Senior Level Associate Principal Scientist Jobs

Senior level associate principal scientist jobs place experienced scientists at the helm of research programs, owning experimental strategy, driving cross-functional decisions, and guiding the teams that deliver results. Openings concentrate in Biotechnology & Pharmaceuticals, Technology & Software, and Healthcare & Medical Services, with a 19% remote or hybrid share, and employers like AbbVie, Amazon, and Exponent hiring at this level now.

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Overview

Open roles84
Top stateCalifornia
Top employerAbbVie
Top citySan Francisco, CA
Work type81% On-site
Top industryBiotechnology

Showing 5 of 84+ Senior Level Associate Principal Scientist jobs

Principal R&D Scientist
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Added 2d ago
Principal R&D Scientist
Dimer Instruments
Santa Barbara County, California
Laboratory Research
Biotech & Life Sciences
Specialized Engineering
Mechanical Engineering
Electrical Engineering
Engineering (Non-Software)
On-Site
Doctorate

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Principal Research Scientist I, Biologics CMC Developability Modeling
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Added 3d ago
Principal Research Scientist I, Biologics CMC Developability Modeling
AbbVie
North Chicago, Illinois
IT Support
Project Management
Technical Program Management
$125k - $237k/yr
Hybrid
Master's degree in chemistry
10,000+

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Principal Scientist, Global Patient Safety Surveillance
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Added 1w ago
Principal Scientist, Global Patient Safety Surveillance
Revolution Medicines
San Francisco Bay Area
Allied Health
Healthcare Administration
Clinical Support
Pharmacy
$211k - $264k/yr
Hybrid
Doctorate

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Principal Research Scientist I
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Added 1w ago
Principal Research Scientist I
AbbVie
North Chicago, Illinois
Data Science & Analytics
Software Engineering
Healthcare Administration
Laboratory Research
Data Science
$125k - $237k/yr
On-Site
Doctorate
10,000+

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Principal Research Scientist II
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Added 1w ago
Principal Research Scientist II
AbbVie
North Chicago, Illinois
Laboratory Research
Biotech & Life Sciences
Clinical Trials & Medical Research
Healthcare Administration
$142k - $269k/yr
On-Site
Doctorate
10,000+

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Senior Level Associate Principal Scientist Job Market

Who's Hiring

AbbVie9 open roles
Amazon6 open roles
Exponent4 open roles

Top Industries Hiring

  • Biotechnology & Pharmaceuticals22
  • Technology & Software21
  • Healthcare & Medical Services8
  • Consulting & Professional Services8
  • Retail6

Senior Level Associate Principal Scientist Jobs: Frequently Asked Questions

How do I get a senior level associate principal scientist job?

Employers hiring at the senior level look for scientists who have moved beyond executing experiments to shaping research direction and mentoring junior staff. A strong candidate brings a record of leading multi-stage projects from hypothesis to publication or regulatory submission, deep technical expertise in a defined domain, and demonstrated ability to collaborate across scientific and business functions. Tailoring your application to highlight ownership, not just contribution, sets you apart.

Which companies hire senior level associate principal scientists?

Companies hiring senior level associate principal scientists right now include AbbVie, Amazon, and Exponent, based on current listings on Migrate Mate as of November 2026. At this level, hiring tends to come from large pharmaceutical and biotech firms, medical device manufacturers, and industrial research organizations that run established R&D programs requiring seasoned scientific leadership.

Are there remote senior level associate principal scientist jobs?

Yes, though lab-based roles still require on-site presence for many positions. About 19% of senior level associate principal scientist openings are remote or hybrid as of November 2026, with remote availability more common in roles centered on data analysis, computational research, regulatory science, or program management than in hands-on laboratory work.

What makes an associate principal scientist role senior level?

A senior level associate principal scientist takes full ownership of research programs rather than contributing to them. That means setting the scientific strategy for a project, making independent technical judgments, representing the team in cross-functional forums, and actively developing the capabilities of less experienced scientists. The distinction from mid-level roles is accountability for outcomes, not just tasks, and the expectation that you shape how the work gets done.

Which industries hire the most senior level associate principal scientists?

Senior level associate principal scientist roles concentrate in Biotechnology & Pharmaceuticals, Technology & Software, and Healthcare & Medical Services, based on current listings on Migrate Mate as of November 2026. These sectors drive hiring at this level because they sustain large internal R&D functions that depend on experienced scientists who can lead long-horizon discovery or development programs with limited direct supervision.