Clinical Operations Manager Jobs in North Carolina
Clinical Operations Manager jobs in North Carolina are in strong and consistent demand, concentrated in pharmaceutical and biotech research, academic medical centers, and multi-site health system operations, with openings at every level from coordinator-to-manager transitions through senior and executive clinical operations roles. The largest hiring metros are the Research Triangle (Raleigh, Durham, and Chapel Hill), Charlotte, and Greensboro, where employers such as Duke University Health System, Novant Health, and Labcorp maintain deep and ongoing hiring needs. The most in-demand specialties include clinical trial operations, ambulatory care coordination, and revenue cycle and quality improvement management. Find a role that fits below and apply directly.
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What you can expect
Location: 2301 Erwin Rd. Durham, NC 27705
This nursing leadership role is responsible for strategic, operational, financial, and quality oversight across a diverse portfolio of highly specialized pediatric and neonatal clinical services. The successful candidate will provide 24/7 leadership and accountability for assigned areas, partnering closely with physician, nursing, and administrative leaders to advance clinical excellence, patient safety, workforce engagement, patient experience, and operational performance. This role offers the opportunity to lead complex programs within a highly collaborative academic health system environment.
Schedule:
- Full Time: Monday - Friday, with off shift visibility and on call 24/7 including weekends.
Incentives & Total Rewards:
- Relocation Assistance: Up to $10,000 for eligible employees moving at least 50 miles from Duke University Hospital.
- Total Rewards: A comprehensive set of pay and benefits designed to support your well-being, professional growth, and work-life balance. Learn more here.
How you will make an impact
- Provide 24/7 leadership and accountability for strategic, operational, financial, and quality performance across assigned departments and a diverse portfolio of highly specialized pediatric and neonatal clinical services.
- Partner with physician, nursing, and administrative leaders to develop, execute, and continuously evaluate strategic and operational priorities.
- Foster a culture of excellence, innovation, safety, and continuous improvement that advances exceptional patient and family-centered care.
- Build, develop, and retain high-performing teams through effective recruitment, engagement, succession planning, and leadership development.
- Drive quality, safety, patient experience, workforce, and operational outcomes through the use of data, evidence-based practices, and performance improvement methodologies.
- Lead the development and refinement of care delivery models to support organizational goals and evolving patient care needs.
- Ensure effective stewardship of resources, including staffing, budgets, facilities, equipment, and operational systems.
- Champion shared governance and interdisciplinary collaboration while strengthening partnerships across the highly collaborative academic health system to achieve strategic objectives.
What you will need
- Bachelor or higher degree in Nursing and Master's Degree in related field.
- Five years of nursing experience is required, including at least 2 years of experience in a management role.
- Must have current or compact RN licensure in the state of North Carolina.
- BLS certification required.
- Ability to manage multiple organization missions.
- Facilitation, consensus-building, and negotiation skills.
- Sensitivity for and understanding of clinical disciplines and issues.
- Understanding of cost containment and managed care systems.
- Ability to work with all types of individuals in multiple settings and locations and to promote diversity in the workplace.
- Knowledge of necessary regulatory bodies, including the North Carolina Nurse Practice Act.
- Expert communication skills.
Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas — an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
What you can expect
Location: 2301 Erwin Rd. Durham, NC 27705
This nursing leadership role is responsible for strategic, operational, financial, and quality oversight across a diverse portfolio of highly specialized pediatric and neonatal clinical services. The successful candidate will provide 24/7 leadership and accountability for assigned areas, partnering closely with physician, nursing, and administrative leaders to advance clinical excellence, patient safety, workforce engagement, patient experience, and operational performance. This role offers the opportunity to lead complex programs within a highly collaborative academic health system environment.
Schedule:
- Full Time: Monday - Friday, with off shift visibility and on call 24/7 including weekends.
Incentives & Total Rewards:
- Relocation Assistance: Up to $10,000 for eligible employees moving at least 50 miles from Duke University Hospital.
- Total Rewards: A comprehensive set of pay and benefits designed to support your well-being, professional growth, and work-life balance. Learn more here.
How you will make an impact
- Provide 24/7 leadership and accountability for strategic, operational, financial, and quality performance across assigned departments and a diverse portfolio of highly specialized pediatric and neonatal clinical services.
- Partner with physician, nursing, and administrative leaders to develop, execute, and continuously evaluate strategic and operational priorities.
- Foster a culture of excellence, innovation, safety, and continuous improvement that advances exceptional patient and family-centered care.
- Build, develop, and retain high-performing teams through effective recruitment, engagement, succession planning, and leadership development.
- Drive quality, safety, patient experience, workforce, and operational outcomes through the use of data, evidence-based practices, and performance improvement methodologies.
- Lead the development and refinement of care delivery models to support organizational goals and evolving patient care needs.
- Ensure effective stewardship of resources, including staffing, budgets, facilities, equipment, and operational systems.
- Champion shared governance and interdisciplinary collaboration while strengthening partnerships across the highly collaborative academic health system to achieve strategic objectives.
What you will need
- Bachelor or higher degree in Nursing and Master's Degree in related field.
- Five years of nursing experience is required, including at least 2 years of experience in a management role.
- Must have current or compact RN licensure in the state of North Carolina.
- BLS certification required.
- Ability to manage multiple organization missions.
- Facilitation, consensus-building, and negotiation skills.
- Sensitivity for and understanding of clinical disciplines and issues.
- Understanding of cost containment and managed care systems.
- Ability to work with all types of individuals in multiple settings and locations and to promote diversity in the workplace.
- Knowledge of necessary regulatory bodies, including the North Carolina Nurse Practice Act.
- Expert communication skills.
Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas — an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
See All 22 Clinical Operations Manager Jobs in North Carolina
Find roles in North Carolina that match your experience and apply in just a few clicks.
Find JobsClinical Operations Manager Jobs by City in North Carolina
Where North Carolina roles are concentrated, by current openings.
Clinical Operations Manager Job Market in North Carolina
A snapshot from current North Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
What North Carolina Employers Look For
The qualifications that appear most often in clinical operations manager jobs across North Carolina.
- Bachelor's degree in health administration, nursing, life sciences, or a related clinical field
- Three or more years of progressive experience in clinical or healthcare operations
- Demonstrated experience managing cross-functional teams in a regulated healthcare environment
- Familiarity with Joint Commission standards, CMS conditions, and North Carolina DHHS compliance requirements
- Proficiency with electronic health record systems such as Epic or Cerner in an operational capacity
- PMP, CPHQ, or equivalent project or quality management certification preferred by many North Carolina employers
Clinical Operations Manager Jobs in North Carolina: Frequently Asked Questions
How do you become a clinical operations manager in North Carolina?
Most clinical operations manager roles in North Carolina require a bachelor's degree in health administration, nursing, public health, or a clinical science, with a master's degree preferred at larger health systems and academic medical centers. There is no single state-issued license for this management role, but candidates coming from a clinical background such as nursing must hold an active license recognized by the North Carolina Board of Nursing. Employers in the Research Triangle and Charlotte corridor consistently prioritize candidates with experience in regulated clinical environments and quality improvement frameworks.
Which companies hire clinical operations managers in North Carolina?
Employers hiring clinical operations managers in North Carolina right now include Trinzic, Duke Health, and CenterWell, based on current listings on Migrate Mate as of October 2026. North Carolina's concentration of pharmaceutical companies, academic health systems, and multi-site ambulatory networks means hiring stays active across both the Research Triangle and the Charlotte market year-round.
Which North Carolina cities have the most clinical operations manager jobs?
The cities with the most clinical operations manager openings in North Carolina are Fort Bragg, Durham, and North Carolina. The Research Triangle dominates because of its dense cluster of major health systems, contract research organizations, and pharmaceutical headquarters, while Charlotte's large hospital networks and growing outpatient market drive consistent hiring, and secondary hubs reflect regional health system expansion across the broader state.
Are there remote clinical operations manager jobs in North Carolina?
Yes, but they are selective. About 75% of clinical operations manager openings tied to North Carolina are remote or hybrid as of October 2026, reflecting the role's blend of on-site leadership responsibilities and administrative oversight work. The functions most likely to be performed remotely include data reporting, vendor management, protocol review, and cross-site program coordination, while direct staff supervision and facility operations typically require on-site presence.
How can I get hired as a clinical operations manager in North Carolina with little or no experience?
The most realistic entry path is moving into the role laterally from a clinical coordinator, patient services supervisor, or practice administrator position within a North Carolina health system or multi-site clinic group. Duke Health, Atrium Health, and UNC Health all run new-grad administrative fellowships and healthcare management development programs that place candidates without direct management experience into structured rotations. Earning a Certified Healthcare Administrative Professional credential or completing a graduate certificate in health administration through a North Carolina university also strengthens early-career applications significantly.
Where can I find and apply to clinical operations manager jobs in North Carolina?
You can find and apply to clinical operations manager jobs in North Carolina on Migrate Mate, which lists current openings from employers actively hiring in the state. Search the available roles, find the ones that match your experience and location, and apply directly to the positions that fit.
See All 22 Clinical Operations Manager Jobs in North Carolina
Find roles in North Carolina that match your experience and apply in just a few clicks.
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