Clinical Trial Project Manager Jobs
Clinical Trial Project Manager jobs are open across biopharmaceuticals, medical devices, contract research organizations, and academic medical centers, at every level from coordinator to director, with specializations in oncology trials, Phase I-III oversight, and regulatory submissions. Find a role that fits below and apply directly.
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Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.
Legend Biotech is seeking an Associate Director, Clinical Trial Budget Planning & Management as part of the Clinical team based in Somerset, NJ.
Role Overview
The Associate Director, Clinical Trial Budget Planning & Management is responsible for enabling the planning, forecasting, tracking, analysis, and financial oversight of clinical operations budgets across the portfolio. This individual will serve as a partner to Clinical Operations Program Leads and Finance to enable accurate trial budget forecasting, vendor budget assessments for cost efficiency, and financial transparency throughout the lifecycle of clinical trials.
The role requires a strong combination of foundational clinical operations knowledge, financial acumen, forecasting expertise, and stakeholder management capabilities. The individual will drive annual budget planning, long-range forecasts for trial budgets, assessing vendor budgets to drive cost efficiency, variance analysis, and ongoing financial performance monitoring to enable cost efficient clinical operations trial delivery.
Key Responsibilities
Clinical Trial Budget Planning & Forecasting
- Collaborate with study Operations Program Leads (OPLs) for development of annual operating budgets, long-range plans, and quarterly forecasts for clinical trial budgets.
- Partner with Clinical Operations and Finance to develop activity-based budget assumptions reflecting efficient labor requirements from vendors (CROs) to support enrollment timelines, site activations, and site monitoring and management strategies.
- Build and maintain detailed trial-level and program-level budget models incorporating planned expenditures, and anticipated timing of spend.
- Develop multi-year forecasts and scenario analyses to support portfolio planning and strategic decision making.
- Evaluate budget impacts associated with protocol amendments, study expansions, country additions, enrollment changes, and vendor scope modifications.
- Support vendor engagement strategy discussions through financial analyses and budget recommendations.
Financial Tracking, Governance & Performance Management
- Maintain visibility into actual spend, committed spend, accruals, and forecasted expenditures across multiple clinical programs.
- Monitor purchase orders, invoices, contract commitments, milestone payments, and activities impacting accrual calculations.
- Perform regular budget reviews and variance analyses to identify key drivers of financial performance.
- Reconcile differences between Finance reports and operational budget tracking systems.
- Develop spending trend analyses and provide proactive identification of financial risks and opportunities.
- Ensure budget assumptions are updated as needed based on actual spend analysis from ongoing programs.
Cross-Functional Partnership
- Serve as a primary financial business partner for Clinical Operations and Finance.
- Collaborate closely with Finance to support forecasting cycles accrual reviews, and budget submissions.
- Facilitate budget planning meetings to align assumptions and timelines.
- Gather budget inputs from OPLs and consolidate information into comprehensive forecast packages.
- Provide early visibility of significant expenditures, budget risks, and high-value commitments to OPL contacts.
- Support OPL decision making through financial insights and scenario modeling. Vendor & Contract Financial Oversight
Vendor & Contract Financial Oversight
- Partner with Vendor Management, Legal, Procurement, and Clinical Operations to ensure alignment between study budgets, contract obligations, and planned expenditures.
- Monitor vendor financial performance against approved budgets.
- Track contract milestones and anticipated expenditures across current and future fiscal years.
- Identify financial risks associated with scope changes, enrollment fluctuations, and contract amendments.
- Support budget negotiations and financial evaluations of vendor proposals when required. Reporting & Business Analytics
Reporting & Business Analytics
- Generate monthly, quarterly, and annual budget reports for OPLs.
- Create dashboards and visualizations (as needed) to communicate portfolio financial performance and forecast accuracy.
- Analyze historical spending patterns to improve future planning assumptions.
- Establish and monitor key performance indicators related to budget predictability, forecast accuracy, and spend efficiency.
Requirements
- Works closely with the Clinical Operations OPLs, Clinical operations management, Finance and collaborates with Procurement, Finance, Legal, and external CRO/vendor partners.
- Bachelor's degree in Finance, Accounting, Business Administration, Life Sciences, Clinical Research, or related field.
- 5+ years of experience in clinical development finance, clinical operations finance, forecasting, FP&A, strategic planning, or related functions within biotechnology, pharmaceutical, CRO, or healthcare industries.
- Experience developing and managing clinical trial budgets and forecasts.
- Strong understanding of clinical trial cost drivers.
- Experience with budget planning, forecasting, accrual management, financial reporting, and variance analysis.
- Advanced Excel modeling and data analysis skills.
- Experience with SAP, Oracle, Adaptive Planning, Anaplan, Hyperion, or comparable financial systems.
- Ability to integrate operational assumptions into financial forecasts.
- Strong analytical, problem-solving, and business partnering capabilities.
#Li-AS1
#Li-Hybrid
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
Work Authorization & Employment Eligibility
Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.
EEO Statement
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.
Legend Biotech is seeking an Associate Director, Clinical Trial Budget Planning & Management as part of the Clinical team based in Somerset, NJ.
Role Overview
The Associate Director, Clinical Trial Budget Planning & Management is responsible for enabling the planning, forecasting, tracking, analysis, and financial oversight of clinical operations budgets across the portfolio. This individual will serve as a partner to Clinical Operations Program Leads and Finance to enable accurate trial budget forecasting, vendor budget assessments for cost efficiency, and financial transparency throughout the lifecycle of clinical trials.
The role requires a strong combination of foundational clinical operations knowledge, financial acumen, forecasting expertise, and stakeholder management capabilities. The individual will drive annual budget planning, long-range forecasts for trial budgets, assessing vendor budgets to drive cost efficiency, variance analysis, and ongoing financial performance monitoring to enable cost efficient clinical operations trial delivery.
Key Responsibilities
Clinical Trial Budget Planning & Forecasting
- Collaborate with study Operations Program Leads (OPLs) for development of annual operating budgets, long-range plans, and quarterly forecasts for clinical trial budgets.
- Partner with Clinical Operations and Finance to develop activity-based budget assumptions reflecting efficient labor requirements from vendors (CROs) to support enrollment timelines, site activations, and site monitoring and management strategies.
- Build and maintain detailed trial-level and program-level budget models incorporating planned expenditures, and anticipated timing of spend.
- Develop multi-year forecasts and scenario analyses to support portfolio planning and strategic decision making.
- Evaluate budget impacts associated with protocol amendments, study expansions, country additions, enrollment changes, and vendor scope modifications.
- Support vendor engagement strategy discussions through financial analyses and budget recommendations.
Financial Tracking, Governance & Performance Management
- Maintain visibility into actual spend, committed spend, accruals, and forecasted expenditures across multiple clinical programs.
- Monitor purchase orders, invoices, contract commitments, milestone payments, and activities impacting accrual calculations.
- Perform regular budget reviews and variance analyses to identify key drivers of financial performance.
- Reconcile differences between Finance reports and operational budget tracking systems.
- Develop spending trend analyses and provide proactive identification of financial risks and opportunities.
- Ensure budget assumptions are updated as needed based on actual spend analysis from ongoing programs.
Cross-Functional Partnership
- Serve as a primary financial business partner for Clinical Operations and Finance.
- Collaborate closely with Finance to support forecasting cycles accrual reviews, and budget submissions.
- Facilitate budget planning meetings to align assumptions and timelines.
- Gather budget inputs from OPLs and consolidate information into comprehensive forecast packages.
- Provide early visibility of significant expenditures, budget risks, and high-value commitments to OPL contacts.
- Support OPL decision making through financial insights and scenario modeling. Vendor & Contract Financial Oversight
Vendor & Contract Financial Oversight
- Partner with Vendor Management, Legal, Procurement, and Clinical Operations to ensure alignment between study budgets, contract obligations, and planned expenditures.
- Monitor vendor financial performance against approved budgets.
- Track contract milestones and anticipated expenditures across current and future fiscal years.
- Identify financial risks associated with scope changes, enrollment fluctuations, and contract amendments.
- Support budget negotiations and financial evaluations of vendor proposals when required. Reporting & Business Analytics
Reporting & Business Analytics
- Generate monthly, quarterly, and annual budget reports for OPLs.
- Create dashboards and visualizations (as needed) to communicate portfolio financial performance and forecast accuracy.
- Analyze historical spending patterns to improve future planning assumptions.
- Establish and monitor key performance indicators related to budget predictability, forecast accuracy, and spend efficiency.
Requirements
- Works closely with the Clinical Operations OPLs, Clinical operations management, Finance and collaborates with Procurement, Finance, Legal, and external CRO/vendor partners.
- Bachelor's degree in Finance, Accounting, Business Administration, Life Sciences, Clinical Research, or related field.
- 5+ years of experience in clinical development finance, clinical operations finance, forecasting, FP&A, strategic planning, or related functions within biotechnology, pharmaceutical, CRO, or healthcare industries.
- Experience developing and managing clinical trial budgets and forecasts.
- Strong understanding of clinical trial cost drivers.
- Experience with budget planning, forecasting, accrual management, financial reporting, and variance analysis.
- Advanced Excel modeling and data analysis skills.
- Experience with SAP, Oracle, Adaptive Planning, Anaplan, Hyperion, or comparable financial systems.
- Ability to integrate operational assumptions into financial forecasts.
- Strong analytical, problem-solving, and business partnering capabilities.
#Li-AS1
#Li-Hybrid
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
Work Authorization & Employment Eligibility
Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.
EEO Statement
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
Clinical Trial Project Manager Jobs by Experience Level
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Find JobsClinical Trial Project Manager Job Market
Who's Hiring
- IQVIA29
- Medpace11
- サイネオス・ヘルス5
- Thermo Fisher Scientific4
- Katalyst Healthcares & Life Sciences4
Top Industries Hiring
- Biotechnology & Pharmaceuticals16
- Healthcare & Medical Services13
- Science & Research5
- Technology & Software3
- Consulting & Professional Services3
What Employers Look For
The qualifications that appear most often in clinical trial project manager jobs.
- Bachelor's degree in life sciences, nursing, or a related clinical field
- Experience managing clinical trial sites from start-up through close-out
- Working knowledge of ICH Good Clinical Practice and FDA regulations
- Proficiency with clinical trial management systems such as Veeva Vault or Medidata Rave
- CCRP, CCRC, or PMP certification preferred or required
- Strong budget tracking and vendor oversight experience across multiple sites
Tips for Your Clinical Trial Project Manager Job Search
Tailor your resume to trial phases
Hiring managers scan for the specific trial phases you've managed. Call out Phase I, II, or III experience by name in your work history, not just 'clinical trials,' so recruiters can instantly match you to the right opening.
Highlight your ICH GCP certification prominently
Many applicants bury certifications at the bottom of their resume. Move your ICH Good Clinical Practice certification or SOCRA CCRP credential near the top, right under your summary, where screeners look first before reading further.
Apply early to roles that fit
Migrate Mate lists clinical trial project manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter openings by therapeutic area
Your oncology or rare disease experience won't translate equally to every listing. When searching, filter or search by therapeutic area so you're applying to trials that match your protocol background and can speak to it fluently in interviews.
Prepare for scenario-based interview questions
Interviewers for this role almost always ask how you've handled a site activation delay or a protocol deviation. Walk through a specific trial, what broke down, what you did, and what the outcome was. Generic answers about 'communication' don't land.
Negotiate start dates around trial timelines
If you're mid-study at your current role, raise that in the offer conversation. Many sponsors and CROs will adjust your start date to avoid handoff gaps, and asking signals you understand how disruptive a rushed transition is for active trials.
Clinical Trial Project Manager Jobs: Frequently Asked Questions
Which companies are hiring the most clinical trial project managers?
The most active employers for clinical trial project managers right now are IQVIA, Medpace, and サイネオス・ヘルス, and the most openings are in Massachusetts, California, and North Carolina, based on current listings on Migrate Mate as of November 2026. Contract research organizations and large biopharma sponsors tend to post the highest volume of these roles.
How many clinical trial project manager jobs are remote?
About 72% of clinical trial project manager openings are fully remote or hybrid as of November 2026, with remote availability concentrated in central monitoring, data management, and regulatory coordination roles rather than positions requiring frequent site travel or hands-on patient interaction.
How do you become a clinical trial project manager?
Start with a degree in a life sciences or health-related field, then gain direct site-level experience as a clinical research coordinator or clinical research associate. Earning a certification like the CCRP or PMP strengthens your candidacy. From there, move into project oversight by managing site relationships, timelines, and budgets on progressively larger studies until you can lead a full trial independently.
Can you get a clinical trial project manager job with little experience?
Yes, but you'll need to show concrete trial exposure rather than general healthcare experience. Roles labeled associate or junior clinical trial project manager specifically target candidates coming from coordinator or CRA backgrounds. Emphasize protocol adherence, IRB submissions, or informed consent experience you handled directly, and apply to CROs, which tend to hire earlier-career candidates more readily than large sponsors.
What does the clinical trial project manager interview process look like?
Most processes run three to four rounds. A recruiter screen is followed by a hiring manager conversation focused on your trial management experience, then a technical or behavioral panel with clinical operations leads who probe your handling of site issues, protocol deviations, and vendor relationships. Some employers add a written case study where you map out a trial timeline or risk mitigation plan before a final decision.
Where can I find and apply to clinical trial project manager jobs?
You can find and apply to clinical trial project manager jobs on Migrate Mate, which lists current openings from across the United States in one place. Find roles that match your experience and therapeutic area background, then apply directly to each listing that fits.
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