Clinical Operations Manager Jobs in Massachusetts
Clinical Operations Manager jobs in Massachusetts are among the most active in the country, concentrated in clinical research, hospital systems, and biotech and pharma operations, with openings from coordinator-level roles stepping into management through senior director positions. Boston, Cambridge, and Worcester drive the bulk of hiring, anchored by institutions and employers such as Mass General Brigham, Dana-Farber Cancer Institute, and Biogen, all of which maintain large and ongoing clinical operations functions. Regulatory affairs oversight, site management, and oncology trial operations are the most consistently in-demand specialties across Massachusetts listings. Find a role that fits below and apply directly.
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Showing 5 of 40+ Clinical Operations Manager jobs
Why Sarepta? Why Now?
Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne Muscular Dystrophy and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. Our next-generation siRNA platform is focused on chronically administered therapies for neurodegenerative and pulmonary diseases.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. Additionally, the candidate will work with early research and other stakeholders to build out the oversight model for Feasibility & Study Start-up. The candidate will drive the study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for 1) directing and overseeing the success of Sarepta’s clinical trial feasibility process, 2) leading the development of feasibility and start-up strategies including study-specific plans, 3) directing and overseeing the success of the Sarepta’s clinical trial start-up activities, 4) and working with both internal and external vendors.
This is a highly cross-functional position, collaborating with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
The Opportunity to Make a Difference
Primary Responsibilities Include:
- Develop and implement the feasibility and start-up strategies to support the success of Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study specific meeting series to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO. The candidate will report metrics to larger teams including senior management.
- Lead calls with Sarepta and the CRO to manage feasibility and study start-up activities and ensure the study timelines are achieved.
- Oversee study feasibility activities including country, site, and investigator selection for participation in Sarepta-lead studies.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentoring to junior members of the Study Start-up and Feasibility Team.
- Create reporting tools to measure ongoing activities and other key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations and CRO teams, and other key stakeholders to implement innovative feasibility efforts including collection of data within CTMS.
- Support and or lead the development of Charters or SOPs as it relates to Study Start-up and Feasibility.
- May have direct reports.
More about You
Desired Education and Skills:
- BA / BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs.
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
#LI-Hybrid This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time. The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
Why Sarepta? Why Now?
Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne Muscular Dystrophy and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. Our next-generation siRNA platform is focused on chronically administered therapies for neurodegenerative and pulmonary diseases.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. Additionally, the candidate will work with early research and other stakeholders to build out the oversight model for Feasibility & Study Start-up. The candidate will drive the study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for 1) directing and overseeing the success of Sarepta’s clinical trial feasibility process, 2) leading the development of feasibility and start-up strategies including study-specific plans, 3) directing and overseeing the success of the Sarepta’s clinical trial start-up activities, 4) and working with both internal and external vendors.
This is a highly cross-functional position, collaborating with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
The Opportunity to Make a Difference
Primary Responsibilities Include:
- Develop and implement the feasibility and start-up strategies to support the success of Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study specific meeting series to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO. The candidate will report metrics to larger teams including senior management.
- Lead calls with Sarepta and the CRO to manage feasibility and study start-up activities and ensure the study timelines are achieved.
- Oversee study feasibility activities including country, site, and investigator selection for participation in Sarepta-lead studies.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentoring to junior members of the Study Start-up and Feasibility Team.
- Create reporting tools to measure ongoing activities and other key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations and CRO teams, and other key stakeholders to implement innovative feasibility efforts including collection of data within CTMS.
- Support and or lead the development of Charters or SOPs as it relates to Study Start-up and Feasibility.
- May have direct reports.
More about You
Desired Education and Skills:
- BA / BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs.
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
#LI-Hybrid This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time. The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
See All 40 Clinical Operations Manager Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find JobsClinical Operations Manager Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Clinical Operations Manager Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Science & Research
- Medical Devices
- Healthcare & Medical Services
What Massachusetts Employers Look For
The qualifications that appear most often in clinical operations manager jobs across Massachusetts.
- Bachelor's degree in life sciences, nursing, or a health-related field required
- Minimum five years of clinical research or healthcare operations experience preferred
- ICH-GCP certification or equivalent clinical research credential expected
- Demonstrated experience managing clinical trial sites or multi-site operations
- Familiarity with FDA regulatory requirements and clinical study protocols
- Strong proficiency in electronic data capture systems such as Medidata or Veeva
Clinical Operations Manager Jobs in Massachusetts: Frequently Asked Questions
How do you become a clinical operations manager in Massachusetts?
Most clinical operations managers in Massachusetts enter the role through clinical research coordination or trial monitoring, typically after earning a bachelor's degree in a life science or health field. Massachusetts does not require a state-issued license specific to this management role, but employers strongly favor candidates who hold credentials such as the Certified Clinical Research Professional designation issued by the Society of Clinical Research Associates, or equivalent certification. Progression from CRC or CRA roles at Massachusetts research hospitals or biotech firms is the most common pathway.
Which companies hire clinical operations managers in Massachusetts?
Employers hiring clinical operations managers in Massachusetts right now include Baystate Health, Adams Clinical, and Tessera Therapeutics, based on current listings on Migrate Mate as of October 2026. Massachusetts's concentration of academic medical centers and global biotech headquarters means many of these employers are running multiple concurrent studies, creating consistent and varied openings across therapeutic areas.
Which Massachusetts cities have the most clinical operations manager jobs?
Boston, Cambridge, and Somerville have the most clinical operations manager openings in Massachusetts. Boston and Cambridge dominate because of their dense cluster of teaching hospitals, biotech headquarters, and contract research organizations, while Worcester's UMass Memorial Health system and growing life sciences corridor account for a meaningful share of listings outside the Route 128 belt.
Are there remote clinical operations manager jobs in Massachusetts?
Yes, and more than many clinical roles, because operations management in research settings involves considerable protocol oversight, vendor coordination, and reporting that can be done off-site. About 67% of clinical operations manager openings tied to Massachusetts are remote or hybrid as of October 2026, reflecting the desk-and-coordination nature of much of the work. Site-facing responsibilities tied to active clinical trial locations are the portions most likely to require on-site presence.
How can I get hired as a clinical operations manager in Massachusetts with little or no experience?
The most realistic entry path is through a clinical research coordinator role at a Massachusetts academic medical center or large community hospital, where you can build direct trial experience before moving into operations management. Mass General Brigham, Boston Children's Hospital, and Dana-Farber all run structured CRC programs that serve as feeders into operations leadership. Earning an entry-level credential such as the ACRP Associate Clinical Research Professional designation strengthens applications, and lateral moves from regulatory affairs or quality assurance roles are also recognized by Massachusetts biotech and pharma employers as relevant operations experience.
Where can I find and apply to clinical operations manager jobs in Massachusetts?
You can find and apply to clinical operations manager jobs in Massachusetts on Migrate Mate, which lists current Massachusetts openings across clinical research, hospital systems, and biotech and pharma employers. Find the roles that fit your background and apply directly.
See All 40 Clinical Operations Manager Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
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