Sub-Investigator Jobs
Sub-Investigator jobs are open across clinical research organizations, pharmaceutical companies, academic medical centers, and specialty clinics, covering roles from entry-level research coordinator to senior sub-investigator, with specializations in oncology trials, Phase I-III studies, and regulatory compliance. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 10+ Sub-Investigator jobs
The Sub-Investigator (Physician Assistant or Nurse Practitioner) is accountable and responsible for ensuring adherence to protocol requirements, protecting the rights and welfare of subjects, assuring the integrity of subject generated data and directing the conduct of research according to federal and state regulations and guidance documents.
DUTIES & RESPONSIBILITIES
- Completing DMCR-required training, including GCP and IATA.
- Maintaining a working knowledge of current FDA regulations, GCP/ICH guidelines, organizational SOPs, guidance documents, and study protocols.
- Maintaining a current, up-to-date curriculum vitae and current licensure to practice.
- Assisting in managing the activities and performance of the clinical staff affiliated with the site.
- Performing clinical-related procedures and/or making important trial-related decisions delegated by the Principal Investigator.
- Performing clinical safety assessments and monitoring for study trial participation to include such items as: physical exams, EKGs, phlebotomy, and lab work evaluation
- Possessing a thorough understanding of the requirements of each protocol.
- Managing the medical care of subjects; protecting the rights and welfare of subjects.
- Ensuring documentation of study-related procedures, processes, and events.
- Attending investigator meetings as necessary for study participation.
- Any other matters as assigned by management
KNOWLEDGE & EXPERIENCE
Education:
- Bachelors or Masters in Nursing
Experience:
- Previous clinical research experience
- Nursing experience in a clinical setting
Credentials:
- Current nursing licensure in good standing (Physician Assistant or Nurse Practitioner)
Knowledge and Skills:
- Basic clinical and patient care skills
- Knowledge of nursing and medical principles and techniques
- Clinical research knowledge
- Strong communication skills, both written and verbal
- Strong diagnostic skills
- Ethical and legal healthcare principles in patient care
- Proficient communication and comprehension skills both verbal and written in the English language are required.
- Proficient Bi-lingual (English/Spanish) communication and comprehension skills both in verbal and written are preferred.
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The Sub-Investigator (Physician Assistant or Nurse Practitioner) is accountable and responsible for ensuring adherence to protocol requirements, protecting the rights and welfare of subjects, assuring the integrity of subject generated data and directing the conduct of research according to federal and state regulations and guidance documents.
DUTIES & RESPONSIBILITIES
- Completing DMCR-required training, including GCP and IATA.
- Maintaining a working knowledge of current FDA regulations, GCP/ICH guidelines, organizational SOPs, guidance documents, and study protocols.
- Maintaining a current, up-to-date curriculum vitae and current licensure to practice.
- Assisting in managing the activities and performance of the clinical staff affiliated with the site.
- Performing clinical-related procedures and/or making important trial-related decisions delegated by the Principal Investigator.
- Performing clinical safety assessments and monitoring for study trial participation to include such items as: physical exams, EKGs, phlebotomy, and lab work evaluation
- Possessing a thorough understanding of the requirements of each protocol.
- Managing the medical care of subjects; protecting the rights and welfare of subjects.
- Ensuring documentation of study-related procedures, processes, and events.
- Attending investigator meetings as necessary for study participation.
- Any other matters as assigned by management
KNOWLEDGE & EXPERIENCE
Education:
- Bachelors or Masters in Nursing
Experience:
- Previous clinical research experience
- Nursing experience in a clinical setting
Credentials:
- Current nursing licensure in good standing (Physician Assistant or Nurse Practitioner)
Knowledge and Skills:
- Basic clinical and patient care skills
- Knowledge of nursing and medical principles and techniques
- Clinical research knowledge
- Strong communication skills, both written and verbal
- Strong diagnostic skills
- Ethical and legal healthcare principles in patient care
- Proficient communication and comprehension skills both verbal and written in the English language are required.
- Proficient Bi-lingual (English/Spanish) communication and comprehension skills both in verbal and written are preferred.
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Who's Hiring
Top Industries Hiring
- Consulting & Professional Services
What Employers Look For
The qualifications that appear most often in Sub-Investigator jobs.
- Current Good Clinical Practice (GCP) certification from an accredited training program
- Experience obtaining informed consent and managing patient enrollment in clinical trials
- Familiarity with electronic data capture systems such as Medidata Rave or Veeva
- Bachelor's or advanced degree in a health science, nursing, or related clinical field
- Understanding of FDA regulations governing clinical investigations and adverse event reporting
- Ability to conduct source document verification and prepare for sponsor and regulatory audits
Tips for Your Sub-Investigator Job Search
Tailor your resume to trial phases
Hiring managers read sub-investigator resumes looking for specific trial phases you've worked on. List Phase I, II, or III experience explicitly for each role, name the therapeutic area, and note whether you obtained informed consent or managed adverse event reporting.
Get your GCP certification current
Most postings require current Good Clinical Practice certification. If yours lapsed, complete a refresher course before applying so the credential date on your resume falls within the last two to three years, which is what most sponsors and CROs expect.
Apply early to roles that fit
Migrate Mate lists sub-investigator openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Target your search by sponsor type
Academic medical centers, contract research organizations, and community research sites each run trials differently. Decide which environment fits how you work, then filter your search accordingly so you're not applying broadly to roles with different day-to-day expectations.
Prepare for protocol-specific interview questions
Interviewers often walk through a real protocol excerpt and ask how you'd handle a deviation or eligibility edge case. Review the ICH E6 guidelines before your interview and practice talking through your decision process on a past deviation you managed.
Negotiate start date around site activation
If a sponsor is mid-activation on a trial, an earlier start date signals readiness and can strengthen your offer. Ask during the final interview when site initiation is scheduled, then confirm you can be credentialed and onboarded before that date.
Sub-Investigator Jobs: Frequently Asked Questions
Which companies are hiring the most sub-investigators?
The IMA, ClinChoice, and InvivoCure are hiring the most sub-investigators right now, with openings concentrated in Texas, Arkansas, and Michigan, based on current listings on Migrate Mate as of November 2026. Sites attached to large health systems and contract research organizations tend to post the most consistently throughout the year.
How many sub-investigator jobs are remote?
About 33% of sub-investigator openings are fully remote or hybrid as of November 2026, though most hands-on clinical roles require on-site presence for patient visits and procedure oversight. Regulatory affairs sub-investigator roles, protocol review positions, and some sponsor-side medical monitor jobs are most likely to offer remote or hybrid arrangements.
How do you become a sub-investigator?
Start by earning a clinical degree in nursing, medicine, pharmacy, or a related health science, then complete a recognized Good Clinical Practice training course. Gain direct trial experience as a research coordinator or clinical research associate, working through informed consent, protocol adherence, and adverse event reporting. Once you've supported at least one complete trial from enrollment to closeout, you have the foundation most sites require before credentialing you as a sub-investigator.
Can you get hired as a sub-investigator with little experience?
Yes, some community research sites and smaller CROs hire candidates with limited trial history if they hold a relevant clinical license and current GCP certification. Emphasize any patient-facing clinical work, familiarity with regulatory documentation, and willingness to work under close PI supervision during your first trial. Applying to sites running straightforward Phase III or IV studies is a practical starting point because those trials typically have more structured onboarding than early-phase work.
What does the sub-investigator interview process look like?
Most sites run a phone or video screen focused on your clinical background and GCP knowledge, followed by an in-person or virtual panel with the principal investigator and research coordinator team. Expect at least one scenario question asking how you'd handle a protocol deviation or eligibility borderline case. Some sponsors or CROs also require a credentialing review of your CV, license, and certifications before extending an offer.
Where can I find and apply to sub-investigator jobs?
You can find and apply to sub-investigator jobs on Migrate Mate, which lists current openings from across the United States. Search for roles that match your therapeutic area, trial phase experience, and location preference, then apply directly to each listing that fits.
See All 10 Sub-Investigator Jobs
Find roles that match your experience and apply in just a few clicks.
Find Sub-Investigator Jobs