Denali Therapeutics Visa Sponsorship Jobs USA
Denali Therapeutics is a clinical-stage biopharmaceutical company focused on neurodegenerative diseases. It sponsors a range of visa types, including H-1B visa and Green Card pathways, making it a viable option for international scientists, researchers, and drug development professionals seeking U.S. work authorization in biotech.
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Get Access To All JobsWe invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
This role calls for a leader who sets the operational agenda, anticipates risks and opportunities, and brings them forward with a considered point of view. The successful candidate builds the management structures, operating cadences, and accountability mechanisms their team needs to execute reliably, and sustains operational standards through periods of change, attrition, or competing priorities. They exercise independent operational judgment, take ownership of outcomes, and lead through clarity of expectations, professional managerial standards, and accountability. They contribute an operational perspective to emerging strategies, including AI infrastructure. They manage a multidisciplinary team of employees, consultants, and contractors, with the function expected to scale alongside Denali’s South San Francisco, Salt Lake City, and Zurich operational footprint.
Key Responsibilities
Leadership & Architectural Partnership
- Lead IT Infrastructure as a function, owning the operational agenda, operating rhythms, and standards by which the team executes
- Build and maintain the management structures, operating cadences, escalation paths, and accountability mechanisms required for reliable delivery
- Anticipate operational risks, capacity constraints, attrition, and capability gaps, and act in advance of service impact
- Operate Platform Engineering decisions within architectural standards and governance forums set by Architecture, including the Architecture Review Board (ARB) for decisions of architectural significance; bring operational experience into architectural decisions and execute engineering work within architectural intent
- Represent Platform Engineering & Operations to peer functions at the appropriate working level; contribute operational perspective and recommendations to enterprise platform strategy, including AI infrastructure, FinOps, and modernization
Service Management & Resilience
- Execute the unified Change Advisory Board (CAB) process integrating IT, SOX, and GxP change control, with leadership oversight on judgment calls of strategic or compliance significance; continuously mature change control as a strategic mechanism for risk-managed delivery
- Prepare and deliver Platforms-area content, analysis, and follow-through for the Quarterly Service Review (QSR) led by the Senior Director
- Execute DR and BCP across platforms, including runbooks, failover testing, recovery validation, and RTO/RPO compliance; maintain DR/BCP as a continuously verified operational capability
- Support the platform layer underpinning OT and manufacturing IT systems in partnership with the Manufacturing IT lead and Technical Operations
- Partner with business and operational stakeholders during platform incidents or degradation events to evaluate operational impact, coordinate temporary workarounds, support continuity procedures, and prioritize restoration activities aligned to business risk and criticality
Platform Services & Enterprise AI Infrastructure
- Lead delivery and operation of Denali’s enterprise observability and integration platforms (e.g., Workato) as shared services, in partnership with Product as the primary business-facing consumer
- Evolve the team toward a platform engineering model with end-to-end lifecycle ownership, including Platform Engineer and Platform Reliability Engineer roles, governed by architectural standards
- Lead the operational ramp of newly deployed enterprise platforms (e.g., SAP, MES, clinical data platforms) from project handoff into sustained operations
- Lead operational delivery of the shared platform layer that supports enterprise AI, including runtime, controls, model access, monitoring, and operational governance
- Deliver and operate validated infrastructure for AI workloads that touch regulated workflows, including security and integration architecture for safely connecting external AI partners
- Implement and operate AI governance touchpoints in partnership with IT Risk, Quality, Legal, and Cybersecurity, including intake controls, access provisioning, audit trails, human-in-the-loop enforcement for regulated outputs, detection of unauthorized AI usage, and AI/ML observability for output quality and drift
- Apply AI within Platform Engineering & Operations (AIOps, predictive incident detection, FinOps anomaly detection, automated remediation, AI-assisted change risk scoring)
Security, Compliance & Vulnerability Management
- Operationalize vulnerability management and patching as sustained, measurable, SLA-driven programs in partnership with Cybersecurity, including continuous discovery, prioritization, remediation, and closure verification
- Execute platform operations in alignment with SOX ITGCs and GxP requirements, ensuring audit-ready evidence; partner with IT Risk on in-scope systems including SAP support
Vendor & People Leadership
- Lead operational management of Managed Service Providers, including SLA enforcement, performance management, and day-to-day vendor relationships
- Proactively manage the consultant and contractor workforce, anticipating capacity gaps and ensuring continuity of capability ahead of disruptions
- Lead, develop, and grow the team; set clear expectations, performance standards, and accountability; build team operating cadences, on-call rotations, and capacity planning
Required Qualifications
- 9+ years of progressive IT experience, including significant time in platform engineering, infrastructure, IT service management, or IT operations
- 3+ years of direct team leadership experience, including building management structures, operating cadences, and accountability mechanisms required for reliable team delivery
- Demonstrated experience setting and driving the operational agenda for a function and contributing operational perspective to enterprise or cross-functional strategy decisions, with specific examples of identifying what needed attention and what was brought to the table
- Demonstrated experience holding operational standards through attrition, competing priorities, or pressure to deprioritize, with specific examples
- Demonstrated experience operationalizing vulnerability management, patching, or comparable sustained operational disciplines as measurable, SLA-driven programs
- Demonstrated experience operating Platform Engineering within an architectural governance framework, including productive engagement with Architecture functions
- Direct experience operating in a regulated life sciences environment with working knowledge of GxP, 21 CFR Part 11, and SOX ITGC requirements
- Hands-on experience operating ITIL-aligned service management (incident, change, problem, service level)
- Experience operating enterprise network, virtualization, multi-cloud (AWS/GCP/Azure), backup and restore, observability tooling, and enterprise AI infrastructure or comparable shared platform services
- Excellent written and verbal communication, with the ability to brief senior leaders concisely with considered recommendations
Preferred Qualifications
- Experience in a commercial-stage biotech or pharmaceutical company with a multi-site operational footprint, including operating AI infrastructure in validated environments for regulated workflows
- Experience supporting the platform layer for OT/manufacturing IT, operationalizing newly deployed enterprise platforms (e.g., SAP, MES, clinical data) into sustained operations, and leading platform engineering teams with end-to-end lifecycle ownership
- Hands-on familiarity with ITSM, Workato, Databricks, Reltio, and modern observability and AIOps tooling; ITIL v4, AWS/GCP/Azure, and/or FinOps foundations
Salary Range: $159,000.00 to $207,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
This role calls for a leader who sets the operational agenda, anticipates risks and opportunities, and brings them forward with a considered point of view. The successful candidate builds the management structures, operating cadences, and accountability mechanisms their team needs to execute reliably, and sustains operational standards through periods of change, attrition, or competing priorities. They exercise independent operational judgment, take ownership of outcomes, and lead through clarity of expectations, professional managerial standards, and accountability. They contribute an operational perspective to emerging strategies, including AI infrastructure. They manage a multidisciplinary team of employees, consultants, and contractors, with the function expected to scale alongside Denali’s South San Francisco, Salt Lake City, and Zurich operational footprint.
Key Responsibilities
Leadership & Architectural Partnership
- Lead IT Infrastructure as a function, owning the operational agenda, operating rhythms, and standards by which the team executes
- Build and maintain the management structures, operating cadences, escalation paths, and accountability mechanisms required for reliable delivery
- Anticipate operational risks, capacity constraints, attrition, and capability gaps, and act in advance of service impact
- Operate Platform Engineering decisions within architectural standards and governance forums set by Architecture, including the Architecture Review Board (ARB) for decisions of architectural significance; bring operational experience into architectural decisions and execute engineering work within architectural intent
- Represent Platform Engineering & Operations to peer functions at the appropriate working level; contribute operational perspective and recommendations to enterprise platform strategy, including AI infrastructure, FinOps, and modernization
Service Management & Resilience
- Execute the unified Change Advisory Board (CAB) process integrating IT, SOX, and GxP change control, with leadership oversight on judgment calls of strategic or compliance significance; continuously mature change control as a strategic mechanism for risk-managed delivery
- Prepare and deliver Platforms-area content, analysis, and follow-through for the Quarterly Service Review (QSR) led by the Senior Director
- Execute DR and BCP across platforms, including runbooks, failover testing, recovery validation, and RTO/RPO compliance; maintain DR/BCP as a continuously verified operational capability
- Support the platform layer underpinning OT and manufacturing IT systems in partnership with the Manufacturing IT lead and Technical Operations
- Partner with business and operational stakeholders during platform incidents or degradation events to evaluate operational impact, coordinate temporary workarounds, support continuity procedures, and prioritize restoration activities aligned to business risk and criticality
Platform Services & Enterprise AI Infrastructure
- Lead delivery and operation of Denali’s enterprise observability and integration platforms (e.g., Workato) as shared services, in partnership with Product as the primary business-facing consumer
- Evolve the team toward a platform engineering model with end-to-end lifecycle ownership, including Platform Engineer and Platform Reliability Engineer roles, governed by architectural standards
- Lead the operational ramp of newly deployed enterprise platforms (e.g., SAP, MES, clinical data platforms) from project handoff into sustained operations
- Lead operational delivery of the shared platform layer that supports enterprise AI, including runtime, controls, model access, monitoring, and operational governance
- Deliver and operate validated infrastructure for AI workloads that touch regulated workflows, including security and integration architecture for safely connecting external AI partners
- Implement and operate AI governance touchpoints in partnership with IT Risk, Quality, Legal, and Cybersecurity, including intake controls, access provisioning, audit trails, human-in-the-loop enforcement for regulated outputs, detection of unauthorized AI usage, and AI/ML observability for output quality and drift
- Apply AI within Platform Engineering & Operations (AIOps, predictive incident detection, FinOps anomaly detection, automated remediation, AI-assisted change risk scoring)
Security, Compliance & Vulnerability Management
- Operationalize vulnerability management and patching as sustained, measurable, SLA-driven programs in partnership with Cybersecurity, including continuous discovery, prioritization, remediation, and closure verification
- Execute platform operations in alignment with SOX ITGCs and GxP requirements, ensuring audit-ready evidence; partner with IT Risk on in-scope systems including SAP support
Vendor & People Leadership
- Lead operational management of Managed Service Providers, including SLA enforcement, performance management, and day-to-day vendor relationships
- Proactively manage the consultant and contractor workforce, anticipating capacity gaps and ensuring continuity of capability ahead of disruptions
- Lead, develop, and grow the team; set clear expectations, performance standards, and accountability; build team operating cadences, on-call rotations, and capacity planning
Required Qualifications
- 9+ years of progressive IT experience, including significant time in platform engineering, infrastructure, IT service management, or IT operations
- 3+ years of direct team leadership experience, including building management structures, operating cadences, and accountability mechanisms required for reliable team delivery
- Demonstrated experience setting and driving the operational agenda for a function and contributing operational perspective to enterprise or cross-functional strategy decisions, with specific examples of identifying what needed attention and what was brought to the table
- Demonstrated experience holding operational standards through attrition, competing priorities, or pressure to deprioritize, with specific examples
- Demonstrated experience operationalizing vulnerability management, patching, or comparable sustained operational disciplines as measurable, SLA-driven programs
- Demonstrated experience operating Platform Engineering within an architectural governance framework, including productive engagement with Architecture functions
- Direct experience operating in a regulated life sciences environment with working knowledge of GxP, 21 CFR Part 11, and SOX ITGC requirements
- Hands-on experience operating ITIL-aligned service management (incident, change, problem, service level)
- Experience operating enterprise network, virtualization, multi-cloud (AWS/GCP/Azure), backup and restore, observability tooling, and enterprise AI infrastructure or comparable shared platform services
- Excellent written and verbal communication, with the ability to brief senior leaders concisely with considered recommendations
Preferred Qualifications
- Experience in a commercial-stage biotech or pharmaceutical company with a multi-site operational footprint, including operating AI infrastructure in validated environments for regulated workflows
- Experience supporting the platform layer for OT/manufacturing IT, operationalizing newly deployed enterprise platforms (e.g., SAP, MES, clinical data) into sustained operations, and leading platform engineering teams with end-to-end lifecycle ownership
- Hands-on familiarity with ITSM, Workato, Databricks, Reltio, and modern observability and AIOps tooling; ITIL v4, AWS/GCP/Azure, and/or FinOps foundations
Salary Range: $159,000.00 to $207,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
Job Roles at Denali Therapeutics
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Get Access To All JobsTips for Finding Denali Therapeutics Visa Sponsorship Jobs USA
Target roles aligned with Denali's core research focus
Denali's work centers on neurodegenerative disease research and drug development. Roles in neuroscience, translational medicine, clinical development, and biomarker research are most likely to attract sponsorship consideration from this science-driven organization.
Understand which visa types Denali actively sponsors
Denali sponsors H-1B, TN, J-1, F-1 OPT, F-1 CPT, and Green Card pathways. Knowing which category fits your background before you apply helps you ask informed questions during recruiting conversations and signals genuine preparation to hiring teams.
Prioritize scientific and technical credentials in your application
Biotechnology employers like Denali evaluate candidates on depth of domain expertise. A PhD, postdoc experience, or specialized industry background in areas like protein engineering, neurobiology, or clinical pharmacology will strengthen your sponsorship case significantly.
Engage Denali's recruiting team early if you're on OPT or CPT
If you're on F-1 OPT or CPT, flag your timeline upfront. Biotech hiring cycles can be lengthy, and Denali sponsors both statuses, early transparency gives recruiters time to align your start date with your authorization window.
Research open roles before reaching out to recruiters
Demonstrating specific role awareness during initial contact makes a strong impression at research-focused companies. Migrate Mate surfaces verified sponsors so you can filter by real sponsorship history and find Denali openings relevant to your visa type.
Position Green Card sponsorship as a long-term conversation
Denali sponsors EB-2 and EB-3 Green Card pathways for qualifying employees. Rather than leading with this in early interviews, demonstrate your value first, sponsorship for permanent residence is typically discussed after an offer or during onboarding at biotech firms.
Frequently Asked Questions
Does Denali Therapeutics sponsor H-1B visas?
Yes, Denali Therapeutics sponsors H-1B visas. The company has a track record of supporting international employees through H-1B petitions, particularly for scientific and technical roles in drug discovery, clinical development, and translational research. If you're targeting an H-1B, look for roles in Denali's core research and development functions, where sponsorship need is most consistent.
What visa types does Denali Therapeutics sponsor?
Denali Therapeutics sponsors a range of visa categories including H-1B, TN visa, J-1 visa, F-1 OPT, F-1 CPT, and Green Card pathways under EB-2 and EB-3 classifications. This breadth makes Denali a practical option for international candidates at various stages of their U.S. work authorization journey, from recent graduates on OPT to experienced professionals pursuing permanent residence.
Which departments or roles at Denali Therapeutics are most likely to receive visa sponsorship?
Sponsorship at Denali is most concentrated in scientific and clinical functions, reflecting the company's focus on neurodegenerative disease research. Roles in neuroscience, translational medicine, biomarker research, clinical pharmacology, protein engineering, and regulatory affairs are strong candidates. Research associate, scientist, and senior scientist titles have historically aligned with the visa types Denali supports.
How do I find open visa-sponsored jobs at Denali Therapeutics?
Migrate Mate is the most direct way to find sponsored roles at Denali Therapeutics. The platform verifies sponsorship history so you're not guessing based on job descriptions that rarely mention visa support explicitly. Filter by company or visa type to surface current Denali openings relevant to your authorization status and background in biotech or pharmaceuticals.
How do I approach the application process at Denali Therapeutics as an international candidate?
Apply through official channels and be transparent about your visa status early in the process. Denali's hiring timelines in biotech can run eight to fourteen weeks from initial screen to offer, so if you're working against an OPT expiration or H-1B cap deadline, communicate that clearly. Tailoring your application to Denali's neuroscience pipeline and demonstrating deep domain expertise will carry more weight than generic sponsorship requests.