Physician Assistant Jobs in Missouri

Physician assistant jobs in Missouri are concentrated in Kansas City, St. Louis, and Springfield, where major health systems like BJC HealthCare, Children's Mercy, and SSM Health maintain steady hiring pipelines for PAs at every career stage. Demand is strongest in primary care, emergency medicine, and orthopedics, with hospital-employed and multispecialty group roles making up the bulk of active openings. The market draws both new graduates and experienced clinicians, with rural and underserved areas across the state increasingly competitive as well. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles41
Top employerMercy
Top citySpringfield, MO
Cities hiring16
Work type70% On-site
Top industryHealthcare

Showing 5 of 41+ Physician Assistant jobs

Mercy
Nurse Practitioner or Physician Assistant - OBGYN Smith Glynn Callaway Clinic - Springfield, MO
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Mercy
Added 1d ago
Nurse Practitioner or Physician Assistant - OBGYN Smith Glynn Callaway Clinic - Springfield, MO
Mercy
Springfield, Missouri
Clinical Support
Healthcare Administration
Medical Specialists
10,000+

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Washington University in St. Louis
Insurance Billing/Collection Assistant II (Hybrid) - Physician Billing Services
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Washington University in St. Louis
Added 1d ago
Insurance Billing/Collection Assistant II (Hybrid) - Physician Billing Services
Washington University in St. Louis
St. Louis, Missouri
Business Operations
Executive Leadership & C-Suite
Project Management
$17.89 - $26.35/hr
Hybrid
High school diploma or GED
10,000+

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Allergy, Asthma & Sinus Care Center
FULL TIME Medical Assistant (Pre-PA & Pre Med Welcome to apply)
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Allergy, Asthma & Sinus Care Center
Added 1d ago
FULL TIME Medical Assistant (Pre-PA & Pre Med Welcome to apply)
Allergy, Asthma & Sinus Care Center
St. Louis, Missouri
Business Development
Growth Marketing
Marketing
On-Site

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K
Physician Assistant
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K
Added 1d ago
Physician Assistant
Kansas City Urology and Oncology
Kansas City, Missouri
Clinical Support
Healthcare Administration
Medical Specialists
On-Site
Master's degree in health science

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CoxHealth
NP or PA for Medical Oncology
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CoxHealth
Added 2d ago
NP or PA for Medical Oncology
CoxHealth
Springfield, Missouri
Healthcare Administration
Nursing
Patient Services & Wellbeing
Master's degree in nursing
10,000+

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Physician Assistant Jobs by City in Missouri

Where Missouri roles are concentrated, by current openings.

Springfield
11 jobs
St. Louis
9 jobs
Kansas City
3 jobs
Bolivar
2 jobs
Lebanon
2 jobs
O'Fallon
2 jobs
Kirksville
2 jobs
Chesterfield
2 jobs
Ozark
1 job

Physician Assistant Job Market in Missouri

A snapshot from current Missouri openings, updated as new roles post.

Who's Hiring

  • Mercy
    Mercy13
  • CoxHealth
    CoxHealth8
  • 7
    77 Consultants2
  • Citizens Memorial Healthcare
    Citizens Memorial Healthcare2
  • Washington University in St. Louis
    Washington University in St. Louis2

Top Industries Hiring

  • Healthcare & Medical Services

What Missouri Employers Look For

The qualifications that appear most often in physician assistant jobs across Missouri.

  • Active Missouri physician assistant license issued by the Missouri State Board of Registration for the Healing Arts
  • Graduation from an ARC-PA accredited physician assistant program
  • Current NCCPA certification or eligibility to sit for the PANCE
  • Current BLS certification required, with ACLS preferred for acute care or hospital settings
  • Experience in a relevant specialty such as primary care, emergency medicine, or orthopedics
  • Strong electronic health record proficiency, with Epic experience commonly preferred by Missouri health systems

Physician Assistant Jobs in Missouri: Frequently Asked Questions

How do you become a physician assistant in Missouri?

To become a physician assistant in Missouri, you must complete a master's-level program accredited by the ARC-PA, pass the PANCE administered by the NCCPA, and then apply for licensure through the Missouri State Board of Registration for the Healing Arts. Missouri requires a licensed supervising physician on file as part of the collaborative practice arrangement. Once licensed, you may practice in any approved setting, including hospitals, outpatient clinics, and rural health centers.

How much do physician assistants make in Missouri?

Physician assistants in Missouri earn a median of about $135,130 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $82,690 for the lowest 10% to over $169,650 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire physician assistants in Missouri?

Companies currently hiring physician assistants in Missouri include Mercy, CoxHealth, and 77 Consultants, per current listings on Migrate Mate as of August 2026. Missouri's large integrated health systems and academic medical centers tend to post the most consistent volume, with multispecialty group practices and federally qualified health centers also representing a meaningful share of openings.

Which Missouri cities have the most physician assistant jobs?

Springfield, St. Louis, and Kansas City have the most physician assistant openings in Missouri. Kansas City and St. Louis drive the highest volume because of their large academic medical centers and integrated hospital networks, while Springfield's growing regional health sector, anchored by CoxHealth and Mercy, keeps it consistently active for PA hiring as well.

Are there remote physician assistant jobs in Missouri?

Yes, but they're rare. Physician assistant work is inherently hands-on and patient-facing, which limits how much of the role can be performed remotely. About 30% of physician assistant openings tied to Missouri are remote or hybrid as of August 2026, and those positions tend to concentrate in telehealth triage, utilization review, or chronic disease management roles rather than traditional clinical practice.

How can I get hired as a physician assistant in Missouri with little or no experience?

The most realistic entry path is applying directly to new-graduate or postgraduate residency programs, several of which are offered by Missouri-based systems including BJC HealthCare and Mercy. These structured programs are designed for candidates coming straight out of accredited PA programs. Beyond residency, new graduates often enter through urgent care, rural health clinics, and federally qualified health centers, which tend to be more open to onboarding early-career PAs. Having your Missouri license and NCCPA certification in hand before you apply gives you a clear advantage over candidates still awaiting results.

Where can I find and apply to physician assistant jobs in Missouri?

You can find and apply to physician assistant jobs in Missouri on Migrate Mate, which lists current Missouri openings across health systems, group practices, and specialty clinics. Search the listings to find roles that match your specialty, experience level, and preferred location, then apply directly to the ones that fit.

See All 41 Physician Assistant Jobs in Missouri

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