COO Jobs in Indianapolis, IN

COO jobs in Indianapolis are concentrated in the Meridian-Kessler corridor, Downtown Indianapolis, and the North Meridian Street business district, with strong demand across healthcare, logistics, and technology. Employers hiring right now include Eli Lilly, Information Technology Senior Management Forum, and Salesforce. Find a role that fits below and apply directly.

Find COO Jobs

Overview

Open roles92
Top employerEli Lilly
Work type67% On-site
Top credentialBachelor's degree
Companies hiring25

Showing 5 of 92+ COO jobs

Information Technology Senior Management Forum
Associate Director, IT Contracts & Business Operations
We won't show you this job again
Information Technology Senior Management Forum
Added 2d ago
Associate Director, IT Contracts & Business Operations
Information Technology Senior Management Forum
Indianapolis, Indiana
Clinical Support
Healthcare Administration
Medical Specialists
$146k - $213k/yr
Master's degree in business administration
51-200

Have you applied for this role?

Optum
Chief Operating Officer (COO) - Optum, American Health Network (AHN) - Hybrid
We won't show you this job again
Optum
Added 3d ago
Chief Operating Officer (COO) - Optum, American Health Network (AHN) - Hybrid
Optum
Indianapolis, Indiana
Business Operations
Business Strategy
Project & Program Management
Project Management
$159k - $273k/yr
Hybrid
Managed care organization experience
10,000+

Have you applied for this role?

Gentiva
Area Director of Operations
We won't show you this job again
Gentiva
Added 4d ago
Area Director of Operations
Gentiva
Indianapolis, Indiana
Clinical Support
Healthcare Administration
Human Resources
Nursing
Bachelor's degree
10,000+

Have you applied for this role?

Information Technology Senior Management Forum
Senior Director - Clinical Tech Design and Operations
We won't show you this job again
Information Technology Senior Management Forum
Added 5d ago
Senior Director - Clinical Tech Design and Operations
Information Technology Senior Management Forum
Indianapolis, Indiana
Program Management
Project Management
Technical Program Management
$158k - $231k/yr
Bachelor's degree in information technology
51-200

Have you applied for this role?

Eli Lilly
Senior Director - Clinical Tech Design and Operations
We won't show you this job again
Eli Lilly
Added 6d ago
Senior Director - Clinical Tech Design and Operations
Eli Lilly
Indianapolis, Indiana
Healthcare Administration
Patient Services & Wellbeing
Social Work & Counseling
$158k - $231k/yr
Bachelor's degree in information technology
10,000+

Have you applied for this role?

See All 92 COO Jobs in Indianapolis

Find roles in Indianapolis that match your experience and apply in just a few clicks.

Find COO Jobs

COO Job Market in Indianapolis

Who's Hiring

  • Eli Lilly
    Eli Lilly12
  • Information Technology Senior Management Forum
    Information Technology Senior Management Forum9
  • Salesforce
    Salesforce6
  • Optum
    Optum3
  • Elanco
    Elanco3

Top Industries Hiring

  • Biotechnology & Pharmaceuticals
  • Healthcare & Medical Services
  • Technology & Software
  • Non-Profit & Social Services

COO Jobs in Indianapolis: Frequently Asked Questions

How do I get a coo job in Indianapolis?

The strongest path into a coo role in Indianapolis runs through its healthcare systems, logistics companies, and mid-market technology firms concentrated Downtown and along the North Meridian corridor. Candidates with operational turnaround experience or a background scaling regional businesses stand out locally. Building relationships through Indy Chamber events and industry groups in those sectors gives you a meaningful edge over applicants coming in cold.

Which companies hire coos in Indianapolis?

Employers hiring coos in Indianapolis right now include Eli Lilly, Information Technology Senior Management Forum, and Salesforce, based on current listings on Migrate Mate as of August 2026. Indianapolis draws a mix of large regional health systems, logistics and distribution companies, and privately held growth-stage businesses, all of which regularly hire senior operations leaders.

Are there remote coo jobs in Indianapolis?

Yes, though remote coo work is limited by nature since the role typically requires direct oversight of teams, facilities, and daily operations. About 33% of coo openings tied to Indianapolis are remote or hybrid as of August 2026, concentrated among technology and professional services firms. Strategy, vendor negotiations, and financial planning duties tend to be the most portable parts of the role.

How can I get a coo job in Indianapolis with little or no experience?

The most realistic entry path in Indianapolis is moving up through operations manager or director-level roles at mid-size Indianapolis companies in logistics, healthcare administration, or manufacturing before stepping into the coo seat. Local employers in distribution and regional healthcare networks frequently promote from within, making those sectors a strong starting point. Volunteering for cross-functional projects and building a record of measurable cost or efficiency improvements accelerates that path significantly.

Which industries hire the most coos in Indianapolis?

The sectors hiring the most coos in Indianapolis are Biotechnology & Pharmaceuticals, Healthcare & Medical Services, and Technology & Software, based on current listings on Migrate Mate as of August 2026. Indianapolis's role as a national logistics hub and a major healthcare market drives sustained demand for senior operations leadership across both established enterprises and growing regional companies.

See All 92 COO Jobs in Indianapolis

Find roles in Indianapolis that match your experience and apply in just a few clicks.

Find COO Jobs