Nurse Practitioner Jobs in St. Louis, MO

Nurse Practitioner jobs in St. Louis are in strong demand, concentrated in the Central West End, Cortex Innovation Community, and South City corridors across health systems, federally qualified health centers, and specialty clinics. Employers hiring right now include BJC HealthCare, Mercy, and Esse Health. See the openings below and apply to the ones that match your experience.

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Overview

Open roles91
Top employerBJC HealthCare
Work type67% On-site
Top credentialDoctoral degree
Companies hiring9

Showing 5 of 91+ Nurse Practitioner jobs

Nurse Practitioner or Physician Assistant (Hybrid) - Breast Oncology
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New 17h ago
Nurse Practitioner or Physician Assistant (Hybrid) - Breast Oncology
Washington University in St. Louis
St. Louis, Missouri
Allied Health
Healthcare Administration
Nursing
$97k - $175k/yr
Hybrid
BLS Certification
10,000+

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Physician Assistant or Nurse Practitioner - PRN
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Added 4d ago
Physician Assistant or Nurse Practitioner - PRN
GoHealth Urgent Care
St. Louis, Missouri
Allied Health
Healthcare Administration
Nursing
Master's degree
501-1,000

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Advanced Practice Provider - Nurse Practitioner or Physician Assistant
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Added 4d ago
Advanced Practice Provider - Nurse Practitioner or Physician Assistant
Shriners Children's
St. Louis, Missouri
Healthcare Administration
Nursing
Patient Services & Wellbeing
On-Site
PALS Certification
5,001-10,000

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Nurse Practitioner, HouseCalls - Missouri Statewide Traveler
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Added 5d ago
Nurse Practitioner, HouseCalls - Missouri Statewide Traveler
Optum
St. Louis, Missouri
Caregiving & Elderly Support
Healthcare Administration
Patient Services & Wellbeing
$110k - $164k/yr
10,000+

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Nurse Practitioner or Physician Assistant – Emergency Department, Mercy Hospital South
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Added 5d ago
Nurse Practitioner or Physician Assistant – Emergency Department, Mercy Hospital South
Mercy
St. Louis, Missouri
Allied Health
Clinical Support
Healthcare Administration
10,000+

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Nurse Practitioner Job Market in St. Louis

Who's Hiring

  • BJC HealthCare24
  • Mercy18
  • Esse Health12
  • Optum6
  • VITAS Healthcare6

Nurse Practitioner Jobs in St. Louis: Frequently Asked Questions

How do I get a nurse practitioner job in St. Louis?

Focus your search on St. Louis's dominant hiring sectors: large academic health systems anchored in the Central West End, community health centers serving underserved neighborhoods in North and South City, and outpatient specialty practices throughout the county. Candidates with experience in primary care, urgent care, or psychiatric mental health tend to move quickly here. Familiarity with Missouri's full-practice authority environment and experience in underserved or rural outreach also stands out to local employers.

Which companies hire nurse practitioners in St. Louis?

Employers hiring nurse practitioners in St. Louis right now include BJC HealthCare, Mercy, and Esse Health, based on current listings on Migrate Mate as of October 2026. St. Louis hiring is led by major academic medical centers, regional health systems, and a growing network of outpatient and specialty clinic groups spread across the city and surrounding county.

Are there remote nurse practitioner jobs in St. Louis?

Yes, though remote roles are limited by nature since most nurse practitioner work requires direct patient contact. About 33% of nurse practitioner openings tied to St. Louis are remote or hybrid as of October 2026, with those roles concentrated in telehealth primary care, behavioral health, and care management. St. Louis-based insurers and regional telehealth networks are the most active sources of fully remote positions locally.

How can I get a nurse practitioner job in St. Louis with little or no experience?

The most realistic entry path in St. Louis is through new-graduate NP programs at large health systems, which offer structured orientation and preceptorship for clinicians transitioning from RN roles. Federally qualified health centers and community mental health agencies in St. Louis also hire new graduates more readily than private specialty practices. Completing clinical rotations with local employers during your NP program is one of the strongest indicators of hire, as many St. Louis sites extend offers to former students they already know.

See All 91 Nurse Practitioner Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

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