Senior Clinical Project Manager Jobs in Columbia, SC

Senior Clinical Project Manager jobs in Columbia, South Carolina are concentrated in the health sciences corridor near the University of South Carolina Health, the Midlands Medical District, and the Palmetto Health-Richland area, with strong demand from clinical research organizations, hospital systems, and life sciences firms. Employers hiring right now include Prisma Health, Lexington Health, and AgFirst Farm Credit Bank. Find a role that fits below and apply directly.

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Overview

Open roles105+
Top employerPrisma Health
Work type64% On-site
Top credentialBachelor's
Companies hiring61

Showing 5 of 105+ Senior Clinical Project Manager jobs

AT&T
Sr Specialist Sales Sys Engineer 1-Ter
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AT&T
New 1m ago
Sr Specialist Sales Sys Engineer 1-Ter
AT&T
Columbia, South Carolina
Account Management
Business Development
Sales
Bachelor of Science
10,000+

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PruittHealth
RN Clinical Competency Coordinator HCC
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PruittHealth
New 1m ago
RN Clinical Competency Coordinator HCC
PruittHealth
Columbia, South Carolina
Clinical Support
Healthcare Administration
Human Resources
CPR Certification
10,000+

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LifeStance Health
Licensed Clinical Therapist (LPC/LISW-CP/LMFT)
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LifeStance Health
New 1m ago
Licensed Clinical Therapist (LPC/LISW-CP/LMFT)
LifeStance Health
Columbia, South Carolina
Caregiving & Elderly Support
Healthcare Administration
Nursing
Patient Services & Wellbeing
Hybrid
5,001-10,000

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Prisma Health
Mgr-Financial Analysis FT, Day
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Prisma Health
New 1m ago
Mgr-Financial Analysis FT, Day
Prisma Health
Columbia, South Carolina
Business Operations
Project Management
Bachelor's degree in finance
10,000+

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CDM Smith
Sr. Design Build Project Manager - Water Services
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CDM Smith
New 1m ago
Sr. Design Build Project Manager - Water Services
CDM Smith
Columbia, South Carolina
Engineering (Non-Software)
Project Management
Technical Program Management
Hybrid
Master's degree in construction management
5,001-10,000

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Senior Clinical Project Manager Job Market in Columbia

Who's Hiring

  • Prisma Health
    Prisma Health9
  • Lexington Health
    Lexington Health7
  • AgFirst Farm Credit Bank
    AgFirst Farm Credit Bank6
  • Circle K
    Circle K5
  • Infojini
    Infojini4

Top Industries Hiring

  • Healthcare & Medical Services21
  • Technology & Software10
  • Consulting & Professional Services7
  • Retail5
  • Banking & Financial Services5

Senior Clinical Project Manager Jobs in Columbia: Frequently Asked Questions

How do I get a senior clinical project manager job in Columbia?

Focus on Columbia's dominant hiring sectors: hospital systems in the Midlands Medical District, CROs operating near the University of South Carolina Health campus, and state-affiliated public health agencies. Candidates with oncology or cardiovascular trial experience stand out locally, as do those with familiarity with multi-site coordination across regional medical centers. Networking through the South Carolina Clinical and Translational Research Institute connects you directly to active hiring teams.

Which companies hire senior clinical project managers in Columbia?

Columbia senior clinical project manager roles are posted by Prisma Health, Lexington Health, and AgFirst Farm Credit Bank and others right now, based on current listings on Migrate Mate as of July 2026. Columbia's hiring base is anchored by large health systems, academic medical affiliates, and contract research organizations serving pharmaceutical clients across the Southeast.

Are there remote senior clinical project manager jobs in Columbia?

Yes, though it depends heavily on the role: protocol development, data oversight, and vendor management tasks are commonly remote, while site initiation visits and on-site monitoring remain in-person. About 36% of senior clinical project manager openings tied to Columbia are remote or hybrid as of July 2026, reflecting broader industry norms. Positions with Columbia's CRO community tend to offer the most hybrid flexibility.

How can I get a senior clinical project manager job in Columbia with little or no experience?

The most realistic entry path in Columbia is moving up from a clinical research coordinator or clinical trial associate role at one of the Midlands-area hospital systems or university-affiliated research programs. Employers like academic medical centers and mid-size CROs operating near the USC Health campus regularly hire coordinators and promote from within. Earning a CCRP credential while working site-level trials accelerates the transition to a project management track locally.

Which industries hire the most senior clinical project managers in Columbia?

The sectors hiring the most senior clinical project managers in Columbia are Healthcare & Medical Services, Technology & Software, and Consulting & Professional Services, based on current listings on Migrate Mate as of July 2026. Columbia's role as home to major academic medical centers and state health agencies makes it a regional hub for clinical operations, driving consistent demand across those sectors.

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