COO Jobs in Indianapolis, IN

COO jobs in Indianapolis are concentrated in the Meridian-Kessler corridor, Downtown Indianapolis, and the North Meridian Street business district, with strong demand across healthcare, logistics, and technology. Employers hiring right now include Gardant, Eli Lilly, and Arby's. Find a role that fits below and apply directly.

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Overview

Open roles84
Top employerGardant
Work type72% On-site
Top credentialBachelor's degree
Companies hiring21

Showing 5 of 84+ COO jobs

Prime Hospitality Group
Director of Operations
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Prime Hospitality Group
Added 2d ago
Director of Operations
Prime Hospitality Group
Indianapolis, Indiana
Business Operations
Hospitality Management
Project Management
On-Site
Bachelor's degree

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Eli Lilly
Associate Director - Operations Process Lead
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Eli Lilly
Added 2d ago
Associate Director - Operations Process Lead
Eli Lilly
Indianapolis, Indiana
Engineering (Non-Software)
Industrial Engineering
Product Management
$119k - $174k/yr
Bachelor's degree in industrial engineering
10,000+

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Evolve Indy
Director of Operations
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Evolve Indy
Added 3d ago
Director of Operations
Evolve Indy
Indianapolis, Indiana
Manufacturing Operations
Warehouse Operations

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G
Director of Home Health Operations
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G
Added 4d ago
Director of Home Health Operations
Graceful Aging Home Care
Indianapolis, Indiana
Customer Service
Customer Support
Hospitality & Guest Services
$90k - $105k/yr
Managed Registered Nurses (RNs)

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Eli Lilly
Associate Director - Radioligand Therapies Operations Lead
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Eli Lilly
Added 4d ago
Associate Director - Radioligand Therapies Operations Lead
Eli Lilly
Indianapolis, Indiana
Program Management
Project Management
Research & Academia
$123k - $180k/yr
Bachelor's degree in engineering
10,000+

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See All 84 COO Jobs in Indianapolis

Find roles in Indianapolis that match your experience and apply in just a few clicks.

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COO Job Market in Indianapolis

Who's Hiring

Gardant
Gardant7 open roles
Eli Lilly
Eli Lilly7 open roles
Arby's
Arby's4 open roles

Top Industries Hiring

  • Biotechnology & Pharmaceuticals
  • Science & Research
  • Logistics & Supply Chain

COO Jobs in Indianapolis: Frequently Asked Questions

How do I get a coo job in Indianapolis?

The strongest path into a coo role in Indianapolis runs through its healthcare systems, logistics companies, and mid-market technology firms concentrated Downtown and along the North Meridian corridor. Candidates with operational turnaround experience or a background scaling regional businesses stand out locally. Building relationships through Indy Chamber events and industry groups in those sectors gives you a meaningful edge over applicants coming in cold.

Which companies hire coos in Indianapolis?

Employers hiring coos in Indianapolis right now include Gardant, Eli Lilly, and Arby's, based on current listings on Migrate Mate as of September 2026. Indianapolis draws a mix of large regional health systems, logistics and distribution companies, and privately held growth-stage businesses, all of which regularly hire senior operations leaders.

Are there remote coo jobs in Indianapolis?

Yes, though remote coo work is limited by nature since the role typically requires direct oversight of teams, facilities, and daily operations. About 28% of coo openings tied to Indianapolis are remote or hybrid as of September 2026, concentrated among technology and professional services firms. Strategy, vendor negotiations, and financial planning duties tend to be the most portable parts of the role.

How can I get a coo job in Indianapolis with little or no experience?

The most realistic entry path in Indianapolis is moving up through operations manager or director-level roles at mid-size Indianapolis companies in logistics, healthcare administration, or manufacturing before stepping into the coo seat. Local employers in distribution and regional healthcare networks frequently promote from within, making those sectors a strong starting point. Volunteering for cross-functional projects and building a record of measurable cost or efficiency improvements accelerates that path significantly.

Which industries hire the most coos in Indianapolis?

The sectors hiring the most coos in Indianapolis are Biotechnology & Pharmaceuticals, Science & Research, and Logistics & Supply Chain, based on current listings on Migrate Mate as of September 2026. Indianapolis's role as a national logistics hub and a major healthcare market drives sustained demand for senior operations leadership across both established enterprises and growing regional companies.

See All 84 COO Jobs in Indianapolis

Find roles in Indianapolis that match your experience and apply in just a few clicks.

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