolution.
- Maintain study calendars, financial triggers, and data completion tracking in CTMS to support billing and study financial management.
- Support monitoring visits, study initiation visits, audits, and inspection readiness, ensuring data quality and completeness.
- Contribute to data management improvements by assisting with EDC builds, creating data standards, preparing reports, participating in CAPA and process improvement initiatives, and mentoring peers.
MINIMUM QUALIFICATIONS
Bachelor’s degree in Science, Health, or a related field from an accredited university, or equivalent relevant work experience.
Minimum of 5–7 years of clinical research or related experience.
Required Certifications:
- Completion of Good Clinical Practice (GCP) training within 1 month of employment.
- Completion of Human Subjects Protection (HSP) training within 1 month of employment.
- Ability to obtain SOCRA or ACRP certification within 2 years of employment.
Systems Knowledge: Experience with Clinical Trial Management Systems (CTMS), Electronic Medical Records (EMR), and eRegulatory systems.
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity, and inclusion, please click here.
To learn more about our Comprehensive Benefits, please CLICK HERE.
Join the transformative team at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. Our dedicated and compassionate employees are driven by a common mission: To deliver the cures of tomorrow to the people who need them today.
ROLE AND RESPONSIBILITIES
The Senior Clinical Trials Data Coordinator supports complex oncology clinical trials from First-in-Human and Phase I through Phase IV by coordinating data collection, entry, quality assurance, and query resolution to ensure accurate, reliable, and compliant research data. The role involves interpreting research protocols, reviewing medical records, resolving discrepancies, and maintaining study visits and financial triggers within the Clinical Trial Management System (CTMS) aligned with Electronic Data Capture (EDC) systems. Working closely with physicians, clinical coordinators, and research teams, the coordinator ensures timely data reporting, supports adverse event data collection, and contributes to study monitoring and regulatory compliance. Additionally, the role includes performing peer data reviews, assisting in the development of data management plans and workflows, and providing training and guidance to research data staff to maintain high-quality clinical trial data and efficient research operations.
As a successful candidate, you will:
- Enter and manage clinical trial data in EMR, CTMS (OnCore), and EDC systems within required timelines while supporting studies from start-up through closeout.
- Ensure data accuracy, completeness, and compliance through quality checks, data cleaning, and timely resolution of queries.
- Maintain regulatory compliance with FDA, ICH-GCP, ALCOA+, HIPAA, and other applicable guidelines for clinical research data management.
- Collaborate with sponsors, physicians, and clinical coordinators to resolve protocol issues, data discrepancies, and ensure proper documentation.
- Manage adverse event documentation and classification using standard dictionaries such as MedDRA, CTCAE, and WHO-DDE, including SAE follow-up and query resolution.
- Maintain study calendars, financial triggers, and data completion tracking in CTMS to support billing and study financial management.
- Support monitoring visits, study initiation visits, audits, and inspection readiness, ensuring data quality and completeness.
- Contribute to data management improvements by assisting with EDC builds, creating data standards, preparing reports, participating in CAPA and process improvement initiatives, and mentoring peers.
MINIMUM QUALIFICATIONS
Bachelor’s degree in Science, Health, or a related field from an accredited university, or equivalent relevant work experience.
Minimum of 5–7 years of clinical research or related experience.
Required Certifications:
- Completion of Good Clinical Practice (GCP) training within 1 month of employment.
- Completion of Human Subjects Protection (HSP) training within 1 month of employment.
- Ability to obtain SOCRA or ACRP certification within 2 years of employment.
Systems Knowledge: Experience with Clinical Trial Management Systems (CTMS), Electronic Medical Records (EMR), and eRegulatory systems.
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity, and inclusion, please click here.
To learn more about our Comprehensive Benefits, please CLICK HERE.
Senior Clinical Data Manager Jobs by Experience Level
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Find JobsSenior Clinical Data Manager Job Market
Who's Hiring
- CVS Health20
- Amazon6
- AbbVie4
- Disney Experiences3
- Bristol Myers Squibb3
Top Industries Hiring
- Biotechnology & Pharmaceuticals
- Technology & Software
- Retail
- E-Commerce & Online Marketplaces
- Consulting & Professional Services
What Employers Look For
The qualifications that appear most often in senior clinical data manager jobs.
- Bachelor's degree in life sciences, statistics, or a related field
- Five or more years of clinical data management experience across multiple trial phases
- Proficiency with EDC systems such as Medidata Rave, Oracle Clinical, or Veeva Vault
- Hands-on experience authoring and executing Data Management Plans
- Working knowledge of CDISC standards including CDASH, SDTM, and ADaM
- Experience with regulatory submissions and FDA or EMA data compliance requirements
Tips for Your Senior Clinical Data Manager Job Search
Tailor your resume to CDISC standards
Hiring managers scan for CDISC compliance experience before anything else. List specific CDASH, SDTM, and ADaM implementation work by study type and phase, not just familiarity. Generic 'data management experience' gets filtered out at the resume screen.
Highlight your DMP ownership experience
Senior roles almost always require you to author or own the Data Management Plan. If you've led DMP development from protocol review through database lock, call that out explicitly on your resume with the therapeutic area and phase of the trial.
Apply early to roles that fit
Migrate Mate lists senior clinical data manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter openings by therapeutic area depth
Oncology, rare disease, and CNS sponsors often require therapeutic-area-specific data management experience. Target openings where your trial history aligns closely with the sponsor's pipeline, since interviewers will probe protocol-level familiarity in technical screens.
Prepare to walk through a discrepancy resolution
Technical interviews for senior clinical data manager roles routinely include a scenario where you're shown a data listing with inconsistencies and asked to work through your resolution process. Practice narrating your query management and edit check logic out loud before your interview.
Negotiate scope, not just compensation
At the senior level, the number of concurrent studies, vendor oversight responsibility, and whether you're managing junior CDMs significantly affects workload. Clarify these boundaries before accepting an offer, as they directly shape your day-to-day role.
Senior Clinical Data Manager Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical data managers?
The companies hiring the most senior clinical data managers right now include CVS Health, Amazon, and AbbVie, with the largest share of openings in California, Illinois, and Texas, based on current listings on Migrate Mate as of August 2026. CROs and mid-size biotech sponsors tend to post the highest volume of senior-level openings relative to their overall headcount.
How many senior clinical data manager jobs are remote?
About 77% of senior clinical data manager openings are fully remote or hybrid as of August 2026, making it one of the more location-flexible roles in clinical operations. Data review, query management, and vendor oversight work tends to be the most remote-compatible, while roles tied to site-level data collection or hands-on EDC build work are more likely to require periodic on-site presence.
How do you become a senior clinical data manager?
Start with a degree in a life science, health informatics, or statistics field, then build your foundation in a clinical data coordinator or CDM role at a CRO or sponsor. Gain hands-on EDC system experience, work across multiple trial phases, earn CDISC certification, and take on DMP ownership and cross-functional lead responsibilities before moving into a senior title.
Can you get hired as a senior clinical data manager without direct senior-level experience?
Yes, if you've functioned in a lead capacity without the formal title. Employers weight demonstrated DMP authorship, independent query resolution, and vendor or CRO oversight over the specific title you held. Candidates who've led database lock activities or mentored junior staff on a trial often successfully transition into senior roles even without a senior CDM title on their resume.
What does the senior clinical data manager interview process look like?
Most processes run three to four rounds. A recruiter screen is typically followed by a hiring manager conversation focused on trial experience and EDC system depth. A technical interview then covers data review scenarios, edit check logic, or discrepancy resolution. Final rounds often include a cross-functional panel with clinical operations, biostatistics, or regulatory affairs stakeholders who assess your collaboration and communication style.
Where can I find and apply to senior clinical data manager jobs?
You can find and apply to senior clinical data manager jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your experience in trial phase, therapeutic area, and EDC platform, then apply directly to each one that fits.
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