Senior Clinical Trial Manager Jobs in Morrisville, NC
Senior Clinical Trial Manager jobs in Morrisville are in strong and consistent demand, with most openings concentrated in the Perimeter Park, Park West, and Morrisville Parkway corridors across pharmaceutical, contract research, and medical device sectors. Employers hiring right now include サイネオス・ヘルス and Syneos Health. Scan the live roles below and apply to whichever ones fit.
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Showing 4 of 103+ Senior Clinical Trial Manager jobs
Updated: Today
Location: Morrisville, NC, United States
Job ID: 25109346
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Description
Senior Site Contracts Specialist (Sponsor Dedicated /Remote – U.S. Only) Clinical Trial Contracts experience required!Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.
Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.
Discover what your 25,000 future colleagues already know:
Why Syneos Health
- We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
- We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.
- We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.
Job Responsibilities
Senior Site Contracts Specialist (Sponsor Dedicated /Remote – U.S. Only)
Lead Clinical Trial Contract & Budget Negotiations That Accelerate Research
Are you an experienced clinical trial contracts professional who enjoys negotiating complex agreements, partnering directly with investigative sites, and driving study start-up success? If so, we'd love to hear from you.
We are seeking a Senior Site Contracts Specialist to join a high-performing, Sponsor-Dedicated team supporting a leading global biopharmaceutical company. In this highly visible role, you will independently manage U.S. and Canadian site contract and budget negotiations, partnering with cross-functional teams to help bring innovative therapies to patients faster.
This is an excellent opportunity for someone who thrives in a collaborative, fast-paced environment and can confidently manage Clinical Trial Agreements (CTAs) and budgets with minimal oversight.
What You'll Do
As a Senior Site Contracts Specialist, you will serve as a key business partner throughout the clinical trial start-up process by:
Independently negotiating and managing Clinical Trial Agreements (CTAs), CTA amendments, and site budgets for U.S. and Canadian clinical research sites.
Drafting, cloning, reviewing, and negotiating site-specific CTAs from approved country templates.
Leading contract and budget negotiations directly with investigative sites while partnering with Sponsor stakeholders until all issues are resolved.
Applying approved CTA fallback language and budget negotiation parameters with minimal supervision.
Maintaining accurate contract negotiation status and milestones within the Sponsor's clinical trial tracking system.
Preparing amendments, revised budgets, and supporting documentation throughout the study lifecycle.
Performing quality control reviews to ensure contracts are complete, accurate, compliant, and execution-ready.
Coordinating contract execution and maintaining all required documentation and metadata within electronic repositories.
Partnering closely with Clinical Operations, Site Start-Up, Finance, Legal, and Site Contract Service Center teams to ensure efficient study activation.
Identifying contractual or operational risks early and proactively driving solutions.
Tracking contracting timelines, deliverables, and project milestones to support study start-up goals.
Serving as a trusted point of contact for internal teams, investigative sites, and Sponsor stakeholders.
Supporting customer meetings, business initiatives, and continuous process improvements.
Mentoring junior team members and contributing to SOPs, training materials, and quality initiatives.
Monitoring contract-related project metrics and escalating issues when appropriate.
What We're Looking For
Required Qualifications
Bachelor's degree in Business, Public Health, Life Sciences, or a related field (or equivalent experience).
2–3+ years of direct clinical trial site contract and budget negotiation experience within a CRO, pharmaceutical company, or Sponsor-dedicated environment.
Demonstrated experience independently managing:
Clinical Trial Agreements (CTAs)
CTA Amendments
Site budget negotiations
Contract lifecycle management with minimal oversight
Strong understanding of:
CTA drafting and negotiation
Contract templates and fallback language
Budget development and negotiation strategies
Clinical trial start-up processes
Experience maintaining negotiation status and documentation within Sponsor clinical trial tracking systems.
Excellent understanding of Phase II-IV clinical trials, ICH-GCP, and clinical development processes.
Strong project management, organization, and prioritization skills.
Exceptional negotiation, communication, and relationship-building abilities.
Proficiency with Microsoft Office Suite.
Preferred Qualifications
Advanced degree.
Previous experience supporting a Sponsor-Dedicated/FSP model.
Leadership or mentoring experience.
Vendor management experience.
Experience supporting process improvement initiatives within Site Start-Up or Site Contracts.
Why You'll Love This Opportunity
This is more than a contracts role—you'll become a trusted partner helping drive clinical studies from start-up to activation. You'll work alongside experienced legal, finance, and clinical operations professionals while supporting one dedicated Sponsor, allowing you to develop deep expertise and build lasting collaborative relationships.
If you enjoy owning negotiations, solving complex challenges, and making a meaningful impact on clinical research, we'd love to speak with you.
At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.
Salary Range:
$56,400.00 - $95,900.00The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.
Get to know Syneos Health
Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.
No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.
http://www.syneoshealth.com
Additional Information
Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.
Summary
Roles within the Site Start-Up/Site ID job family are responsible for managing and executing the site identification process in accordance with regulations, SOPs, and project requirements. This includes completing and negotiating site confidentiality agreements (CDAs) and site information forms (SIFs) with sites, maintaining, reviewing, and reporting on site performance metrics, serving as the primary point of contact for investigative sites, and tracking the completion of site identification for sites. Impact and Contribution Individual contributors with responsibility in a professional or technical discipline or specialty, but may manage two or fewer employees. May direct the work of lower level professionals or manage processes and programs. The majority of time is spent contributing to the design, implementation or delivery of processes, programs, and policies, using knowledge and skills typically acquired through advanced education. Established and productive individual contributor. May manage defined components of projects or processes within area of responsibility. Requires practical knowledge of a professional area, typically obtained through education combined with experience.See All 103+ Senior Clinical Trial Manager Jobs in Morrisville
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Find JobsSenior Clinical Trial Manager Job Market in Morrisville
Who's Hiring
Top Industries Hiring
- Science & Research
Senior Clinical Trial Manager Jobs in Morrisville: Frequently Asked Questions
How do I get a senior clinical trial manager job in Morrisville?
Focus your search on the contract research organizations, pharmaceutical sponsors, and medical device companies clustered in Morrisville's Perimeter Park and Park West business corridors. Candidates with Phase II and III oncology or cardiovascular trial experience stand out in this market. Familiarity with the site networks common to the Research Triangle region, combined with a strong history of vendor and CRO oversight, gives applicants a clear edge over generalist competition.
Which companies hire senior clinical trial managers in Morrisville?
Morrisville senior clinical trial manager roles are posted by サイネオス・ヘルス and Syneos Health and others right now, based on current listings on Migrate Mate as of July 2026. The local employer mix leans heavily toward global pharmaceutical sponsors, mid-size CROs, and specialty biotech firms that maintain operational hubs near Research Triangle Park.
Are there remote senior clinical trial manager jobs in Morrisville?
Yes, though with limits, since senior clinical trial management involves periodic site visits, investigator meetings, and hands-on oversight that require in-person presence at key milestones. About 100% of senior clinical trial manager openings tied to Morrisville are remote or hybrid as of July 2026, with the most flexibility offered for protocol development, vendor management, and data review responsibilities.
How can I get a senior clinical trial manager job in Morrisville with little or no experience?
The most realistic entry path in Morrisville is through a clinical trial associate or clinical research coordinator role at one of the CROs or mid-size biotech companies operating in Perimeter Park. These employers routinely promote internally once candidates demonstrate site management competency and protocol adherence. Volunteering for cross-functional study teams and pursuing ACRP or SOCRA certification signals readiness to move into a senior oversight role faster in this market.
Which industries hire the most senior clinical trial managers in Morrisville?
Most senior clinical trial manager openings in Morrisville sit in Science & Research, per current listings on Migrate Mate as of July 2026. Morrisville's proximity to Research Triangle Park, a dense cluster of life sciences and pharmaceutical R&D operations, drives sustained hiring across those sectors throughout the year.
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