Chief Operating Officer Jobs in Cambridge, MA

Chief Operating Officer jobs in Cambridge are concentrated in Kendall Square, East Cambridge, and the Harvard Square corridor, driven by demand from biotech, life sciences, and university-affiliated research organizations. Employers actively hiring include Harvard University, Biogen, and IPSEN. See the openings below and apply to the ones that match your experience.

Find Chief Operating Officer Jobs

Overview

Open roles189+
Top employerHarvard University
Work type40% On-site
Top credentialMaster's degree in business administration
Companies hiring16

Showing 5 of 189+ Chief Operating Officer jobs

Biogen
Associate Director, Medical Strategy & Operations Lead - Lupus (US Medical Affairs)
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Biogen
Added 1d ago
Associate Director, Medical Strategy & Operations Lead - Lupus (US Medical Affairs)
Biogen
Cambridge, Massachusetts
Program Management
Project & Program Management
Project Management
$162k - $223k/yr
Hybrid
Master's degree in business administration
5,001-10,000

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Sanofi
Director, (Alpha-1 Antitrypsin Deficiency) AATD Patient Support Services Strategy and Operations
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Sanofi
Added 1d ago
Director, (Alpha-1 Antitrypsin Deficiency) AATD Patient Support Services Strategy and Operations
Sanofi
Cambridge, Massachusetts
Communications
Content & Communications
Public Relations (PR)
$179k - $258k.33/yr
Hybrid
Master's degree in business administration
10,000+

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Biogen
Associate Director, Medical Strategy & Operations Lead - Ophthalmology (US Medical Affairs)
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Biogen
Added 2d ago
Associate Director, Medical Strategy & Operations Lead - Ophthalmology (US Medical Affairs)
Biogen
Cambridge, Massachusetts
Business Operations
Compensation & Benefits
Human Resources (HR) — Generalist
$162k - $223k/yr
Hybrid
Master's degree in business administration
5,001-10,000

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IPSEN
Associate Director, Operations, Rare Disease Business Unit
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IPSEN
Added 2d ago
Associate Director, Operations, Rare Disease Business Unit
IPSEN
Cambridge, Massachusetts
Account Management
Business Development
Sales
$143k - $210k/yr
Master's degree in business administration
5,001-10,000

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IPSEN
Director, Digital Platforms & Patient Services Operations
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IPSEN
Added 2d ago
Director, Digital Platforms & Patient Services Operations
IPSEN
Cambridge, Massachusetts
Business Operations
Program Management
Project & Program Management
Project Management
$177k - $260k/yr
Google Analytics Certification
5,001-10,000

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See All 189+ Chief Operating Officer Jobs in Cambridge

Find roles in Cambridge that match your experience and apply in just a few clicks.

Find Chief Operating Officer Jobs

Chief Operating Officer Job Market in Cambridge

Who's Hiring

  • Harvard University
    Harvard University30
  • Biogen
    Biogen23
  • IPSEN
    IPSEN15
  • Flagship Pioneering
    Flagship Pioneering15
  • Agios Pharmaceuticals
    Agios Pharmaceuticals15

Top Industries Hiring

  • Biotechnology & Pharmaceuticals30
  • Science & Research23
  • Education8

Chief Operating Officer Jobs in Cambridge: Frequently Asked Questions

How do I get a chief operating officer job in Cambridge?

The strongest path into a chief operating officer role in Cambridge runs through the city's biotech, life sciences, and research-commercialization sectors, where operational leadership is in consistent demand. Employers in Kendall Square and East Cambridge tend to favor candidates with cross-functional experience, particularly those who have scaled teams or managed regulatory timelines in a startup or research-driven environment. Building relationships through Cambridge's dense innovation network gives candidates a meaningful edge.

Which companies hire chief operating officers in Cambridge?

Employers hiring chief operating officers in Cambridge right now include Harvard University, Biogen, and IPSEN, based on current listings on Migrate Mate as of August 2026. Cambridge's hiring base skews toward growth-stage biotech firms, university spinouts, and established life sciences companies with operational complexity that demands senior leadership.

Are there remote chief operating officer jobs in Cambridge?

Yes, though remote availability is limited for chief operating officers, since the role typically requires on-site presence to manage teams, facilities, and day-to-day operations. About 60% of chief operating officer openings tied to Cambridge are remote or hybrid as of August 2026, with hybrid arrangements most common in strategic and early-stage companies where board-level coordination takes priority over physical oversight.

How can I get a chief operating officer job in Cambridge with little or no experience?

The most realistic entry path in Cambridge is a director of operations or VP of operations role at a growth-stage biotech or life sciences startup in Kendall Square, where smaller teams give rising operators broad ownership early. Cambridge's startup ecosystem also produces chief of staff roles that directly feed into COO tracks. Candidates who have led a cross-functional initiative, managed a product launch, or overseen a regulatory submission stand out in this market.

Which industries hire the most chief operating officers in Cambridge?

The sectors hiring the most chief operating officers in Cambridge are Biotechnology & Pharmaceuticals, Science & Research, and Education, based on current listings on Migrate Mate as of August 2026. Cambridge's concentration of research institutions, biotech firms, and technology companies creates sustained demand for operational leaders who can bridge scientific or technical work with business execution.

See All 189+ Chief Operating Officer Jobs in Cambridge

Find roles in Cambridge that match your experience and apply in just a few clicks.

Find Chief Operating Officer Jobs