Clinical Registered Nurse Jobs in San Diego, CA

Clinical Registered Nurse jobs in San Diego are in high demand across Mission Valley, Kearny Mesa, and the medical corridor near Balboa Park, with strong hiring in acute care, oncology, and critical care. Employers filling roles right now include Sharp HealthCare, Vitalant, and CenterWell. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles349+
Top employerSharp HealthCare
Work type66% Hybrid
Top credentialBLS Certification
Companies hiring16

Showing 5 of 349+ Clinical Registered Nurse jobs

Clinical RN - Sharp Memorial Hospital- Emergency Department - FT - Nights - May be eligible for 5k in relocation assistance
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New 17h ago
Clinical RN - Sharp Memorial Hospital- Emergency Department - FT - Nights - May be eligible for 5k in relocation assistance
Sharp HealthCare
San Diego, California
Clinical Support
Healthcare Administration
Medical Coding & Billing
$64.21 - $93.76/hr
PALS Certification
10,000+

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Clinical Research Specialist-RN - Research/Projects - Sharp Mary Birch - FT 0.9 - 8hr Days
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New 17h ago
Clinical Research Specialist-RN - Research/Projects - Sharp Mary Birch - FT 0.9 - 8hr Days
Sharp HealthCare
San Diego, California
Clinical Support
Healthcare Administration
Medical Coding & Billing
$59.61 - $86.15/hr
Bachelor of Science
10,000+

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Registered Nurse_ Clinical Nurse Educator For Surgical Specialty Clinic/Specialty Procedure Unit
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Added 1d ago
Registered Nurse_ Clinical Nurse Educator For Surgical Specialty Clinic/Specialty Procedure Unit
US Department of Veterans Affairs
San Diego, California
Business Operations
Project & Program Management
Project Management
$104k - $188k/yr
Hybrid
Bachelor of Science
10,000+

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RN Home Health Clinical Manager
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Added 1d ago
RN Home Health Clinical Manager
New Solutions
San Diego, California
Human Resources (HR) — Generalist
Learning & Development
Recruiting & Talent Acquisition
$130k - $150k/yr
Managed Registered Nurses (RNs)

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Home Health Registered Nurse Clinical Manager - RNCM
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Added 3d ago
Home Health Registered Nurse Clinical Manager - RNCM
Lorian Health
San Diego, California
Business Development
Customer Success
Program Management
Project Management
$135k - $145k/yr
Managed Registered Nurses (RNs)
201-500

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Clinical Registered Nurse Job Market in San Diego

Who's Hiring

  • Sharp HealthCare175
  • Vitalant12
  • CenterWell12
  • Lorian Health12
  • New Solutions12

Top Industries Hiring

  • Healthcare & Medical Services

Clinical Registered Nurse Jobs in San Diego: Frequently Asked Questions

How do I get a clinical registered nurse job in San Diego?

San Diego's largest clinical nursing employers are its major health systems, military-affiliated medical centers, and specialty hospitals concentrated in Mission Valley, Hillcrest, and La Jolla. Candidates with experience in acute care, critical care, or oncology have an edge in this market. Completing a clinical rotation or per diem shift at a local facility is one of the most direct ways to get noticed by San Diego hiring teams before a full-time opening is posted.

Which companies hire clinical registered nurses in San Diego?

Employers hiring clinical registered nurses in San Diego right now include Sharp HealthCare, Vitalant, and CenterWell, based on current listings on Migrate Mate as of October 2026. San Diego's hiring mix leans heavily toward large regional health systems, VA-affiliated medical centers, and specialty cancer and cardiac care facilities serving both civilian and military patient populations.

Are there remote clinical registered nurse jobs in San Diego?

Yes, though remote options are limited for hands-on clinical roles since most require direct patient care in a facility. About 100% of clinical registered nurse openings tied to San Diego are remote or hybrid as of October 2026, concentrated in case management, utilization review, and telehealth triage positions rather than bedside nursing.

How can I get a clinical registered nurse job in San Diego with little or no experience?

The most realistic entry path in San Diego is applying to nurse residency or new graduate programs run by the city's major health systems in Hillcrest and Mission Valley, which are designed for nurses with limited hospital hours. Targeting per diem or float pool roles at community hospitals and long-term acute care facilities also opens doors, as these positions often convert to full-time after a few months of consistent performance.

Which industries hire the most clinical registered nurses in San Diego?

San Diego clinical registered nurse roles concentrate in Healthcare & Medical Services, based on current listings on Migrate Mate as of October 2026. The city's combination of large regional hospital networks, a significant military medical presence at facilities like Naval Medical Center San Diego, and a growing biotech sector with affiliated clinical trial sites drives sustained demand across these segments.

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