Clinical Operations Manager Jobs
Clinical Operations Manager jobs are open across pharmaceuticals, biotechnology, medical devices, and health systems, from mid-level coordinator roles to senior and director-level positions, with specializations in clinical trials, regulatory affairs, and site management. Find a role that fits from the openings below and apply directly.
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Director-Clinical Operations, Emergency Department Service Line
Job Description
Overview
Our leaders shape strategic initiatives, develop passionate teams, and work to improve health outcomes. They advance our mission and exemplify excellence, compassion, teamwork and purpose in all that they do. Indiana University Health is seeking individuals who embody these values to join our leadership team in the role of Director-Clinical Operations, ED Service Line.
The Director of Clinical Operations, Emergency Department Service Line, provides strategic and operational leadership for the delivery of safe, high-quality, patient-centered emergency care. This role leads a multidisciplinary team and is accountable for aligning Emergency Department operations with the organization’s mission, values, and goals for people, service, financial performance, and clinical excellence. The Director drives initiatives that strengthen patient experience, quality and safety outcomes, access, throughput, workforce engagement, and efficient use of resources.
In partnership with physicians, nursing leaders, ancillary departments, and operational stakeholders, the Director develops and executes business and unit plans that support sustainable performance improvement. This leader uses operational and clinical data to set priorities, monitor results, remove barriers, and advance evidence-based practices. The Director fosters a culture of accountability, collaboration, continuous improvement, and exceptional service while ensuring compliance with organizational standards, regulatory requirements, and applicable best practices. The role may include 24-hour accountability for Emergency Department operations, staff performance, and overall service-line results.
Key Relationships
Reports to: Vice President – Chief Nursing Officer
Candidate Qualifications
Candidates for the position will be evaluated according to the following criteria and competencies.
Masters of Nursing or related field is required or actively enrolled.
Requires an active Registered Nurse (RN) license in the state of Indiana or an active Nurse Licensure Compact (NLC) RN license.
Requires that the RN has graduated from a nationally accredited nursing program.
Requires Basic Life Support certification through the AHA.
Other advanced life support certifications may be required per unit/department specialty according to patient care policies.
Requires completion Clinical Specialty Professional Certification within 1 year upon meeting eligibility requirements.
Requires 7-10 years of relevant experience.
Indiana University Health is unlike any other healthcare system and we're looking for team members who share the things that matter most to us. IU Health leaders play a crucial role in advancing the mission of our organization and inspiring teams to make a meaningful difference in the lives of patients. As one of Indiana’s largest employers and the most comprehensive medical system in the state, our vision is to lead the transformation of healthcare through quality, innovation and education, and make Indiana one of the nation’s healthiest states.
IU Health is the largest health system in Indiana with nearly 40,000 team members, 15 hospitals and $8.64 billion in operating revenue. The system’s programs in cancer, cardiovascular, neuroscience, orthopedics, pediatrics and transplants have received national recognition for quality patient care. IU Health, in partnership with the Indiana University School of Medicine, bring together highly skilled physicians, researchers, and educators into close collaboration to provide world-class care for children and adults and improve the health of patients and communities across Indiana.
Indiana University Health is dedicated to a fair hiring process and is committed to equal opportunity and nondiscrimination for all individuals, regardless of age, color, disability, ethnicity, marital status, national origin, race, religion, gender identity, expression, sexual orientation, or veteran status.
We are an equal opportunity employer. IU Health does not discriminate on the basis of race, color, religion, sex, sexual orientation, age, disability, genetic information, veteran status, national origin, gender identity and/or expression, marital status or any other characteristic protected by federal, state or local law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Indiana University Health is Indiana’s most comprehensive health system, with 15 hospitals and nearly 40,000 team members serving Hoosiers across the state. Our partnership with the Indiana University School of Medicine gives our team members access to the very latest science and the very best training, advancing care for all. We’re looking for team members who share the things that matter most to us. People who are inspired by challenging and meaningful work for the good of every patient. People who are compassionate and serve with a purpose. People who aspire to excellence every day. People who are always ready to apply themselves.
Director-Clinical Operations, Emergency Department Service Line
Job Description
Overview
Our leaders shape strategic initiatives, develop passionate teams, and work to improve health outcomes. They advance our mission and exemplify excellence, compassion, teamwork and purpose in all that they do. Indiana University Health is seeking individuals who embody these values to join our leadership team in the role of Director-Clinical Operations, ED Service Line.
The Director of Clinical Operations, Emergency Department Service Line, provides strategic and operational leadership for the delivery of safe, high-quality, patient-centered emergency care. This role leads a multidisciplinary team and is accountable for aligning Emergency Department operations with the organization’s mission, values, and goals for people, service, financial performance, and clinical excellence. The Director drives initiatives that strengthen patient experience, quality and safety outcomes, access, throughput, workforce engagement, and efficient use of resources.
In partnership with physicians, nursing leaders, ancillary departments, and operational stakeholders, the Director develops and executes business and unit plans that support sustainable performance improvement. This leader uses operational and clinical data to set priorities, monitor results, remove barriers, and advance evidence-based practices. The Director fosters a culture of accountability, collaboration, continuous improvement, and exceptional service while ensuring compliance with organizational standards, regulatory requirements, and applicable best practices. The role may include 24-hour accountability for Emergency Department operations, staff performance, and overall service-line results.
Key Relationships
Reports to: Vice President – Chief Nursing Officer
Candidate Qualifications
Candidates for the position will be evaluated according to the following criteria and competencies.
Masters of Nursing or related field is required or actively enrolled.
Requires an active Registered Nurse (RN) license in the state of Indiana or an active Nurse Licensure Compact (NLC) RN license.
Requires that the RN has graduated from a nationally accredited nursing program.
Requires Basic Life Support certification through the AHA.
Other advanced life support certifications may be required per unit/department specialty according to patient care policies.
Requires completion Clinical Specialty Professional Certification within 1 year upon meeting eligibility requirements.
Requires 7-10 years of relevant experience.
Indiana University Health is unlike any other healthcare system and we're looking for team members who share the things that matter most to us. IU Health leaders play a crucial role in advancing the mission of our organization and inspiring teams to make a meaningful difference in the lives of patients. As one of Indiana’s largest employers and the most comprehensive medical system in the state, our vision is to lead the transformation of healthcare through quality, innovation and education, and make Indiana one of the nation’s healthiest states.
IU Health is the largest health system in Indiana with nearly 40,000 team members, 15 hospitals and $8.64 billion in operating revenue. The system’s programs in cancer, cardiovascular, neuroscience, orthopedics, pediatrics and transplants have received national recognition for quality patient care. IU Health, in partnership with the Indiana University School of Medicine, bring together highly skilled physicians, researchers, and educators into close collaboration to provide world-class care for children and adults and improve the health of patients and communities across Indiana.
Indiana University Health is dedicated to a fair hiring process and is committed to equal opportunity and nondiscrimination for all individuals, regardless of age, color, disability, ethnicity, marital status, national origin, race, religion, gender identity, expression, sexual orientation, or veteran status.
We are an equal opportunity employer. IU Health does not discriminate on the basis of race, color, religion, sex, sexual orientation, age, disability, genetic information, veteran status, national origin, gender identity and/or expression, marital status or any other characteristic protected by federal, state or local law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Indiana University Health is Indiana’s most comprehensive health system, with 15 hospitals and nearly 40,000 team members serving Hoosiers across the state. Our partnership with the Indiana University School of Medicine gives our team members access to the very latest science and the very best training, advancing care for all. We’re looking for team members who share the things that matter most to us. People who are inspired by challenging and meaningful work for the good of every patient. People who are compassionate and serve with a purpose. People who aspire to excellence every day. People who are always ready to apply themselves.
Clinical Operations Manager Jobs by Experience Level
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Find JobsClinical Operations Manager Job Market
Who's Hiring
- University of Miami27
- KBR12
- Providence10
- WellSpan Health10
- Indiana University Health10
Top Industries Hiring
- Healthcare & Medical Services34
- Biotechnology & Pharmaceuticals21
- Education18
- Science & Research12
- Consulting & Professional Services4
What Employers Look For
The qualifications that appear most often in clinical operations manager jobs.
- Bachelor's degree in life sciences, nursing, or a related clinical field
- Minimum five years of clinical trial or clinical operations experience
- Proficiency with clinical trial management systems such as Veeva or Medidata
- Strong working knowledge of ICH-GCP guidelines and FDA regulations
- Experience managing CROs, vendors, or multi-site study teams
- Project Management Professional or equivalent certification preferred
Tips for Your Clinical Operations Manager Job Search
Tailor your resume to trial phase
Hiring managers scan for Phase I through Phase IV experience. List the specific trial phases you've managed, the therapeutic areas covered, and the size of the sites or patient populations you oversaw. Vague operations experience won't stand out.
Lead with protocol deviation metrics
Clinical operations roles live and die by data quality and compliance. Quantify your deviation rates, audit outcomes, or inspection-readiness scores on your resume. Concrete numbers from real studies tell interviewers far more than a list of responsibilities.
Filter openings by sponsor versus CRO
Sponsor-side roles and CRO roles require different emphases: sponsors want strategic oversight, CROs want throughput and client management. Decide which environment fits your background before applying so your cover letter speaks directly to that model.
Apply early to roles that fit
Migrate Mate lists clinical operations manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare scenario answers on risk escalation
Interviewers routinely ask how you handled a site that fell behind enrollment or triggered a protocol deviation. Prepare two or three specific examples where you identified a risk early, escalated appropriately, and documented the resolution for the sponsor or IRB.
Negotiate start date around study timelines
If you're mid-study at your current role, a hard start date can cost you the offer. When discussing timing, name the milestone you're completing and offer a firm date. Sponsors appreciate candidates who treat protocol continuity as a professional obligation.
Clinical Operations Manager Jobs: Frequently Asked Questions
Which companies are hiring the most clinical operations managers?
The companies hiring the most clinical operations managers right now include University of Miami, KBR, and Providence, with the largest share of openings in California, Florida, and New York, based on current listings on Migrate Mate as of September 2026. Demand is concentrated in large pharmaceutical sponsors, contract research organizations, and integrated health systems running decentralized or hybrid trials.
How many clinical operations manager jobs are remote?
About 52% of clinical operations manager openings are fully remote or hybrid as of September 2026, reflecting the shift toward decentralized trial models. Roles focused on vendor oversight, data management coordination, and regulatory submissions tend to offer the most remote flexibility, while positions requiring hands-on site monitoring or lab oversight more often require on-site presence.
How do you become a clinical operations manager?
Most clinical operations managers start as clinical research associates or trial coordinators, building site management and GCP compliance experience across multiple studies. From there, moving into a lead CRA or senior coordinator role adds the oversight and vendor management skills employers expect. A relevant degree in life sciences or nursing is the typical educational foundation, and many candidates add a project management certification to strengthen their application for manager-level roles.
Can you get a clinical operations manager role with limited experience?
It's possible if you can demonstrate deep hands-on experience in a closely related role. CRAs with strong audit and protocol deviation records, regulatory affairs coordinators, or clinical data managers who have led cross-functional workstreams often move into operations manager roles without a traditional manager title in their history. Targeting smaller sponsors or early-stage biotechs can also lower the experience bar compared to large pharmaceutical companies.
What does the clinical operations manager interview process look like?
The process typically opens with a recruiter screen focused on therapeutic area experience and systems knowledge, followed by a panel interview with clinical operations leadership and cross-functional partners such as data management or regulatory affairs. Candidates are usually asked to walk through a past study from protocol kick-off to close-out, with detailed questions on how they handled site issues, vendor performance, and inspection readiness. A final round may include a case study or take-home scenario.
Where can I find and apply to clinical operations manager jobs?
You can find and apply to clinical operations manager jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your background and apply directly to each listing. Openings are updated regularly, so checking back frequently gives you access to newly posted positions before they fill.
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