Physician Assistant Jobs in St. Louis, MO

Physician Assistant jobs in St. Louis are concentrated across hospital systems and specialty clinics in the Central West End, Clayton, and South County, with strong demand in primary care, orthopedics, and emergency medicine. Employers hiring right now include Mercy, Shriners Children's, and Washington University in St. Louis. See the openings below and apply to the ones that match your experience.

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Overview

Open roles65
Top employerMercy
Work type100% On-site
Top credentialBLS Certification
Companies hiring8

Showing 5 of 65+ Physician Assistant jobs

Physician Assistant or Nurse Practitioner - PRN
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Added 4d ago
Physician Assistant or Nurse Practitioner - PRN
GoHealth Urgent Care
St. Louis, Missouri
Allied Health
Healthcare Administration
Nursing
Master's degree
501-1,000

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Physician Assistant - Bone & Mineral Diseases
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Added 4d ago
Physician Assistant - Bone & Mineral Diseases
Washington University in St. Louis
St. Louis, Missouri
Healthcare Administration
Patient Services & Wellbeing
Physicians
$97k - $175k/yr
BLS Certification
10,000+

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Physician Assistant
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Added 4d ago
Physician Assistant
Shriners Children's
St. Louis, Missouri
Clinical Support
Healthcare Administration
Medical Specialists
$92k.2 - $147k.8/yr
PALS Certification
5,001-10,000

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Advanced Practice Provider - Nurse Practitioner or Physician Assistant
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Added 4d ago
Advanced Practice Provider - Nurse Practitioner or Physician Assistant
Shriners Children's
St. Louis, Missouri
Healthcare Administration
Nursing
Patient Services & Wellbeing
On-Site
PALS Certification
5,001-10,000

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Nurse Practitioner or Physician Assistant – Emergency Department, Mercy Hospital South
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Added 5d ago
Nurse Practitioner or Physician Assistant – Emergency Department, Mercy Hospital South
Mercy
St. Louis, Missouri
Allied Health
Clinical Support
Healthcare Administration
10,000+

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See All 65 Physician Assistant Jobs in St. Louis

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Physician Assistant Job Market in St. Louis

Who's Hiring

  • Mercy20
  • Shriners Children's10
  • Washington University in St. Louis10
  • WP Psych5
  • 77 Consultants5

Physician Assistant Jobs in St. Louis: Frequently Asked Questions

How do I get a physician assistant job in St. Louis?

Target St. Louis's large academic medical systems, regional health networks, and specialty practices in the Central West End and Clayton, which consistently post the most openings. Candidates with urgent care, orthopedics, or emergency medicine experience have an edge here given how those practices are distributed across the metro. Building connections through clinical rotations at St. Louis's teaching hospitals also opens doors that cold applications often don't.

Which companies hire physician assistants in St. Louis?

Employers hiring physician assistants in St. Louis right now include Mercy, Shriners Children's, and Washington University in St. Louis, based on current listings on Migrate Mate as of October 2026. The local market is anchored by large academic medical centers, multispecialty clinic groups, and community health organizations spread across the city and inner suburbs.

Are there remote physician assistant jobs in St. Louis?

Yes, but with clear limits, since most physician assistant work is hands-on and requires in-person patient contact. About 0% of physician assistant openings tied to St. Louis are remote or hybrid as of October 2026, and those tend to cluster in telehealth triage, utilization review, and care management roles rather than clinical practice.

How can I get a physician assistant job in St. Louis with little or no experience?

The most realistic entry path in St. Louis is through community health centers, urgent care networks, and federally qualified health centers in underserved neighborhoods, which regularly hire new graduates. Entry-level roles in hospital float pools and outpatient primary care clinics also give new PAs broad exposure quickly. Completing rotations locally at a St. Louis program and staying visible in those networks gives candidates a meaningful head start.

See All 65 Physician Assistant Jobs in St. Louis

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