Physician Assistant Jobs in Missouri
Physician Assistant jobs in Missouri are open across St. Louis, Columbia, and Springfield and other Missouri metros, with employers like Washington University in St. Louis, University of Missouri, and Mercy hiring at every experience level. Find a role that fits below and apply directly.
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Job Description
Full-Time Role + Critical Care Fellowship Opportunity
This Advanced Practice Provider (APP) position is a full-time, night shift role (6:00 PM – 7:00 AM) at Saint Luke’s North Intensive Care Unit.
Join an expanding Critical Care ICU team at Saint Luke’s Health System in Kansas City, a rapidly growing and increasingly sought-after destination known for its strong healthcare community, affordability, and high quality of life. This is an opportunity to build your career within a respected health system while making a meaningful impact in a high-acuity clinical environment.
We are seeking Advanced Practice Providers (NP/PA) who are passionate about delivering exceptional care while continuing to build and refine their critical care skillset in a collaborative, team-based setting.
Ideal candidates will bring experience in critical care or closely related specialties such as cardiovascular/cardiothoracic ICU, medical ICU, surgical ICU, trauma ICU, or neurocritical care. Experience in emergency medicine, acute care/hospital medicine, pulmonary/critical care, cardiology, anesthesia, or other high-acuity settings is highly valued.
We also welcome new graduates with a strong ICU RN background, including experience in ICU settings (MICU, CVICU, SICU), progressive care (PCU), or emergency department environments.
Why Join Saint Luke’s
- Be part of an expanding ICU program within a leading, nationally recognized health system
- Built-in mentorship and structured learning, with fellowship-style training integrated into daily practice
- Exposure to a high-acuity, diverse patient population
- Collaborative care model alongside physicians, APPs, and residents
- Consistent 3x13-hour shift schedule with shared weekend and holiday rotation
- Competitive compensation package aligned with experience and market benchmarks
- Employee referral bonus opportunity for qualifying hires
What You’ll Do
- Deliver advanced, evidence-based care to critically ill patients
- Assess, diagnose, and manage complex conditions
- Develop, implement, and adjust patient-centered care plans
- Perform procedures within scope of practice
- Collaborate across multidisciplinary teams to optimize outcomes
- Educate patients, families, and clinical staff
- Contribute to quality improvement and clinical excellence initiatives
This role offers the opportunity to grow within an expanding ICU team at Saint Luke’s Health System, with continuous learning and hands-on development embedded into your day-to-day practice—ideal for both experienced APPs and those early in their critical care career.
Job Requirements
Applicable Experience:
1 year
Advanced Cardiac Life Support – Healthstream
Advanced Practice Provider Cert(MO/KS) – Various
Master's Degree
Job Details
Full Time
Night (United States of America)
The best place to get care. The best place to give care. Saint Luke’s 12,000 employees strive toward that vision every day. Our employees are proud to work for the only faith-based, nonprofit, locally owned health system in Kansas City. Joining Saint Luke’s means joining a team of exceptional professionals who strive for excellence in patient care. Do the best work of your career within a highly diverse and inclusive workspace where all voices matter.
Join the Kansas City region's premiere provider of health services. Equal Opportunity Employer.
See All 78 Physician Assistant Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find Physician Assistant JobsPhysician Assistant Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Physician Assistant Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
- Washington University in St. Louis22

- University of Missouri14

- Mercy12

- CoxHealth8

- University of Kansas Medical Center5

Top Industries Hiring
- Education44
- Healthcare & Medical Services41
- Construction & Real Estate1
- Law & Legal Services1
What Missouri Employers Look For
The qualifications that appear most often in physician assistant jobs across Missouri.
- Master of Science in Physician Assistant Studies from an ARC-PA-accredited program
- Current NCCPA certification (PANCE passage or maintenance of certification)
- Active state PA license or eligibility for licensure in the hiring state
- Two or more years of clinical experience in a relevant specialty setting
- Proficiency with electronic health records systems such as Epic or Cerner
- Current BLS certification and ACLS certification for acute care or hospital roles
Physician Assistant Jobs in Missouri: Frequently Asked Questions
How many physician assistant jobs are there in Missouri?
There are 78+ physician assistant openings in Missouri on Migrate Mate as of June 2026, with the most roles in St. Louis, Columbia, and Springfield. New positions post regularly as employers across Missouri hire.
How much do physician assistants make in Missouri?
Physician assistants in Missouri earn a median of about $135,130 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $82,690 for the lowest 10% to over $169,650 for the top 10%. Pay rises with experience, specialty, and employer.
Which Missouri cities have the most physician assistant jobs?
St. Louis, Columbia, and Springfield have the most physician assistant openings in Missouri right now, with additional roles spread across smaller metros statewide.
Which companies hire physician assistants in Missouri?
Employers hiring physician assistants in Missouri include Washington University in St. Louis, University of Missouri, and Mercy, based on current listings on Migrate Mate as of June 2026.
Are there remote physician assistant jobs in Missouri?
Yes. About 3% of physician assistant openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.
How do I apply for physician assistant jobs in Missouri?
You can apply to physician assistant jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.
See All 78 Physician Assistant Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find Physician Assistant Jobs