E-3 Visa Clinical Lead Jobs
Clinical Lead roles in the U.S. qualify as specialty occupations under the E-3 visa, which means Australian nurses and allied health professionals with relevant degrees can pursue sponsorship without entering an H-1B lottery. Most U.S. health systems are familiar with the LCA process, and the E-3 renews indefinitely with continued employment.
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Get Access To All JobsJob Title:
Senior Director, Global Clinical Lead
Job Requisition ID:
1343
Posting Start Date:
4/10/26
At Daiichi Sankyo, we are united by a single purpose, to improve lives around the world through innovative medicines. With a legacy of innovation since 1899, a presence in more than 30 countries, and more than 19,000 employees, we are advancing breakthrough therapies in oncology, cardiovascular disease, rare diseases, and immune disorders. Guided by our 2030 vision to "be an innovative global healthcare company contributing to the sustainable development of society", we are shaping a healthier, more hopeful future for patients, their families, and society.
Job Summary
Oversees early-stage hematology trials, such as global clinical development program for multiple product candidates with one or more indications; Interacts with our Discovery and Research programs for development of early clinical studies. Provides senior level clinical representation at meetings with health authorities; Leads the creation of developmental and regulatory strategy; Accountable for performance of CROs; Routine interactions with senior management of CRO, as needed; Accountable for clinical development plans, protocol profiles and sections of key submission documents; Represents Clinical Development as team leader or as supervisor of team leaders; Accountable for Clinical Development input into commercial strategy including Translational Medicine and biomarker strategy; Thought partner in driving Business Development decisions in collaboration with External Scientific Affairs dept.
Responsibilities
Clinical Monitoring Planning: Oversees and coordinates Sponsor oversight of CRO clinical Monitoring activities, including plan for internal communication and issue escalation with Clinical Study Lead (CSL)
Clinical Surveillance: Documents ongoing Clinical Monitoring review of data for safety (with Clinical Safety Pharmacovigilance) and quality at project level; Ensures global consistency of clinical Monitoring activities; Defines or contributes to department level surveillance activities across projects
Study strategy: Interacts with leaders of each function to develop study strategy; Approves project or TA-level TM and biomarker strategy in collaboration with Translational Medicine and Clinical Pharmacology; Attends regulatory agency meetings and leads clinical strategy discussions
Study planning and execution: Develops prospective contingency plans for management of key risks across a large project or a portfolio of projects or across the Therapeutic Area; Clearly defines priorities and high-level execution plans across projects within and outside of Daiichi Sankyo; Supports effective communication and decision-making process cross-functionally and cross-regionally at department level
Study Outputs: Has strong understanding of statistics and study design principles applicable to primary and efficacy and safety endpoints in registrational trials to critically assess study conclusions and new study designs for early stage.
External collaboration: Ensure continuous, effective alignment within / between CRO and vendors; For large, multiple indication project in late development, develops and leads Ad-Board with top tier KEEs for project level strategic advice; Consults with KEEs for advice on complex development or safety issues; Maintains and leads external collaborations and advisory panels at department level
People Management: Assign staff with appropriate training and experience or arrange requisite support to lead large study teams, coordinate complex studies, lead projects, and/or ensure proper medical oversight; Monitor and manage direct report’s performance in such roles, ensuring that there is proper understanding of task complexity and management of key risks; Participate in department’s planning for staff and cross-functional staffing plans for the Therapeutic Area.
Additional Non-Study related activities: Routine senior management interactions; Influential relationship with top KOLs; Committee member, in-licensing and acquisitions
Qualifications
Education Qualifications
MD or MD/PhD with relevant clinical and industry experience required in clinical hematology
Postgraduate training in TA or related specialty required
Experience Qualifications
7+ years’ experience required
4+ years managing Clinical Development group required
Daiichi Sankyo, Inc. is an equal opportunity/affirmative action employer. Qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected veteran status, age, or any other characteristic protected by law.
Salary Range:
USD$280,350.00 - USD$467,250.00
Download Our Benefits Summary PDF
Job Title:
Senior Director, Global Clinical Lead
Job Requisition ID:
1343
Posting Start Date:
4/10/26
At Daiichi Sankyo, we are united by a single purpose, to improve lives around the world through innovative medicines. With a legacy of innovation since 1899, a presence in more than 30 countries, and more than 19,000 employees, we are advancing breakthrough therapies in oncology, cardiovascular disease, rare diseases, and immune disorders. Guided by our 2030 vision to "be an innovative global healthcare company contributing to the sustainable development of society", we are shaping a healthier, more hopeful future for patients, their families, and society.
Job Summary
Oversees early-stage hematology trials, such as global clinical development program for multiple product candidates with one or more indications; Interacts with our Discovery and Research programs for development of early clinical studies. Provides senior level clinical representation at meetings with health authorities; Leads the creation of developmental and regulatory strategy; Accountable for performance of CROs; Routine interactions with senior management of CRO, as needed; Accountable for clinical development plans, protocol profiles and sections of key submission documents; Represents Clinical Development as team leader or as supervisor of team leaders; Accountable for Clinical Development input into commercial strategy including Translational Medicine and biomarker strategy; Thought partner in driving Business Development decisions in collaboration with External Scientific Affairs dept.
Responsibilities
Clinical Monitoring Planning: Oversees and coordinates Sponsor oversight of CRO clinical Monitoring activities, including plan for internal communication and issue escalation with Clinical Study Lead (CSL)
Clinical Surveillance: Documents ongoing Clinical Monitoring review of data for safety (with Clinical Safety Pharmacovigilance) and quality at project level; Ensures global consistency of clinical Monitoring activities; Defines or contributes to department level surveillance activities across projects
Study strategy: Interacts with leaders of each function to develop study strategy; Approves project or TA-level TM and biomarker strategy in collaboration with Translational Medicine and Clinical Pharmacology; Attends regulatory agency meetings and leads clinical strategy discussions
Study planning and execution: Develops prospective contingency plans for management of key risks across a large project or a portfolio of projects or across the Therapeutic Area; Clearly defines priorities and high-level execution plans across projects within and outside of Daiichi Sankyo; Supports effective communication and decision-making process cross-functionally and cross-regionally at department level
Study Outputs: Has strong understanding of statistics and study design principles applicable to primary and efficacy and safety endpoints in registrational trials to critically assess study conclusions and new study designs for early stage.
External collaboration: Ensure continuous, effective alignment within / between CRO and vendors; For large, multiple indication project in late development, develops and leads Ad-Board with top tier KEEs for project level strategic advice; Consults with KEEs for advice on complex development or safety issues; Maintains and leads external collaborations and advisory panels at department level
People Management: Assign staff with appropriate training and experience or arrange requisite support to lead large study teams, coordinate complex studies, lead projects, and/or ensure proper medical oversight; Monitor and manage direct report’s performance in such roles, ensuring that there is proper understanding of task complexity and management of key risks; Participate in department’s planning for staff and cross-functional staffing plans for the Therapeutic Area.
Additional Non-Study related activities: Routine senior management interactions; Influential relationship with top KOLs; Committee member, in-licensing and acquisitions
Qualifications
Education Qualifications
MD or MD/PhD with relevant clinical and industry experience required in clinical hematology
Postgraduate training in TA or related specialty required
Experience Qualifications
7+ years’ experience required
4+ years managing Clinical Development group required
Daiichi Sankyo, Inc. is an equal opportunity/affirmative action employer. Qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected veteran status, age, or any other characteristic protected by law.
Salary Range:
USD$280,350.00 - USD$467,250.00
Download Our Benefits Summary PDF
See all 103+ Clinical Lead jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Clinical Lead roles.
Get Access To All JobsTips for Finding E-3 Visa Sponsorship as a Clinical Lead
Verify your Australian degree meets requirements
Australian three-year bachelor's degrees in nursing or health sciences are generally accepted as equivalent to U.S. four-year degrees for E-3 purposes. Get a credential evaluation before applying so you can provide documentation immediately when an employer asks.
Target health systems with LCA filing history
Large hospital networks and multi-site health systems have HR and legal teams experienced with DOL Labor Condition Applications. Smaller community hospitals may need more guidance through the sponsorship process, which can slow your timeline significantly.
Distinguish Clinical Lead from staff-level roles in applications
The E-3 requires a specialty occupation with a direct link between your degree and the role. Clinical Lead positions with supervisory and quality-improvement responsibilities make that link clearer. Avoid applying to postings where the degree requirement reads as preferred rather than required.
Use Migrate Mate's E-3 filing service for your paperwork
Once you have an offer, use Migrate Mate's E-3 filing service to handle your LCA and visa paperwork. It manages the full process from DOL certification through consulate appointment preparation, so you and your employer aren't navigating unfamiliar government portals under deadline.
Prepare your clinical licensure documents before the offer stage
U.S. employers will ask for proof of nursing registration or relevant clinical credentials before filing the LCA. Having your AHPRA registration records and any NCLEX documentation ready in advance prevents delays between offer acceptance and the start of DOL processing.
Clarify E-3 transfer terms when negotiating your offer
If you're already in the U.S. on an E-3 with another employer, a new employer must file a fresh LCA before you change roles. Confirm the employer will start DOL filing promptly so your work authorization stays continuous throughout the transition.
Clinical Lead jobs are hiring across the US. Find yours.
Find Clinical Lead JobsClinical Lead E-3 Visa: Frequently Asked Questions
How do I find Clinical Lead jobs that offer E-3 visa sponsorship?
Migrate Mate lets you search Clinical Lead roles specifically filtered for E-3 visa sponsorship, so you're not manually sorting through postings from employers unfamiliar with the visa. Health systems that have filed Labor Condition Applications before are the most reliable targets, since they already have the internal processes to move quickly after an offer.
How much does it cost to get an E-3 visa?
Migrate Mate's E-3 filing service covers the entire process for $499, including the Labor Condition Application, visa document preparation, and consulate appointment guidance. Traditional immigration lawyers charge $2,000–$5,000+ for the same work. The E-3 has less paperwork than most work visas, so paying thousands for legal help is usually unnecessary.
Does a Clinical Lead role qualify as a specialty occupation for the E-3?
Yes, provided the posting requires a bachelor's degree or higher in a specific field such as nursing, health sciences, or a related clinical discipline. The role must tie the degree requirement directly to the duties performed. Clinical Lead positions with defined supervisory, quality, and clinical governance responsibilities typically meet that standard more clearly than general staff nursing roles.
How does the E-3 compare to the H-1B for Clinical Lead roles in the U.S.?
The E-3 has a 10,500-slot annual allocation that has never been fully used, meaning there's no lottery and you can apply at any time of year. The H-1B is subject to an annual lottery with far more applicants than available slots. For Australian Clinical Lead professionals, the E-3 is a more predictable and repeatable pathway, with two-year terms and unlimited renewals.
Can I switch employers as a Clinical Lead on an E-3 visa?
Yes, but your new employer must file a fresh Labor Condition Application with the DOL and you'll need to obtain a new E-3 visa stamp if you travel internationally before the change takes effect. Unlike some other visa categories, the E-3 doesn't have a formal portability provision, so timing the transition carefully and confirming your new employer is ready to file promptly is essential.
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