Chief Operating Officer Jobs in Indianapolis, IN

Chief Operating Officer jobs in Indianapolis are concentrated in the Meridian-Kessler corridor, Downtown's Monument Circle district, and the North Meridian Street business corridor, with steady demand across healthcare systems, logistics, manufacturing, and financial services. Employers currently hiring include Eli Lilly, Elanco, and Prime Hospitality. Scan the live roles below and apply to whichever ones fit.

Find Chief Operating Officer Jobs

Overview

Open roles86
Top employerEli Lilly
Work type73% Hybrid
Top credentialBachelor's degree
Companies hiring27

Showing 4 of 86+ Chief Operating Officer jobs

Director, Franchise Business Consultant and Operations
We won't show you this job again
Added 2d ago
Director, Franchise Business Consultant and Operations
Authority Brands
Indianapolis, Indiana
Business Strategy
Consulting & Professional Services
Project Management
Experience equivalent to degree accepted
1,001-5,000

Have you applied for this role?

Director of Operations – Ruth’s Chris Steak House
We won't show you this job again
Added 3d ago
Director of Operations – Ruth’s Chris Steak House
Prime Hospitality Group
Indianapolis, Indiana
Business Operations
Business Strategy
Consulting & Professional Services
On-Site
Bachelor's degree

Have you applied for this role?

Director of Food and Beverage Operations - The Children's Museum of Indianapolis
We won't show you this job again
Added 4d ago
Director of Food and Beverage Operations - The Children's Museum of Indianapolis
Levy
Indianapolis, Indiana
Account Management
Business Development
Customer Success
$100k - $110k/yr
Bachelor's degree
5,001-10,000

Have you applied for this role?

Director of AI Initiatives & Development Operations
We won't show you this job again
Added 4d ago
Director of AI Initiatives & Development Operations
ISG Enterprises LLC
Indianapolis, Indiana
IT Support
Systems Administration
Technical Program Management
Master's degree in business administration

Have you applied for this role?

See All 86 Chief Operating Officer Jobs in Indianapolis

Find roles in Indianapolis that match your experience and apply in just a few clicks.

Find Chief Operating Officer Jobs

Chief Operating Officer Job Market in Indianapolis

Who's Hiring

  • Eli Lilly11
  • Elanco5
  • Prime Hospitality5
  • Levy3
  • Staff3

Top Industries Hiring

  • Science & Research
  • Biotechnology & Pharmaceuticals

Chief Operating Officer Jobs in Indianapolis: Frequently Asked Questions

How do I get a chief operating officer job in Indianapolis?

The strongest path in Indianapolis runs through its dominant sectors: healthcare systems, third-party logistics, advanced manufacturing, and regional financial services firms. Candidates who combine P&L ownership experience with supply chain or operational turnaround credentials stand out in this market. Concentrating your search on Downtown, North Meridian Street, and the Castleton area gives you access to the highest density of corporate headquarters and regional division offices actively filling COO-level roles.

Which companies hire chief operating officers in Indianapolis?

Companies currently hiring chief operating officers in Indianapolis include Eli Lilly, Elanco, and Prime Hospitality, per current listings on Migrate Mate as of November 2026. Indianapolis attracts a mix of large healthcare networks, regional insurers, logistics operators, and mid-market manufacturers, all of which regularly search for senior operations leadership at the COO level.

Are there remote chief operating officer jobs in Indianapolis?

Yes, though the role is largely in-person by nature given its hands-on operational and leadership responsibilities. About 83% of chief operating officer openings tied to Indianapolis are remote or hybrid as of November 2026, skewing toward technology-enabled businesses and professional services firms. When remote or hybrid arrangements do appear locally, they most often cover strategic planning, performance reporting, and cross-functional team coordination rather than plant-floor or facilities-dependent duties.

How can I get a chief operating officer job in Indianapolis with little or no experience?

The most realistic entry path in Indianapolis is moving up through director-level operations, supply chain, or clinical operations roles at the city's large healthcare networks or logistics companies before stepping into a COO title. Indianapolis employers in high-growth logistics and healthcare frequently promote internal candidates who have managed multi-site teams or led process improvement initiatives. Building exposure to P&L management and cross-departmental leadership within those organizations is what typically bridges the gap to a first COO appointment locally.

Which industries hire the most chief operating officers in Indianapolis?

Most chief operating officer openings in Indianapolis sit in Science & Research and Biotechnology & Pharmaceuticals, per current listings on Migrate Mate as of November 2026. Indianapolis's identity as a healthcare hub, a major Midwest logistics center, and a growing financial services market means those sectors consistently generate the largest share of senior operations leadership searches in the city.

See All 86 Chief Operating Officer Jobs in Indianapolis

Find roles in Indianapolis that match your experience and apply in just a few clicks.

Find Chief Operating Officer Jobs