Clinical Operations Manager Jobs in California
Clinical Operations Manager jobs in California are among the most active in the country, concentrated in biotech and pharmaceutical companies, large academic medical centers, and health system networks, with openings at every level from junior coordinators stepping into management to senior directors overseeing multi-site trials. The biggest hiring centers are San Francisco Bay Area, Los Angeles, and San Diego, where employers like Kaiser Permanente, Genentech, and UCLA Health maintain deep, ongoing demand. The most sought-after specialties are clinical trial operations, care delivery optimization, and cross-functional program management within regulated research environments. Find a role that fits below and apply directly.
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Showing 5 of 19+ Clinical Operations Manager jobs
Career-defining. Life-changing.
At iRhythm, you’ll have the opportunity to grow your skills and your career while impacting the lives of people around the world. iRhythm is shaping a future where everyone, everywhere can access the best possible cardiac health solutions. Every day, we collaborate, create, and constantly reimagine what’s possible. We think big and move fast, driven by our commitment to put patients first and improve lives. We need builders like you. Curious and innovative problem solvers looking for the chance to meaningfully shape the future of cardiac health, our company, and your career.
About This Role:
Job Summary and Purpose:
We are seeking an experienced and results-driven Clinical Operations Manager to lead and optimize the daily operations of our services team. This role will oversee a team of 20-25 non-exempt staff, ensuring high performance in a fast-paced, high-volume environment.
The ideal candidate will have extensive experience in managing large non-exempt teams, driving continuous improvement through KPIs and performance metrics, and utilizing workflow automation tools to enhance operational efficiency.
This position requires excellent leadership skills, cross-functional communication abilities, and a focus on customer service.
Key Responsibilities:
- Team Management: Oversee daily operations of a team of 20-25 non-exempt staff, ensuring performance meets department production, quality, and operational standards.
- Performance Management: Track and evaluate staff performance metrics, implementing process improvements to meet or exceed quality and efficiency goals.
- Coaching & Development: Provide coaching, guidance, and recognition to foster a high-performance culture. Conduct performance reviews and facilitate corrective actions in partnership with HR and senior leadership.
- Escalation & Recovery: Manage customer service in high-volume environments, ensuring efficient escalation and recovery processes to meet service excellence standards.
- Operational Oversight: Ensure day-to-day service delivery in a high-volume environment runs efficiently and in accordance with established policies and regulations.
- Compliance & Regulations: Ensure compliance with FDA regulations and company policies, collaborating with cross-functional teams to maintain and update these standards.
- Strategic Planning: Contribute to strategic planning and leadership initiatives, working closely with senior management to achieve long-term organizational goals.
- Budget & Resource Management: Oversee team budget, managing resources and additional hours needed to achieve targets. Partner with talent acquisition to manage headcount and recruitment strategy.
- Staff Development: Facilitate ongoing staff development by coordinating training with clinical teams to meet performance and quality standards.
- Continuous Improvement: Assist with quality management programs, provide feedback on operational efficiencies, and collaborate on cross-functional projects to support company-wide initiatives.
- Performance Dashboards & Tools: Utilize workflow automation tools and performance dashboards to monitor team performance and operational metrics, ensuring alignment with organizational goals.
Must-Have Skills and Qualifications:
- Team Leadership: Proven experience managing large teams in a service environment, with a focus on performance management and fostering a high-performance culture.
- KPI and Metrics: Expertise in utilizing KPIs and performance metrics to drive operational improvements and meet organizational objectives.
- Clinical Operational Workflow Management: Experience managing clinical operational workflows, overseeing day-to-day service delivery in high-volume environments.
- Workflow Automation Tools: Proficiency with workflow automation tools and familiarity with production software and performance dashboards.
- Cross-functional Communication: Strong communication skills to collaborate effectively with clinical, operational, and leadership teams.
- Customer Service Excellence: Demonstrated experience managing customer service in high-volume settings and implementing recovery processes to enhance customer satisfaction.
- Escalation & Recovery: Experience in managing efficient escalation and recovery processes to resolve operational issues.
- Compliance & Regulatory Knowledge: Understanding of state and federal regulations in healthcare operations and the ability to ensure compliance.
- Staff Performance & Development: Experience in performance management, staff coaching, and fostering staff development through training initiatives.
Qualifications
- Minimum of 4 years of Management experience in operations management, preferably in medical device, healthcare services or clinical setting
- Strong leadership, problem-solving, and organizational skills
- Proven ability to manage high-volume operations and large teams
Nice-to-Have Skills and Qualifications:
- Broader Healthcare Services Knowledge: Familiarity with healthcare services, including telehealth, health insurance, and diagnostics.
- Operational Challenges Across Sectors: Awareness of operational challenges in multiple healthcare sectors.
WORKING ENVIRONMENT / PHYSICAL DEMANDS:
- Must be able to work under pressure and manage tight deadlines.
- Ability to adapt to a fast-paced, evolving work environment.
- Willingness to attend off-site leadership events and participate in professional development activities.
- Ability to attend the local IDTF in person to support staff and handle escalation issues as required by business needs.
Location:
San Francisco
Actual compensation may vary depending on job-related factors including knowledge, skills, experience, and work location.
Estimated Pay Range
$131,000.00 - $170,000.00
As a part of our core values, we ensure an inclusive workforce. We welcome and celebrate people of all backgrounds, experiences, skills, and perspectives. iRhythm Technologies, Inc. is an Equal Opportunity Employer. We will consider for employment all qualified applicants with arrest and conviction records in accordance with all applicable laws.
iRhythm provides reasonable accommodations for qualified individuals with disabilities in job application procedures, including those who may have any difficulty using our online system. If you need such an accommodation, you may contact us at taops@irhythmtech.com.
About iRhythm Technologies
iRhythm is a leading digital healthcare company that creates trusted solutions that detect, predict, and prevent disease. Combining wearable biosensors and cloud-based data analytics with powerful proprietary algorithms, iRhythm distills data from millions of heartbeats into clinically actionable information. Through a relentless focus on patient care, iRhythm’s vision is to deliver better data, better insights, and better health for all.
Make iRhythm your path forward. Zio, the heart monitor that changed the game.
There have been instances where individuals not associated with iRhythm have impersonated iRhythm employees pretending to be involved in the iRhythm recruiting process, or created postings for positions that do not exist. Please note that all open positions will always be shown here on the iRhythm Careers page, and all communications regarding the application, interview and hiring process will come from a @irhythmtech.com email address. Please check any communications to be sure they come directly from @irhythmtech.com email address. If you believe you have been the victim of an imposter or want to confirm that the person you are communicating with is legitimate, please contact taops@irhythmtech.com. Written offers of employment will be extended in a formal offer letter from an @irhythmtech.com email address ONLY.
For more information, see https://www.ftc.gov/business-guidance/blog/2023/01/taking-ploy-out-employment-scams and https://www.ic3.gov/Media/Y2020/PSA200121.
Career-defining. Life-changing.
At iRhythm, you’ll have the opportunity to grow your skills and your career while impacting the lives of people around the world. iRhythm is shaping a future where everyone, everywhere can access the best possible cardiac health solutions. Every day, we collaborate, create, and constantly reimagine what’s possible. We think big and move fast, driven by our commitment to put patients first and improve lives. We need builders like you. Curious and innovative problem solvers looking for the chance to meaningfully shape the future of cardiac health, our company, and your career.
About This Role:
Job Summary and Purpose:
We are seeking an experienced and results-driven Clinical Operations Manager to lead and optimize the daily operations of our services team. This role will oversee a team of 20-25 non-exempt staff, ensuring high performance in a fast-paced, high-volume environment.
The ideal candidate will have extensive experience in managing large non-exempt teams, driving continuous improvement through KPIs and performance metrics, and utilizing workflow automation tools to enhance operational efficiency.
This position requires excellent leadership skills, cross-functional communication abilities, and a focus on customer service.
Key Responsibilities:
- Team Management: Oversee daily operations of a team of 20-25 non-exempt staff, ensuring performance meets department production, quality, and operational standards.
- Performance Management: Track and evaluate staff performance metrics, implementing process improvements to meet or exceed quality and efficiency goals.
- Coaching & Development: Provide coaching, guidance, and recognition to foster a high-performance culture. Conduct performance reviews and facilitate corrective actions in partnership with HR and senior leadership.
- Escalation & Recovery: Manage customer service in high-volume environments, ensuring efficient escalation and recovery processes to meet service excellence standards.
- Operational Oversight: Ensure day-to-day service delivery in a high-volume environment runs efficiently and in accordance with established policies and regulations.
- Compliance & Regulations: Ensure compliance with FDA regulations and company policies, collaborating with cross-functional teams to maintain and update these standards.
- Strategic Planning: Contribute to strategic planning and leadership initiatives, working closely with senior management to achieve long-term organizational goals.
- Budget & Resource Management: Oversee team budget, managing resources and additional hours needed to achieve targets. Partner with talent acquisition to manage headcount and recruitment strategy.
- Staff Development: Facilitate ongoing staff development by coordinating training with clinical teams to meet performance and quality standards.
- Continuous Improvement: Assist with quality management programs, provide feedback on operational efficiencies, and collaborate on cross-functional projects to support company-wide initiatives.
- Performance Dashboards & Tools: Utilize workflow automation tools and performance dashboards to monitor team performance and operational metrics, ensuring alignment with organizational goals.
Must-Have Skills and Qualifications:
- Team Leadership: Proven experience managing large teams in a service environment, with a focus on performance management and fostering a high-performance culture.
- KPI and Metrics: Expertise in utilizing KPIs and performance metrics to drive operational improvements and meet organizational objectives.
- Clinical Operational Workflow Management: Experience managing clinical operational workflows, overseeing day-to-day service delivery in high-volume environments.
- Workflow Automation Tools: Proficiency with workflow automation tools and familiarity with production software and performance dashboards.
- Cross-functional Communication: Strong communication skills to collaborate effectively with clinical, operational, and leadership teams.
- Customer Service Excellence: Demonstrated experience managing customer service in high-volume settings and implementing recovery processes to enhance customer satisfaction.
- Escalation & Recovery: Experience in managing efficient escalation and recovery processes to resolve operational issues.
- Compliance & Regulatory Knowledge: Understanding of state and federal regulations in healthcare operations and the ability to ensure compliance.
- Staff Performance & Development: Experience in performance management, staff coaching, and fostering staff development through training initiatives.
Qualifications
- Minimum of 4 years of Management experience in operations management, preferably in medical device, healthcare services or clinical setting
- Strong leadership, problem-solving, and organizational skills
- Proven ability to manage high-volume operations and large teams
Nice-to-Have Skills and Qualifications:
- Broader Healthcare Services Knowledge: Familiarity with healthcare services, including telehealth, health insurance, and diagnostics.
- Operational Challenges Across Sectors: Awareness of operational challenges in multiple healthcare sectors.
WORKING ENVIRONMENT / PHYSICAL DEMANDS:
- Must be able to work under pressure and manage tight deadlines.
- Ability to adapt to a fast-paced, evolving work environment.
- Willingness to attend off-site leadership events and participate in professional development activities.
- Ability to attend the local IDTF in person to support staff and handle escalation issues as required by business needs.
Location:
San Francisco
Actual compensation may vary depending on job-related factors including knowledge, skills, experience, and work location.
Estimated Pay Range
$131,000.00 - $170,000.00
As a part of our core values, we ensure an inclusive workforce. We welcome and celebrate people of all backgrounds, experiences, skills, and perspectives. iRhythm Technologies, Inc. is an Equal Opportunity Employer. We will consider for employment all qualified applicants with arrest and conviction records in accordance with all applicable laws.
iRhythm provides reasonable accommodations for qualified individuals with disabilities in job application procedures, including those who may have any difficulty using our online system. If you need such an accommodation, you may contact us at taops@irhythmtech.com.
About iRhythm Technologies
iRhythm is a leading digital healthcare company that creates trusted solutions that detect, predict, and prevent disease. Combining wearable biosensors and cloud-based data analytics with powerful proprietary algorithms, iRhythm distills data from millions of heartbeats into clinically actionable information. Through a relentless focus on patient care, iRhythm’s vision is to deliver better data, better insights, and better health for all.
Make iRhythm your path forward. Zio, the heart monitor that changed the game.
There have been instances where individuals not associated with iRhythm have impersonated iRhythm employees pretending to be involved in the iRhythm recruiting process, or created postings for positions that do not exist. Please note that all open positions will always be shown here on the iRhythm Careers page, and all communications regarding the application, interview and hiring process will come from a @irhythmtech.com email address. Please check any communications to be sure they come directly from @irhythmtech.com email address. If you believe you have been the victim of an imposter or want to confirm that the person you are communicating with is legitimate, please contact taops@irhythmtech.com. Written offers of employment will be extended in a formal offer letter from an @irhythmtech.com email address ONLY.
For more information, see https://www.ftc.gov/business-guidance/blog/2023/01/taking-ploy-out-employment-scams and https://www.ic3.gov/Media/Y2020/PSA200121.
See All 19 Clinical Operations Manager Jobs in California
Find roles in California that match your experience and apply in just a few clicks.
Find JobsClinical Operations Manager Jobs by City in California
Where California roles are concentrated, by current openings.
Clinical Operations Manager Job Market in California
A snapshot from current California openings, updated as new roles post.
Who's Hiring
- Revolution Medicines9
- Advanced Clinical1
- Biogen1
- Cedars-Sinai Medical Center1
Top Industries Hiring
- Biotechnology & Pharmaceuticals10
- Healthcare & Medical Services6
- Science & Research3
- Consulting & Professional Services1
What California Employers Look For
The qualifications that appear most often in clinical operations manager jobs across California.
- Bachelor's degree in life sciences, health administration, or a related clinical field
- Minimum three to five years of clinical operations or clinical project management experience
- Demonstrated experience managing cross-functional teams across clinical or research settings
- Familiarity with FDA regulations, GCP guidelines, and California-specific healthcare compliance requirements
- Proficiency with clinical trial management systems or electronic health record platforms
- Strong written and verbal communication skills for stakeholder reporting and regulatory documentation
Clinical Operations Manager Jobs in California: Frequently Asked Questions
How do you become a clinical operations manager in California?
Most clinical operations managers in California build toward the role through a combination of a bachelor's degree in a health sciences or business field and several years in clinical coordination, project management, or research operations. A master's in health administration or public health strengthens candidacy at larger systems and biotech firms. While California does not require a state-issued license specific to this management title, roles embedded in clinical research often expect ICH-GCP training and familiarity with California Department of Public Health regulations governing research sites.
Which companies hire clinical operations managers in California?
Employers hiring clinical operations managers in California right now include Revolution Medicines, Revolution Medicines, and Advanced Clinical, based on current listings on Migrate Mate as of June 2026. California's concentration of integrated health systems and biotech headquarters means demand is spread across both patient-care operations and sponsor-side clinical development.
Which California cities have the most clinical operations manager jobs?
Redwood City, San Francisco, and Calabasas have the most clinical operations manager openings in California. The Bay Area and San Diego lead because of their dense biotech and pharmaceutical headquarters, while Los Angeles draws volume from large academic medical centers and health system networks like Cedars-Sinai and UCLA Health that run complex multi-site clinical programs.
Are there remote clinical operations manager jobs in California?
Yes, and more than most healthcare roles. About 5% of clinical operations manager openings tied to California are remote or hybrid as of June 2026, reflecting the coordination-heavy nature of the work. The functions most commonly done remotely are trial oversight, vendor management, protocol development, and cross-site reporting, while roles with direct site monitoring or staff supervision responsibilities typically require on-site presence.
How can I get hired as a clinical operations manager in California with little or no experience?
The most realistic entry path is transitioning from a clinical coordinator, research associate, or project coordinator role at a California hospital system or biotech sponsor. Large California employers including Kaiser Permanente and UCSF Health run structured clinical operations rotational or associate programs that develop candidates without formal management backgrounds. Building ICH-GCP certification and experience with a clinical trial management system, even in a coordinator capacity, is the credential combination that most directly opens the door to a first operations manager title.
Where can I find and apply to clinical operations manager jobs in California?
You can find and apply to clinical operations manager jobs in California on Migrate Mate, which lists current California openings updated regularly. Search the listings for roles that match your background, experience level, and preferred location within the state, then apply directly to the ones that fit.
See All 19 Clinical Operations Manager Jobs in California
Find roles in California that match your experience and apply in just a few clicks.
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