Principal Scientist Jobs in South Carolina
Principal Scientist jobs in South Carolina are open across Greenville, Fort Mill, and Rock Hill and other South Carolina metros, with employers like Fluor, Westinghouse Electric Company, and LPL Financial hiring at every experience level. Find a role that fits below and apply directly.
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At Fluor, we are proud to design and build projects and careers. We are committed to fostering a welcoming and collaborative work environment that encourages big-picture thinking, brings out the best in our employees, and helps us develop innovative solutions that contribute to building a better world together. If this sounds like a culture you would like to work in, you’re invited to apply for this role.
Fluor is a leading government contractor with a proven track record of delivering high-value technical solutions around the world to U.S. government agencies such as the DOE, NNSA, the Department of Defense and the Intelligence Community.
Job Description
Operating under detailed instructions and review the purpose of this position is to provide the essential technical knowledge and perform the work listed. This role has the responsibility to promote Fluor's competitiveness within the global marketplace by delivering quality services of unmatched value and technical competence. The purpose of this position is to work on design and perform 3D layout of complex scope and may serve as Design Area Lead.
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Conduct review of model using 3D review platform and create 3D models of moderate to advanced complexity
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Apply project drawing standards to design drawings and 3D layout
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Prepare 2D Computer Aided Design (CAD) drawings of advanced complexity
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Review drawings and vendor equipment documentation of advanced complexity within the discipline and from other disciplines for compliance with project requirements, and actively seek discrepancy resolution
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Perform bulk material take-off analysis and tabulations
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Adhere to industry codes and standards as well as department practices and procedures
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Other duties as assigned
Basic Job Requirements
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Accredited two (2) year degree or global equivalent in technical field of study, or; A combination of education and directly related experience equal to fifteen (15) years*; some locations may have additional or different qualifications in order to comply with local requirements
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Ability to communicate effectively with audiences that include but are not limited to management, coworkers, clients, vendors, contractors, and visitors
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Job related technical knowledge necessary to complete the job
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Ability to learn and apply knowledge of applicable local, state/province, and federal/national statutes and guidelines
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Ability to attend to detail and work in a time-conscious and time-effective manner
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Knowledge of commercial availability and cost of materials
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Practical field experience
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Intermediate computer and software skills to include the use of word processing, e-mail, spreadsheet and electronic presentation programs
Other Job Requirements
Preferred Qualifications
- Must be able to provide proof of U.S. citizenship.
We are an equal opportunity employer. All qualified individuals will receive consideration for employment without regard to race, color, age, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, genetic information, or any other criteria protected by governing law.
Benefits Statement: Fluor is proud to offer a comprehensive benefits package designed to promote employee health, wellness, and financial security. Our offerings include medical, dental and vision plans, EAP, disability coverage, life insurance, AD&D, voluntary benefit plans, 401(k) with a company match, paid time off (personal, bereavement, sick, holidays) for salaried employees, paid sick leave per state requirement for craft employees, parental leave, and training and development courses.
Market Rate Statement: The market rate for the role is typically at the mid-point of the salary range; however, variations in final salary are determined by additional factors such as the candidate’s qualifications, relevant years of experience, geographic location, internal pay equity, and prevailing market conditions for the specific role.
Notice to Candidates: Background checks are carried out as part of any conditional offer made, including (but not limited to & role dependent) education, professional registration, employment, references, passport verifications and Global Watchlist screening.
To be Considered Candidates: Must be authorized to work in the country where the position is located.
Salary Range: $95,500.00 - $176,500.00
See All 27 Principal Scientist Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Principal Scientist JobsPrincipal Scientist Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Principal Scientist Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Fluor9

- Westinghouse Electric Company4

- LPL Financial3

- Prisma Health2

- CVS Health1

Top Industries Hiring
- Construction & Real Estate9
- Energy6
- Manufacturing6
- Aerospace & Defense4
- Consulting & Professional Services3
What South Carolina Employers Look For
The qualifications that appear most often in principal scientist jobs across South Carolina.
- PhD in a relevant scientific discipline such as biology, chemistry, biochemistry, or a related field
- Eight or more years of hands-on research experience in industry or government settings
- Demonstrated record of first- or senior-author peer-reviewed publications and patent contributions
- Proficiency with domain-specific tools such as molecular modeling software, analytical instrumentation, or statistical programming languages
- Experience leading cross-functional project teams and mentoring junior scientists or postdoctoral researchers
- Familiarity with regulatory submission processes such as IND, NDA, or equivalent documentation standards
Principal Scientist Jobs in South Carolina: Frequently Asked Questions
How many principal scientist jobs are there in South Carolina?
There are 27+ principal scientist openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Greenville, Fort Mill, and Rock Hill. New positions post regularly as employers across South Carolina hire.
Which South Carolina cities have the most principal scientist jobs?
Greenville, Fort Mill, and Rock Hill have the most principal scientist openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire principal scientists in South Carolina?
Employers hiring principal scientists in South Carolina include Fluor, Westinghouse Electric Company, and LPL Financial, based on current listings on Migrate Mate as of June 2026.
Are there remote principal scientist jobs in South Carolina?
Yes. About 19% of principal scientist openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for principal scientist jobs in South Carolina?
You can apply to principal scientist jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 27 Principal Scientist Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Principal Scientist Jobs