Principal Scientist Jobs in South Carolina

Principal Scientist jobs in South Carolina are open across Greenville, Fort Mill, and Rock Hill and other South Carolina metros, with employers like Fluor, Westinghouse Electric Company, and LPL Financial hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles27+
Top employerFluor
Top cityGreenville, SC
Cities hiring12
Work type81% On-site
Top industryConstruction

Showing 5 of 27+ Principal Scientist jobs

Fluor Corp.
Principal Designer - Piping
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Fluor Corp.
Added 6d ago
Principal Designer - Piping
Fluor Corp.
Greenville, South Carolina
Specialized Engineering
Mechanical Engineering
Civil & Structural Engineering
Engineering (Non-Software)
Civil Engineering
$96k - $177k/yr
On-Site
Associate's
10,000+

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Fluor Corp.
Principal Designer
We won't show you this job again
Fluor Corp.
Added 6d ago
Principal Designer
Fluor Corp.
Greenville, South Carolina
Specialized Engineering
Mechanical Engineering
Civil & Structural Engineering
Engineering (Non-Software)
Civil Engineering
$96k - $177k/yr
On-Site
Associate's
10,000+

Have you applied for this role?

LPL Financial
AVP, Principal Software Engineer Lead – AI, APIs & Cloud
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LPL Financial
Added 1w ago
AVP, Principal Software Engineer Lead – AI, APIs & Cloud
LPL Financial
Fort Mill, South Carolina
Software Engineering
Cloud & DevOps
Technical Product & Program Management
Project & Program Management
AI (Artificial Intelligence)
Cloud Engineering
Project Management
Backend Engineering
$141k - $234k/yr
On-Site
Bachelor's
5,001-10,000

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LPL Financial
Principal Application Security Architect
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LPL Financial
Added 1w ago
Principal Application Security Architect
LPL Financial
Fort Mill, South Carolina
Cybersecurity
Cloud & DevOps
Data Science & Analytics
Security Engineering
Cloud Engineering
$153k - $256k/yr
Hybrid
Bachelor's
5,001-10,000

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Westinghouse Electric Company, LLC
Principal Welding Engineer
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Westinghouse Electric Company, LLC
Added 2w ago
Principal Welding Engineer
Westinghouse Electric Company, LLC
Rock Hill, South Carolina
Specialized Engineering
Mechanical Engineering
Industrial & Manufacturing Engineering
Engineering (Non-Software)
Manufacturing Engineering
$103k - $129k/yr
Hybrid
Bachelor's
5,001-10,000

Have you applied for this role?

See All 27 Principal Scientist Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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Principal Scientist Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Greenville
12 jobs
Fort Mill
3 jobs
Rock Hill
3 jobs
Charleston
1 jobs
Clinton
1 jobs
Columbia
1 jobs
Graniteville
1 jobs
Hopkins
1 jobs
Lexington
1 jobs

Principal Scientist Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Fluor
    Fluor9
  • Westinghouse Electric Company
    Westinghouse Electric Company4
  • LPL Financial
    LPL Financial3
  • Prisma Health
    Prisma Health2
  • CVS Health
    CVS Health1

Top Industries Hiring

  • Construction & Real Estate9
  • Energy6
  • Manufacturing6
  • Aerospace & Defense4
  • Consulting & Professional Services3

What South Carolina Employers Look For

The qualifications that appear most often in principal scientist jobs across South Carolina.

  • PhD in a relevant scientific discipline such as biology, chemistry, biochemistry, or a related field
  • Eight or more years of hands-on research experience in industry or government settings
  • Demonstrated record of first- or senior-author peer-reviewed publications and patent contributions
  • Proficiency with domain-specific tools such as molecular modeling software, analytical instrumentation, or statistical programming languages
  • Experience leading cross-functional project teams and mentoring junior scientists or postdoctoral researchers
  • Familiarity with regulatory submission processes such as IND, NDA, or equivalent documentation standards

Principal Scientist Jobs in South Carolina: Frequently Asked Questions

How many principal scientist jobs are there in South Carolina?

There are 27+ principal scientist openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Greenville, Fort Mill, and Rock Hill. New positions post regularly as employers across South Carolina hire.

Which South Carolina cities have the most principal scientist jobs?

Greenville, Fort Mill, and Rock Hill have the most principal scientist openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire principal scientists in South Carolina?

Employers hiring principal scientists in South Carolina include Fluor, Westinghouse Electric Company, and LPL Financial, based on current listings on Migrate Mate as of June 2026.

Are there remote principal scientist jobs in South Carolina?

Yes. About 19% of principal scientist openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for principal scientist jobs in South Carolina?

You can apply to principal scientist jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 27 Principal Scientist Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Principal Scientist Jobs