Senior Clinical Data Manager Jobs
Senior Clinical Data Manager jobs are open across pharmaceutical, biotechnology, contract research organization, and medical device industries, from mid-level to principal and director, with specializations in clinical trial management, data integrity, and regulatory submissions. Find a role that fits from the openings below and apply directly.
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Position Summary:
The Senior Clinical Data Manager is responsible and manages all aspects of the clinical trial data management process from study start up to post database lock for assigned projects. Standard Operating Procedures / Work Instructions (SOPs/WIs); regulatory directives; study specific plans and guidelines will be followed. This position will also oversee and/or perform database development and testing.
Essential functions of the job include but are not limited to:
- Primary Data Management (DM) contact (Lead DM role) for assigned clinical project(s) / program(s), ensuring that there is back-up, continuity, responsiveness, and that tasks are performed in a timely manner. May support another Lead DM as a back-up and/or team member. May include DM oversight of sponsor programs.
- Oversee project data entry process including development of data entry guidelines, training, data entry quality and resourcing
- May perform quality control of data entry
- Provide input, assesses and manage timelines. Ensure that clinical data management deadlines are met with quality. Assess resource needs for assigned projects, as needed.
- Develop CRF specifications from the clinical study protocol and coordinate the review/feedback from all stakeholders
- May assist in building clinical databases
- Conduct database build UAT and maintain quality controlled database build documentation. Oversee overall quality of the clinical database.
- May specify requirements for all edit check types e.g. electronic, manual data review, edit checks, etc. Oversee development of the edit check specifications and manual data review specifications
- Responsible for creating, revising, appropriate versioning and maintaining data management documentation. Oversee completeness of data management documentation for the Trial Master File.
- Train clinical research personnel on the study specific CRF, EDC, and other project related items as needed.
- Review and query clinical trial data according to the Data Management Plan
- Perform line listing data review based on the guidance provided by the sponsor and/or Lead DM
- Run patient and study level status and metric reporting
- Perform medical coding of medical terms relative to each other in order to ensure medical logic and consistency
- Coordinate SAE/AE reconciliation
- Liaises with third-party vendors such as external data and EDC vendors in a project manager capacity in support of timelines and data-related deliverables
- May assist with SAS programming and quality control of SAS programs used in the Data Management department
- Identify and troubleshoot operational problems, issues, obstacles, and barriers for studies based on metrics data, audit reports, and input from project team members and other stakeholders
- May assist in reviewing and providing feedback on protocols, Statistical Analysis Plans (SAP) and Clinical Study Reports (CSRs), if required by the project
- Participate in the development and maintenance of Standard Operating Procedures (SOPs) and corresponding process documentation related to data management and database management activities
- May attend strategy meetings, bid defense prep meetings, bid defenses, capability presentations, potential client engagement meetings
- May review Request for Proposals (RFP), proposals, provide project estimates
- Provide leadership for cross-functional and organization-wide initiatives, where applicable
- Trains and ensures that all data management project team members have been sufficiently trained
- Communicate with study sponsors, vendors and project teams as needed regarding data, database or other relevant project issues
- May present software demonstrations/trainings, department/company training sessions, present at project meetings
- May require some travel
- Perform other duties as assigned
Qualifications
Minimum Required:
- Bachelors and/or a combination of related experience
Other Required:
- 8+ years' experience as a Sr. Clinical Data Manager and 5 Years as a Clinical Data Manager II
- Proficiency in Microsoft Office: Word, Excel, PowerPoint, Outlook
- Able to handle a variety of clinical research tasks
- Excellent organizational and communication skills
- Professional use of the English language; both written and oral
- Experience in utilizing various clinical database management systems
- Broad knowledge of drug, device and/or biologic development and effective data management practices
- Strong representational skills, ability to communicate effectively orally and in writing
- Strong leadership and interpersonal skills
- Ability to undertake occasional travel
Preferred:
- Experience in a clinical, scientific or healthcare discipline
- Dictionary medical coding (MedDRA and WHODrug)
- Understanding of CDISC standards (CDASH, SDTM, ADaM, etc.…)
- Oncology and/or Orphan Drug therapeutic experience
Any data provided as a part of this application will be stored in accordance with our Privacy Policy. For CA applicants, please also refer to our CA Privacy Notice.
Precision Medicine Group is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status or other characteristics protected by law.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact Precision Medicine Group at QuestionForHR@precisionmedicinegrp.com.
It has come to our attention that some individuals or organizations are reaching out to job seekers and posing as potential employers presenting enticing employment offers. We want to emphasize that these offers are not associated with our company and may be fraudulent in nature. Please note that our organization will not extend a job offer without prior communication with our recruiting team, hiring managers and a formal interview process.
Position Summary:
The Senior Clinical Data Manager is responsible and manages all aspects of the clinical trial data management process from study start up to post database lock for assigned projects. Standard Operating Procedures / Work Instructions (SOPs/WIs); regulatory directives; study specific plans and guidelines will be followed. This position will also oversee and/or perform database development and testing.
Essential functions of the job include but are not limited to:
- Primary Data Management (DM) contact (Lead DM role) for assigned clinical project(s) / program(s), ensuring that there is back-up, continuity, responsiveness, and that tasks are performed in a timely manner. May support another Lead DM as a back-up and/or team member. May include DM oversight of sponsor programs.
- Oversee project data entry process including development of data entry guidelines, training, data entry quality and resourcing
- May perform quality control of data entry
- Provide input, assesses and manage timelines. Ensure that clinical data management deadlines are met with quality. Assess resource needs for assigned projects, as needed.
- Develop CRF specifications from the clinical study protocol and coordinate the review/feedback from all stakeholders
- May assist in building clinical databases
- Conduct database build UAT and maintain quality controlled database build documentation. Oversee overall quality of the clinical database.
- May specify requirements for all edit check types e.g. electronic, manual data review, edit checks, etc. Oversee development of the edit check specifications and manual data review specifications
- Responsible for creating, revising, appropriate versioning and maintaining data management documentation. Oversee completeness of data management documentation for the Trial Master File.
- Train clinical research personnel on the study specific CRF, EDC, and other project related items as needed.
- Review and query clinical trial data according to the Data Management Plan
- Perform line listing data review based on the guidance provided by the sponsor and/or Lead DM
- Run patient and study level status and metric reporting
- Perform medical coding of medical terms relative to each other in order to ensure medical logic and consistency
- Coordinate SAE/AE reconciliation
- Liaises with third-party vendors such as external data and EDC vendors in a project manager capacity in support of timelines and data-related deliverables
- May assist with SAS programming and quality control of SAS programs used in the Data Management department
- Identify and troubleshoot operational problems, issues, obstacles, and barriers for studies based on metrics data, audit reports, and input from project team members and other stakeholders
- May assist in reviewing and providing feedback on protocols, Statistical Analysis Plans (SAP) and Clinical Study Reports (CSRs), if required by the project
- Participate in the development and maintenance of Standard Operating Procedures (SOPs) and corresponding process documentation related to data management and database management activities
- May attend strategy meetings, bid defense prep meetings, bid defenses, capability presentations, potential client engagement meetings
- May review Request for Proposals (RFP), proposals, provide project estimates
- Provide leadership for cross-functional and organization-wide initiatives, where applicable
- Trains and ensures that all data management project team members have been sufficiently trained
- Communicate with study sponsors, vendors and project teams as needed regarding data, database or other relevant project issues
- May present software demonstrations/trainings, department/company training sessions, present at project meetings
- May require some travel
- Perform other duties as assigned
Qualifications
Minimum Required:
- Bachelors and/or a combination of related experience
Other Required:
- 8+ years' experience as a Sr. Clinical Data Manager and 5 Years as a Clinical Data Manager II
- Proficiency in Microsoft Office: Word, Excel, PowerPoint, Outlook
- Able to handle a variety of clinical research tasks
- Excellent organizational and communication skills
- Professional use of the English language; both written and oral
- Experience in utilizing various clinical database management systems
- Broad knowledge of drug, device and/or biologic development and effective data management practices
- Strong representational skills, ability to communicate effectively orally and in writing
- Strong leadership and interpersonal skills
- Ability to undertake occasional travel
Preferred:
- Experience in a clinical, scientific or healthcare discipline
- Dictionary medical coding (MedDRA and WHODrug)
- Understanding of CDISC standards (CDASH, SDTM, ADaM, etc.…)
- Oncology and/or Orphan Drug therapeutic experience
Any data provided as a part of this application will be stored in accordance with our Privacy Policy. For CA applicants, please also refer to our CA Privacy Notice.
Precision Medicine Group is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status or other characteristics protected by law.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact Precision Medicine Group at QuestionForHR@precisionmedicinegrp.com.
It has come to our attention that some individuals or organizations are reaching out to job seekers and posing as potential employers presenting enticing employment offers. We want to emphasize that these offers are not associated with our company and may be fraudulent in nature. Please note that our organization will not extend a job offer without prior communication with our recruiting team, hiring managers and a formal interview process.
See All Senior Clinical Data Manager Jobs
Jump back to the full list of openings and apply to any senior clinical data manager role that fits.
Find JobsSenior Clinical Data Manager Job Market
A snapshot from current openings nationwide, updated as new roles post.
Who's Hiring
- Eikon Therapeutics4
- Katalyst Healthcares & Life Sciences2
- Legend Biotech2
- Agios Pharmaceuticals1
- Cardinal Health1
Top Industries Hiring
- Biotechnology & Pharmaceuticals15
- Consulting & Professional Services2
- Distribution & Wholesale1
- Education1
- Insurance1
What Employers Look For
The qualifications that appear most often in senior clinical data manager jobs.
- Bachelor's degree in life sciences, statistics, or a related field
- Five or more years of clinical data management experience across multiple trial phases
- Proficiency with EDC systems such as Medidata Rave, Oracle Clinical, or Veeva Vault
- Hands-on experience authoring and executing Data Management Plans
- Working knowledge of CDISC standards including CDASH, SDTM, and ADaM
- Experience with regulatory submissions and FDA or EMA data compliance requirements
Tips for Your Senior Clinical Data Manager Job Search
Tailor your resume to CDISC standards
Hiring managers scan for CDISC compliance experience before anything else. List specific CDASH, SDTM, and ADaM implementation work by study type and phase, not just familiarity. Generic 'data management experience' gets filtered out at the resume screen.
Highlight your DMP ownership experience
Senior roles almost always require you to author or own the Data Management Plan. If you've led DMP development from protocol review through database lock, call that out explicitly on your resume with the therapeutic area and phase of the trial.
Apply early to roles that fit
Migrate Mate lists senior clinical data manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter openings by therapeutic area depth
Oncology, rare disease, and CNS sponsors often require therapeutic-area-specific data management experience. Target openings where your trial history aligns closely with the sponsor's pipeline, since interviewers will probe protocol-level familiarity in technical screens.
Prepare to walk through a discrepancy resolution
Technical interviews for senior clinical data manager roles routinely include a scenario where you're shown a data listing with inconsistencies and asked to work through your resolution process. Practice narrating your query management and edit check logic out loud before your interview.
Negotiate scope, not just compensation
At the senior level, the number of concurrent studies, vendor oversight responsibility, and whether you're managing junior CDMs significantly affects workload. Clarify these boundaries before accepting an offer, as they directly shape your day-to-day role.
Senior Clinical Data Manager Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical data managers?
The companies hiring the most senior clinical data managers right now include Eikon Therapeutics, Katalyst Healthcares & Life Sciences, and Legend Biotech, with the largest share of openings in New Jersey, Massachusetts, and California, based on current listings on Migrate Mate as of June 2026. CROs and mid-size biotech sponsors tend to post the highest volume of senior-level openings relative to their overall headcount.
How many senior clinical data manager jobs are remote?
About 27% of senior clinical data manager openings are fully remote or hybrid as of June 2026, making it one of the more location-flexible roles in clinical operations. Data review, query management, and vendor oversight work tends to be the most remote-compatible, while roles tied to site-level data collection or hands-on EDC build work are more likely to require periodic on-site presence.
How do you become a senior clinical data manager?
Start with a degree in a life science, health informatics, or statistics field, then build your foundation in a clinical data coordinator or CDM role at a CRO or sponsor. Gain hands-on EDC system experience, work across multiple trial phases, earn CDISC certification, and take on DMP ownership and cross-functional lead responsibilities before moving into a senior title.
Can you get hired as a senior clinical data manager without direct senior-level experience?
Yes, if you've functioned in a lead capacity without the formal title. Employers weight demonstrated DMP authorship, independent query resolution, and vendor or CRO oversight over the specific title you held. Candidates who've led database lock activities or mentored junior staff on a trial often successfully transition into senior roles even without a senior CDM title on their resume.
What does the senior clinical data manager interview process look like?
Most processes run three to four rounds. A recruiter screen is typically followed by a hiring manager conversation focused on trial experience and EDC system depth. A technical interview then covers data review scenarios, edit check logic, or discrepancy resolution. Final rounds often include a cross-functional panel with clinical operations, biostatistics, or regulatory affairs stakeholders who assess your collaboration and communication style.
Where can I find and apply to senior clinical data manager jobs?
You can find and apply to senior clinical data manager jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your experience in trial phase, therapeutic area, and EDC platform, then apply directly to each one that fits.
See All Senior Clinical Data Manager Jobs
Jump back to the full list of openings and apply to any senior clinical data manager role that fits.
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