Principal Jobs in Cambridge, MA

Principal jobs in Cambridge are concentrated in higher education, life sciences, and K-12 education, with demand anchored in Kendall Square, Harvard Square, and the Alewife corridor. Employers hiring right now include Draper, Novartis, and RTX. Find a role that fits below and apply directly.

Find Principal Jobs

Overview

Open roles205+
Top employerDraper
Work type50% Hybrid
Top credentialMaster's degree
Companies hiring12

Showing 5 of 205+ Principal jobs

Development Coordinator, Principal Gifts
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New 12h ago
Development Coordinator, Principal Gifts
Harvard University
Cambridge, Massachusetts
Business Operations
Program Management
Project Management
Hybrid
1,001-5,000

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Principal Data Engineer
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New 23h ago
Principal Data Engineer
Flagship Pioneering, Inc.
Cambridge, Massachusetts
Cloud & DevOps
Cloud Engineering
DevOps
Solutions Engineering & Architecture
$179k - $236k/yr

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Principal Scientist I/II —CAR-T Lead
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Added 2d ago
Principal Scientist I/II —CAR-T Lead
Novartis
Cambridge, Massachusetts
Biotech & Life Sciences
Clinical Trials & Medical Research
Environmental Science
$109k - $222k/yr
10,000+

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Principal Social Media Manager
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Added 3d ago
Principal Social Media Manager
Cambridge Mobile Telematics
Cambridge, Massachusetts
Brand Marketing
Growth Marketing
Marketing
$113k - $142k/yr
Remote (US)
Bachelor's degree in communications
51-200

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Principal Analyst, Enterprise/IT Service Management and IT Operations
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Added 3d ago
Principal Analyst, Enterprise/IT Service Management and IT Operations
Forrester
Cambridge, Massachusetts
Business Analysis
Business Operations
Project Management
$141k - $263k/yr
Military encouraged
1,001-5,000

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See All 205+ Principal Jobs in Cambridge

Find roles in Cambridge that match your experience and apply in just a few clicks.

Find Principal Jobs

Principal Job Market in Cambridge

Who's Hiring

  • Draper45
  • Novartis36
  • RTX18
  • Biogen18
  • Forrester18

Top Industries Hiring

  • Healthcare & Medical Services

Principal Jobs in Cambridge: Frequently Asked Questions

How do I get a principal job in Cambridge?

Focus your search on Cambridge's dominant hiring sectors: universities and research institutions near Harvard Square, biotech and life sciences firms in Kendall Square, and the Cambridge Public Schools district for K-12 roles. Candidates who stand out typically combine domain expertise with demonstrated leadership at scale. Networking through MIT or Harvard alumni communities and attending local education or innovation events gives Cambridge applicants a meaningful edge over remote applicants.

Which companies hire principals in Cambridge?

Cambridge principal roles are posted by Draper, Novartis, and RTX and others right now, based on current listings on Migrate Mate as of November 2026. Cambridge's employer mix is unusually varied, ranging from world-class research universities and teaching hospitals to venture-backed biotech startups and established technology firms in Kendall Square.

Are there remote principal jobs in Cambridge?

Yes, though availability depends heavily on the type of role. Principal positions tied to school leadership or lab management are almost always on-site, while principal engineers, principal researchers, and strategy-focused principals often have more flexibility. About 67% of principal openings tied to Cambridge are remote or hybrid as of November 2026, with the highest remote share concentrated in technology and research-focused roles rather than education administration.

How can I get a principal job in Cambridge with little or no experience?

The most realistic entry path in Cambridge is through associate or senior individual contributor roles at Kendall Square tech and biotech firms, where internal promotion to principal-level is common and structured. Cambridge Public Schools and charter networks like Prospect Hill Academy also offer assistant principal pipelines for aspiring K-12 leaders. Building visibility through MIT or Harvard continuing education programs, or contributing to open research projects connected to local institutions, strengthens a candidate profile in this market.

Which industries hire the most principals in Cambridge?

Cambridge principal roles concentrate in Healthcare & Medical Services, based on current listings on Migrate Mate as of November 2026. Cambridge's density of research universities, teaching hospitals, and biotech corridors means demand for principals with deep technical or academic expertise is consistently higher here than in most other Massachusetts cities.

See All 205+ Principal Jobs in Cambridge

Find roles in Cambridge that match your experience and apply in just a few clicks.

Find Principal Jobs