Green Card Clinical Research Manager Jobs
Clinical Research Manager roles qualify for EB-2 and EB-3 green card sponsorship through the PERM labor certification process, which requires employers to document recruitment efforts before filing your I-140 petition. Pharmaceutical companies, CROs, and academic medical centers regularly sponsor foreign professionals for permanent residency in this field.
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The UCSF Edward and Pearl Fein Memory and Aging Center (MAC) is an internationally renowned clinical research center with over 200 full time employees with offices and clinical research space located in the Sandler Neurosciences Building and multiple other buildings on the UCSF Mission Bay Campus. The MAC provides clinical care for patients suffering from neurodegenerative disease processes; from this clinical population, external referrals, and direct recruitment efforts we enroll patients into more than 50 structured research protocols and/or treatment trials.
The Boxer Lab at the MAC has a mission to find effective, scientifically based treatments that lead to a cure for neurodegenerative brain diseases. This is accomplished through clinical trials that emphasize patient and family benefits and public health impact, and observational studies that deepen our understanding of the biological mechanisms of neurodegenerative disease.
Job Summary:
The Research Program Manager serves as the central operational authority for projects within the Boxer Lab’s clinical research portfolio, leading coordination of internal and external teams across a large multi-institutional research network to support efficient execution of three concurrent NIH-funded clinical research studies (observational and multi-site clinical trials) focused on neurodegenerative diseases. This role operates with a high degree of autonomy and is responsible for directing complex study operations across 50+ clinical sites, overseeing multidisciplinary teams spanning multiple institutions, and ensuring alignment with broader program objectives. Key functions include, but are not limited to:
- Study Operations Management: Lead day-to-day operations of multiple clinical studies, ensuring adherence with study goals, timelines, and regulatory requirements.
- Team Leadership and Supervision: Directly supervise project management and administrative staff; provide guidance and operational support to research coordinators; manage coordination with external project managers and functional teams to support aligned and effective study execution.
- Resource and Workflow Coordination: Allocate resources across projects, establish priorities, and implement processes to support efficient and effective study execution.
- Financial Oversight: Partner with finance teams to develop and maintain budget tracking tools, monitor study expenditures, and support financial planning activities for three multi-million dollar NIH studies.
- HR and Administrative Functions: Support recruitment, hiring, onboarding, and training of study and lab personnel, and contribute to maintaining a productive team environment.
In addition to supervising two direct reports within the Boxer Lab, the Research Program Manager oversees coordination and collaboration across multidisciplinary teams spanning multiple institutions and functional areas, including the following:
- BEYONDD (Observational Study; seven clinical sites):
- USC-ATRI Team: Project management, data management, and regulatory staff supporting study operations and compliance
- UCSF Study Team: Site investigators, research coordinators, and study staff supporting remote and on-site participant recruitment and data collection; finance analysts managing invoice processing, site and vendor payments, and overall study budget tracking
- Mount Sinai Team: Site investigators, research coordinators, and study staff conducting remote and on-site participant recruitment and data collection
- Clinical Site Teams: Site investigators, research coordinators, and study staff conducting on-site participant data collection
- Vendors: Mobile phlebotomy services on a national scale and laboratory services supporting sample processing and analysis; biobanking and sample distribution; biomarker assay and data coordination; online study portal development, participant recruitment, and engagement support
- ATP (Clinical Trial; 78 sites across the US):
- USC-ATRI Team: Central coordination of multi-site trial operations, including project management, data management, regulatory oversight, clinical and medical monitoring, site support, vendor management, financial oversight, and biomarker analysis
- UCSF Study Team: Site investigators, research coordinators, and study staff conducting participant recruitment, study visits, and data collection; finance analysts managing invoice processing, site and vendor payments, and overall study budget tracking
- Clinical Site Teams: Site investigators, research coordinators, and study staff executing protocol implementation and on-site participant data collection across participating sites
- Industry Partners: External partners providing study drug and supporting study coordination, protocol development, and other aspects of overall trial operations
- Vendors: Imaging services (MRI and PET), central laboratory services, ECG systems, interactive response technology (IRT), central pharmacy, and electronic trial master file (eTMF) systems
- PTP (Clinical Trial; 50 sites across North America):
- USC-ATRI Team: Central coordination of multi-site trial operations, including project management, data management, regulatory oversight, clinical and medical monitoring, site support, vendor management, financial oversight, and biomarker analysis
- UCSF Study Team: Site investigators, research coordinators, and study staff conducting participant recruitment, study visits, and data collection; finance analysts managing invoice processing, site and vendor payments, and overall study budget tracking
- Clinical Site Teams: Site investigators, research coordinators, and study staff executing protocol implementation and on-site participant data collection across participating sites
- Industry Partners: External partners providing study drug and supporting study coordination, protocol development, and other aspects of overall trial operations
- Vendors: Imaging services (MRI), central laboratory services, ECG systems, IRT, central pharmacy, and eTMF systems
This role involves providing both direct supervision and functional oversight across a broad network of clinical research professionals and cross-functional teams spanning multiple studies, institutions, and externally funded programs. The Research Program Manager ensures alignment across internal and external partners, maintains efficient and compliant study operations, and supports financial oversight in coordination with finance teams to ensure responsible management of study budgets. This role also upholds regulatory and ethical standards for research involving human subjects. Effective leadership in this role is critical to supporting high-quality data generation, operational consistency, and the successful execution of complex, multi-site NIH-funded studies.
Minimum Requirements:
- Broad academic knowledge and applied background in clinical research philosophy. Applies knowledge of theoretical concepts and business best practices in a clinical research setting. Proven ability to translate clinical research philosophy into direct and indirect clinical input to design, planning, initiation, execution and reporting of clinical trials.
- Broad knowledge of clinical research concepts, federal, state and local laws and regulations, and industry requirements regarding the proper conduct of clinical trials. Broad theoretical and operational knowledge of clinical and patient safety standards and regulations relating to clinical research.
- Broad knowledge of all phases of clinical research, from study startup through closeout and primary publication and presentation. Knowledgeable about clinical studies involving complex trial design issues.
- Demonstrated management skills supervising, maintaining and developing clinical staff within the study team, and acting as a mentor for professional staff and conducting reviews and performance evaluations. Effectively manages multiple important priorities. Minimum five years lead/supervisory experience.
- Demonstrated ability to work collaboratively with other cross-functional teams and people with a wide range of educational backgrounds. Demonstrated ability to interface with commercial, regulatory, federal and other members of an extended study team. Ability to influence / persuade.
- Demonstrates excellent problem-solving and analytical skills. Creatively addresses complex or new problems. Proven skills to quickly evaluate complex issues and identify multiple options for resolution.
- Strong communicator; includes verbal and written, active listening, critical thinking, persuasiveness, advising and counseling skills. Skill in analyzing and presenting data and strategy to relevant team, governance, external consultant, and regulatory / oversight meetings.
- Demonstrated ability to organize research work functions in an efficient and effective manner. Great organizational skills applied to personal work and improving organization of assigned staff and trial.
Preferred Qualifications:
- Expert user of the campus' clinical information and documentation application programs. Technical proficiency in project management software.
About UCSF
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.
Pride Values
UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values.
In addition to our PRIDE values, UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available here.
Join us to find a rewarding career contributing to improving healthcare worldwide.
Equal Employment Opportunity
The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.
Salary Information
The final salary and offer components are subject to additional approvals based on UC policy.
Your placement within the salary range is dependent on a number of factors including your work experience and internal equity within this position classification at UCSF. For positions that are represented by a labor union, placement within the salary range will be guided by the rules in the collective bargaining agreement.
To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html
Department Overview:
The UCSF Edward and Pearl Fein Memory and Aging Center (MAC) is an internationally renowned clinical research center with over 200 full time employees with offices and clinical research space located in the Sandler Neurosciences Building and multiple other buildings on the UCSF Mission Bay Campus. The MAC provides clinical care for patients suffering from neurodegenerative disease processes; from this clinical population, external referrals, and direct recruitment efforts we enroll patients into more than 50 structured research protocols and/or treatment trials.
The Boxer Lab at the MAC has a mission to find effective, scientifically based treatments that lead to a cure for neurodegenerative brain diseases. This is accomplished through clinical trials that emphasize patient and family benefits and public health impact, and observational studies that deepen our understanding of the biological mechanisms of neurodegenerative disease.
Job Summary:
The Research Program Manager serves as the central operational authority for projects within the Boxer Lab’s clinical research portfolio, leading coordination of internal and external teams across a large multi-institutional research network to support efficient execution of three concurrent NIH-funded clinical research studies (observational and multi-site clinical trials) focused on neurodegenerative diseases. This role operates with a high degree of autonomy and is responsible for directing complex study operations across 50+ clinical sites, overseeing multidisciplinary teams spanning multiple institutions, and ensuring alignment with broader program objectives. Key functions include, but are not limited to:
- Study Operations Management: Lead day-to-day operations of multiple clinical studies, ensuring adherence with study goals, timelines, and regulatory requirements.
- Team Leadership and Supervision: Directly supervise project management and administrative staff; provide guidance and operational support to research coordinators; manage coordination with external project managers and functional teams to support aligned and effective study execution.
- Resource and Workflow Coordination: Allocate resources across projects, establish priorities, and implement processes to support efficient and effective study execution.
- Financial Oversight: Partner with finance teams to develop and maintain budget tracking tools, monitor study expenditures, and support financial planning activities for three multi-million dollar NIH studies.
- HR and Administrative Functions: Support recruitment, hiring, onboarding, and training of study and lab personnel, and contribute to maintaining a productive team environment.
In addition to supervising two direct reports within the Boxer Lab, the Research Program Manager oversees coordination and collaboration across multidisciplinary teams spanning multiple institutions and functional areas, including the following:
- BEYONDD (Observational Study; seven clinical sites):
- USC-ATRI Team: Project management, data management, and regulatory staff supporting study operations and compliance
- UCSF Study Team: Site investigators, research coordinators, and study staff supporting remote and on-site participant recruitment and data collection; finance analysts managing invoice processing, site and vendor payments, and overall study budget tracking
- Mount Sinai Team: Site investigators, research coordinators, and study staff conducting remote and on-site participant recruitment and data collection
- Clinical Site Teams: Site investigators, research coordinators, and study staff conducting on-site participant data collection
- Vendors: Mobile phlebotomy services on a national scale and laboratory services supporting sample processing and analysis; biobanking and sample distribution; biomarker assay and data coordination; online study portal development, participant recruitment, and engagement support
- ATP (Clinical Trial; 78 sites across the US):
- USC-ATRI Team: Central coordination of multi-site trial operations, including project management, data management, regulatory oversight, clinical and medical monitoring, site support, vendor management, financial oversight, and biomarker analysis
- UCSF Study Team: Site investigators, research coordinators, and study staff conducting participant recruitment, study visits, and data collection; finance analysts managing invoice processing, site and vendor payments, and overall study budget tracking
- Clinical Site Teams: Site investigators, research coordinators, and study staff executing protocol implementation and on-site participant data collection across participating sites
- Industry Partners: External partners providing study drug and supporting study coordination, protocol development, and other aspects of overall trial operations
- Vendors: Imaging services (MRI and PET), central laboratory services, ECG systems, interactive response technology (IRT), central pharmacy, and electronic trial master file (eTMF) systems
- PTP (Clinical Trial; 50 sites across North America):
- USC-ATRI Team: Central coordination of multi-site trial operations, including project management, data management, regulatory oversight, clinical and medical monitoring, site support, vendor management, financial oversight, and biomarker analysis
- UCSF Study Team: Site investigators, research coordinators, and study staff conducting participant recruitment, study visits, and data collection; finance analysts managing invoice processing, site and vendor payments, and overall study budget tracking
- Clinical Site Teams: Site investigators, research coordinators, and study staff executing protocol implementation and on-site participant data collection across participating sites
- Industry Partners: External partners providing study drug and supporting study coordination, protocol development, and other aspects of overall trial operations
- Vendors: Imaging services (MRI), central laboratory services, ECG systems, IRT, central pharmacy, and eTMF systems
This role involves providing both direct supervision and functional oversight across a broad network of clinical research professionals and cross-functional teams spanning multiple studies, institutions, and externally funded programs. The Research Program Manager ensures alignment across internal and external partners, maintains efficient and compliant study operations, and supports financial oversight in coordination with finance teams to ensure responsible management of study budgets. This role also upholds regulatory and ethical standards for research involving human subjects. Effective leadership in this role is critical to supporting high-quality data generation, operational consistency, and the successful execution of complex, multi-site NIH-funded studies.
Minimum Requirements:
- Broad academic knowledge and applied background in clinical research philosophy. Applies knowledge of theoretical concepts and business best practices in a clinical research setting. Proven ability to translate clinical research philosophy into direct and indirect clinical input to design, planning, initiation, execution and reporting of clinical trials.
- Broad knowledge of clinical research concepts, federal, state and local laws and regulations, and industry requirements regarding the proper conduct of clinical trials. Broad theoretical and operational knowledge of clinical and patient safety standards and regulations relating to clinical research.
- Broad knowledge of all phases of clinical research, from study startup through closeout and primary publication and presentation. Knowledgeable about clinical studies involving complex trial design issues.
- Demonstrated management skills supervising, maintaining and developing clinical staff within the study team, and acting as a mentor for professional staff and conducting reviews and performance evaluations. Effectively manages multiple important priorities. Minimum five years lead/supervisory experience.
- Demonstrated ability to work collaboratively with other cross-functional teams and people with a wide range of educational backgrounds. Demonstrated ability to interface with commercial, regulatory, federal and other members of an extended study team. Ability to influence / persuade.
- Demonstrates excellent problem-solving and analytical skills. Creatively addresses complex or new problems. Proven skills to quickly evaluate complex issues and identify multiple options for resolution.
- Strong communicator; includes verbal and written, active listening, critical thinking, persuasiveness, advising and counseling skills. Skill in analyzing and presenting data and strategy to relevant team, governance, external consultant, and regulatory / oversight meetings.
- Demonstrated ability to organize research work functions in an efficient and effective manner. Great organizational skills applied to personal work and improving organization of assigned staff and trial.
Preferred Qualifications:
- Expert user of the campus' clinical information and documentation application programs. Technical proficiency in project management software.
About UCSF
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.
Pride Values
UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values.
In addition to our PRIDE values, UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available here.
Join us to find a rewarding career contributing to improving healthcare worldwide.
Equal Employment Opportunity
The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.
Salary Information
The final salary and offer components are subject to additional approvals based on UC policy.
Your placement within the salary range is dependent on a number of factors including your work experience and internal equity within this position classification at UCSF. For positions that are represented by a labor union, placement within the salary range will be guided by the rules in the collective bargaining agreement.
To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html
See all 333+ Green Card Clinical Research Manager Jobs
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Get Access To All JobsTips for Finding Green Card Sponsorship as a Clinical Research Manager
Translate your GCP credentials into PERM language
Your ICH-GCP training certificates, IRB experience, and phase-specific trial history need to map directly to the job duties listed on the PERM application. Gaps between your credentials and the posted requirements can trigger a USCIS Request for Evidence during I-140 review.
Target CROs with established PERM filing history
Contract research organizations running multi-site trials typically have in-house immigration teams and recurring PERM pipelines. Prioritize employers whose job postings explicitly name EB-2 or EB-3 sponsorship rather than relying on negotiating it after an offer.
Verify your role qualifies under EB-2 or EB-3
Clinical Research Manager positions requiring a master's degree or significant specialized experience often qualify for EB-2. Roles requiring a bachelor's degree with standard industry experience typically fall under EB-3. Confirm the classification with your employer before PERM is filed, since it affects your priority date strategy.
Search green card sponsorship jobs using Migrate Mate
Filter by employers with active PERM and I-140 filing histories for Clinical Research Manager roles using Migrate Mate. This surfaces companies already experienced with sponsoring this specific job title, cutting out employers who treat sponsorship as an afterthought.
Confirm the prevailing wage tier before accepting an offer
Your employer's offered salary must meet the DOL prevailing wage for your job zone and location. Look up the applicable wage level using the OFLC Wage Search before signing an offer letter, since a mismatch delays PERM certification and can require salary renegotiation mid-process.
Negotiate PERM filing timing into your start date planning
PERM labor certification currently averages well over a year at DOL. If you're transitioning from H-1B visa status, your employer needs to start the PERM process early enough to allow I-140 filing and adjustment of status without gaps in your authorized stay.
Green Card Clinical Research Manager: Frequently Asked Questions
Do Clinical Research Manager roles typically qualify for EB-2 or EB-3 sponsorship?
Both categories apply depending on how the employer defines the position. Roles requiring a master's degree in a clinical or life sciences field, or a bachelor's degree with substantial specialized experience, often qualify for EB-2. Positions with a standard bachelor's degree requirement and defined industry experience typically fall under EB-3. Your employer's immigration counsel determines the classification when drafting the PERM job description.
How does green card sponsorship differ from H-1B for this role?
Green card sponsorship through PERM leads to permanent residency rather than temporary status, and EB-3 has no annual lottery. The tradeoff is time: PERM labor certification, I-140 approval, and adjustment of status or consular processing can take two to four years or longer depending on your country of birth and USCIS processing backlogs. H-1B gets you to work faster but requires renewal every three years and offers no permanent path on its own.
Which employers most commonly sponsor Clinical Research Managers for green cards?
Pharmaceutical manufacturers, contract research organizations, and large academic medical centers are the most consistent sponsors for this role. These employers typically have internal immigration teams and recurring PERM pipelines tied to clinical development headcount. Use Migrate Mate to find Clinical Research Manager positions with documented green card sponsorship history rather than applying broadly and asking about sponsorship during screening calls.
What happens to my PERM application if my employer changes the job duties?
Material changes to the job description after PERM is filed can invalidate the certification, requiring the employer to restart the process. Your job duties at the time of I-485 filing must also substantially match those described in the original PERM application. If your responsibilities shift significantly before your green card is approved, your employer's immigration counsel should assess whether an amended or new PERM filing is needed.
Does country of birth affect my green card timeline as a Clinical Research Manager?
Yes. EB-2 and EB-3 green cards are subject to per-country annual limits. Applicants born in India or China face multi-year backlogs because demand from those countries exceeds the annual allocation. Applicants born in most other countries, including Australia, the UK, and Canada, typically face far shorter waits under EB-3. Your priority date, which is set when PERM is filed or I-140 is submitted under EB-2, determines your place in the queue.