Physician Assistant Jobs in North Carolina

Physician Assistant jobs in North Carolina are consistently in demand, with the market concentrated in hospital systems, academic medical centers, orthopedics, and urgent care, covering openings from new graduates through experienced senior clinicians. The heaviest hiring activity is in Charlotte, Raleigh-Durham, and Greensboro, where anchors like Atrium Health, Duke Health, and UNC Health run large PA programs across multiple specialties. Cardiology, orthopedics, and emergency medicine post the most consistent openings across the state. Find a role that fits below and apply directly.

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Overview

Open roles115+
Top employerOptum
Top cityGreensboro, NC
Cities hiring59
Work type87% On-site
Top industryHealthcare

Showing 5 of 115+ Physician Assistant jobs

7
Locum MD (Medical Doctor), DO (Osteopathic Doctor) Cardiology
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7
New 21h ago
Locum MD (Medical Doctor), DO (Osteopathic Doctor) Cardiology
77 Consultants
Elizabeth City, North Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians

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Appalachian Mountain Health
Physician Assistant – Nurse Practitioner – Family Practice
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Appalachian Mountain Health
Added 1d ago
Physician Assistant – Nurse Practitioner – Family Practice
Appalachian Mountain Health
Black Mountain, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
On-Site
CPR Certification
51-200

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MainStreet Family Care
Physician Assistant
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MainStreet Family Care
Added 1d ago
Physician Assistant
MainStreet Family Care
Roxboro, North Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians
Master's degree in nursing

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MainStreet Family Care
Physician Assistant
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MainStreet Family Care
Added 1d ago
Physician Assistant
MainStreet Family Care
Eden, North Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians
Master's degree in nursing

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One Medical
Per Diem Primary Care Nurse Practitioner or Physician Assistant (Casual Employee)
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One Medical
Added 1d ago
Per Diem Primary Care Nurse Practitioner or Physician Assistant (Casual Employee)
One Medical
Durham, North Carolina
Clinical Support
Healthcare Administration
Mental & Behavioral Health
1,001-5,000

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See All 115+ Physician Assistant Jobs in North Carolina

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Physician Assistant Jobs by City in North Carolina

Where North Carolina roles are concentrated, by current openings.

Greensboro
16 jobs
Charlotte
8 jobs
Raleigh
7 jobs
Durham
6 jobs
Greenville
4 jobs
Fayetteville
4 jobs
Winston-Salem
4 jobs
Cary
3 jobs
Kinston
3 jobs

Physician Assistant Job Market in North Carolina

A snapshot from current North Carolina openings, updated as new roles post.

Who's Hiring

  • Optum
    Optum11
  • MainStreet Family Care
    MainStreet Family Care10
  • Bethany Medical
    Bethany Medical9
  • Cone Health
    Cone Health7
  • UNC Health
    UNC Health6

Top Industries Hiring

  • Healthcare & Medical Services
  • Insurance

What North Carolina Employers Look For

The qualifications that appear most often in physician assistant jobs across North Carolina.

  • Active Physician Assistant license issued or recognized by the North Carolina Medical Board
  • National Commission on Certification of Physician Assistants certification (NCCPA) required
  • Master's degree from an ARC-PA accredited physician assistant program
  • Clinical experience in a specialty such as orthopedics, cardiology, or emergency medicine
  • Ability to obtain DEA registration and prescriptive authority under North Carolina supervising physician
  • Strong electronic health record proficiency, with Epic experience preferred by most North Carolina systems

Physician Assistant Jobs in North Carolina: Frequently Asked Questions

How do you become a physician assistant in North Carolina?

You become a physician assistant in North Carolina by graduating from an ARC-PA accredited master's level PA program, passing the PANCE exam administered by NCCPA, and applying for licensure through the North Carolina Medical Board. The board requires a completed application, verification of your NCCPA certification, and evidence of a supervising physician practice agreement before you can legally practice in the state.

How much do physician assistants make in North Carolina?

Physician assistants in North Carolina earn a median of about $129,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $101,100 for the lowest 10% to over $164,770 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire physician assistants in North Carolina?

Employers hiring physician assistants in North Carolina right now include Optum, MainStreet Family Care, and Bethany Medical, based on current listings on Migrate Mate as of August 2026. North Carolina's large integrated health systems, including academic medical centers and regional hospital networks, account for the majority of posted openings across the state.

Which North Carolina cities have the most physician assistant jobs?

The cities with the most physician assistant openings in North Carolina are Greensboro, Charlotte, and Raleigh. Charlotte and Raleigh-Durham lead because of their dense concentration of large hospital systems and academic medical centers, while Greensboro and other Piedmont Triad communities add volume through regional health networks and specialty practices that serve significant suburban and rural catchment areas.

Are there remote physician assistant jobs in North Carolina?

Yes, but they're rare. Physician assistant work is largely hands-on and clinic or hospital based, which limits fully remote opportunities. About 13% of physician assistant openings tied to North Carolina are remote or hybrid as of August 2026, and those positions are almost entirely in utilization review, telephonic triage, or case management rather than direct patient care.

How can I get hired as a physician assistant in North Carolina with little or no experience?

The most realistic entry path is applying directly to postgraduate PA residency or fellowship programs run by large North Carolina systems such as Atrium Health, Duke Health, and UNC Health, which accept recent graduates and provide structured clinical training in specialties like emergency medicine and primary care. Candidates who hold active NCCPA certification, a North Carolina Medical Board license, and experience as a medical assistant or surgical technologist before graduation consistently stand out in competitive new-graduate applicant pools.

Where can I find and apply to physician assistant jobs in North Carolina?

You can find and apply to physician assistant jobs in North Carolina on Migrate Mate, which lists current openings from employers actively hiring in the state. Search the listings, find roles that fit your specialty and location, and apply directly to the ones that match.

See All 115+ Physician Assistant Jobs in North Carolina

Find roles in North Carolina that match your experience and apply in just a few clicks.

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