Senior Clinical Project Manager Jobs
Senior Clinical Project Manager jobs are open across pharmaceutical, biotechnology, medical device, and contract research organizations, from mid-level to executive, with specializations in oncology trials, regulatory affairs, and global study management. Find a role that fits from the openings below and apply directly.
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Showing 5 of 74+ Senior Clinical Project Manager jobs
INTRODUCTION
Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
JOB SUMMARY
Manages all recruitment and collection activities for the studies. Functions independently strategizing directly with the PIs. Responsible for the daily execution of principal duties and responsibilities and aspects of project management and administration including operational, budgetary, grant writing, communication, and research subject education components. Also responsible for direct supervision of all research coordinators.
Does this position require Patient Care?
No
ESSENTIAL FUNCTIONS
- Develops detailed protocol documents that meet federal institutional standards.
- Ensures study design's compatibility with clinical practices.
- Provides critical input as to feasibility of study design and available resources.
- Ensures document consistency.
- Responsible for developing/managing the clinical trial’s operating and capital budgets.
QUALIFICATIONS
Education
Bachelor's Degree Related Field of Study required or Master's Degree Related Field of Study preferred
Can this role accept experience in lieu of a degree?
No
Licenses and Credentials
Experience
Research Related Experience 5-7 years required and Supervisory Experience 3-5 years preferred
Knowledge, Skills and Abilities
- Ability to effectively supervise and train Staff.
- Excellent judgement and ability to interpret information and protocol.
- Ability to make independent effective decisions.
- Aptitude for technical problem solving.
- Excellent organizational abilities to formulate and complete rigorous timetables.
ADDITIONAL JOB DETAILS (IF APPLICABLE)
The Senior Clinical Research Program Manager is responsible for strategic and operational decision-making across a diverse portfolio of clinical research studies, including industry-sponsored and investigator-initiated, multi-site IDE trials, retrospective chart review studies, and registries. The ideal candidate will have experience and expertise in running investigator-held, multi-site IDE trials. In this role, you will oversee all aspects of study planning and execution, including timelines, budgets, and data management; lead a team of clinical research professionals, which may include research nurses, clinical research coordinators, data analysts, contract research organizations (CROs), and external vendors, to ensure deliverables are met; and collaborate with internal and external stakeholders to ensure studies are conducted efficiently and in compliance with Good Clinical Practice, FDA regulations, and IRB policies. Success in this role requires strong leadership and organizational skills, excellent communication skills, the ability to problem-solve with good judgment, a comprehensive understanding of clinical research processes, and the ability to proactively identify and mitigate risks and resolve operational challenges while driving process improvements.
REMOTE TYPE
Onsite
WORK LOCATION
55 Fruit Street
SCHEDULED WEEKLY HOURS
40
EMPLOYEE TYPE
Regular
WORK SHIFT
Day (United States of America)
PAY RANGE
$78,936.00 - $128,928.80/Annual
GRADE
8
At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.
EEO STATEMENT:
1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.
MASS GENERAL BRIGHAM COMPETENCY FRAMEWORK
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
INTRODUCTION
Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
JOB SUMMARY
Manages all recruitment and collection activities for the studies. Functions independently strategizing directly with the PIs. Responsible for the daily execution of principal duties and responsibilities and aspects of project management and administration including operational, budgetary, grant writing, communication, and research subject education components. Also responsible for direct supervision of all research coordinators.
Does this position require Patient Care?
No
ESSENTIAL FUNCTIONS
- Develops detailed protocol documents that meet federal institutional standards.
- Ensures study design's compatibility with clinical practices.
- Provides critical input as to feasibility of study design and available resources.
- Ensures document consistency.
- Responsible for developing/managing the clinical trial’s operating and capital budgets.
QUALIFICATIONS
Education
Bachelor's Degree Related Field of Study required or Master's Degree Related Field of Study preferred
Can this role accept experience in lieu of a degree?
No
Licenses and Credentials
Experience
Research Related Experience 5-7 years required and Supervisory Experience 3-5 years preferred
Knowledge, Skills and Abilities
- Ability to effectively supervise and train Staff.
- Excellent judgement and ability to interpret information and protocol.
- Ability to make independent effective decisions.
- Aptitude for technical problem solving.
- Excellent organizational abilities to formulate and complete rigorous timetables.
ADDITIONAL JOB DETAILS (IF APPLICABLE)
The Senior Clinical Research Program Manager is responsible for strategic and operational decision-making across a diverse portfolio of clinical research studies, including industry-sponsored and investigator-initiated, multi-site IDE trials, retrospective chart review studies, and registries. The ideal candidate will have experience and expertise in running investigator-held, multi-site IDE trials. In this role, you will oversee all aspects of study planning and execution, including timelines, budgets, and data management; lead a team of clinical research professionals, which may include research nurses, clinical research coordinators, data analysts, contract research organizations (CROs), and external vendors, to ensure deliverables are met; and collaborate with internal and external stakeholders to ensure studies are conducted efficiently and in compliance with Good Clinical Practice, FDA regulations, and IRB policies. Success in this role requires strong leadership and organizational skills, excellent communication skills, the ability to problem-solve with good judgment, a comprehensive understanding of clinical research processes, and the ability to proactively identify and mitigate risks and resolve operational challenges while driving process improvements.
REMOTE TYPE
Onsite
WORK LOCATION
55 Fruit Street
SCHEDULED WEEKLY HOURS
40
EMPLOYEE TYPE
Regular
WORK SHIFT
Day (United States of America)
PAY RANGE
$78,936.00 - $128,928.80/Annual
GRADE
8
At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.
EEO STATEMENT:
1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.
MASS GENERAL BRIGHAM COMPETENCY FRAMEWORK
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
Senior Clinical Project Manager Jobs by Experience Level
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Find JobsSenior Clinical Project Manager Job Market
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
- Education
- Biotechnology & Pharmaceuticals
- Medical Devices
What Employers Look For
The qualifications that appear most often in senior clinical project manager jobs.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- Minimum five to eight years of clinical trial management experience across multiple phases
- Proficiency with clinical trial management systems such as Veeva Vault or Medidata Rave
- Project Management Professional or equivalent certification preferred by most sponsors
- Deep knowledge of ICH E6 Good Clinical Practice guidelines and FDA regulatory requirements
- Experience managing CROs, budgets, and cross-functional teams on global or multi-site studies
Tips for Your Senior Clinical Project Manager Job Search
Tailor your resume to ICH E6 language
Hiring managers scan for familiarity with ICH E6 Good Clinical Practice guidelines. Use that exact phrasing when describing protocol oversight or monitoring experience, because applicant tracking systems filter for it before a human ever sees your resume.
Highlight cross-functional budget ownership
Senior roles require direct accountability for study budgets, not just cost tracking. Describe specific phases where you owned vendor contracts, managed CRO invoicing, or handled budget variance reporting to show you can lead financial decisions, not just report them.
Apply early to roles that fit
Migrate Mate lists senior clinical project manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter by therapeutic area before applying
Oncology, rare disease, and neuroscience trials each have distinct regulatory timelines and site management demands. Targeting openings that match your therapeutic background makes your application more credible and shortens the ramp-up conversation in interviews.
Prepare a study startup timeline case study
Interviewers at senior level routinely ask you to walk through a complex startup scenario. Have a real example ready that covers site selection, IRB submission timelines, and enrollment delays, and be specific about what you controlled versus escalated.
Negotiate scope before title when switching sponsors
Moving from a CRO to a sponsor, or vice versa, often resets perceived seniority. Before accepting an offer, clarify study portfolio size, number of direct reports, and global versus regional scope, because those determine your actual leverage in future negotiations more than the title does.
Senior Clinical Project Manager Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical project managers?
The companies hiring the most senior clinical project managers right now include IQVIA, Abbott, and CenExel Clinical Research, with the largest share of openings in California, Alabama, and New York, based on current listings on Migrate Mate as of November 2026. Pharmaceutical sponsors and large CROs consistently account for the highest volume of active postings.
How many senior clinical project manager jobs are remote?
About 59% of senior clinical project manager openings are fully remote or hybrid as of November 2026, reflecting a post-pandemic shift in how sponsors and CROs structure study oversight teams. Roles focused on vendor management, data review, and regulatory coordination tend to offer the most remote flexibility, while positions with heavy site monitoring or startup responsibilities more often require regional travel.
How do you become a senior clinical project manager?
Most senior clinical project managers start as clinical research associates or study coordinators, then move into project management roles where they own full study timelines. From there, accumulating experience across multiple therapeutic areas, leading cross-functional teams, and taking accountability for sponsor or CRO budgets builds the profile most hiring managers look for. Earning a project management certification alongside clinical credentials also strengthens the transition into senior-level positions.
Can you get hired as a senior clinical project manager without senior-level experience?
It's possible if you can demonstrate end-to-end study ownership rather than task-level execution in your current role. Candidates who have led a trial from startup through closeout, managed a CRO relationship independently, or stepped into a project lead role during a staffing gap often compete for senior titles without a formal senior credit on their resume. Framing your application around outcomes and accountability, not just responsibilities, closes that gap.
What does the senior clinical project manager interview process look like?
Most processes run three to five rounds, starting with a recruiter screen focused on therapeutic area fit and systems experience. A hiring manager interview typically follows, centered on behavioral questions about managing protocol deviations, vendor escalations, and timeline recovery. Later rounds often involve a cross-functional panel with clinical operations, regulatory, or data management leads, and some sponsors ask candidates to walk through a mock risk mitigation plan or study startup scenario.
Where can I find and apply to senior clinical project manager jobs?
You can find and apply to senior clinical project manager jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your therapeutic background and study experience, then apply directly to each listing.
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Find roles that match your experience and apply in just a few clicks.
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