Chief Operating Officer Jobs in Indianapolis, IN

Chief Operating Officer jobs in Indianapolis are concentrated in the Meridian-Kessler corridor, Downtown's Monument Circle district, and the North Meridian Street business corridor, with steady demand across healthcare systems, logistics, manufacturing, and financial services. Employers currently hiring include Eli Lilly, Information Technology Senior Management Forum, and Salesforce. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles92
Top employerEli Lilly
Work type67% On-site
Top credentialBachelor's degree
Companies hiring25

Showing 5 of 92+ Chief Operating Officer jobs

Information Technology Senior Management Forum
Associate Director, IT Contracts & Business Operations
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Information Technology Senior Management Forum
Added 1d ago
Associate Director, IT Contracts & Business Operations
Information Technology Senior Management Forum
Indianapolis, Indiana
Clinical Support
Healthcare Administration
Medical Specialists
$146k - $213k/yr
Master's degree in business administration
51-200

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Optum
Chief Operating Officer (COO) - Optum, American Health Network (AHN) - Hybrid
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Optum
Added 3d ago
Chief Operating Officer (COO) - Optum, American Health Network (AHN) - Hybrid
Optum
Indianapolis, Indiana
Business Operations
Business Strategy
Project & Program Management
Project Management
$159k - $273k/yr
Hybrid
Managed care organization experience
10,000+

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Gentiva
Area Director of Operations
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Gentiva
Added 4d ago
Area Director of Operations
Gentiva
Indianapolis, Indiana
Clinical Support
Healthcare Administration
Human Resources
Nursing
Bachelor's degree
10,000+

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Information Technology Senior Management Forum
Senior Director - Clinical Tech Design and Operations
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Information Technology Senior Management Forum
Added 4d ago
Senior Director - Clinical Tech Design and Operations
Information Technology Senior Management Forum
Indianapolis, Indiana
Program Management
Project Management
Technical Program Management
$158k - $231k/yr
Bachelor's degree in information technology
51-200

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Eli Lilly
Senior Director - Clinical Tech Design and Operations
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Eli Lilly
Added 5d ago
Senior Director - Clinical Tech Design and Operations
Eli Lilly
Indianapolis, Indiana
Healthcare Administration
Patient Services & Wellbeing
Social Work & Counseling
$158k - $231k/yr
Bachelor's degree in information technology
10,000+

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See All 92 Chief Operating Officer Jobs in Indianapolis

Find roles in Indianapolis that match your experience and apply in just a few clicks.

Find Chief Operating Officer Jobs

Chief Operating Officer Job Market in Indianapolis

Who's Hiring

  • Eli Lilly
    Eli Lilly12
  • I
    Information Technology Senior Management Forum9
  • Salesforce
    Salesforce6
  • Optum
    Optum3
  • Elanco
    Elanco3

Top Industries Hiring

  • Biotechnology & Pharmaceuticals
  • Healthcare & Medical Services
  • Technology & Software
  • Non-Profit & Social Services

Chief Operating Officer Jobs in Indianapolis: Frequently Asked Questions

How do I get a chief operating officer job in Indianapolis?

The strongest path in Indianapolis runs through its dominant sectors: healthcare systems, third-party logistics, advanced manufacturing, and regional financial services firms. Candidates who combine P&L ownership experience with supply chain or operational turnaround credentials stand out in this market. Concentrating your search on Downtown, North Meridian Street, and the Castleton area gives you access to the highest density of corporate headquarters and regional division offices actively filling COO-level roles.

Which companies hire chief operating officers in Indianapolis?

Companies currently hiring chief operating officers in Indianapolis include Eli Lilly, Information Technology Senior Management Forum, and Salesforce, per current listings on Migrate Mate as of August 2026. Indianapolis attracts a mix of large healthcare networks, regional insurers, logistics operators, and mid-market manufacturers, all of which regularly search for senior operations leadership at the COO level.

Are there remote chief operating officer jobs in Indianapolis?

Yes, though the role is largely in-person by nature given its hands-on operational and leadership responsibilities. About 33% of chief operating officer openings tied to Indianapolis are remote or hybrid as of August 2026, skewing toward technology-enabled businesses and professional services firms. When remote or hybrid arrangements do appear locally, they most often cover strategic planning, performance reporting, and cross-functional team coordination rather than plant-floor or facilities-dependent duties.

How can I get a chief operating officer job in Indianapolis with little or no experience?

The most realistic entry path in Indianapolis is moving up through director-level operations, supply chain, or clinical operations roles at the city's large healthcare networks or logistics companies before stepping into a COO title. Indianapolis employers in high-growth logistics and healthcare frequently promote internal candidates who have managed multi-site teams or led process improvement initiatives. Building exposure to P&L management and cross-departmental leadership within those organizations is what typically bridges the gap to a first COO appointment locally.

Which industries hire the most chief operating officers in Indianapolis?

Most chief operating officer openings in Indianapolis sit in Biotechnology & Pharmaceuticals, Healthcare & Medical Services, and Technology & Software, per current listings on Migrate Mate as of August 2026. Indianapolis's identity as a healthcare hub, a major Midwest logistics center, and a growing financial services market means those sectors consistently generate the largest share of senior operations leadership searches in the city.

See All 92 Chief Operating Officer Jobs in Indianapolis

Find roles in Indianapolis that match your experience and apply in just a few clicks.

Find Chief Operating Officer Jobs