Mid Level Principal Scientist Jobs
Mid level principal scientist jobs go to researchers ready to own projects end to end, guide junior colleagues, and shape experimental direction with limited oversight. Roles are a mix of on-site, remote, and hybrid across Biotechnology & Pharmaceuticals, Science & Research, and Retail, with employers like Capital One, Novartis, and Intuit hiring at this level now.
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The Position
The Opportunity
SE7
As a Principal Scientist in Small Molecule Biomarkers (Metabolomics & Lipidomics) within our Drug Metabolism and Pharmacokinetics (DMPK) team, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by developing high-throughput mass spectrometry workflows and applying modern tools—including Generative AI—to drive biological insights.
Key Responsibilities:
- Method Development: Design and apply LC-HRMS and LC-MS/MS methods to acquire high-quality mass spectrometry biomarker data supporting drug discovery and development.
- Experimental Execution: Prepare and execute global and targeted metabolomics and lipidomics protocols across diverse biological specimens, including biofluids, tissues, and cells.
- Data & AI Workflows: Perform mass spectrometry data processing and statistical analysis; build or leverage Generative AI tools and software workflows to scale analysis and reporting.
- Quality & Insight: Oversee rigorous bioanalytical quality control using common industry practices and critical analytical reasoning.
- Cross-Functional Collaboration: Partner with multidisciplinary teams and project stakeholders to translate complex omics data into actionable drug target research.
Who You Are
You are an innovative analytical scientist with a passion for cellular metabolism, mass spectrometry technology, and emerging computational tools. You thrive in collaborative, high-impact environments and want to translate cutting-edge omics data into life-changing medicines.
Qualifications & Experience:
- Education & Industry Experience: PhD in biological, chemical, pharmaceutical sciences, or a related field, accompanied by 3–5 years of direct experience in the biotechnology or pharmaceutical industry.
- Bioanalytical Expertise: Proven experience designing and executing assays for endogenous small molecule metabolites or lipids, including sample preparation techniques like precipitation, liquid-liquid, or solid-phase extraction.
- Technical Mastery: Practical experience operating and troubleshooting modern LC-MS platforms (e.g., UHPLC, triple quadrupole, high-resolution mass spectrometers) and using analytical data processing software.
- Metabolic & Computational Insight: Solid foundation in cellular metabolism, coupled with hands-on experience or strong aptitude using Generative AI tools for coding and biological insight generation.
- Collaboration & Communication: Excellent communication skills with a proven track record of working effectively in multidisciplinary project teams.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $143,200 - $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
The Position
The Opportunity
SE7
As a Principal Scientist in Small Molecule Biomarkers (Metabolomics & Lipidomics) within our Drug Metabolism and Pharmacokinetics (DMPK) team, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by developing high-throughput mass spectrometry workflows and applying modern tools—including Generative AI—to drive biological insights.
Key Responsibilities:
- Method Development: Design and apply LC-HRMS and LC-MS/MS methods to acquire high-quality mass spectrometry biomarker data supporting drug discovery and development.
- Experimental Execution: Prepare and execute global and targeted metabolomics and lipidomics protocols across diverse biological specimens, including biofluids, tissues, and cells.
- Data & AI Workflows: Perform mass spectrometry data processing and statistical analysis; build or leverage Generative AI tools and software workflows to scale analysis and reporting.
- Quality & Insight: Oversee rigorous bioanalytical quality control using common industry practices and critical analytical reasoning.
- Cross-Functional Collaboration: Partner with multidisciplinary teams and project stakeholders to translate complex omics data into actionable drug target research.
Who You Are
You are an innovative analytical scientist with a passion for cellular metabolism, mass spectrometry technology, and emerging computational tools. You thrive in collaborative, high-impact environments and want to translate cutting-edge omics data into life-changing medicines.
Qualifications & Experience:
- Education & Industry Experience: PhD in biological, chemical, pharmaceutical sciences, or a related field, accompanied by 3–5 years of direct experience in the biotechnology or pharmaceutical industry.
- Bioanalytical Expertise: Proven experience designing and executing assays for endogenous small molecule metabolites or lipids, including sample preparation techniques like precipitation, liquid-liquid, or solid-phase extraction.
- Technical Mastery: Practical experience operating and troubleshooting modern LC-MS platforms (e.g., UHPLC, triple quadrupole, high-resolution mass spectrometers) and using analytical data processing software.
- Metabolic & Computational Insight: Solid foundation in cellular metabolism, coupled with hands-on experience or strong aptitude using Generative AI tools for coding and biological insight generation.
- Collaboration & Communication: Excellent communication skills with a proven track record of working effectively in multidisciplinary project teams.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $143,200 - $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
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Mid Level Principal Scientist Jobs: Frequently Asked Questions
How do I get a mid level principal scientist job?
Position your existing work around ownership and outcomes, not just tasks. Highlight studies or projects you led independently, decisions you made without close supervision, and any mentoring or cross-functional collaboration you drove. Applications that connect your methodology skills to a measurable scientific outcome, such as a published finding or a validated model, stand out most at this level.
Which companies hire mid level principal scientists?
Companies hiring mid level principal scientists right now include Capital One, Novartis, and Intuit, based on current listings on Migrate Mate as of August 2026. Hiring at this level comes from a mix of large research-driven organizations, biotechnology and pharmaceutical firms, and technology companies building in-house science functions.
Are there remote mid level principal scientist jobs?
Yes, though availability depends on the discipline and employer. About 27% of mid level principal scientist openings are remote or hybrid as of August 2026, with fully remote roles most common in data-heavy or computational research areas and hybrid arrangements more typical for lab-based or regulated science environments.
How do I move up to a mid level principal scientist role?
Progression from entry level to mid level comes from accumulating demonstrated ownership over time. Focus on taking full responsibility for a research question or product workstream, building technical depth in your specialization, and documenting measurable impact such as publications, patents, or process improvements. Consistently mentoring peers and contributing to project design, rather than just execution, signals readiness for mid level responsibilities.
Which industries hire the most mid level principal scientists?
Mid Level principal scientist roles concentrate in Biotechnology & Pharmaceuticals, Science & Research, and Retail, based on current listings on Migrate Mate as of August 2026. These sectors drive hiring at this level because they rely on scientists who can independently advance complex research programs, translate findings into applied outcomes, and sustain continuous development pipelines.