Clinical Data Management Jobs
Clinical data management jobs are open across pharmaceutical, biotech, CRO, and medical device industries, from entry-level data coordinators to senior managers and directors, with specializations in EDC systems, clinical trial databases, and data quality oversight. Find a role that fits from the openings below and apply directly.
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About Us
Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Founded in 2015, Nkarta is on a mission to harness the body's natural killer cells – the immune system's first responders – to deliver a safe, accessible form of cell therapy to treat B cell-mediated autoimmune diseases. Our vision is to make cell therapy more broadly available to patients by pioneering allogeneic NK cells that can be dosed in outpatient, community health settings.
Nkarta's engineering process enhances the natural ability of NK cells to fight disease by identifying and eliminating unhealthy cells, including malfunctioning B cells at the root of many autoimmune conditions. Our lead NK cell therapy candidate, NKX019, uses NK cells collected from healthy donors rather than burdening the patient with a blood collection. Using donor-derived cells allows us to develop CAR NK cells off the shelf and on demand.
Nkarta is a people-driven company looking for passionate, collaborative, determined team members galvanized by a paradigm-shifting opportunity to change the cell therapy landscape.
THE OPPORTUNITY
Nkarta is seeking a Senior Director or Executive Director to serve as Head of Clinical Data Management (CDM). This is a hands-on leadership role for an experienced data management executive who will own the strategy, operating model, and quality of clinical data across the NKX019 autoimmune program—from ongoing multi-indication Phase 1/2 studies through potential future pivotal trials and a Biologics License Application (BLA).
NKX019 is being studied in multiple autoimmune indications under rapidly evolving protocols. The Head of CDM will ensure every protocol change is reflected promptly and correctly in the database, that data are analysis-ready for frequent data cuts, and that the function is built to deliver a submission-quality database for future pivotal studies.
Reporting to the VP, Program Management and Head of Clinical Trial Services, this leader will direct Nkarta's internal data managers and contract staff, hold the biometrics CRO and data vendors accountable for quality and timelines, and partner closely with Clinical Development, Clinical Operations, Biostatistics, Drug Safety, Medical Writing and Regulatory Affairs.
WHAT YOU'LL DO
Strategic Direction & Functional Leadership
- Serve as Head of Clinical Data Management and set the vision, strategy and operating model for CDM across all Nkarta clinical studies.
- Establish portfolio-wide clinical data governance covering data ownership, standards, system interoperability and decision rights across internal functions and external partners.
- Build a CDM function that scales from the current Phase 1/2 portfolio to future pivotal studies and BLA readiness, with the right balance of in-house, contract and CRO resources.
- Define and execute a pivotal-readiness roadmap before study initiation, encompassing data standards, system architecture, vendor capabilities, resourcing, quality controls and inspection-ready documentation.
- Align CDM plans, resources and timelines with corporate objectives and study milestones; flag risks early with recommendations.
- Represent CDM on program teams and in leadership forums, and drive cross-functional data strategy with Clinical Development, Biostatistics, Clinical Operations, Regulatory Affairs, Drug Safety, Translational Medicine and Medical Writing so that data are clinically meaningful, traceable and fit for analysis and regulatory use.
Study Data Delivery & Database Lock
- Participate in protocol development and amendment review to ensure that what the protocol requires can be collected, cleaned and analyzed; drive CRF and electronic data capture (EDC) design accordingly.
- Own EDC change control for protocol amendments—specifications, edit checks, user acceptance testing (UAT), migration and release—delivered on time without loss of data integrity.
- Develop and maintain data management plans covering data collection, processing, medical coding, reconciliation (including SAE and central laboratory data), review and storage.
- Own the end-to-end strategy for external data flows, including transfer specifications and agreements, ingestion validation, traceability, reconciliation, exception handling and timely availability of laboratory, imaging, biomarker, safety and cell-product data.
- Plan and deliver clean data snapshots and locked databases, as appropriate, for interim analyses, safety and data monitoring committee reviews, congress presentations, regulatory submissions and study close-out.
- Lead cross-functional data review with Clinical Development, Biostatistics and Drug Safety; direct discrepancy and query management and resolve data issues at their root.
- Establish risk-based data quality oversight that identifies trends in delayed entry, unresolved queries and recurring vendor or site issues; lead root-cause analysis and corrective actions.
Vendor Oversight & Budget
- Provide sponsor oversight of the biometrics CRO, data management contractors and other data vendors: define scope, key performance indicators, sponsor acceptance criteria and escalation pathways; review deliverables against specification; and drive remediation of performance issues.
- Lead selection, auditing and onboarding of CDM and Biometrics vendors, including vendor strategy for pivotal and global studies.
- Oversee the quality and integrity of clinical trial data from third-party vendors (e.g., CROs, central and specialty labs, eCOA/ePRO, imaging, IRT), reviewing vendor data for accuracy, completeness and timeliness and resolving discrepancies. Own CDM resource planning, budget forecasting and change-order review.
Quality, Compliance & Inspection Readiness
- Lead the creation and continuous improvement of CDM Global Standard Operating Procedures (GSOPs), work instructions and standards aligned with CDISC (CDASH/SDTM), Good Clinical Practice (GCP), Good Clinical Data Management Practices (GCDMP), 21 CFR Part 11, applicable data privacy requirements and International Council for Harmonisation (ICH) E6 guidelines.
- Maintain complete, current, inspection-ready CDM documentation in the Trial Master File—eCRF specifications and completion guidelines, annotated CRFs, data validation specifications, data transfer agreements, data management plans and change-control logs—with traceable evidence that data management controls operated effectively.
- Prepare the CDM function and its vendors for BLA submission, regulatory inspection and audit; lead CDM responses to audit findings and quality events.
People Leadership
- Recruit, develop and lead CDM employees and consultants; set clear expectations, coach for growth, and create a team culture of accountability and data quality.
- At either level, own portfolio-wide data strategy, governance and pivotal readiness; at Executive Director level, take on broader scope, including portfolio-wide data standards, systems and analytics, ex-US CDM strategy, and greater organizational leadership and enterprise influence.
WHAT WE'RE LOOKING FOR
Required
- BS/BA and/or MS degree in a science- or health-related field, or an equivalent combination of education and experience.
- 12+ years of clinical data management experience in the pharmaceutical or biotechnology industry (15+ years for Executive Director), including 5+ years leading a CDM function or CDM for a major program.
- Demonstrated leadership of data management through database lock for a pivotal (Phase 3 or registrational) study, and CDM contribution to at least one marketing application (BLA, NDA or MAA).
- Deep knowledge of CDM processes, EDC systems (including Medidata Rave), database build and change control, data validation, external data reconciliation, MedDRA and WHODrug coding, quality management and current CDM technology.
- Strong knowledge of GCP, CDISC standards (including CDASH and SDTM), FDA and ICH guidelines, and CDM best practices.
- Proven sponsor-side oversight of CROs and data vendors, including scope, budget and performance management.
- Demonstrated success building or transforming a sponsor-side CDM operating model in a resource-lean biotechnology organization, including rapid amendments, multi-indication studies and frequent interim data cuts.
- Demonstrated line-management experience, with the ability to lead and inspire CDM employees, consultants and external partners.
- Outstanding problem-solving, influencing, negotiation and communication skills; strong attention to detail; and the ability to manage multiple priorities in a fast-paced, resource-lean environment.
Preferred
- Experience in immunology or rheumatology, cell therapy, gene therapy or other complex biologics.
- Experience with complex composite and responder endpoints, patient-reported outcomes and external data sources (central laboratory, imaging, cell-product and biomarker data).
- Experience preparing a CDM function for a first BLA and regulatory inspection in a small or mid-sized company.
- Experience supporting global (US and EU) clinical studies.
LOCATION & WORK ENVIRONMENT
Priority will be given to candidates who can work a hybrid schedule and based in South San Francisco, CA. Travel may be required for health-authority meetings, conferences, vendor oversight, and other business needs.
Working at Nkarta
There are several factors taken into consideration in determining base salary, including but not limited to: job-related qualifications, skills, education and experience, as well as the value of other elements of an employee's total compensation package. Nkarta also offers an annual discretionary bonus, equity grant(s), medical, dental, vision and life insurance coverage, in accordance with the terms and conditions of the applicable plans. Other benefits include 401K plan, flexible spending account, ESPP, employee assistance program, paid vacation, holiday and personal days, paid parental, pregnancy, and bereavement leave.
The 100+ team members describe working at Nkarta through some of the following comments. While getting better work-life balance and improving communications between groups in an early stage start up environment are two areas on which we are working, here are real, anonymous comments about or regarding why people think Nkarta is a great place to work.
- "People are always open to ideas."
- "Exceptionally talented, committed, *kind* & supportive team."
- "The CEO is transparent and honest with expectations for the whole company. There is genuine care amongst the leadership team for their peers and employees. I believe this is unique."
- "Not to sound corny, but the emphasis on people as a valuable resource is something I recognize doesn't often exist elsewhere, and it's here in ample supply, which is great."
- "It's the first place that I've worked where the executive team truly values the employees. It's a pretty amazing thing not to hear that employees can be replaced with someone new. Institutional knowledge is understood."
- "We have a very diverse team with executives that are friendly and accessible."
- "Smart and dedicated colleagues. Mission to make a difference in patients' lives. Empower us with tools needed to succeed. Open and transparent culture. Transparent leadership."
To learn more about our work at Nkarta and the career opportunities that will drive us forward to serve patients, please visit the company's website at https://www.nkartatx.com.
About Us
Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Founded in 2015, Nkarta is on a mission to harness the body's natural killer cells – the immune system's first responders – to deliver a safe, accessible form of cell therapy to treat B cell-mediated autoimmune diseases. Our vision is to make cell therapy more broadly available to patients by pioneering allogeneic NK cells that can be dosed in outpatient, community health settings.
Nkarta's engineering process enhances the natural ability of NK cells to fight disease by identifying and eliminating unhealthy cells, including malfunctioning B cells at the root of many autoimmune conditions. Our lead NK cell therapy candidate, NKX019, uses NK cells collected from healthy donors rather than burdening the patient with a blood collection. Using donor-derived cells allows us to develop CAR NK cells off the shelf and on demand.
Nkarta is a people-driven company looking for passionate, collaborative, determined team members galvanized by a paradigm-shifting opportunity to change the cell therapy landscape.
THE OPPORTUNITY
Nkarta is seeking a Senior Director or Executive Director to serve as Head of Clinical Data Management (CDM). This is a hands-on leadership role for an experienced data management executive who will own the strategy, operating model, and quality of clinical data across the NKX019 autoimmune program—from ongoing multi-indication Phase 1/2 studies through potential future pivotal trials and a Biologics License Application (BLA).
NKX019 is being studied in multiple autoimmune indications under rapidly evolving protocols. The Head of CDM will ensure every protocol change is reflected promptly and correctly in the database, that data are analysis-ready for frequent data cuts, and that the function is built to deliver a submission-quality database for future pivotal studies.
Reporting to the VP, Program Management and Head of Clinical Trial Services, this leader will direct Nkarta's internal data managers and contract staff, hold the biometrics CRO and data vendors accountable for quality and timelines, and partner closely with Clinical Development, Clinical Operations, Biostatistics, Drug Safety, Medical Writing and Regulatory Affairs.
WHAT YOU'LL DO
Strategic Direction & Functional Leadership
- Serve as Head of Clinical Data Management and set the vision, strategy and operating model for CDM across all Nkarta clinical studies.
- Establish portfolio-wide clinical data governance covering data ownership, standards, system interoperability and decision rights across internal functions and external partners.
- Build a CDM function that scales from the current Phase 1/2 portfolio to future pivotal studies and BLA readiness, with the right balance of in-house, contract and CRO resources.
- Define and execute a pivotal-readiness roadmap before study initiation, encompassing data standards, system architecture, vendor capabilities, resourcing, quality controls and inspection-ready documentation.
- Align CDM plans, resources and timelines with corporate objectives and study milestones; flag risks early with recommendations.
- Represent CDM on program teams and in leadership forums, and drive cross-functional data strategy with Clinical Development, Biostatistics, Clinical Operations, Regulatory Affairs, Drug Safety, Translational Medicine and Medical Writing so that data are clinically meaningful, traceable and fit for analysis and regulatory use.
Study Data Delivery & Database Lock
- Participate in protocol development and amendment review to ensure that what the protocol requires can be collected, cleaned and analyzed; drive CRF and electronic data capture (EDC) design accordingly.
- Own EDC change control for protocol amendments—specifications, edit checks, user acceptance testing (UAT), migration and release—delivered on time without loss of data integrity.
- Develop and maintain data management plans covering data collection, processing, medical coding, reconciliation (including SAE and central laboratory data), review and storage.
- Own the end-to-end strategy for external data flows, including transfer specifications and agreements, ingestion validation, traceability, reconciliation, exception handling and timely availability of laboratory, imaging, biomarker, safety and cell-product data.
- Plan and deliver clean data snapshots and locked databases, as appropriate, for interim analyses, safety and data monitoring committee reviews, congress presentations, regulatory submissions and study close-out.
- Lead cross-functional data review with Clinical Development, Biostatistics and Drug Safety; direct discrepancy and query management and resolve data issues at their root.
- Establish risk-based data quality oversight that identifies trends in delayed entry, unresolved queries and recurring vendor or site issues; lead root-cause analysis and corrective actions.
Vendor Oversight & Budget
- Provide sponsor oversight of the biometrics CRO, data management contractors and other data vendors: define scope, key performance indicators, sponsor acceptance criteria and escalation pathways; review deliverables against specification; and drive remediation of performance issues.
- Lead selection, auditing and onboarding of CDM and Biometrics vendors, including vendor strategy for pivotal and global studies.
- Oversee the quality and integrity of clinical trial data from third-party vendors (e.g., CROs, central and specialty labs, eCOA/ePRO, imaging, IRT), reviewing vendor data for accuracy, completeness and timeliness and resolving discrepancies. Own CDM resource planning, budget forecasting and change-order review.
Quality, Compliance & Inspection Readiness
- Lead the creation and continuous improvement of CDM Global Standard Operating Procedures (GSOPs), work instructions and standards aligned with CDISC (CDASH/SDTM), Good Clinical Practice (GCP), Good Clinical Data Management Practices (GCDMP), 21 CFR Part 11, applicable data privacy requirements and International Council for Harmonisation (ICH) E6 guidelines.
- Maintain complete, current, inspection-ready CDM documentation in the Trial Master File—eCRF specifications and completion guidelines, annotated CRFs, data validation specifications, data transfer agreements, data management plans and change-control logs—with traceable evidence that data management controls operated effectively.
- Prepare the CDM function and its vendors for BLA submission, regulatory inspection and audit; lead CDM responses to audit findings and quality events.
People Leadership
- Recruit, develop and lead CDM employees and consultants; set clear expectations, coach for growth, and create a team culture of accountability and data quality.
- At either level, own portfolio-wide data strategy, governance and pivotal readiness; at Executive Director level, take on broader scope, including portfolio-wide data standards, systems and analytics, ex-US CDM strategy, and greater organizational leadership and enterprise influence.
WHAT WE'RE LOOKING FOR
Required
- BS/BA and/or MS degree in a science- or health-related field, or an equivalent combination of education and experience.
- 12+ years of clinical data management experience in the pharmaceutical or biotechnology industry (15+ years for Executive Director), including 5+ years leading a CDM function or CDM for a major program.
- Demonstrated leadership of data management through database lock for a pivotal (Phase 3 or registrational) study, and CDM contribution to at least one marketing application (BLA, NDA or MAA).
- Deep knowledge of CDM processes, EDC systems (including Medidata Rave), database build and change control, data validation, external data reconciliation, MedDRA and WHODrug coding, quality management and current CDM technology.
- Strong knowledge of GCP, CDISC standards (including CDASH and SDTM), FDA and ICH guidelines, and CDM best practices.
- Proven sponsor-side oversight of CROs and data vendors, including scope, budget and performance management.
- Demonstrated success building or transforming a sponsor-side CDM operating model in a resource-lean biotechnology organization, including rapid amendments, multi-indication studies and frequent interim data cuts.
- Demonstrated line-management experience, with the ability to lead and inspire CDM employees, consultants and external partners.
- Outstanding problem-solving, influencing, negotiation and communication skills; strong attention to detail; and the ability to manage multiple priorities in a fast-paced, resource-lean environment.
Preferred
- Experience in immunology or rheumatology, cell therapy, gene therapy or other complex biologics.
- Experience with complex composite and responder endpoints, patient-reported outcomes and external data sources (central laboratory, imaging, cell-product and biomarker data).
- Experience preparing a CDM function for a first BLA and regulatory inspection in a small or mid-sized company.
- Experience supporting global (US and EU) clinical studies.
LOCATION & WORK ENVIRONMENT
Priority will be given to candidates who can work a hybrid schedule and based in South San Francisco, CA. Travel may be required for health-authority meetings, conferences, vendor oversight, and other business needs.
Working at Nkarta
There are several factors taken into consideration in determining base salary, including but not limited to: job-related qualifications, skills, education and experience, as well as the value of other elements of an employee's total compensation package. Nkarta also offers an annual discretionary bonus, equity grant(s), medical, dental, vision and life insurance coverage, in accordance with the terms and conditions of the applicable plans. Other benefits include 401K plan, flexible spending account, ESPP, employee assistance program, paid vacation, holiday and personal days, paid parental, pregnancy, and bereavement leave.
The 100+ team members describe working at Nkarta through some of the following comments. While getting better work-life balance and improving communications between groups in an early stage start up environment are two areas on which we are working, here are real, anonymous comments about or regarding why people think Nkarta is a great place to work.
- "People are always open to ideas."
- "Exceptionally talented, committed, *kind* & supportive team."
- "The CEO is transparent and honest with expectations for the whole company. There is genuine care amongst the leadership team for their peers and employees. I believe this is unique."
- "Not to sound corny, but the emphasis on people as a valuable resource is something I recognize doesn't often exist elsewhere, and it's here in ample supply, which is great."
- "It's the first place that I've worked where the executive team truly values the employees. It's a pretty amazing thing not to hear that employees can be replaced with someone new. Institutional knowledge is understood."
- "We have a very diverse team with executives that are friendly and accessible."
- "Smart and dedicated colleagues. Mission to make a difference in patients' lives. Empower us with tools needed to succeed. Open and transparent culture. Transparent leadership."
To learn more about our work at Nkarta and the career opportunities that will drive us forward to serve patients, please visit the company's website at https://www.nkartatx.com.
Clinical Data Management Jobs by Experience Level
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Find Clinical Data Management JobsClinical Data Management Job Market
Who's Hiring
Top Industries Hiring
- Biotechnology & Pharmaceuticals12
- Education2
- Technology & Software1
- Healthcare & Medical Services1
What Employers Look For
The qualifications that appear most often in clinical data management jobs.
- Bachelor's degree in life sciences, health informatics, or a related field
- Hands-on experience with EDC systems such as Medidata Rave or Oracle Inform
- Working knowledge of CDISC standards including CDASH and SDTM
- Familiarity with ICH E6 Good Clinical Practice guidelines and regulatory requirements
- Experience authoring or reviewing Data Management Plans and data validation specifications
- SCDM or CCDM certification is a preferred or required qualification at many sponsors and CROs
Tips for Your Clinical Data Management Job Search
Tailor your resume to EDC platforms
Hiring managers scan for specific system experience first. Call out every EDC tool you've used, Medidata Rave, Oracle Inform, Veeva Vault, and your role in each study, whether you built forms, validated data, or managed listings.
Highlight CDISC standards knowledge prominently
CDASH and SDTM compliance appear in almost every job posting. If you've mapped raw data to submission-ready SDTM domains or supported FDA submissions, put that on page one of your resume, not buried in a bullet.
Target roles by phase and therapeutic area
Phase I oncology trials have very different data complexity than Phase III cardiovascular studies. Filter openings by therapeutic area or phase if the listings allow it, and match your cover letter language to the specific program the employer is running.
Apply early to roles that fit
Migrate Mate lists clinical data management openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare for a data review technical screen
Many CDM interviews include a live or take-home discrepancy review exercise. Practice identifying missing values, out-of-range flags, and protocol deviations in a sample listing so you can walk through your decision-making process clearly.
Negotiate scope, not just compensation
After an offer, ask whether the role covers one study or a portfolio, how many external vendors you'll manage, and whether DMP authorship is expected. These factors affect workload and career growth more than title alone.
Clinical Data Management Jobs: Frequently Asked Questions
Which companies are hiring the most clinical data managements?
The companies hiring the most clinical data managements right now include PTC Therapeutics, Merck, and PTC Therapeutics, with the largest share of openings in New Jersey, California, and Massachusetts, based on current listings on Migrate Mate as of November 2026. Large CROs and mid-size biotech sponsors tend to post the highest volume of openings consistently throughout the year.
How many clinical data management jobs are remote?
About 65% of clinical data management openings are fully remote or hybrid as of November 2026, making it one of the more remote-accessible roles in clinical operations. Database build, data review, and DMP authorship tasks transfer well to remote settings, while site-facing or vendor oversight roles more often require at least partial on-site presence.
How do you become a clinical data management?
Start with a bachelor's degree in a life science, health informatics, or statistics field, then gain exposure to clinical trial processes through an entry-level role such as clinical data coordinator or data entry associate. Build proficiency in at least one major EDC platform, study CDISC standards through free CDISC online training modules, and pursue SCDM membership or the CCDM credential once you have hands-on study experience to document.
Can you get a clinical data management job with little experience?
Yes, entry-level clinical data coordinator and junior CDM roles at CROs are specifically designed for candidates with limited direct experience. Employers at this level prioritize attention to detail, familiarity with spreadsheet tools, and basic understanding of GCP over years on the job. A relevant internship, academic research project involving data collection, or completion of an EDC training course can offset a thin work history during early applications.
What does the clinical data management interview process look like?
Most CDM interviews begin with a phone or video screen focused on your study experience and EDC background, followed by a technical round where you may be asked to walk through a data discrepancy scenario or explain how you'd build a validation check. Senior roles often add a panel interview with biostatistics or clinical operations stakeholders and may include a take-home data review exercise before a final offer conversation.
Where can I find and apply to clinical data management jobs?
You can find and apply to clinical data management jobs on Migrate Mate, which lists current openings from across the United States in one place. Find roles that match your experience level, therapeutic area, or preferred work arrangement and apply directly to each listing without leaving the platform.
See All 40 Clinical Data Management Jobs
Find roles that match your experience and apply in just a few clicks.
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