Senior Level Associate Principal Scientist Jobs
Senior level associate principal scientist jobs place experienced scientists at the helm of research programs, owning experimental strategy, driving cross-functional decisions, and guiding the teams that deliver results. Openings concentrate in Biotechnology & Pharmaceuticals, Technology & Software, and Healthcare & Medical Services, with a 19% remote or hybrid share, and employers like AbbVie, Amazon, and Exponent hiring at this level now.
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Job Title: Principal R&D Scientist
Reports to: Chief Technology officer
FLSA Status: Full time, Regular, Salary, Exempt
About us
At Dimer Instruments we’re creating the next generation of laboratory analytical instruments for the pharmaceutical market. Our products use multiple light-based spectroscopic methods to interrogate solutions containing molecules and particles, providing researchers not just with data but with organized information allowing them to make informed decisions. At Dimer you’ll be working with a high-quality, high-performing, highly collaborative, and enjoyable team of Engineers and Scientists to create products that make a difference in the world. We have fun while we’re creating great products.
Summary
The Principal Research and Development Scientist will be a critical member of the team designing and developing Analytical instruments. They will be expert in the use of optics, optical breadboarding, and optical systems, and in addition to optics they will use a combination of science, math, analysis, scripting/programming, mechanics, data acquisition, and electronics to contribute hands-on through all phases of research and development, including 1) initial math, analysis, simulation, 2) measurement system design, 3) building real-world prototypes that demonstrate proof of concept for individual measurement modalities and functionality, 4) building system prototypes, 5) bringing products from R&D into Manufacturing, 6) demonstrating product performance at every stage in the product lifecycle, and 7) supporting product release and early rapid product improvement. The Principal R&D Scientist will collaborate closely with Mechanical, Electrical, and Software Engineers, and with in-house Application Scientists. The successful Principal R&D Scientist will be able to be scientifically careful and rigorous, able to theoretically understand and experimentally tease apart subtle contributors to data and signals, and also be action-oriented and able to come to quick, practical, and manufacturable solutions. They will be designing and creating scientific instruments that provide cutting edge data and yet are robust in the real world, able to ship to Japan or Europe without optics mis-aligning, and able to reliably operate in sometimes non-ideal laboratory conditions. The successful Principal R&D Scientist will not shy away from tackling the sometimes less glamorous work of contributing to work instructions and assembly instructions (e.g. for an optical alignment or calibration method to be used in manufacturing), generating and documenting manufacturing tools (which can sometimes be complicated analytical instruments in their own right), contributing to user documentation, and running and analyzing user samples. The successful R&D Principal scientist will be highly collaborative, both with Dimer staff across the organization and with external researchers. The Principal R&D Scientist will also be willing and able to educate customers, internal Dimer staff, and other stakeholders regarding the science behind the Dimer products, generating presentations and demonstrations and presenting at conferences, trade shows, customer sites, and for internal training as needed. Dimer Instruments products are scientific instruments and analytical tools used by scientists. The Principal R&D Scientist will be a key member of a collaborative team inventing, designing, developing, and launching products that solve real world challenges and improve the pace of science and pharmaceutical development.
Essential Duties and Responsibilities
- Design, build, and demonstrate performance of optical measurement systems, including imaging and non-imaging systems from UV into the NIR
- Use standard optical and measurement tools to assess performance of optical components including single mode and multi-mode optical fibers, lens, filters, mirrors, optomechanical and assemblies
- Math, simulation, and analysis to predict real world performance of physical systems, e.g. noise floor for a particular optical measurement, cooling rate of a thermoelectric module assembly, signal strength from molecules in solution being probed by various modalities, etc., etc.
- Electronics troubleshooting, including op-amp circuits associated with laser drive, photocurrent measurement, and similar, and digital circuits associated with GPIO, system control, and similar
- Contribute to system level architecture and design of laboratory analytical instrument products
- Demonstrate proof of concept performance of physical systems by designing, building, and demonstrating using prototype systems
- Contribute to DFMEA and generate mitigations for the higher impact failures identified
- Programming and scripting to automate measurements or manufacturing steps, e.g. calibration of a component as a function of temperature
- Perform research and analysis demonstrating the scientific added value of Dimer products by collaborating with industry pharmaceutical researchers, and/or conceiving of novel demonstration measurements
- Contribute to project and product planning, including schedule and budgets, and contribute to project and product reports and updates
- Generate Manufacturing procedures and documentation as needed
- Generate User facing procedures and documentation as needed
- Create and present internally and externally intro level explanations of the science and technology that power Dimer Instruments products
- Scientific publications and presentations
- Contribute to patent applications
- Other tasks as assigned by your supervisor
Qualifications
- Ph.D. in Physics, EE, MechE, ChemE, or equivalent training, work experience, and skills
- Expert in the design and use of optical systems. Strong knowledge of high level math, programming/scripting, data acquisition, electronics, general science
- Demonstrated ability to create and work with real world measurement systems.
Additional Skills
Must have the social “soft skills” required to be collaborative across the organization. Socially adept, able to navigate different groups and functions with competing needs, and able to work with stakeholders to create solutions requiring compromise. Must be able to understand and communicate well in English, both spoken and written, and be able to write reports, work instructions, business correspondence, procedures, and manuals. Must be able to present work in an organized way both for project/progress reviews and design reviews.
Physical Requirements
When working in machine shop, chemistry, or optics lab, appropriate protective gear must be worn including eyewear, eye protection from laser or UV light, lab coats, and closed toed shoes.
Work Environment
Office space, optics lab, chemistry lab, warehouse, and electronics and optical manufacturing space. The employee may occasionally be exposed to moderate noise levels, e.g. from loud fans in electronics equipment. Travel may occasionally be required, e.g. to test labs, customer sites, for conferences and trade shows, or for training.
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Top Industries Hiring
- Biotechnology & Pharmaceuticals22
- Technology & Software21
- Healthcare & Medical Services8
- Consulting & Professional Services8
- Retail6
Senior Level Associate Principal Scientist Jobs: Frequently Asked Questions
How do I get a senior level associate principal scientist job?
Employers hiring at the senior level look for scientists who have moved beyond executing experiments to shaping research direction and mentoring junior staff. A strong candidate brings a record of leading multi-stage projects from hypothesis to publication or regulatory submission, deep technical expertise in a defined domain, and demonstrated ability to collaborate across scientific and business functions. Tailoring your application to highlight ownership, not just contribution, sets you apart.
Which companies hire senior level associate principal scientists?
Companies hiring senior level associate principal scientists right now include AbbVie, Amazon, and Exponent, based on current listings on Migrate Mate as of November 2026. At this level, hiring tends to come from large pharmaceutical and biotech firms, medical device manufacturers, and industrial research organizations that run established R&D programs requiring seasoned scientific leadership.
Are there remote senior level associate principal scientist jobs?
Yes, though lab-based roles still require on-site presence for many positions. About 19% of senior level associate principal scientist openings are remote or hybrid as of November 2026, with remote availability more common in roles centered on data analysis, computational research, regulatory science, or program management than in hands-on laboratory work.
What makes an associate principal scientist role senior level?
A senior level associate principal scientist takes full ownership of research programs rather than contributing to them. That means setting the scientific strategy for a project, making independent technical judgments, representing the team in cross-functional forums, and actively developing the capabilities of less experienced scientists. The distinction from mid-level roles is accountability for outcomes, not just tasks, and the expectation that you shape how the work gets done.
Which industries hire the most senior level associate principal scientists?
Senior level associate principal scientist roles concentrate in Biotechnology & Pharmaceuticals, Technology & Software, and Healthcare & Medical Services, based on current listings on Migrate Mate as of November 2026. These sectors drive hiring at this level because they sustain large internal R&D functions that depend on experienced scientists who can lead long-horizon discovery or development programs with limited direct supervision.