Acute Care Nurse Practitioner Jobs in St. Louis, MO
Acute Care Nurse Practitioner jobs in St. Louis are concentrated across major health systems in the Central West End, Cortex Innovation Community, and downtown medical corridor, with strong demand in critical care, cardiovascular, and oncology settings. Employers hiring right now include BJC HealthCare, American Traveler, and SSM Health. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 47+ Acute Care Nurse Practitioner jobs
Company Overview
Shriners Children’s is an organization that respects, supports, and values each other. Named as the 2025 best mid-sized employer by Forbes, we are engaged in providing excellence in patient care, embracing multi-disciplinary education, and research with global impact. We foster a learning environment that values evidenced based practice, experience, innovation, and critical thinking. Our compassion, integrity, accountability, and resilience define us as leaders in pediatric specialty care for our children and their families.
With 20+ hospitals, outpatient clinics, ambulatory care centers and outreach locations across the globe, we provide excellent care to children up to age 18 regardless of their family’s ability to pay or insurance status. Please click here to learn more about our locations.
Job Description
Shriners Children's St. Louis has an opportunity for a Nurse Manager in our Inpatient and PACU departments. Join a team of professionals committed to improving children's lives. Our top healthcare professionals excel in their practices and provide compassionate, family-centered care to children who need it most.
Key Responsibilities:
The Nurse Manager provides leadership in working cooperatively with ancillary nursing and other patient care personnel in maintaining standards for professional nursing practice in the clinical setting.
The Nurse Manager maintains clinical skills and acts as both a clinical leader and resource nurse, as well as, administrative leader, assuming 24-hour responsibility for the unit.
Responsibilities include assessment, direction, planning, evaluating, and development of the In-patient Nursing and PACU divisions in coordination with the identified needs of patients and families.
This position will be responsible for overseeing daily nursing practice in an assigned department to ensure that safe and appropriate care is provided.
The Nurse Manager will collaborate actively with medical, administrative, and interdisciplinary leadership to ensure optimal patient care outcomes.
Required Qualifications:
Bachelor’s degree (BSN)
Active RN license in state of practice
5 years’ experience as a clinical nurse
5 years’ experience charge nurse / team lead
Critical care experience
Basic Life Support (BLS) certification
Preferred Qualifications:
1 year of pediatric and/or orthopedic experience
1 year experience in clinical research
Pediatric Advanced Life Support (PALS) certification
Advanced Cardiovascular Life Support (ACLS) certification
Company Overview
Shriners Children’s is an organization that respects, supports, and values each other. Named as the 2025 best mid-sized employer by Forbes, we are engaged in providing excellence in patient care, embracing multi-disciplinary education, and research with global impact. We foster a learning environment that values evidenced based practice, experience, innovation, and critical thinking. Our compassion, integrity, accountability, and resilience define us as leaders in pediatric specialty care for our children and their families.
With 20+ hospitals, outpatient clinics, ambulatory care centers and outreach locations across the globe, we provide excellent care to children up to age 18 regardless of their family’s ability to pay or insurance status. Please click here to learn more about our locations.
Job Description
Shriners Children's St. Louis has an opportunity for a Nurse Manager in our Inpatient and PACU departments. Join a team of professionals committed to improving children's lives. Our top healthcare professionals excel in their practices and provide compassionate, family-centered care to children who need it most.
Key Responsibilities:
The Nurse Manager provides leadership in working cooperatively with ancillary nursing and other patient care personnel in maintaining standards for professional nursing practice in the clinical setting.
The Nurse Manager maintains clinical skills and acts as both a clinical leader and resource nurse, as well as, administrative leader, assuming 24-hour responsibility for the unit.
Responsibilities include assessment, direction, planning, evaluating, and development of the In-patient Nursing and PACU divisions in coordination with the identified needs of patients and families.
This position will be responsible for overseeing daily nursing practice in an assigned department to ensure that safe and appropriate care is provided.
The Nurse Manager will collaborate actively with medical, administrative, and interdisciplinary leadership to ensure optimal patient care outcomes.
Required Qualifications:
Bachelor’s degree (BSN)
Active RN license in state of practice
5 years’ experience as a clinical nurse
5 years’ experience charge nurse / team lead
Critical care experience
Basic Life Support (BLS) certification
Preferred Qualifications:
1 year of pediatric and/or orthopedic experience
1 year experience in clinical research
Pediatric Advanced Life Support (PALS) certification
Advanced Cardiovascular Life Support (ACLS) certification
See All 47 Acute Care Nurse Practitioner Jobs in St. Louis
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Find JobsAcute Care Nurse Practitioner Job Market in St. Louis
Who's Hiring
- BJC HealthCare27
- American Traveler5
- SSM Health3
- Medical Director Services PC2
- Washington University in St. Louis2
Top Industries Hiring
- Education1
- Healthcare & Medical Services1
Acute Care Nurse Practitioner Jobs in St. Louis: Frequently Asked Questions
How do I get an acute care nurse practitioner job in St. Louis?
Targeting St. Louis's large academic medical centers and specialty hospital systems gives you the strongest footing, as they run the highest volume of critical care and post-surgical openings. The Central West End and Cortex corridor concentrate the most postings, so focusing your search there helps. Candidates with experience in cardiovascular, pulmonary, or oncology acute care stand out most in this market, and prior clinical rotations at a St. Louis institution often accelerates hiring decisions.
Which companies hire acute care nurse practitioners in St. Louis?
Employers hiring acute care nurse practitioners in St. Louis right now include BJC HealthCare, American Traveler, and SSM Health, based on current listings on Migrate Mate as of July 2026. St. Louis's hiring base skews heavily toward large academic health systems, specialty cardiovascular centers, and multi-site regional hospital networks that maintain dedicated advanced practice provider programs.
Are there remote acute care nurse practitioner jobs in St. Louis?
Remote opportunities are limited for acute care nurse practitioners because the role is fundamentally hands-on and requires direct patient contact in hospital or clinical settings. About 33% of acute care nurse practitioner openings tied to St. Louis are remote or hybrid as of July 2026, and those positions tend to involve telehealth triage, care coordination, or utilization review functions rather than direct bedside practice.
How can I get an acute care nurse practitioner job in St. Louis with little or no experience?
The most realistic entry path in St. Louis is through residency or fellowship programs offered by the city's large academic medical systems, which are specifically structured for new acute care NPs. Targeting hospitalist or progressive care unit roles at community hospitals in the surrounding metro area, where competition is lower than at flagship academic centers, also opens doors quickly. Completing clinical hours at a St. Louis institution before graduation gives candidates a significant edge when those employers post full-time openings.
Which industries hire the most acute care nurse practitioners in St. Louis?
St. Louis acute care nurse practitioner roles concentrate in Education and Healthcare & Medical Services, based on current listings on Migrate Mate as of July 2026. St. Louis's strong base of academic medical centers, cardiovascular specialty hospitals, and regional health networks drives consistent demand across those sectors throughout the year.
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See All 47 Acute Care Nurse Practitioner Jobs in St. Louis
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