Clinical Data Manager Jobs in Massachusetts
Clinical Data Manager jobs in Massachusetts are concentrated in the Boston metro, Cambridge, and the Route 128 corridor, where the state's dense cluster of biopharma, clinical research organizations, and academic medical centers creates one of the most active markets in the country. Employers like Biogen, Takeda, and Dana-Farber Cancer Institute have a lasting presence here and hire clinical data managers at every level from associate to director. The most in-demand specialties are oncology trials, rare disease studies, and EDC system management. Find a role that fits below and apply directly.
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Showing 5 of 14+ Clinical Data Manager jobs
X4 is focused on restoring healthy immune system function by developing novel therapeutics to treat chronic neutropenic disorders, including WHIM syndrome, a rare primary immunodeficiency. We are advancing a novel, late-stage clinical candidate, mavorixafor, that we believe has the potential to become a new standard of care for patients with these disorders. We know that developing innovative, new medicines is challenging, and we invite new colleagues who share our values and commitment to join us in achieving our mission.
This opportunity will …
Provide strategic and operational leadership for clinical data management activities across one or more clinical development programs. The Associate Director will oversee CRO partners and vendors, drive data quality and inspection readiness, support regulatory submissions, and ensure the timely delivery of high-quality clinical trial data.
This role will serve as a key cross-functional leader, partnering with Clinical Operations, Biostatistics, Statistical Programming, Medical Writing, Pharmacovigilance, Regulatory Affairs, and external vendors to deliver study objectives while maintaining compliance with regulatory requirements and industry standards.
Accountabilities and Responsibilities:
Clinical Data Management Leadership
- Lead and oversee all clinical data management activities for assigned clinical trials from protocol development through database lock and study closeout.
- Develop and execute data management strategies that support program timelines, quality objectives, and regulatory submission readiness.
- Ensure consistent application of Good Clinical Practice (GCP), ICH guidelines, company SOPs, and industry best practices.
- Provide leadership and guidance to CROs and vendors performing outsourced data management activities.
- Serve as the primary sponsor representative for outsourced data management activities.
- Establish governance and performance oversight processes, including KPIs, quality metrics, and issue escalation pathways.
-
Review and approve vendor deliverables, including:
- Data Management Plans
- CRF specifications
- Edit Check Specifications
- Data Review Plans
- Database Validation Documentation
- Data Transfer Specifications
- Reconciliation Plans
- Monitor CRO performance and ensure accountability for quality, timelines, and budget adherence.
- Establish and monitor key study metrics related to data quality, data cleaning, query management, and database readiness.
- Lead ongoing review of data trends and identify risks requiring mitigation.
- Ensure audit and inspection readiness through comprehensive documentation and process compliance.
- Support internal audits and health authority inspections as the data management subject matter expert.
- Serve as the Data Management representative on Clinical Study Teams and Development Teams.
- Effectively communicate study status, risks, mitigation plans, and performance metrics to leadership.
- Foster strong collaborative relationships with internal teams and external partners.
- Identify opportunities to improve clinical data management processes, systems, and efficiencies.
- Contribute to the development and maintenance of SOPs, work instructions, templates, and best practices.
- Support implementation of innovative technologies and risk-based approaches to data management.
Requirements: Proven Experience, Skills, and Education:
- Minimum 8+ years of clinical data management experience within biotechnology, pharmaceutical, or CRO environments.
- Minimum 3+ years of leadership experience overseeing clinical data management activities and vendor relationships.
- Experience supporting Phase 2, Phase 3, and regulatory submission programs.
- Experience overseeing outsourced clinical data management models.
- Strategic thinker with strong operational execution skills.
- Excellent vendor management capabilities.
- Effective problem-solving and risk management abilities.
- Excellent written and verbal communication skills.
- Commitment to patient-focused drug development and data quality excellence
- Rare disease experience preferred.
Strong understanding of:
- ICH-GCP
- FDA and EMA regulations
- CDISC standards (SDTM and related submission requirements)
- Clinical trial data lifecycle
- Risk-based quality management principles
This position is based in Boston, MA, and offers a flexible hybrid work model with a minimum of 2 days/week in the office.
We encourage you to learn more about X4 Pharmaceuticals. Click on the links below!
About Us
Pipeline
X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.
Please note that effective January 1, 2022, as a condition of employment at X4 Pharmaceuticals, all employees and new hires must have received their complete dose of the COVID-19 vaccine, unless they have been granted an exemption.
X4 is focused on restoring healthy immune system function by developing novel therapeutics to treat chronic neutropenic disorders, including WHIM syndrome, a rare primary immunodeficiency. We are advancing a novel, late-stage clinical candidate, mavorixafor, that we believe has the potential to become a new standard of care for patients with these disorders. We know that developing innovative, new medicines is challenging, and we invite new colleagues who share our values and commitment to join us in achieving our mission.
This opportunity will …
Provide strategic and operational leadership for clinical data management activities across one or more clinical development programs. The Associate Director will oversee CRO partners and vendors, drive data quality and inspection readiness, support regulatory submissions, and ensure the timely delivery of high-quality clinical trial data.
This role will serve as a key cross-functional leader, partnering with Clinical Operations, Biostatistics, Statistical Programming, Medical Writing, Pharmacovigilance, Regulatory Affairs, and external vendors to deliver study objectives while maintaining compliance with regulatory requirements and industry standards.
Accountabilities and Responsibilities:
Clinical Data Management Leadership
- Lead and oversee all clinical data management activities for assigned clinical trials from protocol development through database lock and study closeout.
- Develop and execute data management strategies that support program timelines, quality objectives, and regulatory submission readiness.
- Ensure consistent application of Good Clinical Practice (GCP), ICH guidelines, company SOPs, and industry best practices.
- Provide leadership and guidance to CROs and vendors performing outsourced data management activities.
- Serve as the primary sponsor representative for outsourced data management activities.
- Establish governance and performance oversight processes, including KPIs, quality metrics, and issue escalation pathways.
-
Review and approve vendor deliverables, including:
- Data Management Plans
- CRF specifications
- Edit Check Specifications
- Data Review Plans
- Database Validation Documentation
- Data Transfer Specifications
- Reconciliation Plans
- Monitor CRO performance and ensure accountability for quality, timelines, and budget adherence.
- Establish and monitor key study metrics related to data quality, data cleaning, query management, and database readiness.
- Lead ongoing review of data trends and identify risks requiring mitigation.
- Ensure audit and inspection readiness through comprehensive documentation and process compliance.
- Support internal audits and health authority inspections as the data management subject matter expert.
- Serve as the Data Management representative on Clinical Study Teams and Development Teams.
- Effectively communicate study status, risks, mitigation plans, and performance metrics to leadership.
- Foster strong collaborative relationships with internal teams and external partners.
- Identify opportunities to improve clinical data management processes, systems, and efficiencies.
- Contribute to the development and maintenance of SOPs, work instructions, templates, and best practices.
- Support implementation of innovative technologies and risk-based approaches to data management.
Requirements: Proven Experience, Skills, and Education:
- Minimum 8+ years of clinical data management experience within biotechnology, pharmaceutical, or CRO environments.
- Minimum 3+ years of leadership experience overseeing clinical data management activities and vendor relationships.
- Experience supporting Phase 2, Phase 3, and regulatory submission programs.
- Experience overseeing outsourced clinical data management models.
- Strategic thinker with strong operational execution skills.
- Excellent vendor management capabilities.
- Effective problem-solving and risk management abilities.
- Excellent written and verbal communication skills.
- Commitment to patient-focused drug development and data quality excellence
- Rare disease experience preferred.
Strong understanding of:
- ICH-GCP
- FDA and EMA regulations
- CDISC standards (SDTM and related submission requirements)
- Clinical trial data lifecycle
- Risk-based quality management principles
This position is based in Boston, MA, and offers a flexible hybrid work model with a minimum of 2 days/week in the office.
We encourage you to learn more about X4 Pharmaceuticals. Click on the links below!
About Us
Pipeline
X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.
Please note that effective January 1, 2022, as a condition of employment at X4 Pharmaceuticals, all employees and new hires must have received their complete dose of the COVID-19 vaccine, unless they have been granted an exemption.
See All 14 Clinical Data Manager Jobs in Massachusetts
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Find Clinical Data Manager JobsClinical Data Manager Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Clinical Data Manager Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Consulting & Professional Services
- Insurance
- Science & Research
- Biotechnology & Pharmaceuticals
What Massachusetts Employers Look For
The qualifications that appear most often in clinical data manager jobs across Massachusetts.
- Bachelor's degree in life sciences, informatics, or a related field required
- Hands-on experience with EDC platforms such as Medidata Rave or Oracle InForm
- Working knowledge of CDISC standards including CDASH and SDTM
- Familiarity with FDA regulations governing clinical data collection and integrity
- Strong proficiency in data validation, discrepancy management, and quality review
- Experience supporting Phase I through Phase III oncology or rare disease trials preferred
Clinical Data Manager Jobs in Massachusetts: Frequently Asked Questions
How do you become a clinical data manager in Massachusetts?
Most clinical data manager roles in Massachusetts require a bachelor's degree in life sciences, biostatistics, health informatics, or a closely related field. There is no state-issued license for this role in Massachusetts, but employers in the Boston biopharma corridor consistently expect proficiency with CDISC standards and EDC platforms. A Certified Clinical Data Manager credential from the Society for Clinical Data Management strengthens candidates significantly and is widely recognized by Massachusetts hiring teams.
Which companies hire clinical data managers in Massachusetts?
Employers hiring clinical data managers in Massachusetts right now include CVS Health, Katalyst Healthcares & Life Sciences, and RadNet, based on current listings on Migrate Mate as of August 2026. Massachusetts's concentration of global biopharma headquarters and contract research organizations along the Route 128 and I-495 corridors means hiring is unusually consistent throughout the year.
Which Massachusetts cities have the most clinical data manager jobs?
Boston, Cambridge, and Massachusetts have the most clinical data manager openings in Massachusetts. Boston and Cambridge dominate because of the region's dense concentration of biopharma headquarters, academic medical centers, and contract research organizations, while suburban locations along Route 128 reflect major employers who have anchored operations outside the city core.
Are there remote clinical data manager jobs in Massachusetts?
Yes, and more than most fields. Clinical data management is a desk-based analytical role with no patient-facing requirement, making it well suited to remote and hybrid arrangements. About 88% of clinical data manager openings tied to Massachusetts are remote or hybrid as of August 2026, with data review, query management, and database lock activities being the tasks most commonly performed off-site.
How can I get hired as a clinical data manager in Massachusetts with little or no experience?
The most realistic entry path is moving from a clinical data coordinator or data entry associate role at a contract research organization or hospital-based research office in the Boston area. Massachusetts employers including large academic medical centers and CROs with local offices regularly hire for these associate-level positions, which build the EDC and CDISC exposure hiring managers want. Completing a CCDM prep course and earning the credential signals readiness even without years of direct experience.
Where can I find and apply to clinical data manager jobs in Massachusetts?
You can find and apply to clinical data manager jobs in Massachusetts on Migrate Mate, which lists current Massachusetts openings. Find the roles that fit your background and apply directly.
See All 14 Clinical Data Manager Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
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